Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil

European Journal of Pharmacology

Volumn 718, Issue 1-3, 2013, Pages 428-434

  Selvatici, Rita ^a   Brullo, Chiara ^b   Bruno, Olga ^b   Spisani, Susanna ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Chemotaxis; fMLF OMe; IL8; Neutrophil chemotactic inhibitors; Signaling pathways

Indexed keywords

ANTIINFLAMMATORY AGENT; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTERLEUKIN 8; LYSOZYME; MITOGEN ACTIVATED PROTEIN KINASE P38; N (1 NAPHTHYL) 2 PHENYL 2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE 1 CARBOXAMIDE; N 7 PIPERIDINYL N 1 (3 FLUOROPHENYL) 2 DIPHENYL 2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE 1,7 DICARBOXAMIDE; N1 (3 FLUOROPHENYL) 2 PHENYL 2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE 1,7 DICARBOXAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CHEMOTAXIS; FMLF-OME; IL8; NEUTROPHIL CHEMOTACTIC INHIBITORS; SIGNALING PATHWAYS.;

CHEMOTAXIS; HUMANS; IMIDAZOLES; INTERLEUKIN-8; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PYRAZOLES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 84887068000     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.07.045     Document Type: Article

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