Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury

Journal of Neurotrauma

Volumn 19, Issue 8, 2002, Pages 965-973

  Kulkarni, Miriam ^a   Armstead, William M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cerebral circulation; Excitatory amino acids; Newborn; Opioids; Oxygen free radicals

Indexed keywords

CYCLOOXYGENASE 2; DYNORPHIN; EXCITATORY AMINO ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYL DEXTRO ASPARTIC ACID; NITROBLUE TETRAZOLIUM; NOCICEPTIN; NORBINALTORPHIMINE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; BRAIN CIRCULATION; BRAIN FUNCTION; BRAIN INJURY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; NONHUMAN; PIA ARTERY; RECEPTOR BLOCKING; SWINE; VASODILATATION;

EID: 0036673683     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771502320317113     Document Type: Article

References (33)

1. Nociceptin/orphanin FQ contributes to age dependent impairment of N-methyl-D-aspartate induced cerebrovasodilation after brain injury
2. Role of nociceptin/orphanin FQ in age-dependent cerebral hemodynamic effects of brain injury
3. The role of opioids in newborn pig fluid percussion brain injury
4. Role of opioids in the physiologic and pathophysiologic control of the cerebral circulation
5. The shaken baby syndrome. A clinical, pathological, and biomechanical study
6. Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury
7. Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury
8. Nitric oxide mediates vasodilation in response to activation to N-methyl-D-aspartate receptors in the brain
9. NS398, a new antiinflammatory agent, selectively inhibits prostaglandin G/H synthase, cyclooxygenase 2 (COX2) activity in vivo
10. Animal models of human head injury
11. Modulation of enkephalin release by nociceptin (orphanin FQ)
12. Inducible cyclooxygenase 2 expression after experimental intracerebral hemorrhage
13. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
14. COX-2, a synaptically induced enzyme is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex
15. Oxygen radicals in brain injury
16. Superoxide generation links nociceptin/orphanin FQ (NOC/oFQ) release to impaired N-methyl-D-aspartate cerebrovasodilation after brain injury
17. Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia
18. Role of the eicosanoids in cerebral hemodynamics
19. Novel pharmacologic therapies in the treatment of experimental traumatic brain injury
20. Traumatic brain injury in the rat: Characterization of a lateral fluid percussion mode
21. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
22. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
23. Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex
24. Cyclooxygenase-2 participates in selected vasodilator responses of the cerebral circulation
25. Orphanin FQ: A neuropeptide that activates an opioid like G protein-coupled receptor
26. Role of cyclooxygenase 2 in acute spinal cord injury
27. Childhood injuries in the United States
28. Cyclooxygenase-2 is induced globally in infarcted human brain
29. Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglial brain macrophages in cats
30. Head injury induces increased prostaglandin synthesis in rat brain
31. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat
32. Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats
33. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids