Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression

European Heart Journal

Volumn 31, Issue 13, 2010, Pages 1573-1582

  Zafar, M Urooj ^a   Paz Yepes, Manuel ^a   Shimbo, Daichi ^b   Vilahur, Gemma ^a   Burg, Matthew M ^b,c   Chaplin, William ^d   Fuster, Valentin ^a   Davidson, Karina W ^b   Badimon, Juan J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ST JOHN'S UNIVERSITY   (United States)

Author keywords

Anxiety; Coronary artery disease; Depression; Myocardial infarction; Platelets

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRINOGEN; SEROTONIN;

ADULT; ANXIETY; ARTICLE; BECK DEPRESSION INVENTORY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; CORRELATION ANALYSIS; DEPRESSION; FEMALE; FLOW CYTOMETRY; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; PREDICTION; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; AGED; ANGINA, UNSTABLE; ANXIETY DISORDERS; ASPIRIN; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SEROTONIN; TICLOPIDINE;

EID: 77954325172     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp602     Document Type: Article

References (67)

1. Chida Y, Steptoe A. The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Coll Cardiol 2009;53:936-946.
2. Wellenius GA, Mukamal KJ, Kulshreshtha A, Asonganyi S, Mittleman MA. Depressive symptoms and the risk of atherosclerotic progression among patients with coronary artery bypass grafts. Circulation 2008;117:2313-2319.
3. Brotman DJ, Golden SH, Wittstein IS. The cardiovascular toll of stress. Lancet 2007;370:1089-1100.
4. Cohen S, Janicki-Deverts D, Miller GE. Psychological stress and disease. J Am Med Assoc 2007;298:1685-1687.
5. Davidson KW, Kupfer DJ, Bigger JT, Califf RM, Carney RM, Coyne JC, Czajkowski SM, Frank E, Frasure-Smith N, Freedland KE, Froelicher ES, Glassman AH, Katon WJ, Kaufmann PG, Kessler RC, Kraemer HC, Krishnan KR, Lesperance F, Rieckmann N, Sheps DS, Suls JM. Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group Report. Psychosom Med 2006;68: 645-650.
6. Rozanski A, Blumenthal JA, Davidson KW, Saab PG, Kubzansky L. The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol 2005;45: 637-651.
7. Ziegelstein RC. Acute emotional stress and cardiac arrhythmias. J Am Med Assoc 2007;298:324-329.
8. Dimsdale JE. Psychological stress and cardiovascular disease. J Am Coll Cardiol 2008;51:1237-1246.
9. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004;364:937-952.
10. Whang W, Kubzansky LD, Kawachi I, Rexrode KM, Kroenke CH, Glynn RJ, Garan H, Albert CM. Depression and risk of sudden cardiac death and coronary heart disease in women: results from the Nurses? Health Study. J Am Coll Cardiol 2009;53:950-958.
11. Kuper H, Marmot M, Hemingway H. Systematic Review of Prospective Cohort Studies of Psychosocial Factors in the Etiology and Prognosis of Coronary Heart Disease. Semin Vasc Med 2002;2:267-314.
12. Hemingway H, Marmot M. Evidence based cardiology: psychosocial factors in the aetiology and prognosis of coronary heart disease. Systematic review of prospective cohort studies. BMJ 1999;318:1460-1467.
13. Suls J, Bunde J. Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions. Psychol Bull 2005;131:260-300.
14. Steptoe A, Strike PC, Perkins-Porras L, McEwan JR, Whitehead DL. Acute depressed mood as a trigger of acute coronary syndromes. Biol Psychiatry 2006; 60:837-842.
15. Lampert R, Joska T, Burg MM, Batsford WP, McPherson CA, Jain D. Emotional and physical precipitants of ventricular arrhythmia. Circulation 2002;106: 1800-1805.
16. Whang W, Albert CM, Sears SF Jr, Lampert R, Conti JB, Wang PJ, Singh JP, Ruskin JN, Muller JE, Mittleman MA. Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators: results from the Triggers of Ventricular Arrhythmias (TOVA) study. J Am Coll Cardiol 2005;45:1090-1095.
17. Thombs BD, Bass EB, Ford DE, Stewart KJ, Tsilidis KK, Patel U, Fauerbach JA, Bush DE, Ziegelstein RC. Prevalence of depression in survivors of acute myocar-dial infarction. J Gen Intern Med 2006;21:30-38.
18. Rutledge T, Vaccarino V, Johnson BD, Bittner V, Olson MB, Linke SE, Cornell CE, Eteiba W, Sheps DS, Francis J, Krantz DS, Bairey Merz CN, Parashar S, Handberg E, Vido DA, Shaw LJ. Depression and cardiovascular health care costs among women with suspected myocardial ischemia: prospective results from the WISE (Women?s Ischemia Syndrome Evaluation) Study. J Am Coll Cardiol 2009;53:176-183.
