Repairing neural injuries using human umbilical cord blood

Molecular Neurobiology

Volumn 47, Issue 3, 2013, Pages 938-945

  Sun, Tao ^a   Ma, Quan Hong ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

Embryonic stem cells; Human umbilical cord blood; Mesenchymal stem cells; Neural injuries; Neural repair; Neural stem cells

Indexed keywords

ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; CELL TYPE; DEGENERATIVE DISEASE; EMBRYONIC STEM CELL; GLIA CELL; HEMATOPOIETIC STEM CELL; HUMAN; MESENCHYMAL STEM CELL; NERVE CELL; NERVOUS SYSTEM INJURY; NONHUMAN; QUANTITATIVE ANALYSIS; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; UMBILICAL CORD BLOOD; UNRESTRICTED SOMATIC STEM CELL; ANIMAL; CYTOLOGY; FETUS BLOOD; NERVE REGENERATION; PATHOLOGY; REVIEW; STEM CELL;

ANIMALS; FETAL BLOOD; HUMANS; NERVE REGENERATION; NEURONS; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 84887044461     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8388-0     Document Type: Article

References (75)

1. Harder F, Henschler R, Junghahn I., Lamers MC, Muller A.M. (2002) Human hematopoiesis in murine embryos after injecting human cord blood-derived hematopoietic stem cells into murine blastocysts. Blood 99(2):719-721
2. Pittenger MF, Mackay AM, Beck S.C., Jaiswal RK, Douglas R, Mosca JD, Moorman M.A., Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143-147
3. Flynn A, Barry F, O'Brien T (2007) UC blood-derived mesenchymal stromal cells: an overview. Cytotherapy 9(8):717-726
4. Gage FH (2000) Mammalian neural stem cells. Science 287 (5457):1433-1438
5. Temple S (2001) The development of neural stem cells. Nature 414 (6859):112-117
6. Gluckman E, Broxmeyer HA, Auerbach A.D., Friedman HS, Douglas GW, Devergie A, Esperou H., Thierry D, Socie G, Lehn P et al (1989) Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 321(17):1174-1178
7. Kogler G, Sensken S, Airey J.A., Trapp T., Muschen M, Feldhahn N, Liedtke S., Sorg RV, Fischer J, Rosenbaum C et al (2004) A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 200(2):123-135
8. Gluckman E (2009) Ten years of cord blood transplantation: from bench to bedside. Br J Haematol 147(2):192-199
9. Erices A, Conget P, Minguell J.J. (2000) Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 109(1):235-242
10. Baksh D, Yao R, Tuan R.S. (2007) Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 25 (6):1384-1392
11. Zhao Y, Wang H, Mazzone T. (2006) Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res 312(13):2454-2464
12. McGuckin C, Jurga M, Ali H., Strbad M, Forraz N. (2008) Culture of embryonic-like stem cells from human umbilical cord blood and onward differentiation to neural cells in vitro. Nat Protoc 3 (6):1046-1055
13. Forraz N, McGuckin C.P. (2011) The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. Cell Prolif 44(SUPPL. 1):60-69
14. Lee MW, Jang IK, Yoo K.H., Sung KW, Koo H.H. (2010) Stem and progenitor cells in human umbilical cord blood. Int J Hematol 92 (1):45-51
15. Arien-Zakay H., Lazarovici P, Nagler A. (2010) Tissue regeneration potential in human umbilical cord blood. Best Pract Res Clin Haematol 23(2):291-303
16. Arien-Zakay H., Lecht S, Nagler A., Lazarovici P. (2010) Human umbilical cord blood stem cells: rational for use as a neuroprotectant in ischemic brain disease. Int J Mol Sci 11(9):3513-3528
17. Buzanska L, Machaj EK, Zablocka B, Pojda Z., Domanska-Janik K (2002) Human cord blood-derived cells attain neuronal and glial features in vitro. J Cell Sci 115 (Pt 10):2131-2138
18. Buzanska L, Jurga M, Domanska-Janik K (2006) Neuronal differentiation of human umbilical cord blood neural stem-like cell line. Neurodegener Dis 3 (1-2):19-26
