Stress and hemostasis: An update

Seminars in Thrombosis and Hemostasis

Volumn 39, Issue 8, 2013, Pages 902-912

  Austin, Anthony W ^a,b   Wissmann, Thomas ^c   Von Kanel, Roland ^c,d,e  

^a HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^b Gina Cody School of Engineering and Computer Science   (Canada)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

^e BERN UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

blood coagulation; fibrinolysis; platelets; psychological stress; risk factor

Indexed keywords

ACETYLSALICYLIC ACID; BENIDIPINE; BLOOD CLOTTING FACTOR 12; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8; C REACTIVE PROTEIN; CITALOPRAM; D DIMER; FIBRINOGEN; GEMFIBROZIL; HYDROCORTISONE; INTERLEUKIN 6; MELATONIN; PADGEM PROTEIN; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROPRANOLOL; RAMIPRIL; SERTRALINE; SIMVASTATIN; THROMBIN ANTITHROMBIN COMPLEX; TISSUE PLASMINOGEN ACTIVATOR; VERAPAMIL; VON WILLEBRAND FACTOR;

ACUTE CORONARY SYNDROME; ACUTE STRESS; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CAREGIVER BURDEN; CHRONIC STRESS; COGNITIVE BEHAVIORAL STRESS MANAGEMENT; DISTRESS SYNDROME; ESSENTIAL HYPERTENSION; HEALTH HAZARD; HEART RATE VARIABILITY; HEMOCONCENTRATION; HEMODYNAMIC STRESS; HEMOSTASIS; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; HYPERCOAGULABILITY; INTERNATIONAL NORMALIZED RATIO; ISCHEMIC HEART DISEASE; JOB STRESS; LEUKOCYTE AGGREGATION; MENTAL STRESS; MORBIDITY; NEUROTRANSMISSION; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PLATELET REACTIVITY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTHROMBIN TIME; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SINGLE DRUG DOSE; SOCIAL PSYCHOLOGY; SOCIAL STATUS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ADAPTATION, PSYCHOLOGICAL; BLOOD COAGULATION FACTORS; CARDIOVASCULAR AGENTS; HEMOSTASIS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MODELS, BIOLOGICAL; PITUITARY-ADRENAL SYSTEM; STRESS, PSYCHOLOGICAL; THROMBOSIS;

EID: 84887098963     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0033-1357487     Document Type: Article

References (124)

1. Thrall G., Lane D., Carroll D., Lip G. Y. A systematic review of the effects of acute psychological stress and physical activity on haemorheology, coagulation, fibrinolysis and platelet reactivity: Implications for the pathogenesis of acute coronary syndromes. Thromb Res: 2007; 120 6 819 847
2. Borissoff J. I., Spronk H. M., ten Cate H. The hemostatic system as a modulator of atherosclerosis. N Engl J Med: 2011; 364 18 1746 1760
3. Lippi G., Franchini M., Favaloro E. J. Unsuspected triggers of venous thromboembolism-trivial or not so trivial? Semin Thromb Hemost: 2009; 35 7 597 604
4. von Känel R., Mills P. J., Fainman C., Dimsdale J. E. Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease? Psychosom Med: 2001; 63 4 531 544
5. von Känel R., Bacon S. L. Hemostasis and endothelial function. In: Waldstein S. R., Kop W. J., Katzel L. I., eds. Cardiovascular Behavioral Medicine. New York, NY Springer: 2013
6. Strike P. C., Magid K., Whitehead D. L., Brydon L., Bhattacharyya M. R., Steptoe A. Pathophysiological processes underlying emotional triggering of acute cardiac events. Proc Natl Acad Sci U S A: 2006; 103 11 4322 4327
7. Austin A. W., Patterson S. M., von Känel R. Hemoconcentration and hemostasis during acute stress: interacting and independent effects. Ann Behav Med: 2011; 42 2 153 173
8. Steptoe A., Kivimäki M. Stress and cardiovascular disease: an update on current knowledge. Annu Rev Public Health: 2013; 34 337 354
9. von Känel R. Psychosocial stress and cardiovascular risk: current opinion. Swiss Med Wkly: 2012; 142 0
10. Yusuf S., Hawken S., Ounpuu S., et al. INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet: 2004; 364 9438 937 952
11. Rosengren A., Fredén M., Hansson P. O., Wilhelmsen L., Wedel H., Eriksson H. Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men. J Thromb Haemost: 2008; 6 4 558 564
12. Holst A. G., Jensen G., Prescott E. Risk factors for venous thromboembolism: results from the Copenhagen City Heart Study. Circulation: 2010; 121 17 1896 1903
13. Enga K. F., Brækkan S. K., Hansen-Krone I. J., Hansen J. B. Emotional states and future risk of venous thromboembolism: the Tromso Study. Thromb Haemost: 2012; 107 3 485 493
14. Watanabe H., Kodama M., Tanabe N., et al. Impact of earthquakes on risk for pulmonary embolism. Int J Cardiol: 2008; 129 1 152 154
15. Schobersberger W., Schobersberger B., Mittermayr M., Fries D., Streif W. Air travel, hypobaric hypoxia, and prothrombotic changes. JAMA: 2006; 296 19 2313 2314, author reply 2314-2315
16. Goldhaber S. Z. Risk factors for venous thromboembolism. J Am Coll Cardiol: 2010; 56 1 1 7
17. Lee K. W., Lip G. Y. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: a systematic review. Arch Intern Med: 2003; 163 19 2368 2392
18. Brydon L., Magid K., Steptoe A. Platelets, coronary heart disease, and stress. Brain Behav Immun: 2006; 20 2 113 119
19. Hjemdahl P., von Känel R. Haemostatic effects of stress. In: Hjemdahl P., Rosengren A., Steptoe A., eds. Stress and Cardiovascular Disease. London, England Springer: 2012; 89 110
20. Koolhaas J. M., Bartolomucci A., Buwalda B., et al. Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev: 2011; 35 5 1291 1301
21. Lazarus R. S., Folkman S. Stress, Appraisal, and Coping. New York, NY Springer: 1984
22. Wirtz P. H., Ehlert U., Emini L., et al. Anticipatory cognitive stress appraisal and the acute procoagulant stress response in men. Psychosom Med: 2006; 68 6 851 858
23. Gianaros P. J., Sheu L. K. A review of neuroimaging studies of stressor-evoked blood pressure reactivity: emerging evidence for a brain-body pathway to coronary heart disease risk. Neuroimage: 2009; 47 3 922 936
24. Gunn C. G., Hampton J. W. CNS influence on plasma levels of factor 8 activity. Am J Physiol: 1967; 212 1 124 130
25. Shimbo D., Child J., Davidson K., et al. Exaggerated serotonin-mediated platelet reactivity as a possible link in depression and acute coronary syndromes. Am J Cardiol: 2002; 89 3 331 333
26. Zafar M. U., Paz-Yepes M., Shimbo D., et al. Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression. Eur Heart J: 2010; 31 13 1573 1582
27. Lesch K. P., Wolozin B. L., Murphy D. L., Reiderer P. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem: 1993; 60 6 2319 2322
28. Becker R. C. Editor's page: fundamentals in neurocardiology: the brain-platelet-coronary artery interface. J Thromb Thrombolysis: 2008; 26 1 74 77
29. von Känel R., Mills P. J., Ziegler M. G., Dimsdale J. E. Effect of beta2-adrenergic receptor functioning and increased norepinephrine on the hypercoagulable state with mental stress. Am Heart J: 2002; 144 1 68 72
30. von Känel R., Preckel D., Zgraggen L., et al. The effect of natural habituation on coagulation responses to acute mental stress and recovery in men. Thromb Haemost: 2004; 92 6 1327 1335
31. Austin A. W., Wirtz P. H., Patterson S. M., Stutz M., von Känel R. Stress-induced alterations in coagulation: assessment of a new hemoconcentration correction technique. Psychosom Med: 2012; 74 3 288 295
