Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 558-567

  Nury, Thomas ^a   Samadi, Mohammad ^b   Zarrouk, Amira ^a,c   Riedinger, Jean Marc ^d   Lizard, Gérard ^a  

^a Faculté des Sciences Gabriel   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITY OF MONASTIR   (Tunisia)

^d Centre de Lutte Contre le Cancer GF Leclerc   (France)

Author keywords

158N murine oligodendrocytes; 4 Hydroxycholesterol; 4 Hydroxycholesterol; C6 rat glioma cells; Cell growth; Cell viability; Glial cells primary culture; SK N BE human neuroblastoma cells

Indexed keywords

4ALPHA HYDROXYCHOLESTEROL; 4BETA HYDROXYCHOLESTEROL; 7 OXOCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; CYTOTOXIC AGENT; OXYSTEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; OXIDATION; STRUCTURE ACTIVITY RELATION;

158N MURINE OLIGODENDROCYTES; 4Α-HYDROXYCHOLESTEROL; 4Β-HYDROXYCHOLESTEROL; C6 RAT GLIOMA CELLS; CELL GROWTH; CELL VIABILITY; GLIAL CELLS PRIMARY CULTURE; SK-N-BE HUMAN NEUROBLASTOMA CELLS;

CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROXYCHOLESTEROLS; KETOCHOLESTEROLS; MOLECULAR CONFORMATION; OXIDATION-REDUCTION; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887043169     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.028     Document Type: Article

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