19. Barth J, Schumacher M, Herrmann-Lingen C. Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med 2004;66:802-813.
20. Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J 2006;27:2763-2774.
21. van Melle JP, de Jonge P, Spijkerman TA, Tijssen JG, Ormel J, van Veldhuisen DJ, van den Brink RH, van den Berg MP. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom Med 2004;66:814-822.
22. Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A. Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psych 2007;22:613-626.
23. Lichtman JH, Bigger JT Jr, Blumenthal JA, Frasure-Smith N, Kaufmann PG, Lesperance F, Mark DB, Sheps DS, Taylor CB, Froelicher ES. Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation 2008;118:1768-1775.
24. Lavie CJ, Milani RV. Prevalence of anxiety in coronary patients with improvement following cardiac rehabilitation and exercise training. Am J Cardiol 2004;93: 336-339.
25. Lavie CJ, Milani RV. Adverse psychological and coronary risk profiles in young patients with coronary artery disease and benefits of formal cardiac rehabilitation. Arch Intern Med 2006;166:1878-1883.
26. Kessler RC, Chiu WT, Demler O, Walters EE. Prevalence, severity, and comor-bidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiat 2005;62:617-627. (Pubitemid 40973437) (Pubitemid 40973437)
27. Davidson KW, Rieckmann N, Rapp M. Definitions and distinctions among depressive syndromes and symptoms: implications for a better understanding of the depression-cardiovascular disease association. Psychosom Med 2005;67: S6-S9.
28. Heim C, Nemeroff CB. The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. Biol Psychiat 1999;46:1509-1522.
29. Roy-Byrne PP, Davidson KW, Kessler RC, Asmundson GJ, Goodwin RD, Kubzansky L, Lydiard RB, Massie MJ, Katon W, Laden SK, Stein MB. Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry 2008;30:208-225.
30. Kubzansky LD, Cole SR, Kawachi I, Vokonas P, Sparrow D. Shared and unique contributions of anger, anxiety, and depression to coronary heart disease: a prospective study in the normative aging study. Ann Behav Med 2006;31:21-29.
31. Rothenbacher D, Hahmann H, Wusten B, Koenig W, Brenner H. Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Eur J Cardiovasc Prev Rehabil 2007; 14:547-554.
32. Strik J, Denollet J, Lousberg R, Honig A. Comparing symptoms of depression and anxiety as predictors of cardiac events and increased health care consumption after myocardial infarction. J Am Coll Cardiol 2003;42:1801-1807.
33. Shen B-J, Avivi YE, Todaro JF, Spiro A III, Laurenceau J-P, Ward KD, Niaura R. Anxiety characteristics independently and prospectively predict myocardial infarction in men: the unique contribution of anxiety among psychologic factors. J Am Coll Cardiol 2008;51:113-119.
34. Frasure-Smith N, Lesperance F. Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Arch Gen Psychiat 2008;65:62-71.
35. Nemeroff CB, Musselman DL. Are platelets the link between depression and ischemic heart disease? Am Heart J 2000;140:57-62.
36. Schins A, Honig A, Crijns H, Baur L, Hamulyak K. Increased coronary events in depressed cardiovascular patients: 5-HT2A receptor as missing link? Psychosom Med 2003;65:729-737.
37. Shimbo D, Davidson KW, Haas DC, Fuster V, Badimon JJ. Negative impact of depressiononoutcomes inpatients with coronary artery disease: mechanisms, treatment considerations, and future directions. J Thromb Haemost 2005;3:897-908.
38. Bruce EC, Musselman DL. Depression, alterations in platelet function, and ischemic heart disease. Psychosom Med 2005;67(Suppl. 1):S34-S36.
39. Lederbogen F, Baranyai R, Gilles M, Menart-Houtermans B, Tschoepe D, Deuschle M. Effect of mental and physical stress on platelet activation markers in depressed patients and healthy subjects: a pilot study. Psychiatry Res 2004;127:55-64.
40. Aschbacher K, Mills PJ, von Kanel R, Hong S, Mausbach BT, Roepke SK, Dimsdale JE, Patterson TL, Ziegler MG, Ancoli-Israel S, Grant I. Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers. Brain Behav Immun 2008;22:493-502.
41. Markovitz JH, Matthews KA, Kiss J, Smitherman TC. Effects of hostility on platelet reactivity to psychological stress in coronary heart disease patients and in healthy controls. Psychosom Med 1996;58:143-149.
