Synthesis and biological evaluation of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors

ACS Medicinal Chemistry Letters

Volumn 3, Issue 2, 2012, Pages 88-93

  Kim, Se Hoan ^a,b   Bok, Ju Han ^a   Lee, Jae Hong ^a,b   Kim, Il Hyang ^a,b   Kwon, Sung Wook ^a,b   Lee, Gui Bin ^a   Kang, Seung Kyu ^a   Park, Ji Seon ^a   Jung, Won Hoon ^a   Kim, Hee Yeon ^a   Rhee, Sang Dal ^a   Ahn, Sung Hoon ^a   Bae, Myung Ae ^a   Ha, Deok Chan ^b   Kim, Ki Young ^a   Ahn, Jin Hee ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Korea University   (South Korea)

Author keywords

11 hydroxysteroid dehydrogenase type 1; adamantyl group; antidiabetic agents; cyclic sulfamide; diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; CARBENOXOLONE; OXIDOREDUCTASE INHIBITOR; SULFAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HAPLORHINI; IC 50; IN VIVO STUDY; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTITUTION REACTION;

RATTUS;

EID: 84863151299     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200226x     Document Type: Article

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