메뉴 건너뛰기




Volumn 17, Issue 4, 2013, Pages 1051-1066

Cry1Ac protoxin from Bacillus thuringiensis promotes macrophage activation by upregulating CD80 and CD86 and by inducing IL-6, MCP-1 and TNF-α cytokines

Author keywords

Cry1Ac protoxin; Macrophage activation; Mucosal adjuvant

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; B7 ANTIGEN; CD86 ANTIGEN; CRY1AC TOXIN; GAMMA INTERFERON; INTERLEUKIN 12P70; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84887038774     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.10.005     Document Type: Article
Times cited : (37)

References (50)
  • 1
    • 0023938398 scopus 로고
    • Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens
    • J.D. Clements, N.M. Hartzog, and F.L. Lyon Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens Vaccine 6 1988 269 277
    • (1988) Vaccine , vol.6 , pp. 269-277
    • Clements, J.D.1    Hartzog, N.M.2    Lyon, F.L.3
  • 2
    • 0027530649 scopus 로고
    • Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen
    • DOI 10.1016/0264-410X(93)90004-H
    • A.D. Wilson, A. Robinson, L. Irons, and C.R. Stokes Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen Vaccine 11 1993 113 118 (Pubitemid 23031494)
    • (1993) Vaccine , vol.11 , Issue.2 , pp. 113-118
    • Wilson, A.D.1    Robinson, A.2    Irons, L.3    Stokes, C.R.4
  • 3
    • 0031255006 scopus 로고    scopus 로고
    • The mechanism of cholera toxin adjuvanticity
    • DOI 10.1016/S0923-2494(98)80144-2
    • N. Lycke The mechanism of cholera toxin adjuvanticity Res Immunol 148 1997 504 520 (Pubitemid 28179014)
    • (1997) Research in Immunology , vol.148 , Issue.8-9 , pp. 504-520
    • Lycke, N.1
  • 5
    • 0035313205 scopus 로고    scopus 로고
    • How Bacillus thuringiensis has evolved specific toxins to colonize the insect world
    • DOI 10.1016/S0168-9525(01)02237-5, PII S0168952501022375
    • R.A. de Maagd, A. Bravo, and N. Crickmore How Bacillus thuringiensis has evolved specific toxins to colonize the insect world Trends Genet 17 2001 193 199 (Pubitemid 32239538)
    • (2001) Trends in Genetics , vol.17 , Issue.4 , pp. 193-199
    • De Maagd, R.A.1    Bravo, A.2    Crickmore, N.3
  • 7
    • 0025052573 scopus 로고
    • Hyperexpression of a Bacillus thuringiensis delta-endotoxin-encoding gene in Escherichia coli: Properties of the product
    • DOI 10.1016/0378-1119(90)90134-D
    • A.Z. Ge, R.M. Pfister, and D.H. Dean Hyperexpression of a Bacillus thuringiensis delta-endotoxin-encoding gene in Escherichia coli: properties of the product Gene 93 1990 49 54 (Pubitemid 20353081)
    • (1990) Gene , vol.93 , Issue.1 , pp. 49-54
    • Ge, A.Z.1    Pfister, R.M.2    Dean, D.H.3
  • 8
    • 0343253741 scopus 로고    scopus 로고
    • Intragastric and intraperitoneal administration of Cry1Ac protoxin from Bacillus thuringiensis induces systemic and mucosal antibody responses in mice
    • DOI 10.1016/S0024-3205(99)00136-8, PII S0024320599001368
    • R.I. Vazquez-Padron, L. Moreno-Fierros, L. Neri-Bazan, G.A. de la Riva, and R. Lopez-Revilla Intragastric and intraperitoneal administration of Cry1Ac protoxin from Bacillus thuringiensis induces systemic and mucosal antibody responses in mice Life Sci 64 1999 1897 1912 (Pubitemid 29215191)
    • (1999) Life Sciences , vol.64 , Issue.21 , pp. 1897-1912
    • Vazquez-Padron, R.I.1    Moreno-Fierros, L.2    Neri-Bazan, L.3    De La Riva, G.A.4    Lopez-Revilla, R.5
  • 9
    • 0033942940 scopus 로고    scopus 로고
    • Intranasal, rectal and intraperitoneal immunization with protoxin Cry1Ac from Bacillus thuringiensis induces compartmentalized serum, intestinal, vaginal and pulmonary immune responses in Balb/c mice
    • DOI 10.1016/S1286-4579(00)00398-1