32. Strike P. C., Magid K., Brydon L., Edwards S., McEwan J. R., Steptoe A. Exaggerated platelet and hemodynamic reactivity to mental stress in men with coronary artery disease. Psychosom Med: 2004; 66 4 492 500
33. Wirtz P. H., Redwine L. S., Baertschi C., Spillmann M., Ehlert U., von Känel R. Coagulation activity before and after acute psychosocial stress increases with age. Psychosom Med: 2008; 70 4 476 481
34. Jern C., Eriksson E., Tengborn L., Risberg B., Wadenvik H., Jern S. Changes of plasma coagulation and fibrinolysis in response to mental stress. Thromb Haemost: 1989; 62 2 767 771
35. Jern C., Manhem K., Eriksson E., Tengborn L., Risberg B., Jern S. Hemostatic responses to mental stress during the menstrual cycle. Thromb Haemost: 1991; 66 5 614 618
36. Steptoe A., Kunz-Ebrecht S., Owen N., et al. Socioeconomic status and stress-related biological responses over the working day. Psychosom Med: 2003; 65 3 461 470
37. Wallén N. H., Held C., Rehnqvist N., Hjemdahl P. Effects of mental and physical stress on platelet function in patients with stable angina pectoris and healthy controls. Eur Heart J: 1997; 18 5 807 815
38. von Känel R., Dimsdale J. E., Ziegler M. G., et al. Effect of acute psychological stress on the hypercoagulable state in subjects (spousal caregivers of patients with Alzheimer's disease) with coronary or cerebrovascular disease and/or systemic hypertension. Am J Cardiol: 2001; 87 12 1405 1408
39. Canevari A., Tacconi F., Zucchella M., Pacchiarini L., Soffiantino F., Grignani G. Antithrombin III biological activity and emotional stress in patients with coronary artery disease. Haematologica: 1992; 77 2 180 182
40. Palermo A., Bertalero P., Pizza N., Amelotti R., Libretti A. Decreased fibrinolytic response to adrenergic stimulation in hypertensive patients. J Hypertens Suppl: 1989; 7 6 S162 S163
41. Hamer M., Williams E., Vuonovirta R., Giacobazzi P., Gibson E. L., Steptoe A. The effects of effort-reward imbalance on inflammatory and cardiovascular responses to mental stress. Psychosom Med: 2006; 68 3 408 413
42. von Känel R., Dimsdale J. E., Patterson T. L., Grant I. Acute procoagulant stress response as a dynamic measure of allostatic load in Alzheimer caregivers. Ann Behav Med: 2003; 26 1 42 48
43. Aschbacher K., Mills P. J., von Känel R., et al. Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers. Brain Behav Immun: 2008; 22 4 493 502
44. Steptoe A., Wardle J., Marmot M. Positive affect and health-related neuroendocrine, cardiovascular, and inflammatory processes. Proc Natl Acad Sci U S A: 2005; 102 18 6508 6512
45. Steptoe A., Gibson E. L., Vuononvirta R., et al. The effects of tea on psychophysiological stress responsivity and post-stress recovery: a randomised double-blind trial. Psychopharmacology (Berl): 2007; 190 1 81 89
46. Preckel D., von Känel R. Regulation of hemostasis by the sympathetic nervous system: any contribution to coronary artery disease? HeartDrug: 2004; 4 3 123 130
47. von Känel R., Dimsdale J. E. Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Haematol: 2000; 65 6 357 369
48. Hao Z., Jiang X., Sharafeih R., et al. Stimulated release of tissue plasminogen activator from artery wall sympathetic nerves: implications for stress-associated wall damage. Stress: 2005; 8 2 141 149
49. Zgraggen L., Fischer J. E., Mischler K., Preckel D., Kudielka B. M., von Känel R. Relationship between hemoconcentration and blood coagulation responses to acute mental stress. Thromb Res: 2005; 115 3 175 183
50. von Känel R., Dimsdale J. E., Adler K. A., Dillon E., Perez C. J., Mills P. J. Effects of nonspecific beta-adrenergic stimulation and blockade on blood coagulation in hypertension. J Appl Physiol: 2003; 94 4 1455 1459
