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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2384-2390

Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories

(10) Hartung, Ingo V a Hitchcock, Marion a Pühler, Florian a Neuhaus, Roland a Scholz, Arne a Hammer, Stefanie a Petersen, Kirstin a Siemeister, Gerhard a Brittain, Dominic a Hillig, Roman C a

a BAYER PHARMA AG (Germany)

Author keywords

Allosteric MEK inhibitor; Blood brain barrier; Oncology; Structure based drug design

Indexed keywords

ALKYL ARYL ETHER; B RAF KINASE; ESTER; GLYCOPROTEIN; HYDROXAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; RAS PROTEIN; SULFANILAMIDE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CELL LINE; ENZYME ACTIVITY; IN VIVO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; XENOGRAFT;

ALLOSTERIC REGULATION; ANIMALS; BENZAMIDES; DIPHENYLAMINE; DRUG DESIGN; MAP KINASE KINASE KINASES; MICE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84875411534 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.02.028 Document Type: Article

Times cited : (14)

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