2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 13, 2007, Pages 3696-3701

  Bruno, Olga ^a   Brullo, Chiara ^a   Bondavalli, Francesco ^a   Ranise, Angelo ^a   Schenone, Silvia ^a   Falzarano, Maria Sofia ^b   Varani, Katia ^b   Spisani, Susanna ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

2 Phenyl 2,3 dihydro 1H imidazo 1,2 b pyrazoles; FMLP receptors (FPRs); N Formyl methionyl leucyl phenylalanine (fMLP); Neutrophil chemotaxis; Neutrophil inflammation

Indexed keywords

2 PHENYL 2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE DERIVATIVE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DEGRANULATION; DRUG INHIBITION; DRUG SYNTHESIS; IN VITRO STUDY; NEUTROPHIL CHEMOTAXIS; PROTEIN BINDING; RESPIRATORY BURST;

ANTI-INFLAMMATORY AGENTS; BINDING, COMPETITIVE; CHEMISTRY, PHARMACEUTICAL; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PROTEIN BINDING; PYRAZOLES; SIGNAL TRANSDUCTION;

EID: 34250215974     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.036     Document Type: Article

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