Acute treatment with polyphenol quercetin improves postischemic recovery of isolated perfused rat hearts after global ischemia

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 4, 2010, Pages 465-471

  Barteková, Monika ^a   Čarnická, Slávka ^a   Pancza, Dezider ^a   Ondrejčáková, Mária ^a,b   Breier, Albert ^c   Ravingerova, Táňa ^a  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^c INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

Author keywords

Ischemia reperfusion; Isolated heart; Quercetin

Indexed keywords

BIOFLAVONOID; POLYPHENOL; QUERCETIN; TETRAZOLIUM; CARDIOTONIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY FLOW RESERVE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE ENDDIASTOLIC PRESSURE; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; ANIMAL; BLOOD PRESSURE; DRUG EFFECTS; HEART; HEART INFARCTION; HEART VENTRICLE PRESSURE; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; CARDIOTONIC AGENTS; HEART; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; QUERCETIN; RATS; RATS, WISTAR; VENTRICULAR PRESSURE;

EID: 77952022568     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y10-025     Document Type: Article

References (43)

1. Andriambeloson, E., Magnier, C., Haan-Archipoff, G., Lobstein, A., Anton, R., Beretz, A., et al. 1998. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J. Nutr. 128(12): 2324-2333. PMID:9868177. (Pubitemid 29012979)
2. Arts, I.C.V., and Hollman, P.C.H. 2005. Polyphenols and disease risk in epidemiologic studies. Am. J. Clin. Nutr. 81(1 Suppl): 317S-325S. PMID:15640497.
3. 4 administration. Physiol. Res. 55(3): 245-251. PMID:16083304.
4. Bernátová, I., Pechánová, O., Babál, P., Kyselá, S., Stvrtina, S., and Andriantsitohaina, R. 2002. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am. J. Physiol. Heart Circ. Physiol. 282(3): H942-H948. PMID:11834490.
5. Brookes, P.S., Digerness, S.B., Parks, D.A., and Darley-Usmar, V. 2002. Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin. Free Radic. Biol. Med. 32(11): 1220-1228. doi:10.1016/S0891-5849(02)00839-0. PMID:12031906.
6. Carusio, N., Wangensteen, R., Filippelli, A., and Andriantsitohaina, R. 2008. Oral administration of polyphenolic compounds from cognac decreases ADP-induced platelet aggregation and reduces chronotropic effect of isoprenaline in rats. Physiol. Res. 57(4): 517-524. PMID:17705676.
7. Chan, H.M., Zhu, L.F., Zhong, R., Grant, D., Goyer, R.A., and Cherian, M.G. 1993. Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol. Appl. Pharmacol. 123(1): 89-96. doi:10.1006/taap.1993.1225. PMID:8236266.
8. 2: role in vasodilatation. Cardiovasc. Res. 73(2): 424-431. doi:10.1016/j.cardiores. 2006.09.008. PMID:17055466.
9. Conquer, J.A., Maiani, G., Azzini, E., Raguzzini, A., and Holub, B.J. 1998. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J. Nutr. 128(3): 593-597. PMID:9482769. (Pubitemid 28188358)
10. Dajas, F., Rivera, F., Blasina, F., Arredondo, F., Echeverry, C., Lafon, L., et al. 2003. Cell culture protection and in vivo neuroprotective capacity of flavonoids. Neurotox. Res. 5(6): 425-432. doi:10.1007/BF03033172. PMID:14715446.
11. Das, S., Tosaki, A., Bagchi, D., Maulik, N., and Das, D.K. 2005. Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways. J. Pharmacol. Exp. Ther. 314(2): 762-769. doi:10.1124/jpet.105.084285. PMID:15879002.