19. Buzanska L, Jurga M, Stachowiak E.K., Stachowiak MK, Domanska-Janik K (2006) Neural stem-like cell line derived from a nonhematopoietic population of human umbilical cord blood. Stem Cells Dev 15(3):391-406
20. El-Badri N.S., Hakki A, Saporta S., Liang X, Madhusodanan S, Willing A.E., Sanberg CD, Sanberg PR (2006) Cord blood mesen-chymal stem cells: Potential use in neurological disorders. Stem Cells Dev 15(4):497-506
21. Jeong JA, Gang EJ, Hong S.H., Hwang SH, Kim SW, Yang IH, Ahn C, Han H., Kim H. (2004) Rapid neural differentiation of human cord blood-derived mesenchymal stem cells. Neuroreport 15 (11):1731-1734
22. Zwart I, Hill AJ, Girdlestone J, Manca M.F., Navarrete R., Navarrete C, Jen L.S. (2008) Analysis of neural potential of human umbilical cord blood-derived multipotent mesenchymal stem cells in response to a range of neurogenic stimuli. J Neurosci Res 86 (9):1902-1915
23. Lim JY, Park SI, Oh J.H., Kim SM, Jeong CH, Jun JA, Lee K.S., Oh W., Lee JK, Jeun SS (2008) Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways. J Neurosci Res 86(10):2168-2178
24. Arien-Zakay H., Nagler A, Galski H., Lazarovici P. (2007) Neuronal conditioning medium and nerve growth factor induce neuronal differentiation of collagen-adherent progenitors derived from human umbilical cord blood. J Mol Neurosci 32(3):179-191
25. Chen N, Kamath S, Newcomb J., Hudson J, Garbuzova-Davis S, Bickford P, Davis-Sanberg C, Sanberg P., Zigova T, Willing A (2007) Trophic factor induction of human umbilical cord blood cells in vitro and in vivo. J Neural Eng 4(2):130-145
26. Arien-Zakay H., Lecht S, Bercu M.M., Amariglio N., Rechavi G, Galski H, Lazarovici P., Nagler A. (2009) Interferon-gamma-induced neuronal differentiation of human umbilical cord blood-derived progenitors. Leukemia 23(10):1790-1800
27. Szymczak P, Wojcik-Stanaszek L, Sypecka J., Sokolowska A, Zalewska T. (2010) Effect of matrix metalloproteinases inhibition on the proliferation and differentiation of HUCB-NSCs cultured in the presence of adhesive substrates. Acta Neurobiol Exp (Wars) 70 (4):325-336
28. Ali H, Forraz N, McGuckin C.P., Jurga M., Lindsay S, Ip BK, Trevelyan A, Basford C., Habibollah S, Ahmad S et al (2012) In vitro modelling of cortical neurogenesis by sequential induction of human umbilical cord blood stem cells. Stem Cell Rev 8(1):210-223
29. Zigova T, Song S, Willing A.E., Hudson JE, Newman MB, Saporta S, Sanchez-Ramos J, Sanberg P.R. (2002) Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain. Cell Transplant 11(3):265-274
30. Coenen M, Kogler G, Wernet P., Brustle O. (2005) Transplantation of human umbilical cord blood-derived adherent progenitors into the developing rodent brain. J Neuropathol Exp Neurol 64(8):681-688
31. Goodwin HS, Bicknese AR, Chien S.N., Bogucki BD, Quinn CO, Wall D.A. (2001) Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant 7(11):581-588
32. Jang YK, Park JJ, Lee M.C., Yoon BH, Yang YS, Yang SE, Kim S.U. (2004) Retinoic acid-mediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells. J Neurosci Res 75(4):573-584
33. Sypecka J, Dragun-Szymczak P, Zalewska T., Domanska-Janik K (2009) Laminin promotes oligogliogenesis and increases MMPs activity in human neural stem cells of HUCB-NSC line. Acta Neurobiol Exp (Wars) 69(1):37-45
34. Tanabe Y, Tajima F, Nakamura Y., Shibasaki E, Wakejima M, Shimomura T., Murai R, Murawaki Y, Hashiguchi K, Kanbe T et al (2004) Analyses to clarify rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion. Biochem Biophys Res Commun 324(2):711-718
35. Ishikawa F, Shimazu H, Shultz L.D., Fukata M., Nakamura R, Lyons B, Shimoda K., Shimoda S, Kanemaru T, Nakamura K et al (2006) Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion. FASEB J 20(7):950-952
36. Koh SH, Kim KS, Choi M.R., Jung KH, Park KS, Chai YG, Roh W, Hwang S.J., Ko HJ, Huh YM et al (2008) Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats. Brain Res 1229:233-248
