Effects of a novel calcium antagonist, benidipine hydrochloride, on platelet responsiveness to mental stress in patients with essential hypertension

Journal of Cardiovascular Pharmacology

Volumn 34, Issue 2, 1999, Pages 248-253

  Tomoda, Fumihiro ^a   Takata, Masanobu ^a   Kagitani, Satoshi ^a   Kinuno, Hiroyuki ^a   Yasumoto, Kotaro ^a   Tomita, Shin ^a   Inoue, Hiroshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Calcium antagonist; Essential hypertension; Mental stress; Platelet function

Indexed keywords

ADENOSINE DIPHOSPHATE; BENIDIPINE; BETA THROMBOGLOBULIN; CALCIUM ANTAGONIST;

ADULT; AGED; ARTICLE; CALCIUM ANTAGONISM; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MENTAL STRESS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THROMBOCYTE AGGREGATION;

ADULT; AGED; BETA-THROMBOGLOBULIN; BLOOD PLATELETS; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; STRESS, PSYCHOLOGICAL;

EID: 0032778918     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199908000-00010     Document Type: Article

References (45)

1. Kjeldsen SE, Gjesdal K, Eide I, et al. Increased β-thromboglobulin in essential hypertension: interactions between arterial plasma adrenaline, platelet function and blood lipids. Acta Med Scand 1983;213:369-73.
2. Erne P, Bolli P, Burgisser E, Buhler FR. Correlation of platelet calcium with blood pressure: effect of antihypertensive therapy. N Engl J Med 1984;310:1084-8.
3. Oh-hashi S, Takata M, Ueno H, et al. Cytosolic free calcium concentration in platelets in patients with renovascular hypertension and primary aldosteronism. J Hum Hypertens 1992;6:71-4.
4. Nyrop M, Zweifler AJ. Platelet aggregation in hypertension and the effects of antihypertensive treatment. J Hypertens 1988;6: 263-9.
5. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-9.
6. Hjemdahl P, Larsson PT, Wallén NH. Effects of stress and β-blockade on platelet function. Circulation 1991;84(suppl VI): VI-44-61.
7. Folkow B. Physiological aspects of primary hypertension. Physiol Rev 1982;62:347-504.
8. Hansson L, Zanchetti A, Carruthers SG, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998;351:1755-62.
9. Hjemdahl P, Wallén NH. Calcium antagonist treatment, sympathetic activity and platelet function. Eur Heart J 1977;18(suppl A):A36-50.
10. Gebara OCE, Jimenez AH, McKenna C, et al. Stress-induced hemodynamic and hemostatic changes in patients with systemic hypertension: effect of verapamil. Clin Cardiol 1996;19:205-11.
11. Sinzinger H, Virgolini I, Rauscha F, Fitscha P, O'Grady J. Isradipine improves platelet function in hypertensives. Eur J Clin Pharmacol 1992;42:43-6.
12. Levine SP, Towell BL, Suarez AM, Knieriem LK, Harris MM, George JN. Platelet activation and secretion associated with emotional stress. Circulation 1985;71:1129-34.
13. Larsson PT, Hjemdahl P, Olsson G, Egberg N, Hornstra G. Altered platelet function during mental stress and adrenaline infusions in humans: evidence for an increased aggregability in vivo as measured by filtragometry. Clin Sci 1989;76:369-76.
14. Wallén NH, Held C, Rehnqvist N, Hjemdahl P. Platelet aggregability in vivo is attenuated by verapamil but not by metoprolol in patients with stable angina pectoris. Am J Cardiol 1995;75:1-6.
15. Matsukawa T, Gotoh E, Uneda S, et al. Augmented sympathetic nerve activity in response to stressors in young hypertensive men. Acta Physiol Scand 1991;141:157-65.
16. Baba S, Ozawa H, Nakamoto Y, Ueshima H, Omae T. Enhanced blood pressure response to regular daily stress in urban hypertensive men. J Hypertens 1990;8:647-55.
17. Julius S. Sympathetic hyperactivity and coronary risk in hypertension. Hypertension 1993;21:886-93.
18. Tofler GH, Brezinski DD, Schafer AI, et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med 1987;316:1514-8.