12. Duarte, J., Pérez-Palencia, R., Vargas, F., Ocete, M.A., Pérez-Vizcaino, F., Zarzuelo, A., and Tamargo, J. 2001. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br. J. Pharmacol. 133(1): 117-124. doi:10.1038/sj.bjp.0704064. PMID:11325801.
13. Duarte, J., Andriambeloson, E., Diebolt, M., and Andriantsitohaina, R. 2004. Wine polyphenols stimulate superoxide anion production to promote calcium signaling and endothelial-dependent vasodilatation. Physiol. Res. 53(6): 595-602. PMID:15588126.
14. Edwards, R.L., Lyon, T., Litwin, S.E., Rabovsky, A., Symons, J.D., and Jalili, T. 2007. Quercetin reduces blood pressure in hypertensive subjects. J. Nutr. 137(11): 2405-2411. PMID:17951477. (Pubitemid 350058708)
15. Erlund, I., Silaste, M.L., Alfthan, G., Rantala, M., Kesäniemi, Y.A., and Aro, A. 2002. Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables. Eur. J. Clin. Nutr. 56(9): 891-898. doi:10.1038/sj.ejcn.1601409. PMID:12209378.
16. Fitzpatrick, D.F., Hirschfield, S.L., and Coffey, R.G. 1993. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am. J. Physiol. 265(2 Pt 2): H774-H778. PMID:8396352.
17. Fitzpatrick, D.F., Hirschfield, S.L., Ricci, T., Jantzen, P., and Coffey, R.G. 1995. Endothelium-dependent vasorelaxation caused by various plant extracts. J. Cardiovasc. Pharmacol. 26(1): 90-95. doi:10.1097/00005344- 199507000-00015. PMID:7564372.
18. Formica, J.V., and Regelson, W. 1995. Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. 33(12): 1061-1080. PMID:8847003.
19. Guglielmone, H.A., Agnese, A.M., Núñez Montoya, S.C., and Cabrera, J.L. 2002. Anticoagulant effect and action mechanism of sulphated flavonoids from Flaveria bidentis. Thromb. Res. 105(2): 183-188. doi:10.1016/S0049-3848(01)00419-4. PMID:11958811.
20. Hammond, B., and Hess, M.L. 1985. The oxygen free radical system: potential mediator of myocardial injury. J. Am. Coll. Cardiol. 6(1): 215-220. PMID:2989350.
21. Hertog, M.G.L., Hollman, P.C.H., Katan, M.B., and Kromhout, D. 1993. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr. Cancer, 20(1): 21-29. doi:10.1080/ 01635589309514267. PMID:8415127.
22. Ikizler, M., Erkasap, N., Dernek, S., Kural, T., and Kaygisiz, Z. 2007. Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Anadolu Kardiyol. Derg. 7(4): 404-410. PMID:18065337.
23. Inal, M., Altinişik, M., and Bilgin, M.D. 2002. The effect of quercetin on renal ischemia and reperfusion injury in the rat. Cell Biochem. Funct. 20(4): 291-296. doi:10.1002/cbf.953. PMID:12415562.
24. +- ATPase during development and persistence of hypertension in rats. Exp. Physiol. 89(1): 73-81. doi:10.1113/expphysiol.2003. 002613. PMID:15109212.
25. Kaiserová, H., Simůnek, T., van der Vijgh, W.J., Bast, A., and Kvasnicková, E. 2007. Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase. Biochim. Biophys. Acta, 1772(9): 1065-1074. PMID:17572073.
26. Kolchin, IuN., Maksiutina, N.P., Balanda, P.P., Luik, A.I., Bulakh, V.N., and Moibenko, A.A. 1991. The cardioprotective action of quercetin in experimental occlusion and reperfusion of the coronary artery in dogs. Farmakol. Toksikol. 54(6): 20-23. [In Russian.] PMID:1804685.
27. Manach, C., Morand, C., Texier, O., Favier, M.L., Agullo, G., Demigne ́, C., et al. 1995. Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. J. Nutr. 125(7): 1911-1922. PMID:7616308.
28. Manach, C., Morand, C., Crespy, V., Demigné, C., Texier, O., Régérat, F., and Rémésy, C. 1998. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett. 426(3): 331-336. doi:10.1016/S0014-5793(98)00367-6. PMID:9600261. (Pubitemid 28218374)
