Direct determination of diazepam and its glucuronide metabolites in human whole blood by μElution solid-phase extraction and liquid chromatography-tandem mass spectrometry

Forensic Science International

Volumn 233, Issue 1-3, 2013, Pages 304-311

  Wang, Rong ^a   Wang, Xin ^a,b   Liang, Chen ^a   Ni, Chunfang ^a   Xiong, Lingjuan ^a,b   Rao, Yulan ^c   Zhang, Yurong ^a  

^a Shanghai Key Laboratory of Criminal Scene Evidence   (China)

^b Key Laboratory of Rational Drug and Pharmaceutical Technology   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

96 Well Elution plate solid phase extraction; Diazepam; Diazepam glucuronides; Human whole blood; LC MS MS

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIAZEPAM; ESTAZEPAM; ESTAZOLAM; METHANOL; NORDAZEPAM; OXAZEPAM; OXAZEPAM GLUCURONIDE; TEMAZEPAM; TEMAZEPAM GLUCURONIDE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MISUSE; FORENSIC IDENTIFICATION; FORENSIC TOXICOLOGY; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MONITORING; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

96-WELL ΜELUTION PLATE SOLID-PHASE EXTRACTION; DIAZEPAM; DIAZEPAM GLUCURONIDES; HUMAN WHOLE BLOOD; LC-MS/MS;

CHROMATOGRAPHY, LIQUID; DIAZEPAM; FORENSIC TOXICOLOGY; HUMANS; HYPNOTICS AND SEDATIVES; LIMIT OF DETECTION; NORDAZEPAM; OXAZEPAM; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TEMAZEPAM;

EID: 84886841475     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2013.10.004     Document Type: Article

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