TPA-S481A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1

Journal of Neurotrauma

Volumn 30, Issue 22, 2013, Pages 1898-1907

  Armstead, William M ^a,b   Bohman, Leif Erik ^b   Riley, John ^a   Yarovoi, Serge ^c   Higazi, Abd Al Roof ^c,d   Cines, Douglas B ^c  

^a Departments of Anesthesiology and Critical Care   (United States)

^b Department of Pharmacology ^*  (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

cerebral autoregulation; cerebral blood flow; excitatory amino acids; newborn; plasminogen activators; traumatic brain injury

Indexed keywords

ENDOTHELIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID; TISSUE PLASMINOGEN ACTIVATOR; TISSUE PLASMINOGEN ACTIVATOR 481 A; TISSUE PLASMINOGEN ACTIVATOR DERIVATIVE; UNCLASSIFIED DRUG;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOREGULATION; BINDING SITE; CEREBROVASCULAR AUTOREGULATION; CONTROLLED STUDY; ENZYME BINDING; FEMALE; MALE; NEWBORN; NONHUMAN; PIA ARTERY; PROTEIN DEGRADATION; TRAUMATIC BRAIN INJURY; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; BRAIN INJURIES; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; FEMALE; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, N-METHYL-D-ASPARTATE; SWINE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; UP-REGULATION;

EID: 84887079795     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2013.2962     Document Type: Article

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