Determination of benzodiazepines in ante-mortem and post-mortem whole blood by solid-supported liquid-liquid extraction and UPLC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 883-884, Issue , 2012, Pages 177-188

  Sauve, E N ^a,b   Langodegard M ^a   Ekeberg, D ^b   Oiestad A M L ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

Benzodiazepines; Quantitative analysis; Solid supported liquid liquid extraction; Ultra performance liquid chromatography tandem mass spectrometry; Whole blood

Indexed keywords

ALPRAZOLAM; ANALYTES; BENZODIAZEPINES; BORATE BUFFER; BROMAZEPAM; CALIBRATION CURVES; CLONAZEPAM; DEUTERATED ANALOGUE; DRIVING UNDER THE INFLUENCE; EQUILIBRATION TIME; EXTERNAL QUALITY; FLUNITRAZEPAM; GOOD CORRELATIONS; INTERNAL STANDARDS; LC-MS METHODS; LEGISLATIVE SYSTEMS; LIQUID-LIQUID EXTRACTION; LORAZEPAM; MATRIX EFFECTS; METHOD VALIDATIONS; METHYL TERT BUTYL ETHER; MIDAZOLAM; MULTIPLE REACTION MONITORING; OXAZEPAM; POSITIVE MODE; RUNTIMES; SECOND-ORDER CALIBRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-MS/MS; WHOLE BLOOD;

ANESTHETICS; BLOOD; CALIBRATION; CHEMICAL ANALYSIS; DEUTERIUM; ETHERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SOLVENT EXTRACTION; STANDARDS;

LIQUIDS;

7 AMINO 1,3 DIHYDRO 5 PHENYL 2H 1,4 BENZODIAZEPIN 2 ONE; ALPRAZOLAM; AMLODIPINE; ATENOLOL; BENZODIAZEPINE; BISOPROLOL; BROMAZEPAM; CARVEDILOL; CLONAZEPAM; DIAZEPAM; DILTIAZEM; FLECAINIDE; FLUNITRAZEPAM; IRBESARTAN; LORAZEPAM; LOSARTAN; METOPROLOL; MIDAZOLAM; NITRAZEPAM; NORDAZEPAM; OXAZEPAM; PHENAZEPAM; PROPRANOLOL; SOTALOL; TELMISARTAN; TRAMADOL; UNINDEXED DRUG; VALSARTAN; VENLAFAXINE; VERAPAMIL;

ACCURACY; ARTICLE; AUTOPSY; BLOOD; BLOOD SAMPLING; CALIBRATION; CHEMICAL REACTION; CORRELATION ANALYSIS; DRIVING ABILITY; DRUG BLOOD LEVEL; HUMAN; HUMAN TISSUE; LIQUID LIQUID EXTRACTION; NORWAY; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID SUPPORTED LIQUID LIQUID EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AUTOPSY; BENZODIAZEPINES; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FORENSIC TOXICOLOGY; HUMANS; LIMIT OF DETECTION; LIQUID-LIQUID EXTRACTION; NORWAY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84856484556     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.10.033     Document Type: Article

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