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Volumn 12, Issue 11, 2013, Pages 3210-3220

Identification and quantification of AKT isoforms and phosphoforms in breast cancer using a novel nanofluidic immunoassay

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN AKT 1; PROTEIN AKT 3; PROTEIN KINASE B; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG;

EID: 84887034220     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M112.023119     Document Type: Article
Times cited : (35)

References (32)
  • 1
    • 67749122122 scopus 로고    scopus 로고
    • Targeting pi3k signalling in cancer: Opportunities, challenges and limitations
    • Engelman, J. A. (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat. Rev. Cancer 9(8), 550-562.
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.8 , pp. 550-562
    • Engelman, J.A.1
  • 2
    • 34547574720 scopus 로고    scopus 로고
    • A New Mutational aktivation in the PI3K Pathway
    • DOI 10.1016/j.ccr.2007.07.014, PII S1535610807002097
    • Brugge, J., Hung, M. C., and Mills, G. B. (2007) A new mutational AKTivation in the PI3K pathway. Cancer Cell 12(2), 104-107. (Pubitemid 47199129)
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 104-107
    • Brugge, J.1    Hung, M.-C.2    Mills, G.B.3
  • 3
    • 54949109808 scopus 로고    scopus 로고
    • Pi3k/akt: Getting it right matters
    • Franke, T. F. (2008) PI3K/Akt: getting it right matters. Oncogene 27(50), 6473-6488.
    • (2008) Oncogene , vol.27 , Issue.50 , pp. 6473-6488
    • Franke, T.F.1
  • 4
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
    • Coffer, P. J., Jin, J., and Woodgett, J. R. (1998) Protein kinase B (c-akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 1(335 Pt 1), 1-13. (Pubitemid 28477043)
    • (1998) Biochemical Journal , vol.335 , Issue.1 , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 6
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    • Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Characterization of a 3-phosphoinositide- dependent protein kinase which phosphorylates and activates protein kinase balpha. Curr. Biol. 7(4), 261-269. (Pubitemid 27176852)
    • (1997) Current Biology , vol.7 , Issue.4 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.J.5    Reese, C.B.6    Cohen, P.7
  • 7
    • 0030799706 scopus 로고    scopus 로고
    • Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
    • DOI 10.1126/science.277.5325.567
    • Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. (1997) Dual role of phosphatidylinositol-3, 4, 5-trisphosphate in the activation of protein kinase B. Science 277(5325), 567-570. (Pubitemid 27369005)
    • (1997) Science , vol.277 , Issue.5325 , pp. 567-570
    • Stokoe, D.1    Stephens, L.R.2    Copeland, T.3    Gaffney, P.R.J.4    Reese, C.B.5    Painter, G.F.6    Holmes, A.B.7    McCormick, F.8    Hawkins, P.T.9
  • 8
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307(5712), 1098-1101. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 9
    • 39049171769 scopus 로고    scopus 로고
    • The PI3K/Akt pathway: Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors
    • DOI 10.2174/156800908783497096
    • Lindsley, C. W., Barnett, S. F., Layton, M. E., and Bilodeau, M. T. (2008) The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors. Curr. Cancer Drug Targets 8(1), 7-18. (Pubitemid 351237905)
    • (2008) Current Cancer Drug Targets , vol.8 , Issue.1 , pp. 7-18
    • Lindsley, C.W.1    Barnett, S.F.2    Layton, M.E.3    Bilodeau, M.T.4
  • 11
    • 34548266099 scopus 로고    scopus 로고
    • AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
    • Koseoglu, S., Lu, Z., Kumar, C., Kirschmeier, P., and Zou, J. (2007) AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer Biol. Ther. 6(5), 755-762. (Pubitemid 47328358)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.5 , pp. 755-762
    • Koseoglu, S.1    Lu, Z.2    Kumar, C.3    Kirschmeier, P.4    Zou, J.5
  • 12
    • 77957851665 scopus 로고    scopus 로고
    • Akt isoform-specific inhibition of mda-mb-231 cell proliferation
    • Yang, W., Ju, J. H., Lee, K. M., and Shin, I. (2011) Akt isoform-specific inhibition of MDA-MB-231 cell proliferation. Cell Signal. 23(1), 19-26.
    • (2011) Cell Signal , vol.23 , Issue.1 , pp. 19-26
    • Yang, W.1    Ju, J.H.2    Lee, K.M.3    Shin, I.4
