SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6223-6227

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

(16) Aoki, Toshihiro a Hyohdoh, Ikumi a Furuichi, Noriyuki a Ozawa, Sawako a Watanabe, Fumio a Matsushita, Masayuki a Sakaitani, Masahiro a Ori, Kazutomo a Takanashi, Kenji a Harada, Naoki a Tomii, Yasushi a Tabo, Mitsuyasu a Yoshinari, Kiyoshi a Aoki, Yuko a Shimma, Nobuo a Iikura, Hitoshi a

a CHUGAI PHARMACEUTICAL CO LTD (Japan)

Author keywords

Anticancer; Kinase inhibitor; MEK; Raf; Sulfamide

Indexed keywords

ANTINEOPLASTIC AGENT; COUMARIN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RAF PROTEIN; SULFAMIDE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; EXPERIMENTAL MONKEY; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; LIVER MICROSOME; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANIMALIA;

2-HYDROXYPROPYL-Β-CYCLODEXTRIN; ANTICANCER; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; HERG; HPCD; HUMAN ETHER-A-GO-GO RELATED GENE; KINASE INHIBITOR; LYOPHILIZED SOLUBILITY ASSAY; LYSA; MEK; MITOGEN-ACTIVATED PROTEIN KINASE; PAMPA; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY; PEG; POLYETHYLENE GLYCOL; RAF; SULFAMIDE; TGI; TUMOR GROWTH INHIBITION;

AMIDES; ANIMALS; BIOLOGICAL AVAILABILITY; COUMARINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HAPLORHINI; MICE; PROTEIN KINASE INHIBITORS; RAF KINASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886947974 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.10.001 Document Type: Article

Times cited : (20)

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