tPA regulates pulmonary vascular activity through NMDA receptors

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 301, Issue 3, 2011, Pages

  Nassar, Taher ^a,b   Bdeir, Khalil ^a   Yarovoi, Serge ^a   Fanne, Rami Abu ^b   Murciano, Juan Carlos ^c   Idell, Steven ^d   Allen, Timothy Craig ^d   Cines, Douglas B ^a   Higazi, Abd Al Roof ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^d UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

Fibrinolytic enzymes; N methyl D aspartate; Plasminogen activators; Pulmonary emboli; Tissue type plasminogen activator

Indexed keywords

ALTEPLASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL PERMEABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; HUMAN; HUMAN CELL; LUNG EMBOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; RAT;

ANIMALS; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; HUMANS; MALE; MICE; MICE, INBRED C57BL; PHENYLEPHRINE; PULMONARY ARTERY; PULMONARY EMBOLISM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TISSUE PLASMINOGEN ACTIVATOR; VASOCONSTRICTION;

EID: 80052355803     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00429.2010     Document Type: Article

References (22)

1. Abu Fanne R, Nassar T, Yarovoi S, Rayan A, Lamensdorf I, Karakoveski M, Vadim P, Jammal M, Cines D, Higazi A. Blood-brain barrier permeability and tPA-mediated neurotoxicity. Neuropharmacology 58: 972-980, 2010.
2. Agnelli G, Becattini C, Kirschstein T. Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis. Arch Intern Med 162: 2537-2541, 2002.
3. Armstead W, Riley J, Kiessling J, Cines D, Higazi AA. Novel plasminogen activator inhibitor-1 derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK. Am J Physiol Regul Integr Comp Physiol 299: R480-R485, 2010.
4. Bdeir K, Murciano JC, Tomaszewski J, Koniares L, Martinez J, Cines DB, Muzykantov V, Higazi AA. Urokinase contributes to fibrinolysis in the pulmonary microcirculation. Blood 96: 1820-1826, 2000.
5. Fanne R, Nassar T, Yarovoi S, Rayan A, Lamensdorf I, Karakoveski M, Polianski V, Mahmud Jammal M, Cines D, Higazi A. Blood-brain barrier permeability and tPA-mediated neurotoxicity. Neuropharmacology 58: 972-980, 2010.
6. Fu P, Birukova A, Xing J, Sammani S, Murley J, Garcia J, Grdina D, Birukov K. Amifostine reduces lung vascular permeability via suppression of inflammatory signalling. Eur Respir J 33: 612-624, 2009.
7. Higazi AAR, Barghouti II, Abu-Much R. Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils. J Biol Chem 270: 9472-9477, 1995.
8. Kuhlmann D, Zehendner C, Gerigk M, Closhen D, Bender B, Friedl P, Luhmann H. MK801 blocks hypoxic blood-brain-barrier disruption and leukocyte adhesion. Neurosci Lett 449: 168-172, 2009.
9. Madison EL, Goldsmith EJ, Gerard RD, Gething MJH, Sambrook JF, Bassel-Duby RS. Amino acid residues that affect interaction of tissue plasminogen activator with plasminogen activator inhibitor 1. Proc Natl Acad Sci USA 87: 3530-3534, 1990.
10. Martins-Green M, Petreaca M, Yao M. An assay system for in vitro detection of permeability in human "endothelium". Methods Enzymol 443: 137-153, 2008.
11. Nassar T, Akkawi S, Shina A, Haj-Yehia A, Bdeir K, Tarshis M, Heyman S, Higazi A. The in vitro and in vivo effect of tPA and PAI-1 on blood vessel tone. Blood 103: 897-902, 2004.
12. Nassar T, Haj-Yeha S, Akkawi S, Kuo A, Bdeir K, Mazar A, Cines DB, Higazi A. Binding of urokinase to low density lipoprotein-related receptor (LRP) regulates vascular smooth muscle cell contraction. J Biol Chem 277: 40499-40504, 2002.
13. Nassar T, Yarovoi S, Abu Fanne R, Akkawi S, Jammal M, Allen T, Idell S, Cines DB, Higazi A. Regulation of airways contractility by plasminogen activators through NMDA Receptor-1. Am J Respir Cell Mol Biol 43: 703-711, 2010.
14. Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, Vivien D, Buisson A. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med 7: 59-64, 2001.
15. Said S, Berisha H, Pakbaz H. Excitotoxicity in the lung: N-methyl-Daspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly (ADP-ribose) polymerase. Proc Natl Acad Sci USA 93: 4688-4692, 1996.
16. Samson A, Nevin S, Croucher D, Niego B, Daniel P, Weiss T, Moreno E, Monard D, Lawrence D, Medcalf R. Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function. J Neurochem 107: 10911101, 2008.
17. Su JE, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, Gao Y, Pietras K, Mann K, Yepes M, Strickland KD, Betsholtz C, Eriksson U, Lawrence AD. Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med 14: 731-737, 2008.
18. Tardy B, Venet C, Zeni F, Coudrot M, Guyomarc'h S, Mismetti P. Short term effect of recombinant tissue plasminogen activator in patients with hemodynamically stable acute pulmonary embolism: Results of a meta-analysis involving 464 patients. Thromb Res 124: 672-677, 2009.
19. Thabut G, Thabut D, Myers R, Bernard-Chabert B, Marrash-Chahla R, Mal H, Fournier M. Thrombolytic therapy of pulmonary embolism: a meta-analysis. J Am Coll Cardiol 40: 1660-1667, 2002.
20. Wan S, Quinlan D, Agnelli G, Eikelboom J. Thrombolysis compared with heparin for the initial treatment of pulmonary embolism. Circulation 110: 744-749, 2004.
21. Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DS, Lawrence DA. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest 112: 1533-1540, 2003.
22. Zhang L, Strickland DK, Cines DB, Higazi AAR. Regulation of single chain urokinase binding, internalization and degradation by a plasminogen activator inhibitor 1-derived peptide. J Biol Chem 272: 27053-27057, 1997.