51. Kjeldsen S. E., Rostrup M., Gjesdal K., Eide I. The epinephrine-blood platelet connection with special reference to essential hypertension. Am Heart J: 1991; 122 1 Pt 2 330 336
52. Bacon S. L., Ring C., Lip G. Y., Carroll D. Increases in lipids and immune cells in response to exercise and mental stress in patients with suspected coronary artery disease: effects of adjustment for shifts in plasma volume. Biol Psychol: 2004; 65 3 237 250
53. Fall L., Bailey D. M. Interpretive limitations associated with plasma volume shifts in the clinical assessment of hemostasis. Psychosom Med: 2013; 75 2 222 223
54. Muldoon M. F. Challenges in controlling for the effects of hematoconcentration. Psychosom Med: 2013; 75 2 223
55. Austin A. W., Wirtz P. H., Patterson S. M., Stutz M., von Känel R. Reply to letters from Fall and Bailey, and Muldoon. Psychosom Med: 2013; 75 2 223 226
56. von Känel R., Kudielka B. M., Haeberli A., Stutz M., Fischer J. E., Patterson S. M. Prothrombotic changes with acute psychological stress: combined effect of hemoconcentration and genuine coagulation activation. Thromb Res: 2009; 123 4 622 630
57. Steptoe A., Brydon L. Emotional triggering of cardiac events. Neurosci Biobehav Rev: 2009; 33 2 63 70
58. von Känel R., Kudielka B. M., Hanebuth D., Preckel D., Fischer J. E. Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation. Clin Sci (Lond): 2005; 109 1 61 67
59. Kopp M. S., Skrabski A., Székely A., Stauder A., Williams R. Chronic stress and social changes: socioeconomic determination of chronic stress. Ann N Y Acad Sci: 2007; 1113 325 338
60. Kaptoge S., White I. R., Thompson S. G., et al. Fibrinogen Studies Collaboration. Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration. Am J Epidemiol: 2007; 166 8 867 879
61. Theorell T., Karasek R. A. Current issues relating to psychosocial job strain and cardiovascular disease research. J Occup Health Psychol: 1996; 1 1 9 26
62. Siegrist J. Adverse health effects of high-effort/low-reward conditions. J Occup Health Psychol: 1996; 1 1 27 41
63. Frimerman A., Miller H. I., Laniado S., Keren G. Changes in hemostatic function at times of cyclic variation in occupational stress. Am J Cardiol: 1997; 79 1 72 75
64. Chang S. J., Koh S. B., Cha B. S., Park J. K. Job characteristics and blood coagulation factors in Korean male workers. J Occup Environ Med: 2002; 44 11 997 1002
65. Hansen A. M., Larsen A. D., Rugulies R., Garde A. H., Knudsen L. E. A review of the effect of the psychosocial working environment on physiological changes in blood and urine. Basic Clin Pharmacol Toxicol: 2009; 105 2 73 83
66. von Känel R., Dimsdale J. E., Mills P. J., et al. Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimer. J Gerontol A Biol Sci Med Sci: 2006; 61 9 963 969
67. von Känel R., Dimsdale J. E., Ancoli-Israel S., et al. Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer's disease. J Am Geriatr Soc: 2006; 54 3 431 437
68. Mausbach B. T., Ancoli-Israel S., von Känel R., et al. Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer disease. Sleep: 2006; 29 10 1347 1352
69. von Känel R., Mausbach B. T., Dimsdale J. E., et al. Problem behavior of dementia patients predicts low-grade hypercoagulability in spousal caregivers. J Gerontol A Biol Sci Med Sci: 2010; 65 9 1004 1011
70. Mausbach B. T., Aschbacher K., Patterson T. L., et al. Effects of placement and bereavement on psychological well-being and cardiovascular risk in Alzheimer's caregivers: a longitudinal analysis. J Psychosom Res: 2007; 62 4 439 445
71. von Känel R., Hepp U., Traber R., et al. Measures of endothelial dysfunction in plasma of patients with posttraumatic stress disorder. Psychiatry Res: 2008; 158 3 363 373
72. von Känel R., Hepp U., Buddeberg C., et al. Altered blood coagulation in patients with posttraumatic stress disorder. Psychosom Med: 2006; 68 4 598 604
73. Robicsek O., Makhoul B., Klein E., Brenner B., Sarig G. Hypercoagulation in chronic post-traumatic stress disorder. Isr Med Assoc J: 2011; 13 9 548 552
74. von Känel R., Abbas C. C., Schmid J. P., et al. Momentary stress moderates procoagulant reactivity to a trauma-specific interview in patients with posttraumatic stress disorder caused by myocardial infarction. J Psychiatr Res: 2010; 44 14 956 963
75. Vidović A., Vilibić M., Markotić A., et al. Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patients with posttraumatic stress disorder: a pilot study. Psychiatry Res: 2007; 150 2 211 216
76. Vidović A., Grubišić-Ilić M., Kozarić-Kovačić D., et al. Exaggerated platelet reactivity to physiological agonists in war veterans with posttraumatic stress disorder. Psychoneuroendocrinology: 2011; 36 2 161 172
77. von Känel R., Abbas C. C., Begré S., Saner H., Gander M. L., Schmid J. P. Posttraumatic stress disorder and soluble cellular adhesion molecules at rest and in response to a trauma-specific interview in patients after myocardial infarction. Psychiatry Res: 2010; 179 3 312 317
78. von Känel R. Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: how strong is the evidence? Acta Psychiatr Scand: 2004; 110 3 163 177
79. Serebruany V. L., Glassman A. H., Malinin A. I., et al. Enhanced platelet/endothelial activation in depressed patients with acute coronary syndromes: evidence from recent clinical trials. Blood Coagul Fibrinolysis: 2003; 14 6 563 567
80. Matthews K. A., Schott L. L., Bromberger J., Cyranowski J., Everson-Rose S. A., Sowers M. F. Associations between depressive symptoms and inflammatory/hemostatic markers in women during the menopausal transition. Psychosom Med: 2007; 69 2 124 130
81. Von Känel R., Bellingrath S., Kudielka B. M. Association between longitudinal changes in depressive symptoms and plasma fibrinogen levels in school teachers. Psychophysiology: 2009; 46 3 473 480
82. Goldman-Mellor S., Brydon L., Steptoe A. Psychological distress and circulating inflammatory markers in healthy young adults. Psychol Med: 2010; 40 12 2079 2087
83. Lahlou-Laforet K., Alhenc-Gelas M., Pornin M., et al. Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease. Am J Cardiol: 2006; 97 9 1287 1291
84. Lukas P. S., Neugebauer A., Schnyder S., et al. Depressive symptoms, perceived social support, and prothrombotic measures in patients with venous thromboembolism. Thromb Res: 2012; 130 3 374 380
85. Von Känel R., Vökt F., Biasiutti F. D., Stauber S., Wuillemin W. A., Lukas P. S. Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy. J Thromb Haemost: 2012; 10 8 1547 1555
86. Black P. H., Garbutt L. D. Stress, inflammation and cardiovascular disease. J Psychosom Res: 2002; 52 1 1 23
87. Hawk T. L., Havrda D. E. Effect of stress on international normalized ratio during warfarin therapy. Ann Pharmacother: 2002; 36 4 617 620
88. Geiser F., Meier C., Wegener I., et al. Association between anxiety and factors of coagulation and fibrinolysis. Psychother Psychosom: 2008; 77 6 377 383
89. Geiser F., Conrad R., Imbierowicz K., et al. Coagulation activation and fibrinolysis impairment are reduced in patients with anxiety and depression when medicated with serotonergic antidepressants. Psychiatry Clin Neurosci: 2011; 65 5 518 525
