메뉴 건너뛰기




Volumn 127, Issue 2, 2011, Pages 423-428

Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1

Author keywords

Glycolysis; Hexokinase; Quercetin; Trypanosoma brucei

Indexed keywords

GLUCOSE; HEXOKINASE 1; QUERCETIN; TRYPTOPHAN;

EID: 78751576238     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.10.011     Document Type: Article
Times cited : (31)

References (32)
  • 3
    • 0028929650 scopus 로고
    • Function of N-terminal import signals in trypanosome microbodies
    • Blattner J., Dorsam H., Clatyon C.E. Function of N-terminal import signals in trypanosome microbodies. FEBS Lett. 1995, 360:310-314.
    • (1995) FEBS Lett. , vol.360 , pp. 310-314
    • Blattner, J.1    Dorsam, H.2    Clatyon, C.E.3
  • 5
    • 0037192787 scopus 로고    scopus 로고
    • Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death
    • Bryson J.M., Coy P.E., Gottlob K., Hay N., Robey R.B. Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death. J. Biol. Chem. 2002, 277:11392-11400.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11392-11400
    • Bryson, J.M.1    Coy, P.E.2    Gottlob, K.3    Hay, N.4    Robey, R.B.5
  • 6
    • 39049107429 scopus 로고    scopus 로고
    • The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1
    • Chambers J.W., Fowler M.L., Morris M.T., Morris J.C. The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. Mol. Biochem. Parasitol. 2008, 158:202-207.
    • (2008) Mol. Biochem. Parasitol. , vol.158 , pp. 202-207
    • Chambers, J.W.1    Fowler, M.L.2    Morris, M.T.3    Morris, J.C.4
  • 7
    • 47249126343 scopus 로고    scopus 로고
    • Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme
    • Chambers J.W., Kearns M.T., Morris M.T., Morris J.C. Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme. J. Biol. Chem. 2008, 283:14963-14970.
    • (2008) J. Biol. Chem. , vol.283 , pp. 14963-14970
    • Chambers, J.W.1    Kearns, M.T.2    Morris, M.T.3    Morris, J.C.4
  • 8
    • 33745060757 scopus 로고    scopus 로고
    • Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei
    • Colasante C., Ellis M., Ruppert T., Voncken F. Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei. Proteomics 2006, 6:3275-3293.
    • (2006) Proteomics , vol.6 , pp. 3275-3293
    • Colasante, C.1    Ellis, M.2    Ruppert, T.3    Voncken, F.4
  • 9
    • 0020519825 scopus 로고
    • Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria
    • Floridi A., Lehninger A.L. Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria. Arch. Biochem. Biophy. 1983, 226:73-83.
    • (1983) Arch. Biochem. Biophy. , vol.226 , pp. 73-83
    • Floridi, A.1    Lehninger, A.L.2
  • 10
    • 0034983918 scopus 로고    scopus 로고
    • Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
    • Gottlob K., Majewski N., Kennedy S., Kandel E., Robey R.B., Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev. 2001, 15:1406-1418.
    • (2001) Genes Dev. , vol.15 , pp. 1406-1418
    • Gottlob, K.1    Majewski, N.2    Kennedy, S.3    Kandel, E.4    Robey, R.B.5    Hay, N.6
  • 11
    • 0036339229 scopus 로고    scopus 로고
    • The ATP site of protein kinases as target for drug development: from natural compounds to gleevec
    • Granot Y. The ATP site of protein kinases as target for drug development: from natural compounds to gleevec. Isr. Med. Assoc. J. 2002, 4:633-635.
    • (2002) Isr. Med. Assoc. J. , vol.4 , pp. 633-635
    • Granot, Y.1
  • 12
    • 0017359666 scopus 로고
    • Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria
    • Graziani Y. Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria. Biochim. Biophy. Acta 1977, 460:364-373.
