Extending the detection window of diazepam by directly analyzing its glucuronide metabolites in human urine using liquid chromatography-tandem mass spectrometry

Journal of Chromatography A

Volumn 1268, Issue , 2012, Pages 29-34

  Wang, Xin ^a,b   Wang, Rong ^b   Zhang, Yurong ^b   Liang, Chen ^b   Ye, Haiying ^b   Cao, Fangqi ^b   Rao, Yulan ^c  

^a SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

^b Shanghai Institute of Forensic Science   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Detection window; Diazepam; Glucuronide metabolites; Human urine; LC MS MS; SPE

Indexed keywords

DETECTION WINDOWS; DIAZEPAM; GLUCURONIDES; HUMAN URINE; LC-MS/MS; SPE;

BIOMOLECULES; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

BODY FLUIDS;

DIAZEPAM; DRUG METABOLITE; NORDAZEPAM; OXAZEPAM; OXAZEPAM GLUCURONIDE; TEMAZEPAM; TEMAZEPAM GLUCURONIDE; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; DRUG DETERMINATION; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; PRIORITY JOURNAL; PROCESS DEVELOPMENT; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINALYSIS; VALIDATION PROCESS;

CHROMATOGRAPHY, LIQUID; DIAZEPAM; GLUCURONIDES; HUMANS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84869883320     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.10.012     Document Type: Article

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