A systematic review of the importance of milk TGF-β on immunological outcomes in the infant and young child

Pediatric Allergy and Immunology

Volumn 21, Issue 1 PART I, 2010, Pages 47-59

  Oddy, Wendy H ^a   Rosales, Francisco ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Mead Johnson Nutritionals   (United States)

Author keywords

Immunological outcomes; Infant and young child; Milk transforming growth factor beta; Systematic review

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 6; PROBIOTIC AGENT; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ALLERGY; ATOPIC DERMATITIS; ATOPY; BREAST MILK; CHILD; CLINICAL TRIAL; COLOSTRUM; CONTROLLED CLINICAL TRIAL; ECZEMA; HUMAN; IMMUNE RESPONSE; IMMUNITY; INFANT; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVIEW; SYSTEMATIC REVIEW; WHEEZING;

ANIMALS; CHILD, PRESCHOOL; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNE SYSTEM; INFANT; INFANT, NEWBORN; MILK, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

EID: 76149093558     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2009.00913.x     Document Type: Review

References (60)

1. Goldman AS, Rudloff HE. Are cytokines in human milk? Adv Exp Med Biol 1991 : 310 : 93 7.
2. Srivastava MD, Srivastava A, Brouhard B, Saneto R, Groh-Wargo S, Kubit J. Cytokines in human milk. Res Commun Mol Pathol Pharmacol 1996 : 93 : 263 287.
3. Stoeck M, Ruegg C, Miescher S, et al. Comparison of immunosuppressive properties of milk growth factors and transforming growth factors beta-1 and beta-2. J Immunol 1989 : 143 : 3258 3265.
4. Buts JP. Bioactive factors in milk. Arch Pediatr 1998 : 5 : 298 306.
5. Chinoy MR, Zgleszewski SE, Cilley RE, et al. Influence of epidermal growth factor and transforming growth factor beta-1 on patterns of fetal mouse lung branching morphogenesis in organ culture. Pediatr Pulmonol 1998 : 25 : 244 256.
6. Zhao Y, Young SL, McIntosh JC, Steele MP, Silbajoris R. Ontogeny and localization of TGF-beta type I receptor expression during lung development. Am J Physiol - Lung Cell Mol Physiol 2000 : 278 : L1231 9.
7. Bottcher MF, Jenmalm MC, Garofalo R, Bjorksten B. Cytokines in breastmilk from allergic and nonallergic mothers. Pediatr Res 2000 : 47 : 157 162. (Pubitemid 30038906)
8. Kalliomaki M, Ouwehand A, Arvilommi H, Kero P, Isolauri E. Transforming growth factor-beta in breast milk: a potential regulator of atopic disease at an early age. J Allergy Clin Immunol 1999 : 104 : 1251 1257.
9. Goldman AS. Modulation of the gastrointestinal tract of infants by human milk. Interfaces and interactions. An evolutionary perspective. J Nutr 2000 : 130 : 426S 31S.
10. Goldman AS, Chheda S, Garofalo R. Evolution of immunologic functions of the mammary gland and the postnatal development of immunity. Pediatr Res 1998 : 43 : 155 162.
11. Hasselbalch H, Engelmann MD, Ersboll AK, Jeppesen DL, Fleischer-Michaelsen K. Breast-feeding influences thymic size in late infancy. Eur J Pediatr 1999 : 158 : 964 967.
12. Letterio JJ. Murine models define the role of TGF-beta as a master regulator of immune cell function. Cytokine Growth Factor Rev 2000 : 11 : 81 7.
13. Letterio JJ, Geiser AG, Kulkarni AB, Roche NS, Sporn MB, Roberts AB. Maternal rescue of transforming growth factor-beta 1 null mice. Science 1994 : 264 : 1936 1938.
14. Noda K, Umeda M, Ono T. Transforming growth factor activity in human colostrum. Gann 1984 : 75 : 109 112.
15. Tuboly S, Bernáth S. Intestinal absorption of colostral lymphoid cells in newborn animals. In : Davis MK, ed. Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation. New York : Kluwer Academic/Plenum Publishing, 2002 : 338.
16. Lebman DA, Edmiston JS. The role of TGF-beta in growth, differentiation, and maturation of B lymphocytes. Microbes Infect 1999 : 1 : 1297 1304.
17. Strobel S. Oral tolerance, systemic immunoregulation, and autoimmunity. Ann N Y Acad Sci 2002 : 958 : 47 58.
18. 2 in human milk during the first three months postpartum. Pediatr Res 1999 : 46 : 194 199.
19. Abu-Ghazaleh RI, Fujisawa T, Mestecky J, Kyle RA, Gleich GJ. IgA-induced eosinophil degranulation. J Immunol 1989 : 142 : 2393 2400.
20. Schwarze J, Cieslewicz G, Joetham A, et al. Antigen-specific immunoglobulin-A prevents increased airway responsiveness and lung eosinophilia after airway challenge in sensitized mice. Am J Respir Crit Care Med 1998 : 158 : 519 525. (Pubitemid 28378182)
21. Ogawa J, Sasahara A, Yoshida T, et al. Role of transforming growth factor-beta in breast milk for initiation of IgA production in newborn infants. Early Hum Dev 2004 : 77 : 67 75.
22. Savilahti E, Siltanen M, Kajosaari M, Vaarala O, Saarinen KM. IgA antibodies, TGF-beta1 and -beta2, and soluble CD14 in the colostrum and development of atopy by age 4. Pediatr Res 2005 : 58 : 1300 1305.
23. Donnet-Hughes A, Duc N, Serrant P, Vidal K, Schiffrin EJ. Bioactive molecules in milk and their role in health and disease: the role of transforming growth factor-beta. Immunol Cell Biol 2000 : 78 : 74 9.
24. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. New Engl J Med 1995 : 332 : 133 138.