42. Shimbo D, Chaplin W, Kuruvilla S, Wasson LT, Abraham D, Burg MM. Hostility and platelet reactivity in individuals without a history of cardiovascular disease events. Psychosom Med 2009;71:741-747.
43. Maes M, Van Gastel A, Delmeire L, Kenis G, Bosmans E, Song C. Platelet alpha2-adrenoceptor density in humans: relationships to stress-induced anxiety, psychasthenic constitution, gender and stress-induced changes in the inflammatory response system. Psychol Med 2002;32:919-928.
44. Vanhoutte PM. Platelet-derived serotonin, the endothelium, and cardiovascular disease. J Cardiovasc Pharmacol 1991;17(Suppl. 5):S6-S12.
45. Shimbo D, Child J, Davidson K, Geer E, Osende JI, Reddy S, Dronge A, Fuster V, Badimon JJ. Exaggerated serotonin-mediated platelet reactivity as a possible link in depression and acute coronary syndromes. Am J Cardiol 2002;89:331-333.
46. Badimon L, Martinez-Gonzalez J, Royo T, Lassila R, Badimon JJ. A sudden increase in plasma epinephrine levels transiently enhances platelet deposition on severely damaged arterial wall-studies in a porcine model. Thromb Haemost 1999;82: 1736-1742.
47. von Kanel R. Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: how strong is the evidence? Acta Psychiatr Scand 2004;110:163-177.
48. Roevens P, De Clerck F, de Chaffoy de Courcelles D. The synergistic effect of 5-hydroxytryptamine and epinephrine on the human platelet is related to the activation of phospholipase C. Eur J Pharmacol 1993;245:273-280.
49. Barlow DH. Anxiety and Its Disorders. 3rd ed. New York: The Guilford Press; 2002.
50. Beck AT, Ward CH, Mendelson M. An inventory for measuring depression. Arch Gen Psychiat 1961;4:561-571.
51. Buros OK. The Hospital Anxiety and Depression Scale. Highland Park, NJ: Gryphon Press; 1970.
52. Herrmann C. International experiences with the Hospital Anxiety and Depression Scale\a review of validation data and clinical results. J Psychosom Res 1997;42:17-41.
53. Kuijpers PM, Denollet J, Lousberg R, Wellens HJ, Crijns H, Honig A. Validity of the hospital anxiety and depression scale for use with patients with noncardiac chest pain. Psychosomatics 2003;44:329-335.
54. Vilahur G, Choi BG, Zafar MU, Viles-Gonzalez JF, Vorchheimer DA, Fuster V, Badimon JJ. Normalization of platelet reactivity in clopidogrel-treated subjects. J Thromb Haemost 2007;5:82-90.
55. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007;370: 1453-1457.
56. Jagroop IA, Matsagas MI, Geroulakos G, Mikhailidis DP. The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease. Platelets 2004;15:117-125.
57. Lane D, Carroll D, Ring C, Beevers DG, Lip GY. In-hospital symptoms of depression do not predict mortality 3 years after myocardial infarction. Int J Epidemiol 2002;31:1179-1182.
58. Shibeshi WA, Young-Xu Y, Blatt CM. Anxiety worsens prognosis in patients with coronary artery disease. J Am Coll Cardiol 2007;49:2021-2027.
59. Carney RM, Freedland KE, Veith RC. Depression, the autonomic nervous system, and coronary heart disease. Psychosom Med 2005;67(Suppl. 1):S29-S33.
60. Frasure-Smith N, Lesperance F, Irwin MR, Sauve C, Lesperance J, Theroux P. Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biol Psychiatry 2007;62:302-308.
61. Bankier B, Barajas J, Martinez-Rumayor A, Januzzi JL. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Eur Heart J 2008;29:2212-2217.
62. Tracey KJ. The inflammatory reflex. Nature 2002;420:853-859.
63. Carney RM, Freedland KE, Stein PK, Miller GE, Steinmeyer B, Rich MW, Duntley SP. Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease. J Psychosom Res 2007;62:463-467.
64. Milani RV, Lavie CJ. Impact of cardiac rehabilitation on depression and its associated mortality. Am J Med 2007;120:799-806.
65. Blumenthal JA, Babyak M, Wei J, O?Connor C, Waugh R, Eisenstein E, Mark D, Sherwood A, Woodley PS, Irwin RJ, Reed G. Usefulness of psychosocial treatment of mental stress-induced myocardial ischemia in men. Am J Cardiol 2002;89:164-168.
66. Roose SP. Depression, anxiety, and the cardiovascular system: the psychiatrist?s perspective. J Clin Psychiatry 2001;62(Suppl. 8):19-22. discussion 23.
67. Friedman BH, Thayer JF. Autonomic balance revisited: panic anxiety and heart rate variability. J Psychosom Res 1998;44:133-151.