90. von Känel R., Kudielka B. M., Schulze R., Gander M. L., Fischer J. E. Hypercoagulability in working men and women with high levels of panic-like anxiety. Psychother Psychosom: 2004; 73 6 353 360
91. Pitsavos C., Panagiotakos D. B., Papageorgiou C., Tsetsekou E., Soldatos C., Stefanadis C. Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA study. Atherosclerosis: 2006; 185 2 320 326
92. Buckley T., Morel-Kopp M. C., Ward C., et al. Inflammatory and thrombotic changes in early bereavement: a prospective evaluation. Eur J Prev Cardiol: 2012; 19 5 1145 1152
93. Kudielka B. M., Bellingrath S., von Känel R. Circulating fibrinogen but not D-dimer level is associated with vital exhaustion in school teachers. Stress: 2008; 11 4 250 258
94. Kop W. J., Hamulyák K., Pernot C., Appels A. Relationship of blood coagulation and fibrinolysis to vital exhaustion. Psychosom Med: 1998; 60 3 352 358
95. Roy B., Diez-Roux A. V., Seeman T., Ranjit N., Shea S., Cushman M. Association of optimism and pessimism with inflammation and hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA). Psychosom Med: 2010; 72 2 134 140
96. Jain S., Mills P. J., von Känel R., Hong S., Dimsdale J. E. Effects of perceived stress and uplifts on inflammation and coagulability. Psychophysiology: 2007; 44 1 154 160
97. Steptoe A., Demakakos P., de Oliveira C., Wardle J. Distinctive biological correlates of positive psychological well-being in older men and women. Psychosom Med: 2012; 74 5 501 508
98. von Känel R., Kudielka B. M., Abd-el-Razik A., Gander M. L., Frey K., Fischer J. E. Relationship between overnight neuroendocrine activity and morning haemostasis in working men. Clin Sci (Lond): 2004; 107 1 89 95
99. von Känel R., Mausbach B. T., Kudielka B. M., Orth-Gomér K. Relation of morning serum cortisol to prothrombotic activity in women with stable coronary artery disease. J Thromb Thrombolysis: 2008; 25 2 165 172
100. Lippi G., Franchini M., Salvagno G. L., Montagnana M., Guidi G. C. Higher morning serum cortisol level predicts increased fibrinogen but not shortened APTT. J Thromb Thrombolysis: 2008; 26 2 103 105
101. von Känel R., Nelesen R. A., Ziegler M. G., Mausbach B. T., Mills P. J., Dimsdale J. E. Relation of autonomic activity to plasminogen activator inhibitor-1 plasma concentration and the role of body mass index. Blood Coagul Fibrinolysis: 2007; 18 4 353 359
102. von Känel R., Orth-Gomér K. Autonomic function and prothrombotic activity in women after an acute coronary event. J Womens Health (Larchmt): 2008; 17 8 1331 1337
103. Isingrini E., Belzung C., d'Audiffret A., Camus V. Early and late-onset effect of chronic stress on vascular function in mice: a possible model of the impact of depression on vascular disease in aging. Am J Geriatr Psychiatry: 2011; 19 4 335 346
104. Yamamoto K., Takeshita K., Shimokawa T., et al. Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals. Proc Natl Acad Sci U S A: 2002; 99 2 890 895
105. Venugopal B., Sharon R., Abramovitz R., Khasin A., Miskin R. Plasminogen activator inhibitor-1 in cardiovascular cells: rapid induction after injecting mice with kainate or adrenergic agents. Cardiovasc Res: 2001; 49 2 476 483
106. von Känel R., Thayer J. F., Fischer J. E. Nighttime vagal cardiac control and plasma fibrinogen levels in a population of working men and women. Ann Noninvasive Electrocardiol: 2009; 14 2 176 184
107. Hänsel A., Hong S., Cámara R. J., von Känel R. Inflammation as a psychophysiological biomarker in chronic psychosocial stress. Neurosci Biobehav Rev: 2010; 35 1 115 121
