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Volumn 21, Issue 23, 2013, Pages 7239-7249
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Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition
a
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Author keywords
Breast cancer cell lines; Liver mitochondria; Mitochondrial depolarization; Mitochondrial permeability transition; Triterpenoid derivatives
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Indexed keywords
28 (4' DIMETHYLAMINOPYRIDINIUM 1' ACETOXY) 3BETA HYDROXYLUP 20(29)ENE CHLORIDE;
AMINOPYRIDINE DERIVATIVE;
BETULIN 30 [4' (DIMETHYLAMINO)PYRIDINIUM 1' YL] 3BETA,28 DI[4' (DIMETHYLAMINO)PYRIDINIUM 1 YL ACETOXY] TRIBROMIDE;
BETULIN 3BETA,28 DI[(40 DIMETHYLAMINOPYRIDINIUM 10 YL)ACETOXY]BROMIDE;
BETULINIC ACID 28 (40 DIMETHYLAMINOPYRIDINIUM 10 YL)BROMIDE;
DIMETHYLAMINOPYRIDINE DERIVATIVE;
LUP 20(29)ENE 3BETA (40 DIMETHYLAMINOPYRIDINIUMACETOXY)CHLORIDE;
TRITERPENOID;
UNCLASSIFIED DRUG;
ARTICLE;
CELL STRAIN MCF 7;
CONTROLLED STUDY;
DRUG STRUCTURE;
HUMAN;
HUMAN CELL;
LIVER MITOCHONDRION;
MALE;
MELANOMA CELL;
MEMBRANE DEPOLARIZATION;
MEMBRANE TRANSPORT;
MITOCHONDRIAL MEMBRANE POTENTIAL;
MITOCHONDRIAL PERMEABILITY;
MITOCHONDRIAL RESPIRATION;
MITOCHONDRIAL TOXICITY;
MITOCHONDRION SWELLING;
NONHUMAN;
RAT;
LUP-20-(29)-ENE-3Β-(4′-DIMETHYLAMINOPYRIDINIUMACETOXY)CHLORIDE;
28-(4′-DIMETHYLAMINOPYRIDINIUM-1′-ACETOXY)-3Β-HYDROXYLUP-20(29)-ENE CHLORIDE;
BETULIN 30-[4′-(DIMETHYLAMINO) PYRIDINIUM-1′-YL]-3Β,28-DI[4′-(DIMETHYLAMINO)PYRIDINIUM-1-YL ACETOXY)] TRIBROMIDE;
BETULIN 3Β,28-DI[(4′-DIMETHYLAMINOPYRIDINIUM-1′-YL)ACETOXY] BROMIDE;
BETULINIC ACID 28-(4′-DIMETHYLAMINOPYRIDINIUM-1′-YL) BROMIDE;
BOVINE SERUM ALBUMIN;
BREAST CANCER CELL LINES;
BSA;
CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE;
COMPOUND (1);
COMPOUND (2);
COMPOUND (3);
COMPOUND (4);
COMPOUND (5);
CSA;
CYCLOSPORIN A;
DIMETHYLAMINOPYRIDINE;
DIMETHYLSULFOXIDE;
DMAP;
DMEM;
DMSO;
DULBECCO'S MODIFIED EAGLE'S MEDIUM;
FCCP;
HEPES;
LIVER MITOCHONDRIA;
MITOCHONDRIAL DEPOLARIZATION;
MITOCHONDRIAL PERMEABILITY TRANSITION;
MITOCHONDRIAL TRANSMEMBRANE ELECTRIC POTENTIAL;
MPT;
N-(2-HYDROXYETHYL) PIPERAZINE-N′-(2-ETHANESULFONIC ACID);
OXIDATIVE PHOSPHORYLATION;
OXPHOS;
PBS;
PBS TWEEN;
PBST;
PHOSPHATE BUFFERED SALINE SOLUTION;
QSARS;
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS;
RCR;
REACTIVE OXYGEN SPECIES;
RESPIRATORY CONTROL RATIO;
ROS;
SEM;
SRB;
STANDARD ERROR OF THE MEAN;
SULFORHODAMINE B;
TETRAPHENYLPHOSPHONIUM CATION;
TPP(+);
TRITERPENOID DERIVATIVES;
ΔΨ(M);
ANIMALS;
ANTINEOPLASTIC AGENTS;
BREAST NEOPLASMS;
CELL LINE;
CELL LINE, TUMOR;
CELL RESPIRATION;
FEMALE;
HUMANS;
MALE;
MELANOMA;
MEMBRANE POTENTIALS;
MITOCHONDRIA, LIVER;
MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS;
PERMEABILITY;
PYRIDINES;
RATS;
RATS, WISTAR;
TRITERPENES;
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EID: 84886951814
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2013.09.066 Document Type: Article |
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Times cited : (32)
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References (22)
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