    • (1977) Biochim. Biophy. Acta , vol.460 , pp. 364-373
    • Graziani, Y.1
  • 13
    • 0020635362 scopus 로고
    • The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo
    • Graziani Y., Erikson E., Erikson R.L. The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. Eur. J. Biochem. 1983, 135:583-589.
    • (1983) Eur. J. Biochem. , vol.135 , pp. 583-589
    • Graziani, Y.1    Erikson, E.2    Erikson, R.L.3
  • 14
    • 0035342444 scopus 로고    scopus 로고
    • Protein-flavonol interaction: fluorescence spectroscopic study
    • Guharay J., Sengupta B., Sengupta P.K. Protein-flavonol interaction: fluorescence spectroscopic study. Proteins 2001, 43:75-81.
    • (2001) Proteins , vol.43 , pp. 75-81
    • Guharay, J.1    Sengupta, B.2    Sengupta, P.K.3
  • 15
    • 0035922187 scopus 로고    scopus 로고
    • Synergistic effect of cadmium chloride and acetaldehyde on cytotoxicity and its prevention by quercetin and glycyrrhizin
    • Hu C.C., Chen W.K., Liao P.H., Yu W.C., Lee Y.J. Synergistic effect of cadmium chloride and acetaldehyde on cytotoxicity and its prevention by quercetin and glycyrrhizin. Mutat. Res. 2001, 496:117-127.
    • (2001) Mutat. Res. , vol.496 , pp. 117-127
    • Hu, C.C.1    Chen, W.K.2    Liao, P.H.3    Yu, W.C.4    Lee, Y.J.5
  • 16
    • 0034617194 scopus 로고    scopus 로고
    • The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action
    • Kuser P.R., Krauchenco S., Antunes O.A., Polikarpov I. The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action. J. Biol. Chem. 2000, 275:20814-20821.
    • (2000) J. Biol. Chem. , vol.275 , pp. 20814-20821
    • Kuser, P.R.1    Krauchenco, S.2    Antunes, O.A.3    Polikarpov, I.4
  • 18
    • 0034065043 scopus 로고    scopus 로고
    • Import of proteins into the trypanosome nucleus and their distribution at karyokinesis
    • Marchetti M.A., Tschudi C., Kwon H., Wolin S.L., Ullu E. Import of proteins into the trypanosome nucleus and their distribution at karyokinesis. J. Cell Sci. 2000, 113(Pt 5):899-906.
    • (2000) J. Cell Sci. , vol.113 , Issue.PART 5 , pp. 899-906
    • Marchetti, M.A.1    Tschudi, C.2    Kwon, H.3    Wolin, S.L.4    Ullu, E.5
  • 19
    • 0026726483 scopus 로고
    • The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
    • Matter W.F., Brown R.F., Vlahos C.J. The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem. Biophy. Res. Commun. 1992, 186:624-631.
    • (1992) Biochem. Biophy. Res. Commun. , vol.186 , pp. 624-631
    • Matter, W.F.1    Brown, R.F.2    Vlahos, C.J.3
  • 20
    • 0021753882 scopus 로고
    • Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei
    • Misset O., Opperdoes F.R. Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei. Eur. J. Biochem. 1984, 144:475-483.
    • (1984) Eur. J. Biochem. , vol.144 , pp. 475-483
    • Misset, O.1    Opperdoes, F.R.2
  • 21
    • 0034199017 scopus 로고    scopus 로고
    • Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis
    • Mittra B., Saha A., Chowdhury A.R., Pal C., Mandal S., Mukhopadhyay S., Bandyopadhyay S., Majumder H.K. Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mol. Med. 2000, 6:527-541.
    • (2000) Mol. Med. , vol.6 , pp. 527-541
    • Mittra, B.1    Saha, A.2    Chowdhury, A.R.3    Pal, C.4    Mandal, S.5    Mukhopadhyay, S.6    Bandyopadhyay, S.7    Majumder, H.K.8
  • 23
    • 0037009442 scopus 로고    scopus 로고
    • Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library
    • Morris J.C., Wang Z., Drew M.E., Englund P.T. Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library. EMBO J. 2002, 21:4429-4438.
    • (2002) EMBO J. , vol.21 , pp. 4429-4438
    • Morris, J.C.1    Wang, Z.2    Drew, M.E.3    Englund, P.T.4
  • 24
    • 33845604555 scopus 로고    scopus 로고
    • Activity of a second Trypanosoma brucei hexokinase is controlled by an 18-amino-acid C-terminal tail
    • Morris M.T., DeBruin C., Yang Z., Chambers J.W., Smith K.S., Morris J.C. Activity of a second Trypanosoma brucei hexokinase is controlled by an 18-amino-acid C-terminal tail. Eukaryot. Cell 2006, 5:2014-2023.
    • (2006) Eukaryot. Cell , vol.5 , pp. 2014-2023
    • Morris, M.T.1    DeBruin, C.2    Yang, Z.3    Chambers, J.W.4    Smith, K.S.5    Morris, J.C.6
  • 25
    • 33745851827 scopus 로고    scopus 로고
    • Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei
    • Motyka S.A., Drew M.E., Yildirir G., Englund P.T. Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei. J. Biol. Chem. 2006, 281:18499-18506.
    • (2006) J. Biol. Chem. , vol.281 , pp. 18499-18506
    • Motyka, S.A.1    Drew, M.E.2    Yildirir, G.3    Englund, P.T.4
  • 26
    • 0024195898 scopus 로고
    • The role of mitochondrial hexokinase in neoplastic phenotype and its sensitivity to lonidamine. Ann. N Y Acad. Sci.
    • Paggi, M.G., Fanciulli, M., Perrotti, N., Floridi, A., Zeuli, M., Silvestrini, B., Caputo, A., 1988. The role of mitochondrial hexokinase in neoplastic phenotype and its sensitivity to lonidamine. Ann. N Y Acad. Sci. 551, 358-360.
    • (1988) , vol.551 , pp. 358-360
    • Paggi, M.G.1    Fanciulli, M.2    Perrotti, N.3    Floridi, A.4    Zeuli, M.5    Silvestrini, B.6    Caputo, A.7
  • 27
    • 0036434544 scopus 로고    scopus 로고
    • The interaction of quercetin with human serum albumin: a fluorescence spectroscopic study
    • Sengupta B., Sengupta P.K. The interaction of quercetin with human serum albumin: a fluorescence spectroscopic study. Biochem. Biophy.Res. Commun. 2002, 299:400-403.
    • (2002) Biochem. Biophy.Res. Commun. , vol.299 , pp. 400-403
    • Sengupta, B.1    Sengupta, P.K.2
  • 29
    • 0022249093 scopus 로고
    • Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin
    • Srivastava A.K. Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin. Biochem. Biophy. Res. Commun. 1985, 131:1-5.
    • (1985) Biochem. Biophy. Res. Commun. , vol.131 , pp. 1-5
    • Srivastava, A.K.1
  • 30
    • 0016821736 scopus 로고
    • The effect of flavonoids on aerobic glycolysis and growth of tumor cells
    • Suolinna E.M., Buchsbaum R.N., Racker E. The effect of flavonoids on aerobic glycolysis and growth of tumor cells. Cancer Res. 1975, 35:1865-1872.
    • (1975) Cancer Res. , vol.35 , pp. 1865-1872
    • Suolinna, E.M.1    Buchsbaum, R.N.2    Racker, E.3
  • 31
    • 0034704084 scopus 로고    scopus 로고
    • Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters
    • Wang Z., Morris J.C., Drew M.E., Englund P.T. Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J. Biol. Chem. 2000, 275:40174-40179.
    • (2000) J. Biol. Chem. , vol.275 , pp. 40174-40179
    • Wang, Z.1    Morris, J.C.2    Drew, M.E.3    Englund, P.T.4
  • 32
    • 0035990006 scopus 로고    scopus 로고
    • Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase
    • Willson M., Sanejouand Y.H., Perie J., Hannaert V., Opperdoes F. Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase. Chem. Biol. 2002, 9:839-847.
    • (2002) Chem. Biol. , vol.9 , pp. 839-847
    • Willson, M.1    Sanejouand, Y.H.2    Perie, J.3    Hannaert, V.4    Opperdoes, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.