108. von Känel R., Nelesen R. A., Mills P. J., Ziegler M. G., Dimsdale J. E. Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects. Brain Behav Immun: 2008; 22 4 461 468
109. von Känel R., Kudielka B. M., Helfricht S., et al. The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects. J Cardiovasc Pharmacol: 2008; 51 3 231 238
110. von Känel R., Kudielka B. M., Helfricht S., et al. Effects of aspirin and propranolol on the acute psychological stress response in factor VIII coagulant activity: a randomized, double-blind, placebo-controlled experimental study. Blood Coagul Fibrinolysis: 2008; 19 1 75 81
111. Tomoda F., Takata M., Kagitani S., et al. Effects of a novel calcium antagonist, benidipine hydrochloride, on platelet responsiveness to mental stress in patients with essential hypertension. J Cardiovasc Pharmacol: 1999; 34 2 248 253
112. Gebara O. C., Jimenez A. H., McKenna C., et al. Stress-induced hemodynamic and hemostatic changes in patients with systemic hypertension: effect of verapamil. Clin Cardiol: 1996; 19 3 205 211
113. Wirtz P. H., Bärtschi C., Spillmann M., Ehlert U., von Känel R. Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: a randomized placebo-controlled study. J Pineal Res: 2008; 44 4 358 365
114. Ekholm M., Wallén N. H., Johnsson H., Eliasson K., Kahan T. Long-term angiotensin-converting enzyme inhibition with ramipril reduces thrombin generation in human hypertension. Clin Sci (Lond): 2002; 103 2 151 155
115. Bröijersén A., Eriksson M., Leijd B., Angelin B., Hjemdahl P. No influence of simvastatin treatment on platelet function in vivo in patients with hypercholesterolemia. Arterioscler Thromb Vasc Biol: 1997; 17 2 273 278
116. Bröijersén A., Eriksson M., Angelin B., Hjemdahl P. Gemfibrozil enhances platelet activity in patients with combined hyperlipoproteinemia. Arterioscler Thromb Vasc Biol: 1995; 15 1 121 127
117. Serebruany V. L., Glassman A. H., Malinin A. I., et al. Sertraline AntiDepressant Heart Attack Randomized Trial Study Group. Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. Circulation: 2003; 108 8 939 944
118. van Zyl L. T., Lespérance F., Frasure-Smith N., et al. Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) biomarker sub-study. J Thromb Thrombolysis: 2009; 27 1 48 56
119. Morel-Kopp M. C., McLean L., Chen Q., et al. The association of depression with platelet activation: evidence for a treatment effect. J Thromb Haemost: 2009; 7 4 573 581
120. Geiser F., Gessler K., Conrad R., Imbierowicz K., Albus C., Harbrecht U. Can activation of coagulation and impairment of fibrinolysis in patients with anxiety and depression be reversed after improvement of psychiatric symptoms? Results of a pilot study. J Nerv Ment Dis: 2012; 200 8 721 723
121. Claesson M., Birgander L. S., Jansson J. H., et al. Cognitive-behavioural stress management does not improve biological cardiovascular risk indicators in women with ischaemic heart disease: a randomized-controlled trial. J Intern Med: 2006; 260 4 320 331
122. Vlachopoulos C., Xaplanteris P., Alexopoulos N., et al. Divergent effects of laughter and mental stress on arterial stiffness and central hemodynamics. Psychosom Med: 2009; 71 4 446 453
123. Blombäck M., Konkle B. A., Manco-Johnson M. J., Bremme K., Hellgren M., Kaaja R.; ISTH SSC Subcommittee on Women's Health Issues. Preanalytical conditions that affect coagulation testing, including hormonal status and therapy. J Thromb Haemost: 2007; 5 4 855 858
124. Tofler G. H., Muller J. E. Triggering of acute cardiovascular disease and potential preventive strategies. Circulation: 2006; 114 17 1863 1872