  • 13
    • 33744953051 scopus 로고    scopus 로고
    • Autophosphorylation of Akt at threonine 72 and serine 246: A potential mechanism of regulation of Akt kinase activity
    • DOI 10.1074/jbc.M602060200
    • Li, X., Lu, Y., Jin, W., Liang, K., Mills, G. B., and Fan, Z. (2006) Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity. J. Biol. Chem. 281(19), 13837-13843. (Pubitemid 43855299)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.19 , pp. 13837-13843
    • Li, X.1    Lu, Y.2    Jin, W.3    Liang, K.4    Mills, G.B.5    Fan, Z.6
  • 18
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • DOI 10.1038/35077225
    • Blume-Jensen, P., and Hunter, T. (2001) Oncogenic kinase signalling. Nature 411(6835), 355-365. (Pubitemid 32467045)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 19
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers, I., Vincent, E. E., and Tavare, J. M. (2011) Akt signalling in health and disease. Cell Signal. 23(10), 1515-1527.
    • (2011) Cell Signal , vol.23 , Issue.10 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 20
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • DOI 10.1016/S0898-6568(01)00271-6, PII S0898656801002716
    • Nicholson, K. M., and Anderson, N. G. (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14(5), 381-395. (Pubitemid 34214843)
    • (2002) Cellular Signalling , vol.14 , Issue.5 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 21
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • DOI 10.1038/sj.onc.1209085, PII 1209085
    • Altomare, D. A., and Testa, J. R. (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24(50), 7455-7464. (Pubitemid 41637985)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 22
    • 27844598284 scopus 로고    scopus 로고
    • The Akt/PKB pathway: Molecular target for cancer drug discovery
    • DOI 10.1038/sj.onc.1209088, PII 1209088
    • Cheng, J. Q., Lindsley, C. W., Cheng, G. Z., Yang, H., and Nicosia, S. V. (2005) The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 24(50), 7482-7492. (Pubitemid 41637988)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7482-7492
    • Cheng, J.Q.1    Lindsley, C.W.2    Cheng, G.Z.3    Yang, H.4    Nicosia, S.V.5
  • 23
    • 51849111556 scopus 로고    scopus 로고
    • Pi3k pathway alterations in cancer: Variations on a theme
    • Yuan, T. L., and Cantley, L. C. (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27(41), 5497-5510.
    • (2008) Oncogene , vol.27 , Issue.41 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 24
    • 0030980781 scopus 로고    scopus 로고
    • Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor α is frequent in resectable non-small cell lung cancer but does not predict tumor progression
    • Rusch, V., Klimstra, D., Venkatraman, E., Pisters, P. W., Langenfeld, J., and Dmitrovsky, E. (1997) Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin. Cancer Res. 3(4), 515-522. (Pubitemid 27211827)
    • (1997) Clinical Cancer Research , vol.3 , Issue.4 , pp. 515-522
    • Rusch, V.1    Klimstra, D.2    Venkatraman, E.3    Pisters, P.W.T.4    Langenfeld, J.5    Dmitrovsky, E.6
  • 26
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • DOI 10.1038/nrc969
    • Downward, J. (2003) Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3(1), 11-22. (Pubitemid 37328883)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 28
    • 0035913188 scopus 로고    scopus 로고
    • Oncogenic transformation induced by membrane-targeted Akt2 and Akt3
    • DOI 10.1038/sj.onc.1204486
    • Mende, I., Malstrom, S., Tsichlis, P. N., Vogt, P. K., and Aoki, M. (2001) Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene 20(32), 4419-4423. (Pubitemid 32726886)
    • (2001) Oncogene , vol.20 , Issue.32 , pp. 4419-4423
    • Mende, I.1    Malstrom, S.2    Tsichlis, P.N.3    Vogt, P.K.4    Aoki, M.5
  • 31
    • 0001582482 scopus 로고
    • Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
    • DOI 10.1073/pnas.84.14.5034
    • Staal, S. P. (1987) Molecular cloning of the Akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma. Proc. Natl. Acad. Sci. U.S.A. 84(14), 5034-5037. (Pubitemid 17095859)
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.14 , pp. 5034-5037
    • Staal, S.P.1


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