Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 128-137

  Sandhu, Hardip ^a   Ansar, Saema ^a   Edvinsson, Lars ^a,b  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cerebral arteries; G protein coupled receptor upregulation; MEK ERK pathway; Organ culture; U0126; Vascular smooth muscle cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 5 (2,2 DICYANOVINYL) 2 NITROPHENOL; ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROSTANOID RECEPTOR; SEROTONIN 1B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFICACY; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION;

ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; MIDDLE CEREBRAL ARTERY; MITOGEN-ACTIVATED PROTEIN KINASES; ORGAN CULTURE TECHNIQUES; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, THROMBOXANE; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 77955767817     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.053     Document Type: Article

References (52)

1. Adner M., Erlinge D., Salford L.G., Yee F., Wahlestedt C., Edvinsson L. Human endothelin ETA receptor antisense oligodeoxynucleotides inhibit endothelin-1 evoked vasoconstriction. Eur. J. Pharmacol. 1994, 261:281-284.
2. Adner M., Geary G.G., Edvinsson L. Appearance of contractile endothelin-B receptors in rat mesenteric arterial segments following organ culture. Acta Physiol. Scand. 1998, 163:121-129.
3. Alessandrini A., Namura S., Moskowitz M.A., Bonventre J.V. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:12866-12869.
4. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. J. Biol. Chem. 1995, 270:27489-27494.
5. Angstwurm K., Hanisch U.K., Gassemi T., Bille M.B., Prinz M., Dirnagl U., Kettenmann H., Weber J.R. Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infect. Immun. 2004, 72:3294-3298.
6. Ansar S., Edvinsson L. Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Stroke 2008, 39:185-190.
7. Ansar S., Vikman P., Nielsen M., Edvinsson L. Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H3750-H3758.
8. Atkins C.M., Selcher J.C., Petraitis J.J., Trzaskos J.M., Sweatt J.D. The MAPK cascade is required for mammalian associative learning. Nat. Neurosci. 1998, 1:602-609.
9. Beg S.A., Hansen-Schwartz J.A., Vikman P.J., Xu C.B., Edvinsson L.I. ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat. J. Cereb. Blood Flow Metab. 2006, 26:846-856.
10. Boess F.G., Martin I.L. Molecular biology of 5-HT receptors. Neuropharmacology 1994, 33:275-317.
11. Chen Q.W., Edvinsson L., Xu C.B. Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells. BMC Cell Biol. 2009, 10:52.
12. Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 2000, 351:95-105.
13. Dudley D.T., Hubbell S.E., Summerfelt R.M. Characterization of angiotensin II (AT2) binding sites in R3T3 cells. Mol. Pharmacol. 1991, 40:360-367.
14. Dudley D.T., Pang L., Decker S.J., Bridges A.J., Saltiel A.R. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:7686-7689.
15. Elting J.W., Sulter G.A., Kaste M., Lees K.R., Diener H.C., Hommel M., Versavel M., Teelken A.W., De K.J. AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels. Stroke 2002, 33:2813-2818.
16. Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., Trzaskos J.M. Identification of a novel inhibitor of mitogen-activated protein kinase. J. Biol. Chem. 1998, 273:18623-18632.
17. Garrington T.P., Johnson G.L. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 1999, 11:211-218.
18. Hanisch U.K., Prinz M., Angstwurm K., Hausler K.G., Kann O., Kettenmann H., Weber J.R. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol. 2001, 31:2104-2115.
19. Hansen-Schwartz J., Svensson C.L., Xu C.B., Edvinsson L. Protein kinase mediated upregulation of endothelin A, endothelin B and 5-hydroxytryptamine 1B/1D receptors during organ culture in rat basilar artery. Br. J. Pharmacol. 2002, 137:118-126.
20. Hansen-Schwartz J., Hoel N.L., Xu C.B., Svendgaard N.A., Edvinsson L. Subarachnoid hemorrhage-induced upregulation of the 5-HT1B receptor in cerebral arteries in rats. J. Neurosurg. 2003, 99:115-120.
21. Hansen-Schwartz J., Hoel N.L., Zhou M., Xu C.B., Svendgaard N.A., Edvinsson L. Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries. Neurosurgery 2003, 52:1188-1194.
22. Henriksson M., Stenman E., Edvinsson L. Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat. Stroke 2003, 34:1479-1483.
23. Henriksson M., Xu C.B., Edvinsson L. Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries. Br. J. Pharmacol. 2004, 142:1155-1161.
24. Henriksson M., Stenman E., Vikman P., Edvinsson L. MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia. Exp. Brain Res. 2007, 178:470-476.
25. Hoel N.L., Hansen-Schwartz J., Edvinsson L. Selective up-regulation of 5-HT(1B/1D) receptors during organ culture of cerebral arteries. NeuroReport 2001, 12:1605-1608.
