The mucosal factors retinoic acid and TGF-β1 induce phenotypically and functionally distinct dendritic cell types

International Archives of Allergy and Immunology

Volumn 162, Issue 3, 2013, Pages 225-236

  Den Hartog, Gerco ^a,c   Van Altena, Christine ^a   Savelkoul, Huub F J ^a   Van Neerven, R J Joost ^a,b  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b FRIESLANDCAMPINA   (Netherlands)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Activation; CCR7; CD103; Dendritic cell; Diet; Mucosal factors; 7

Indexed keywords

BETA7 INTEGRIN; CD103 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; PEPTIDOGLYCAN; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; LYMPH NODE; MONOCYTE; NONHUMAN; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 84887048148     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000353243     Document Type: Article

References (39)

1. Sun C-M, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y: Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007; 204: 1775-1785.
2. Pabst O, Mowat AM: Oral tolerance to food protein. Mucosal Immunol 2012; 5: 232-239.
3. Iliev ID, Spadoni I, Mileti E, Matteoli G, Sonzogni A, Sampietro GM, Foschi D, Caprioli F, Viale G, Rescigno M: Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 2009; 58: 1481-1489.
4. Mora JR, von Andrian UH: Role of retinoic acid in the imprinting of gut-homing IgA-secreting cells. Semin Immunol 2009; 21: 28-35.
5. Coombes JL, Siddiqui KRR, Arancibia-Cárcamo CV, Hall J, Sun C-M, Belkaid Y, Powrie F: A functionally specialized population of mucosal CD103 + DCs induces Foxp3 + regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism. J Exp Med 2007; 204: 1757-1764.
6. DePaolo R, Abadie V, Tang F, Fehlner-Peach H, Hall J, Wang W, Marietta E, Kasarda D, Waldmann T, Murray J: Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 2011; 471: 220-224.
7. Hall JA, Grainger JR, Spencer SP, Belkaid Y: The role of retinoic acid in tolerance and immunity. Immunity 2011; 35: 13-22.
8. Mora JR, Iwata M, von Andrian UH: Vitamin effects on the immune system: vitamins a and d take centre stage. Nat Rev Immunol 2008; 8: 685-698.
9. Oddy WH, Rosales F: A systematic review of the importance of milk TGF-β on immunological outcomes in the infant and young child. Pediatr Allergy Immunol 2010; 21: 47-59.
10. Varol C, Vallon-Eberhard A, Elinav E, Aychek T, Shapira Y, Luche H, Fehling HJ, Hardt W-D, Shakhar G, Jung S: Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 2009; 31: 502-512.
11. Waskow C, Liu K, Darrasse-Jeze G, Guermonprez P, Ginhoux F, Merad M, Shengelia T, Yao K, Nussenzweig M: The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol 2008; 9: 676-683.
12. Feng T, Cong Y, Qin H, Benveniste EN, Elson CO: Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid. J Immunol 2010; 185: 5915-5925.
13. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song S-Y: Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004; 21: 527-538.
14. Smit JJ, Bol-Schoenmakers M, Hassing I, Fiechter D, Boon L, Bleumink R, Pieters RHH: The role of intestinal dendritic cells subsets in the establishment of food allergy. Clin Exp Allergy 2011; 41: 890-898.
15. Schulz O, Jaensson E, Persson EK, Liu X, Worbs T, Agace WW, Pabst O: Intestinal CD103 + , but not CX3CR1 + , antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 2009; 206: 3101-3114.
16. Laffont S, Siddiqui KRR, Powrie F: Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells. Eur J Immunol 2010; 40: 1877-1883.
17. Gibbons DL, Spencer J: Mouse and human intestinal immunity: same ballpark, different players; different rules, same score. Mucosal Immunol 2011; 4: 148-157.
18. Duester G: Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis. Biochemistry 1996; 35: 12221-12227.