    • L. Moreno-Fierros, N. Garcia, R. Gutierrez, R. Lopez-Revilla, and R.I. Vazquez-Padron Intranasal, rectal and intraperitoneal immunization with protoxin Cry1Ac from Bacillus thuringiensis induces compartmentalized serum, intestinal, vaginal and pulmonary immune responses in Balb/c mice Microbes Infect 2 2000 885 890 (Pubitemid 30483183)
    • (2000) Microbes and Infection , vol.2 , Issue.8 , pp. 885-890
    • Moreno-Fierros, L.1    Garcia, N.2    Gutierrez, R.3    Lopez-Revilla, R.4    Vazquez-Padron, R.I.5
  • 10
    • 0346880531 scopus 로고    scopus 로고
    • Intranasal Cry1Ac Protoxin is an Effective Mucosal and Systemic Carrier and Adjuvant of Streptococcus pneumoniae Polysaccharides in Mice
    • DOI 10.1046/j.1365-3083.2003.01190.x
    • L. Moreno-Fierros, E.J. Ruiz-Medina, R. Esquivel, R. Lopez-Revilla, and S. Pina-Cruz Intranasal Cry1Ac protoxin is an effective mucosal and systemic carrier and adjuvant of Streptococcus pneumoniae polysaccharides in mice Scand J Immunol 57 2003 45 55 (Pubitemid 38019087)
    • (2003) Scandinavian Journal of Immunology , vol.57 , Issue.1 , pp. 45-55
    • Moreno-Fierros, L.1    Ruiz-Medina, E.J.2    Esquivel, R.3    Lopez-Revilla, R.4    Pina-Cruz, S.5
  • 11
    • 3343026081 scopus 로고    scopus 로고
    • Intranasal coadministration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis
    • DOI 10.1128/IAI.72.8.4368-4375.2004
    • S. Rojas-Hernandez, M.A. Rodriguez-Monroy, R. Lopez-Revilla, A.A. Resendiz-Albor, and L. Moreno-Fierros Intranasal coadministration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis Infect Immun 72 2004 4368 4375 (Pubitemid 38989292)
    • (2004) Infection and Immunity , vol.72 , Issue.8 , pp. 4368-4375
    • Rojas-Hernandez, S.1    Rodriguez-Monroy, M.A.2    Lopez-Revilla, R.3    Resendiz-Albor, A.A.4    Moreno-Fierros, L.5
  • 12
    • 77951678430 scopus 로고    scopus 로고
    • Pretreatment with Cry1Ac protoxin modulates the immune response, and increases the survival of Plasmodium-infected CBA/Ca mice
    • M. Legorreta-Herrera, R.O. Meza, and L. Moreno-Fierros Pretreatment with Cry1Ac protoxin modulates the immune response, and increases the survival of Plasmodium-infected CBA/Ca mice J Biomed Biotechnol 2010 2010 198921
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 198921
    • Legorreta-Herrera, M.1    Meza, R.O.2    Moreno-Fierros, L.3
  • 13
    • 0030935238 scopus 로고    scopus 로고
    • New developments in adjuvants
    • DOI 10.1016/S0047-6374(96)01810-6, PII S0047637496018106
    • J.J. Donnelly New developments in adjuvants Mech Ageing Dev 93 1997 171 177 (Pubitemid 27138339)
    • (1997) Mechanisms of Ageing and Development , vol.93 , Issue.1-3 , pp. 171-177
    • Donnelly, J.J.1
  • 17
    • 33644669825 scopus 로고    scopus 로고
    • B7-1 and B7-2: Similar costimulatory ligands with different biochemical, oligomeric and signaling properties
    • DOI 10.1016/j.imlet.2005.11.019, PII S0165247805003573, Signal and Signaling Processing in the Immune System
    • S. Bhatia, M. Edidin, S.C. Almo, and S.G. Nathenson B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties Immunol Lett 104 2006 70 75 (Pubitemid 43330711)
    • (2006) Immunology Letters , vol.104 , Issue.1-2 , pp. 70-75
    • Bhatia, S.1    Edidin, M.2    Almo, S.C.3    Nathenson, S.G.4
  • 18
    • 0029890168 scopus 로고    scopus 로고
    • Endotoxin signal transduction in macrophages
    • M.J. Sweet, and D.A. Hume Endotoxin signal transduction in macrophages J Leukoc Biol 60 1996 8 26 (Pubitemid 26248877)
    • (1996) Journal of Leukocyte Biology , vol.60 , Issue.1 , pp. 8-26
    • Sweet, M.J.1    Hume, D.A.2
  • 19
    • 0031452476 scopus 로고    scopus 로고
    • Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