29. Mojžišová, G., Mirossay, L., Kučerová, D., Kyselovič, J., Miroššay, A., and Mojžiš, J. 2006. Protective effect of selected flavonoids on in vitro daunorubicin-induced cardiotoxicity. Phytother. Res. 20(2): 110-114. doi:10.1002/ptr.1811. PMID:16444662.
30. Mokni, M., Limam, F., Elkahoui, S., Amri, M., and Aouani, E. 2007. Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Arch. Biochem. Biophys. 457(1): 1-6. doi:10.1016/j.abb.2006.10.015. PMID:17125727.
31. Pecháňová, O., Bernátová, I., Babál, P., Martínez, M.C., Kyselá, S., Štvrtina, S., and Andriantsitohaina, R. 2004. Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J. Hypertens. 22(8): 1551-1559. doi:10.1097/01.hjh.0000133734.32125.c7. PMID:15257179.
32. Pérez-Vizcáno, F., Ibarra, M., Cogolludo, A.L., Duarte, J., Zaragozá-Arnáez, F., Moreno, L., et al. 2002. Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. J. Pharmacol. Exp. Ther. 302(1): 66-72. doi:10.1124/jpet.302.1.66. PMID:12065701.
33. Psotová, J., Chlopćková, Š., Miketová, P., Hrbác, J., and Simánek, V. 2004. Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes: Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin. Phytother. Res. 18(7): 516-521. doi:10.1002/ptr.1462. PMID:15305308.
34. Púzserová, A., Csizmadiová, Z., Andriantsitohaina, R., and Bernátová, I. 2006. Vascular effects of red wine polyphenols in chronic stress-exposed Wistar-Kyoto rats. Physiol. Res. 55(Suppl 1): S39-S47. PMID:17177625.
35. Ravingerová, T., Džurba, A., Vrbjar, N., Tribulová, N., Ziegelhocombining double acute accentffer, A., and Slezák, J. 1994. Free oxygen radicals-induced impairment of heart function: the role of Na,K-ATPase. Pharmacol. (Life Sci. Adv.) 13: 133-140.
36. Ravingerová, T., Neckár, J., and Kolár, F. 2003. Ischemic tolerance of rat hearts in acute and chronic phases of experimental diabetes. Mol. Cell. Biochem. 249(1-2): 167-174. doi:10.1023/A:1024751109196. PMID:12956412.
37. Rice-Evans, C.A., Miller, N.J., Bolwell, P.G., Bramley, P.M., and Pridham, J.B. 1995. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic. Res. 22(4): 375-383. doi:10.3109/ 10715769509145649. PMID:7633567.
38. Robak, J., and Gryglewski, R.J. 1988. Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 37(5): 837-841. doi:10.1016/0006-2952(88) 90169-4. PMID:2830882.
39. Sanhueza, J., Valdes, J., Campos, R., Garrido, A., and Valenzuela, A. 1992. Changes in the xanthine dehydrogenase/xanthine oxidase ratio in the rat kidney subjected to ischemia-reperfusion stress: preventive effect of some flavonoids. Res. Commun. Chem. Pathol. Pharmacol. 78(2): 211-218. PMID:1475527.
40. Su, J.F., Guo, C.J., Wei, J.Y., Yang, J.J., Jiang, Y.G., and Li, Y.F. 2003. Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin. Biomed. Environ. Sci. 16(1): 1-8. PMID:12747002.
41. Wan, L.L., Xia, J., Ye, D., Liu, J., Chen, J., and Wang, G. 2009. Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbit. Cardiovasc Ther. 27(1): 28-33. doi:10.1111/j.1755-5922.2009.00071.x. PMID:19207477.
42. Zenebe, W., Pechánová, O., and Andriantsitohaina, R. 2003. Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity. Physiol. Res. 52(4): 425-432. PMID:12899654.
43. Zern, T.L., Wood, R.J., Greene, C., West, K.L., Liu, Y.Z., Aggarwal, D., et al. 2005. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J. Nutr. 135(8): 1911-1917. PMID:16046716. (Pubitemid 41099749)