19. Half JI, Fani K. Stress and the induction of intravascular platelet aggregation in the heart. Circulation 1973;48:164-9.
20. Jovicic A, Mandic S. Circadian variations of platelet aggregability and fibrinolytic activity in healthy subjects. Thromb Res 1991;62: 65-74.
21. Karasawa A, Kubo K, Oka T, Nakamizo N. Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonists in conscious spontaneously hypertensive rats. Arzneimittelforschung 1988;38:1691-4.
22. Karasawa A, Kubo K. Calcium antagonistic effects and the in vitro duration of actions of KW-3049: a new 1,4-dihydropyridine derivative, in isolated canine coronary arteries. Jpn J Pharmacol 1988;47:35-44.
23. Kitahara Y, Imataka K, Nakaoka H, Ishibashi M, Yamaji T, Fujii J. Hematocrit increase by mental stress in hypertensive patients. Jpn Heart J 1988;29:429-35.
24. Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962;194:927-9.
25. Mori K. Automated measurement of catecholamines in urine, plasma and tissue homogenates by high-performance liquid chromatography with fluorometric detection. J Chromatogr 1981;218: 631-7.
26. Haber E, Koerner T, Page LB, et al. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab 1969;29:1349-55.
27. Ogihara T, Iinuma K, Nishi K, et al. A non-chromatographic non-extraction radioimmunoassay for serum aldosterone. J Clin Endocrinol Metab 1977;45:726-31.
28. Ludlam CA, Moore S, Bolton AE, Pepper DS, Cash JD. The release of human platelet-specific protein measured by a radioimmunoassay. Thromb Res 1975;6:543-8.
29. Dale J, Landmark KH, Myhre E. The effects of nifedipine, a calcium antagonist, on platelet function. Am Heart J 1983;105:103-5.
30. Fujinishi A, Takahara K, Ohba C, Nakashima Y, Kuroiwa A. Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease. Angiology 1997;48:515-21.
31. 2 formation: an in vivo double blind randomized study. Thromb Res 1990;59: 531-9.
32. Knight CJ, Panesar M, Wilson DJ, et al. Different effects of calcium antagonists, nitrates, and β-blockers on platelet function: possible importance for the treatment of unstable angina. Circulation 1997;95:125-32.
33. O'Grady J, Kritz H, Schmid P, Pirich C, Sinzinger H. Effect of isradipine on in-vivo platelet function. Thromb Res 1997;96:363-71.
34. Doyle VM, Ruegg UT. Lack of evidence for voltage dependent calcium channels on platelets. Biochem Biophys Res Commun 1985;127:161-7.
35. Badimon L, Badimon JJ, Galvez A, Chesebro JH, Fuster V. Influence of arterial damage and wall shear rate on platelet deposition: ex vivo study in a swine model. Arteriosclerosis 1986;6:312-20.
36. Hjemdahl P, Chronos NAF, Wilson DJ, Bouloux P, Goodall AH. Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression. Arterioscler Thromb 1994;14:77-84.
37. Moore TJ, Williams GH. Angiotensin II receptors on human platelets. Circ Res 1981;51:314-20.
38. Moncada S, Radomski MW, Palmer RMJ. Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem Pharmacol 1988; 37:2459-501.
39. Ruschitzka FT, Lüscher TF. Is there a rationale for combining angiotensin-converting enzyme inhibitors and calcium antagonists in cardiovascular disease? Am Heart J 1997;134:S31-47.
40. 2+ influx into stimulated platelets. Blood 1985;66:731-4.
41. Hiroki T, Inoue T, Yoshida T, Arakawa K. Effect of the calcium antagonistic agent nifedipine on platelet aggregation response to exercise in patients with angina pectoris. Arzneimittelforschung 1982;32:1572-4.
42. Dohi Y, Kojima M, Sato K. Benidipine improves endothelial function in renal resistance arteries of hypertensive rats. Hypertension 1996;28:58-63.
43. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22-7.
44. Müller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation 1989;79:733-43.
45. Wolf S. Psychological forces in myocardial infarction and sudden death. Circulation 1969;40(suppl IV):IV74-83.