    • C.A. Dinarello Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock Chest 112 1997 321S 329S (Pubitemid 28013408)
    • (1997) Chest , vol.112 , Issue.6
    • Dinarello, C.A.1
  • 20
    • 84859022123 scopus 로고    scopus 로고
    • The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis
    • J.G. Bode, C. Ehlting, and D. Haussinger The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis Cell Signal 24 2012 1185 1194
    • (2012) Cell Signal , vol.24 , pp. 1185-1194
    • Bode, J.G.1    Ehlting, C.2    Haussinger, D.3
  • 21
    • 70450015733 scopus 로고    scopus 로고
    • Immunization with Cry1Ac from Bacillus thuringiensis increases intestinal IgG response and induces the expression of FcRn in the intestinal epithelium of adult mice
    • S.L. Verdin-Teran, A. Vilches-Flores, and L. Moreno-Fierros Immunization with Cry1Ac from Bacillus thuringiensis increases intestinal IgG response and induces the expression of FcRn in the intestinal epithelium of adult mice Scand J Immunol 70 2009 596 607
    • (2009) Scand J Immunol , vol.70 , pp. 596-607
    • Verdin-Teran, S.L.1    Vilches-Flores, A.2    Moreno-Fierros, L.3
  • 23
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • DOI 10.1146/annurev.immunol.18.1.621
    • M. Karin, and Y. Ben-Neriah Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity Annu Rev Immunol 18 2000 621 663 (Pubitemid 30365393)
    • (2000) Annual Review of Immunology , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 25
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • DOI 10.1016/S0898-6568(00)00149-2, PII S0898656800001492
    • M. Guha, and N. Mackman LPS induction of gene expression in human monocytes Cell Signal 13 2001 85 94 (Pubitemid 32222977)
    • (2001) Cellular Signalling , vol.13 , Issue.2 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 26
    • 0037165950 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase activation in the production of inflammatory mediators: Differences between primary rat alveolar macrophages and macrophage cell lines
    • DOI 10.1080/00984100290071027
    • K.M. Rao, T. Meighan, and L. Bowman Role of mitogen-activated protein kinase activation in the production of inflammatory mediators: differences between primary rat alveolar macrophages and macrophage cell lines J Toxicol Environ Health A 65 2002 757 768 (Pubitemid 34553597)
    • (2002) Journal of Toxicology and Environmental Health - Part A , vol.65 , Issue.10 , pp. 757-768
    • Murali Krishna Rao, K.1    Meighan, T.2    Bowman, L.3
  • 27
    • 10844273239 scopus 로고    scopus 로고
    • Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells
    • DOI 10.1093/intimm/dxh171
    • T. Nakahara, H. Uchi, K. Urabe, Q. Chen, M. Furue, and Y. Moroi Role of c-Jun N-terminal kinase on lipopoly saccharide induced maturation of human monocyte-derived dendritic cells Int Immunol 16 2004 1701 1709 (Pubitemid 40003858)
    • (2004) International Immunology , vol.16 , Issue.12 , pp. 1701-1709
    • Nakahara, T.1    Uchi, H.2    Urabe, K.3    Chen, Q.4    Furue, M.5    Moroi, Y.6
  • 28
    • 77449161040 scopus 로고    scopus 로고
    • Striking activation of NALT and nasal passages lymphocytes induced by intranasal immunization with Cry1Ac protoxin
    • M.A. Rodriguez-Monroy, and L. Moreno-Fierros Striking activation of NALT and nasal passages lymphocytes induced by intranasal immunization with Cry1Ac protoxin Scand J Immunol 71 2010 159 168
    • (2010) Scand J Immunol , vol.71 , pp. 159-168
    • Rodriguez-Monroy, M.A.1    Moreno-Fierros, L.2
  • 29
    • 58849167699 scopus 로고    scopus 로고
    • The isolation and characterization of murine macrophages
    • 10.1002/0471142735.im1401s83 [John Wiley & Sons, Inc.]