37. Schira J, Gasis M, Estrada V., Hendricks M, Schmitz C, Trapp T., Kruse F, Kogler G, Wernet P, Hartung HP et al (2012) Significant clinical, neuropathological and behavioural recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood. Brain 135 (Pt 2):431-446
38. Ali H, Bahbahani H. (2010) Umbilical cord blood stem cells-potential therapeutic tool for neural injuries and disorders. Acta Neurobiol Exp (Wars) 70(3):316-324
39. Rosenkranz K, Meier C. (2011) Umbilical cord blood cell transplantation after brain ischemia-from recovery of function to cellular mechanisms. Ann Anat 193(4):371-379
40. Trapp T, Kogler G, El-Khattouti A, Sorg R.V., Besselmann M., Focking M, Buhrle CP, Trompeter I, Fischer J.C., Wernet P. (2008) Hepatocyte growth factor/c-MET axis-mediated tropism of cord blood-derived unrestricted somatic stem cells for neuronal injury. J Biol Chem 283(47):32244-32253
41. Newman MB, Willing AE, Manresa J.J., Davis-Sanberg C, Sanberg P.R. (2005) Stroke-induced migration of human umbilical cord blood cells: time course and cytokines. Stem Cells Dev 14 (5):576-586
42. Chen J, Sanberg PR, Li Y, Wang L., Lu M, Willing AE, Sanchez-Ramos J, Chopp M. (2001) Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32(11):2682-2688
43. Xiao J, Nan Z, Motooka Y., Low W.C. (2005) Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem Cells Dev 14(6):722-733
44. Willing AE, Lixian J, Milliken M., Poulos S, Zigova T, Song S., Hart C, Sanchez-Ramos J, Sanberg PR (2003) Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res 73(3):296-307
45. Borlongan CV, Hadman M, Sanberg C.D., Sanberg P.R. (2004) Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 35(10):2385-2389
46. Streit WJ, Walter SA, Pennell N.A. (1999) Reactive microgliosis. Prog Neurobiol 57(6):563-581
47. Jiang L, Womble T, Saporta S., Chen N, Sanberg CD, Sanberg P.R., Willing A.E. (2010) Human umbilical cord blood cells decrease microglial survival in vitro. Stem Cells Dev 19(2):221-228
48. Pimentel-Coelho P.M., Magalhaes ES, Lopes L.M., deAzevedo LC, Santiago MF, Mendez-Otero R (2010) Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum. Stem Cells Dev 19(3):351-358
49. Rosenkranz K, Kumbruch S, Tenbusch M., Marcus K, Marschner K, Dermietzel R., Meier C. (2012) Transplantation of human umbilical cord blood cells mediated beneficial effects on apoptosis, angiogenesis and neuronal survival after hypoxic-ischemic brain injury in rats. Cell Tissue Res 348(3):429-438
50. Yasuhara T, Hara K, Maki M., Xu L, Yu G, Ali M.M., Masuda T., Yu SJ, Bae EK, Hayashi T et al (2010) Mannitol facilitates neuro-trophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts. J Cell Mol Med 14(4):914-921
51. Arien-Zakay H., Lecht S, Nagler A., Lazarovici P. (2011) Neuroprotection by human umbilical cord blood-derived progenitors in ischemic brain injuries. Arch Ital Biol 149(2):233-245
52. Vendrame M, Gemma C, de Mesquita D, Collier L, Bickford P.C., Sanberg CD, Sanberg PR, Pennypacker KR, Willing AE (2005) Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev 14(5):595-604
53. Vendrame M, Gemma C, Pennypacker K.R., Bickford PC, Davis Sanberg C, Sanberg PR, Willing A.E. (2006) Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol 199(1):191-200
54. Ingram DA, Mead LE, Tanaka H, Meade V., Fenoglio A, Mortell K, Pollok K., Ferkowicz MJ, Gilley D, Yoder MC (2004) Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 104 (9):2752-2760
55. Pesce M, Orlandi A, Iachininoto M.G., Straino S., Torella AR, Rizzuti V, Pompilio G, Bonanno G., Scambia G, Capogrossi MC (2003) Myoendothelial differentiation of human umbilical cord blood-derived stem cells in ischemic limb tissues. Circ Res 93 (5):e51-e62