19. Tokuyama H, Tokuyama Y: The regulatory effects of all-trans-retinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switching. Cell Immunol 1999; 192: 41-47.
20. Zan H, Cerutti A, Dramitinos P, Schaffer A, Casali P: CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β: evidence for TGF-β but not IL-10-dependent direct Sμ → Sα and sequential Sμ → Sγ, Sγ → Sα DNA recombination. J Immunol 1998; 161: 5217-5225.
21. Villamor E, Fawzi WW: Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev 2005; 18: 446-464.
22. Bernardo D, Al-Hassi HO, Mann ER, Tee CT, Murugananthan AU, Peake STC, Hart AL, Knight SC: T cell proliferation and forkhead box P3 expression in human T cells are dependent on T cell density: physics of a confined space? Hum Immunol 2012; 73: 223-231.
23. Ravetch JV, Bolland S: IgG Fc receptors. Annu Rev Immunol 2001; 19: 275-290.
24. Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, Stanley ER, Nussenzweig M, Lira SA, Randolph GJ, Merad M: Origin of the lamina propria dendritic cell network. Immunity 2009; 31: 513-525.
25. del Rio M-L, Rodriguez-Barbosa J-I, Kremmer E, Förster R: CD103 - and CD103 + bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4 + and CD8 + T cells. J Immunol 2007; 178: 6861-6866.
26. Mann ER, Landy JD, Bernardo D, Peake STC, Hart AL, Al-Hassi HO, Knight SC: Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men. Immunol Lett 2013; 150: 30-40.
27. Butler M, Ng CY, van Heel DA, Lombardi G, Lechler R, Playford RJ, Ghosh S: Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium. Eur J Immunol 2006; 36: 864-874.
28. Hintzen G, Ohl L, del Rio M-L, Rodriguez-Barbosa J-I, Pabst O, Kocks JR, Krege J, Hardtke S, Förster R: Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J Immunol 2006; 177: 7346-7354.
29. Molenaar R, Knippenberg M, Goverse G, Olivier BJ, de Vos AF, O'Toole T, Mebius RE: Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gutdraining lymph node stromal cells is controlled by dietary vitamin A. J Immunol 2011; 186: 1934-1942.
30. Al-Hassi HO, Bernardo D, Murugananthan AU, Mann ER, English NR, Jones A, Kamm MA, Arebi N, Hart AL, Blakemore AIF, Stagg AJ, Knight SC: A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease. Mucosal Immunol 2013; 6: 751-761.
31. Fanger NA, Voigtlaender D, Liu C, Swink S, Wardwell K, Fisher J, Graziano RF, Pfefferkorn LC, Guyre PM: Characterization of expression, cytokine regulation, and effector function of the high affinity IgG receptor Fc gamma RI (CD64) expressed on human blood dendritic cells. J Immunol 1997; 158: 3090-3098.
32. Boross P, Poel K, Winkel JG, Leusen JH: Fc receptors. eLS 2008, DOI: 10.1002/ 9780470015902.a0000916.pub2.
33. Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, Nespoli A, Viale G, Allavena P, Rescigno M: Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005; 6: 507-514.
34. Jankovic D, Kullberg MC, Hieny S, Caspar P, Collazo CM, Sher A: In the absence of IL-12, CD4 + T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10 -/- setting. Immunity 2002; 16: 429-439.
35. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G: Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993; 178: 1041-1048.
36. Rogers M-L, Goddard C, Regester GO, Ballard FJ, Belford DA: Transforming growth factor β in bovine milk: concentration, stability and molecular mass forms. J Endocrinol 1996; 151: 77-86.
37. den Hartog G, Savelkoul HFJ, Schoemaker R, Tijhaar E, Westphal AH, de Ruiter T, van de Weg-Schrijver E, van Neerven RJJ: Modulation of human immune responses by bovine interleukin-10. PLoS ONE 2011; 6:e18188.
38. Gregori S, Tomasoni D, Pacciani V, Scirpoli M, Battaglia M, Magnani CF, Hauben E, Roncarolo M-G: Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 2010; 116: 935-944.
39. Steinbrink K, Wölfl M, Jonuleit H, Knop J, Enk AH: Induction of tolerance by IL- 10-treated dendritic cells. J Immunol 1997; 159: 4772-4780.