    • X. Zhang, R. Goncalves, and D.M. Mosser The isolation and characterization of murine macrophages Curr Protoc Immunol 14 SUPPL 83 2008 14.1.1 14.1.14 10.1002/0471142735.im1401s83 [John Wiley & Sons, Inc.]
    • (2008) Curr Protoc Immunol , vol.14 , Issue.SUPPL. 83 , pp. 1411-14114
    • Zhang, X.1    Goncalves, R.2    Mosser, D.M.3
  • 30
    • 33847039079 scopus 로고    scopus 로고
    • Phenotypic and functional differences between lymphocytes from NALT and nasal passages of mice
    • M.A. Rodriguez-Monroy, S. Rojas-Hernandez, and L. Moreno-Fierros Phenotypic and functional differences between lymphocytes from NALT and nasal passages of mice Scand J Immunol 65 2007 276 288
    • (2007) Scand J Immunol , vol.65 , pp. 276-288
    • Rodriguez-Monroy, M.A.1    Rojas-Hernandez, S.2    Moreno-Fierros, L.3
  • 31
    • 80055015168 scopus 로고    scopus 로고
    • Roxatidine suppresses inflammatory responses via inhibition of NF-kappaB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages
    • E.J. Cho, H.J. An, J.S. Shin, H.E. Choi, J. Ko, and Y.W. Cho Roxatidine suppresses inflammatory responses via inhibition of NF-kappaB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages J Cell Biochem 112 2011 3648 3659
    • (2011) J Cell Biochem , vol.112 , pp. 3648-3659
    • Cho, E.J.1    An, H.J.2    Shin, J.S.3    Choi, H.E.4    Ko, J.5    Cho, Y.W.6
  • 32
    • 56949083956 scopus 로고    scopus 로고
    • Ikarisoside A inhibits inducible nitric oxide synthase in lipopolysaccharide-stimulated RAW 264.7 cells via p38 kinase and nuclear factor-kappaB signaling pathways
    • H.J. Choi, J.S. Eun, Y.R. Park, D.K. Kim, R. Li, and W.S. Moon Ikarisoside A inhibits inducible nitric oxide synthase in lipopolysaccharide- stimulated RAW 264.7 cells via p38 kinase and nuclear factor-kappaB signaling pathways Eur J Pharmacol 601 2008 171 178
    • (2008) Eur J Pharmacol , vol.601 , pp. 171-178
    • Choi, H.J.1    Eun, J.S.2    Park, Y.R.3    Kim, D.K.4    Li, R.5    Moon, W.S.6
  • 33
    • 33745875334 scopus 로고    scopus 로고
    • Production of a short recombinant C4V3 HIV-1 immunogen that induces strong anti-HIV responses by systemic and mucosal routes without the need of adjuvants
    • DOI 10.1089/vim.2006.19.237
    • J.T. Varona-Santos, R.I. Vazquez-Padron, and L. Moreno-Fierros Production of a short recombinant C4V3 HIV-1 immunogen that induces strong anti-HIV responses by systemic and mucosal routes without the need of adjuvants Viral Immunol 19 2006 237 249 (Pubitemid 44050322)
    • (2006) Viral Immunology , vol.19 , Issue.2 , pp. 237-249
    • Varona-Santos, J.T.1    Vazquez-Padron, R.I.2    Moreno-Fierros, L.3
  • 34
    • 80355124236 scopus 로고    scopus 로고
    • The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to monitor lymphocyte proliferation
    • 10.3791/2259 [Published online 2010 October 12]
    • B.J. Quah, and C.R. Parish The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to monitor lymphocyte proliferation J. Vis. Exp 44 2010 2259 10.3791/2259 [Published online 2010 October 12]
    • (2010) J. Vis. Exp , vol.44 , pp. 2259
    • Quah, B.J.1    Parish, C.R.2
  • 35
    • 69849088244 scopus 로고    scopus 로고
    • Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis
    • G.W. Roberts, D. Baird, K. Gallagher, R.E. Jones, C.J. Pepper, and J.D. Williams Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis J Am Soc Nephrol 20 2009 1895 1900
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1895-1900
    • Roberts, G.W.1    Baird, D.2    Gallagher, K.3    Jones, R.E.4    Pepper, C.J.5    Williams, J.D.6
  • 36
    • 0028211011 scopus 로고
    • Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-κB
    • Y. Zhang, M. Broser, and W.N. Rom Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B Proc Natl Acad Sci U S A 91 1994 2225 2229 (Pubitemid 24092076)
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.6 , pp. 2225-2229
    • Zhang, Y.1    Broser, M.2    Rom, W.N.3
  • 37
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • DOI 10.1146/annurev.immunol.14.1.649
    • A.S. Baldwin Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights Annu Rev Immunol 14 1996 649 683 (Pubitemid 26130197)
    • (1996) Annual Review of Immunology , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 38
    • 77949351074 scopus 로고    scopus 로고
    • Presenting exogenous antigen to T cells
    • [John Wiley & Sons, Inc.]
    • C.V. Harding, and L. Ramachandra Presenting exogenous antigen to T cells Curr Protoc Immunol 88 2010 16.2.1 16.2.18 [John Wiley & Sons, Inc.]
    • (2010) Curr Protoc Immunol , vol.88 , pp. 1621-16218
    • Harding, C.V.1    Ramachandra, L.2
  • 40
    • 34548800403 scopus 로고    scopus 로고
    • P38 pathway kinases as anti-inflammatory drug targets
    • J.F. Schindler, J.B. Monahan, and W.G. Smith p38 pathway kinases as anti-inflammatory drug targets J Dent Res 86 2007 800 811
    • (2007) J Dent Res , vol.86 , pp. 800-811
    • Schindler, J.F.1    Monahan, J.B.2    Smith, W.G.3
  • 41
    • 27144517972 scopus 로고    scopus 로고
    • Regulation of B7.1 costimulatory molecule is mediated by the IFN regulatory factor-7 through the activation of JNK in lipopolysaccharide- stimulated human monocytic cells
    • W. Lim, K. Gee, S. Mishra, and A. Kumar Regulation of B7.1 costimulatory molecule is mediated by the IFN regulatory factor-7 through the activation of JNK in lipopolysaccharide-stimulated human monocytic cells J Immunol 175 2005 5690 5700 (Pubitemid 41508051)
    • (2005) Journal of Immunology , vol.175 , Issue.9 , pp. 5690-5700
    • Lim, W.1    Gee, K.2    Mishra, S.3    Kumar, A.4
  • 42
    • 0035958007 scopus 로고    scopus 로고
    • The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages
    • W. Ma, W. Lim, K. Gee, S. Aucoin, D. Nandan, and M. Kozlowski The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages J Biol Chem 276 2001 13664 13674
    • (2001) J Biol Chem , vol.276 , pp. 13664-13674
    • Ma, W.1    Lim, W.2    Gee, K.3    Aucoin, S.4    Nandan, D.5    Kozlowski, M.6
  • 43
    • 1442333588 scopus 로고    scopus 로고
    • Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression
    • DOI 10.1016/j.phrs.2003.11.004, PII S1043661803003694
    • S.H. Kim, J. Kim, and R.P. Sharma Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression Pharmacol Res 49 2004 433 439 (Pubitemid 38283863)
    • (2004) Pharmacological Research , vol.49 , Issue.5 , pp. 433-439