56. Au P, Daheron LM, Duda D.G., Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden D.T., Jain R.K. (2008) Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood 111(3):1302-1305
57. Taguchi A, Soma T, Tanaka H., Kanda T, Nishimura H, Yoshikawa H., Tsukamoto Y, Iso H, Fujimori Y, Stern DM et al (2004) Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 114(3):330-338
58. Hu CH, Wu GF, Wang X.Q., Yang YH, Du ZM, He XH, Xiang P. (2006) Transplanted human umbilical cord blood mononuclear cells improve left ventricular function through angiogenesis in myocardial infarction. Chin Med J (Engl) 119(18):1499-1506
59. Kim BO, Tian H, Prasongsukarn K., Wu J, Angoulvant D, Wnendt S., Muhs A, Spitkovsky D, Li RK (2005) Cell transplantation improves ventricular function after a myocardial infarction: a pre-clinical study of human unrestricted somatic stem cells in a porcine model. Circulation 112 (9 Suppl):I96-I104
60. Arenillas JF, Sobrino T, Castillo J., Davalos A. (2007) The role of angiogenesis in damage and recovery from ischemic stroke. Curr Treat Options Cardiovasc Med 9(3):205-212
61. Park DH, Borlongan CV, Willing A.E., Eve DJ, Cruz LE, Sanberg CD, Chung Y.G., Sanberg P.R. (2009) Human umbilical cord blood cell grafts for brain ischemia. Cell Transplant 18(9):985-998
62. Zhao ZM, Li HJ, Liu H.Y., Lu SH, Yang RC, Zhang QJ, Han Z.C. (2004) Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats. Cell Transplant 13(2):113-122
63. Kao CH, Chen SH, Chio C.C., Lin M.T. (2008) Human umbilical cord blood-derived CD34+ cells may attenuate spinal cord injury by stimulating vascular endothelial and neurotrophic factors. Shock 29(1):49-55
64. Saporta S, Kim JJ, Willing A.E., Fu ES, Davis CD, Sanberg P.R. (2003) Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior. J Hematother Stem Cell Res 12(3):271-278
65. Park DH, Lee JH, Borlongan C.V., Sanberg PR, Chung YG, Cho T.H. (2011) Transplantation of umbilical cord blood stem cells for treating spinal cord injury. Stem Cell Rev 7(1):181-194
66. Dasari VR, Spomar DG, Gondi C.S., Sloffer CA, Saving KL, Gujrati M, Rao J.S., Dinh D.H. (2007) Axonal remyelination by cord blood stem cells after spinal cord injury. J Neurotrauma 24(2):391-410
67. Chen CT, Foo NH, Liu W.S., Chen S.H. (2008) Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vascu-logenic and neurotrophic mechanisms. Pediatr Neonatol 49(3):77-83
68. Dasari VR, Spomar DG, Li L, Gujrati M., Rao JS, Dinh D.H. (2008) Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Neurochem Res 33(1):134-149
69. Li X, Li H, Bi J., Chen Y, Jain S, Zhao Y. (2012) Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons. Biochem Biophys Res Commun 419(1):110-116
70. Fu YS, Cheng YC, Lin M.Y., Cheng H., Chu PM, Chou SC, Shih YH, Ko M.H., Sung M.S. (2006) Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells 24(1):115-124
71. Ende N, Chen R, Ende-Harris D (2001) Human umbilical cord blood cells ameliorate Alzheimer's disease in transgenic mice. J Med 32 (3-4):241-247
72. Nikolic WV, Hou H, Town T., Zhu Y, Giunta B, Sanberg C.D., Zeng J., Luo D, Ehrhart J, Mori T et al (2008) Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev 17 (3):423-439
73. Lee HJ, Lee JK, Lee H, Shin J.W., Carter JE, Sakamoto T, Jin HK, Bae J.S. (2010) The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease. Neurosci Lett 481(1):30-35
74. Garbuzova-Davis S., Willing AE, Zigova T, Saporta S., Justen EB, Lane JC, Hudson JE, Chen N, Davis C.D., Sanberg P.R. (2003) Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation. J Hematother Stem Cell Res 12 (3):255-270
75. Habisch HJ, Janowski M, Binder D., Kuzma-Kozakiewicz M, Widmann A, Habich A., Schwalenstocker B, Hermann A, Brenner R, Lukomska B et al (2007) Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm 114(11):1395-1406