26. Hogestatt E.D., Andersson K.E., Edvinsson L. Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol. Scand. 1983, 117:49-61.
27. Kann O., Hoffmann A., Schumann R.R., Weber J.R., Kettenmann H., Hanisch U.K. The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level. J. Neurochem. 2004, 90:513-525.
28. Lincoln J., Loesch A., Burnstock G. Localization of vasopressin, serotonin and angiotensin II in endothelial cells of the renal and mesenteric arteries of the rat. Cell Tissue Res. 1990, 259:341-344.
29. Loesch A., Burnstock G. Ultrastructural localisation of serotonin and substance P in vascular endothelial cells of rat femoral and mesenteric arteries. Anat. Embryol. (Berl) 1988, 178:137-142.
30. Loesch A., Burnstock G. Endothelin in human cerebrovascular nerves. Clin.Sci.(Lond) 2002, 103(Suppl 48):404S-407S.
31. Maddahi A., Edvinsson L. Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway. BMC Neurosci. 2008, 9:85.
32. Maddahi A., Chen Q., Edvinsson L. Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat. BMC Neurosci. 2009, 10:56.
33. Moon S.K., Lee H.Y., Li J.D., Nagura M., Kang S.H., Chun Y.M., Linthicum F.H., Ganz T., Andalibi A., Lim D.J. Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. Biochim. Biophys. Acta 2002, 1590:41-51.
34. Mulvany M.J., Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 1977, 41:19-26.
35. Murphy T.J., Alexander R.W., Griendling K.K., Runge M.S., Bernstein K.E. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 1991, 351:233-236.
36. Namura S., Iihara K., Takami S., Nagata I., Kikuchi H., Matsushita K., Moskowitz M.A., Bonventre J.V., Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc. Natl Acad. Sci. USA 2001, 98:11569-11574.
37. Novogrodsky A., Vanichkin A., Patya M., Gazit A., Osherov N., Levitzki A. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 1994, 264:1319-1322.
38. O'Collins V.E., Macleod M.R., Donnan G.A., Horky L.L., van der Worp B.H., Howells D.W. 1026 experimental treatments in acute stroke. Ann. Neurol. 2006, 59:467-477.
39. Pucell A.G., Hodges J.C., Sen I., Bumpus F.M., Husain A. Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor. Endocrinology 1991, 128:1947-1959.
40. Rauh-Adelmann C., Moskow J.M., Graham J.R., Yen L.G., Boucher J.I., Murphy C.E., Nadler T.K., Gordon N.F., Radding J.A. Quantitative measurement of epidermal growth factor receptor-mitogen-activated protein kinase signal transduction using a nine-plex, peptide-based immunoassay. Anal. Biochem. 2008, 375:255-264.
41. Rosamond W., Flegal K., Friday G., Furie K., Go A., Greenlund K., Haase N., Ho M., Howard V., Kissela B., Kittner S., Lloyd-Jones D., McDermott M., Meigs J., Moy C., Nichol G., O'Donnell C.J., Roger V., Rumsfeld J., Sorlie P., Steinberger J., Thom T., Wasserthiel-Smoller S., Hong Y. Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007, 115:e69-e171.
42. Rosamond W., Flegal K., Furie K., Go A., Greenlund K., Haase N., Hailpern S.M., Ho M., Howard V., Kissela B., Kittner S., Lloyd-Jones D., McDermott M., Meigs J., Moy C., Nichol G., O'Donnell C., Roger V., Sorlie P., Steinberger J., Thom T., Wilson M., Hong Y. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008, 117:e25-e146.
43. Sakamoto A., Yanagisawa M., Sawamura T., Enoki T., Ohtani T., Sakurai T., Nakao K., Toyo-oka T., Masaki T. Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J. Biol. Chem. 1993, 268:8547-8553.
44. Sasaki K., Yamano Y., Bardhan S., Iwai N., Murray J.J., Hasegawa M., Matsuda Y., Inagami T. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature 1991, 351:230-233.
45. Scherle P.A., Ma W., Lim H., Dey S.K., Trzaskos J.M. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J. Biol. Chem. 2000, 275:37086-37092.
46. Shenker A., Goldsmith P., Unson C.G., Spiegel A.M. The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. J. Biol. Chem. 1991, 266:9309-9313.
47. Stenman E., Edvinsson L. Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats. Stroke 2004, 35:970-974.
48. Stenman E., Malmsjo M., Uddman E., Gido G., Wieloch T., Edvinsson L. Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat. Stroke 2002, 33:2311-2316.
49. Szok D., Hansen-Schwartz J., Edvinsson L. In depth pharmacological characterization of endothelin B receptors in the rat middle cerebral artery. Neurosci. Lett. 2001, 314:69-72.
50. Tsutsumi K., Stromberg C., Viswanathan M., Saavedra J.M. Angiotensin-II receptor subtypes in fetal tissue of the rat: autoradiography, guanine nucleotide sensitivity, and association with phosphoinositide hydrolysis. Endocrinology 1991, 129:1075-1082.
51. Vikman P., Edvinsson L. Gene expression profiling in the human middle cerebral artery after cerebral ischemia. Eur. J. Neurol. 2006, 13:1324-1332.
52. Wang X., Wang H., Xu L., Rozanski D.J., Sugawara T., Chan P.H., Trzaskos J.M., Feuerstein G.Z. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J. Pharmacol. Exp. Ther. 2003, 304:172-178.