25. Saarinen KM, Juntunen-Backman K, Jarvenpaa AL, et al. Breast-feeding and the development of cows' milk protein allergy. Adv Exp Med Biol 2000 : 478 : 121 130.
26. Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992 : 359 : 693 699.
27. Kulkarni AB, Karlsson S. Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. Am J Pathol 1993 : 143 : 3 9.
28. Gorelik L, Flavell RA. Transforming growth factor-beta in T-cell biology. Nature Rev Immunol 2002 : 2 : 46 53.
29. Li MO, Wan YY, Sanjabi S, Robertson AKL, Flavell RA. Transforming growth factor-β regulation of immune responses. Ann Rev Immunol 2006 : 24 : 99 146.
30. Penttila I. Effects of transforming growth factor-beta and formula feeding on systemic immune responses to dietary beta-lactoglobulin in allergy-prone rats. Pediatr Res 2006 : 59 : 650 655.
31. Penttila IA, Flesch IE, McCue AL, et al. Maternal milk regulation of cell infiltration and interleukin 18 in the intestine of suckling rat pups. Gut 2003 : 52 : 1579 1586.
32. Penttila IA, van Spriel AB, Zhang MF, et al. Transforming growth factor-beta levels in maternal milk and expression in postnatal rat duodenum and ileum. Pediatr Res 1998 : 44 : 524 531.
33. Ando T, Hatsushika K, Wako M, et al. Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immunol 2007 : 120 : 916 923.
34. Saarinen KM, Vaarala O, Klemetti P, Savilahti E. Transforming growth factor-β1 in mothers' colostrum and immune responses to cows' milk proteins in infants with cows' milk allergy. J Allergy Clin Immunol 1999 : 104 : 1093 1098.
35. Verhasselt V, Milcent V, Cazareth J, et al. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nature Med 2008 : 14 : 170 175.
36. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005 : 5 : 13.
37. Kankaanpää P, Nurmela K, Erkkila A, et al. Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy. Allergy 2001 : 56 : 633 638.
38. Isolauri E, Arvola T, Sutas Y, Moilanen E, Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy 2000 : 30 : 1605 1610.
39. Saito S, Yoshida M, Ichijo M, Ishizaka S, Tsujii T. Transforming growth factor-beta (TGF-beta) in human milk. Clin Exp Immunol 1993 : 94 : 220 224.
40. Rautava S, Kalliomaki M, Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol 2002 : 109 : 119 121.
41. Böttcher MF, Jenmalm MC, Bjorksten B. Cytokine, chemokine and secretory IgA levels in human milk in relation to atopic disease and IgA production in infants. Pediatr Allergy Immunol 2003 : 14 : 35 41.
42. Snijders BEP, Damoiseaux JGMC, Penders J, et al. Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). Clin Exp Allergy 2006 : 36 : 1609 1615.
43. Oddy WH, Halonen M, Martinez FD, et al. TGF-ß in human milk is associated with wheeze in infancy. J Allergy Clin Immunol 2003 : 112 : 723 728.
44. Prokešová L, Lodinová- Žádníková R, Žižka J, et al. Cytokine levels in healthy and allergic mothers and their children during the first year of life Pediatr Allergy Immunol 2006 : 17 : 175 183.
45. Laiho K, Lampi AM, Hamalainen M, et al. Breast milk fatty acids, eicosanoids, and cytokines in mothers with and without allergic disease. Pediatr Res 2003 : 53 : 642 647.
46. Rigotti E, Piacentini GL, Ress M, Pigozzi R, Boner AL, Peroni DG. Transforming growth factor-β1 and interleukin-10 in breast milk and development of atopic diseases in infants. Clin Exp Allergy 2006 : 36 : 614 618.
47. Kalliomäki M, Salminen S, Arvolommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001 : 357 : 1076 1079.
48. Huibregtse IL, Snoeck V, de Creus A, et al. Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumGastroenterology 2007 : 133 : 517 528.
49. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Ann Rev Immunol 1998 : 16 : 137 161.
50. Ishizaka S, Kimoto M, Tsujii T, Saito S. Antibody production system modulated by oral administration of human milk and TGF-β. Cell Immunol 1994 : 159 : 77 84.
51. Gray JD, Hirokawa M, Horwitz DA. The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells. J Exp Med 1994 : 180 : 1937 1942.
52. Strober W, Kelsall B, Marth T. Oral tolerance. J Clin Immunol 1998 : 18 : 1 30.
53. van Vlasselaer P, Punnonen J, de Vries JE. Transforming growth factor-beta directs IgA switching in human B cells. J Immunol 1992 : 148 : 2062 2067.
54. Planchon SM, Martins CA, Guerrant RL, Roche JK. Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine. J Immunol 1994 : 153 : 5730 5739.
55. Hawkes JS, Bryan DL, Gibson RA. Variations in transforming growth factor beta in human milk are not related to levels in plasma. Cytokine 2002 : 17 : 182 186.
56. Hawkes JS, Bryan D-L, Neumann MA, Makrides M, Gibson RA. Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. Lipids 2001 : 36 : 1179 1181.
57. Bannerman D, Paapea MJ, Chockalingamb A. Staphylococcus aureus intramammary infection elicits increased production of transforming growth factor-α, β1, and β2. Vet Immunol Immunopathol 2006 : 112 : 309 315.
58. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFß activation. J Cell Sci 2003 : 116 : 217 224.
59. Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol 1988 : 106 : 1659 1665.
60. Penttila I. Immune modulation in suckling rat pups by a growth factor extract derived from milk whey. J Dairy Res 2001 : 68 : 587 599.