    • Kim, S.H.1    Kim, J.2    Sharma, R.P.3
  • 44
    • 33645068450 scopus 로고    scopus 로고
    • Mesenteric lymph nodes at the center of immune anatomy
    • A.J. Macpherson, and K. Smith Mesenteric lymph nodes at the center of immune anatomy J Exp Med 203 2006 497 500
    • (2006) J Exp Med , vol.203 , pp. 497-500
    • Macpherson, A.J.1    Smith, K.2
  • 45
    • 38549139719 scopus 로고    scopus 로고
    • Regulation of immunological homeostasis in the respiratory tract
    • DOI 10.1038/nri2236, PII NRI2236
    • P.G. Holt, D.H. Strickland, M.E. Wikstrom, and F.L. Jahnsen Regulation of immunological homeostasis in the respiratory tract Nat Rev Immunol 8 2008 142 152 (Pubitemid 351161302)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.2 , pp. 142-152
    • Holt, P.G.1    Strickland, D.H.2    Wikstrom, M.E.3    Jahnsen, F.L.4
  • 46
    • 80052155297 scopus 로고    scopus 로고
    • Intestinal macrophages - Specialised adaptation to a unique environment
    • C.C. Bain, and A.M. Mowat Intestinal macrophages - specialised adaptation to a unique environment Eur J Immunol 41 2011 2494 2498
    • (2011) Eur J Immunol , vol.41 , pp. 2494-2498
    • Bain, C.C.1    Mowat, A.M.2
  • 47
    • 33749245144 scopus 로고    scopus 로고
    • + macrophages
    • DOI 10.1002/jcp.20732
    • G. Liu, X.P. Xia, S.L. Gong, and Y. Zhao The macrophage heterogeneity: difference between mouse peritoneal exudate and splenic F4/80 + macrophages J Cell Physiol 209 2006 341 352 (Pubitemid 44484624)
    • (2006) Journal of Cellular Physiology , vol.209 , Issue.2 , pp. 341-352
    • Liu, G.1    Xia, X.-P.2    Gong, S.-L.3    Zhao, Y.4
  • 48
    • 0029201182 scopus 로고
    • Monophosphoryl lipid A as an adjuvant. Past experiences and new directions
    • J.T. Ulrich, and K.R. Myers Monophosphoryl lipid A as an adjuvant. Past experiences and new directions Pharm Biotechnol 6 1995 495 524
    • (1995) Pharm Biotechnol , vol.6 , pp. 495-524
    • Ulrich, J.T.1    Myers, K.R.2
  • 49
    • 0030588642 scopus 로고    scopus 로고
    • Role of Monocyte Chemoattractant Protein-1 (MCP-1) in Th1 (Mycobacterial) and Th2 (Schistosomal) Antigen-Induced Granuloma Formation: Relationship to Local Inflammation, Th Cell Expression, and IL-12 Production
    • S.W. Chensue, K.S. Warmington, J.H. Ruth, P.S. Sanghi, P. Lincoln, and S.L. Kunkel Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production J Immunol 157 1996 4602 4608 (Pubitemid 126449382)
    • (1996) Journal of Immunology , vol.157 , Issue.10 , pp. 4602-4608
    • Chensue, S.W.1    Warmington, K.S.2    Ruth, J.H.3    Sanghi, P.S.4    Lincoln, P.5    Kunkel, S.L.6
  • 50
    • 0027526048 scopus 로고
    • Regulation of T helper cell cytokine expression: Functional dichotomy of antigen-presenting cells
    • DOI 10.1002/eji.1830230130
    • J. Schmitz, M. Assenmacher, and A. Radbruch Regulation of T helper cell cytokine expression: functional dichotomy of antigen-presenting cells Eur J Immunol 23 1993 191 199 (Pubitemid 23031915)
    • (1993) European Journal of Immunology , vol.23 , Issue.1 , pp. 191-199
    • Schmitz, J.1    Assenmacher, M.2    Radbruch, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.