Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons

Biochemical and Biophysical Research Communications

Volumn 419, Issue 1, 2012, Pages 110-116

  Li, Xiaohong ^a   Li, Heng ^a   Bi, Jianfen ^a   Chen, Yana ^a   Jain, Sumit ^b   Zhao, Yong ^b  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

All trans retinoic acid; Differentiation; Dopamine neurons; Parkinson's disease; Stem cells; Umbilical cord blood

Indexed keywords

DOPAMINE; DOPAMINE TRANSPORTER; MESSENGER RNA; NUCLEAR RECEPTOR RELATED FACTOR 1; POTASSIUM; RETINOIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EN1; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; WNT1 PROTEIN;

ARTICLE; CELL SHAPE; CELL STRUCTURE; CULTURE MEDIUM; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MULTIPOTENT STEM CELL; NERVE CELL DIFFERENTIATION; NORMAL HUMAN; PARKINSON DISEASE; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION; UMBILICAL CORD BLOOD;

CELL DIFFERENTIATION; DOPAMINERGIC NEURONS; FETAL BLOOD; HOMEODOMAIN PROTEINS; HUMANS; MULTIPOTENT STEM CELLS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; PARKINSON DISEASE; TRETINOIN; WNT1 PROTEIN;

EID: 84862818242     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.142     Document Type: Article

References (26)

1. Kim H.J. Stem cell potential in Parkinson's disease and molecular factors for the generation of dopamine neurons. Biochim. Biophys. Acta 1812, 2011:1-11.
2. Zhao Y., Mazzone T. Human cord blood stem cells and the journey to a cure for type 1 diabetes. Autoimmun. Rev. 2010, 10:103-107.
3. Joyce N., Annett G., Wirthlin L., Olson S., Bauer G., Nolta J.A. Mesenchymal stem cells for the treatment of neurodegenerative disease. Regen. Med. 2010, 5:933-946.
4. Lunn J.S., Sakowski S.A., Hur J., Feldman E.L. Stem cell technology for neurodegenerative diseases. Ann. Neurol. 2011, 70:353-361.
5. Cho M.S., Lee Y.E., Kim J.Y., Chung S., Cho Y.H., Kim D.S., Kang S.M., Lee H., Kim M.H., Kim J.H., Leem J.W., Oh S.K., Choi Y.M., Hwang D.Y., Chang J.W., Kim D.W. Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells Proc. Natl. Acad. Sci. USA 2008, 105:3392-3397.
6. Rossler R., Boddeke E., Copray S. Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons. Neuroscience 2010, 170:417-428.
7. Rhee Y.H., Ko J.Y., Chang M.Y., Yi S.H., Kim D., Kim C.H., Shim J.W., Jo A.Y., Kim B.W., Lee H., Lee S.H., Suh W., Park C.H., Koh H.C., Lee Y.S., Lanza R., Kim K.S., Lee S.H. Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J. Clin. Invest. 2011, 121:2326-2335.
8. Trzaska K.A., Kuzhikandathil E.V., Rameshwar P. Specification of a dopaminergic phenotype from adult human mesenchymal stem cells. Stem cells 2007, 25:2797-2808.
9. Trzaska K.A., Rameshwar P. Dopaminergic neuronal differentiation protocol for human mesenchymal stem cells. Methods Mol. Biol. 2011, 698:295-303.
10. Baxter M.A., Wynn R.F., Jowitt S.N., Wraith J.E., Fairbairn L.J., Bellantuono I. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 2004, 22:675-682.
11. Stolzing A., Scutt A. Age-related impairment of mesenchymal progenitor cell function. Aging Cell 2006, 5:213-224.
12. Stolzing A., Jones E., McGonagle D., Scutt A. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech. Ageing Dev. 2008, 129:163-173.
13. Zhao Y., Wang H., Mazzone T. Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp. Cell Res. 2006, 312:2454-2464.
14. Zhao Y., Jiang Z., Zhao T., Ye M., Hu C., Yin Z., Li H., Zhang Y., Diao Y., Li Y., Chen Y., Sun X., Fisk M.B., Skidgel R., Holterman M., Prabhakar B., Mazzone T. Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med. 2012, 10:3.
15. Zhao Y., Jiang Z., Guo C. New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells. Autoimmun. Rev. 2011, 11:137-142.
16. Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat. Rev. Neurosci. 2007, 8:755-765.
17. Castro D.S., Hermanson E., Joseph B., Wallen A., Aarnisalo P., Heller A., Perlmann T. Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells. J. Biol. Chem. 2001, 276:43277-43284.
18. Zhao Y., Lin B., Darflinger R., Zhang Y., Holterman M.J., Skidgel R.A. Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS One 2009, 4:e4226.
19. Zhao Y., Huang Z., Qi M., Lazzarini P., Mazzone T. Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. Immunol. Lett. 2007, 108:78-87.
20. Smidt M.P., Burbach J.P. How to make a mesodiencephalic dopaminergic neuron. Nat. Rev. Neurosci. 2007, 8:21-32.
21. Lee S.H., Lumelsky N., Studer L., Auerbach J.M., McKay R.D. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. 2000, 18:675-679.
22. Greschat S., Schira J., Kury P., Rosenbaum C., de Souza Silva M.A., Kogler G., Wernet P., Muller H.W. Unrestricted somatic stem cells from human umbilical cord blood can be differentiated into neurons with a dopaminergic phenotype. Stem Cells Dev. 2008, 17:221-232.
23. Kogler G., Sensken S., Airey J.A., Trapp T., Muschen M., Feldhahn N., Liedtke S., Sorg R.V., Fischer J., Rosenbaum C., Greschat S., Knipper A., Bender J., Degistirici O., Gao J., Caplan A.I., Colletti E.J., Meida-Porada G., Muller H.W., Zanjani E., Wernet P. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J. Exp. Med. 2004, 200:123-135.
24. Cooper O., Hargus G., Deleidi M., Blak A., Osborn T., Marlow E., Lee K., Levy A., Perez-Torres E., Yow A., Isacson O. Differentiation of human ES and parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol. Cell Neurosci. 2010, 45:258-266.
25. Paul J. Price, Gregory J. Brewer, Serum-Free Media for Neural Cell Cultures Adult and Embryonic Protocols for Neural Cell Culture, 2001, pp. 255-264 (Chapter 19).
26. Brewer G.J., Torricelli J.R., Evege E.K., Price P.J. Optimized survival of hippocampal neurons in B27-supplemented neurobasal, a new serum-free medium combination. J. Neurosci. Res. 1993, 35:567-576.