메뉴 건너뛰기




Volumn 400, Issue 1, 2011, Pages 51-67

Simultaneous LC-HRMS determination of 28 benzodiazepines and metabolites in hair

Author keywords

Benzodiazepines; Hair analysis; HRMS; Orbitrap

Indexed keywords

ABSOLUTE VALUES; ANALYTES; ANALYTICAL COLUMNS; BENZODIAZEPINES; CONCENTRATION LEVELS; DEUTERATED ANALOGUE; EXTRACTION EFFICIENCIES; FORENSIC TOXICOLOGY; GRADIENT ELUTION; HAIR ANALYSIS; HIGH RESOLUTION MASS SPECTROMETRY; HRMS; INTERNAL STANDARDS; ION ELECTROSPRAY IONIZATION; LIMITS OF QUANTIFICATION; LIQUID/LIQUID EXTRACTION; MATRIX EFFECTS; MEAN RELATIVE ERROR; ORBITRAP; PHOSPHATE BUFFERS; REAL SAMPLES; RELATIVE STANDARD DEVIATIONS; RESOLVING POWER; SAMPLE PREPARATION; SCAN MODE; SIMULTANEOUS IDENTIFICATION; TRUE POSITIVE;

EID: 79954428972     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-4742-8     Document Type: Article
Times cited : (65)

References (36)
  • 2
    • 4344687302 scopus 로고    scopus 로고
    • Hair to document drug-facilitated crimes: Four cases involving bromazepam
    • M Villain M Chèze V Dumestre B Ludes P Kintz 2004 Hair to document drug-facilitated crimes: four cases involving bromazepam J Anal Toxicol 28 516 9 1:CAS:528:DC%2BD2cXnsVehurY%3D (Pubitemid 39150377)
    • (2004) Journal of Analytical Toxicology , vol.28 , Issue.6 , pp. 516-519
    • Villain, M.1    Cheze, M.2    Dumestre, V.3    Ludes, B.4    Kintz, P.5
  • 3
    • 12244288817 scopus 로고    scopus 로고
    • Drug-Facilitated Robbery or Sexual Assault: Problems Associated with Amnesia
    • DOI 10.1097/00007691-200404000-00021
    • JP Goulle JP Anger 2004 Drug-facilitated robbery or sexual assault: problems associated with amnesia Ther Drug Monit 26 206 210 10.1097/00007691- 200404000-00021 1:CAS:528:DC%2BD2cXjvFOku70%3D (Pubitemid 38501219)
    • (2004) Therapeutic Drug Monitoring , vol.26 , Issue.2 , pp. 206-210
    • Goulle, J.-P.1    Anger, J.-P.2
  • 4
    • 69849101246 scopus 로고    scopus 로고
    • Knock-out drugs: Their prevalence, modes of action, and means of detection
    • B Madea F Musshoff 2009 Knock-out drugs: their prevalence, modes of action, and means of detection Dtsch Arztebl Int 106 341 7
    • (2009) Dtsch Arztebl Int , vol.106 , pp. 341-7
    • Madea, B.1    Musshoff, F.2
  • 6
    • 0036293351 scopus 로고    scopus 로고
    • Soumission chimique: Quels produits, quels prélevement, quelles analyses?
    • P Kintz 2002 Soumission chimique: quels produits, quels prélèvements, quelles analyses? J Med Leg Droit Med 45 158 160 (Pubitemid 34712464)
    • (2002) Journal de Medecine Legale Droit Medical , vol.45 , Issue.2-3 , pp. 158-160
    • Kintz, P.1
  • 7
    • 0030710949 scopus 로고    scopus 로고
    • Screening for forensically relevant benzodiazepines in human hair by gas chromatography-negative ion chemical ionization-mass spectrometry
    • DOI 10.1016/S0378-4347(97)00337-X, PII S037843479700337X
    • V Cirimele P Kintz B Ludes 1997 Screening for forensically relevant benzodiazepines in human hair by gas chromatography-negative ion chemical ionization-mass spectrometry J Chromatogr B Biomed Sci Appl 700 119 129 10.1016/S0378-4347(97)00337-X 1:CAS:528:DyaK2sXntVOgtrY%3D (Pubitemid 27473984)
    • (1997) Journal of Chromatography B: Biomedical Applications , vol.700 , Issue.1-2 , pp. 119-129
    • Cirimele, V.1    Kintz, P.2    Ludes, B.3
  • 8
    • 0032844963 scopus 로고    scopus 로고
    • Highly sensitive micro-plate enzyme immunoassay screening and NCI-GC-MS confirmation of flunitrazepam and its major metabolite 7-aminoflunitrazepam in hair
    • A Negruz C Moore D Deitermann D Lewis K Kaleciak R Kronstrand B Feeley RS Niedbala 1999 Highly sensitive micro-plate enzyme immunoassay screening and NCI-GC-MS confirmation of flunitrazepam and its major metabolite 7-aminoflunitrazepam in hair J Anal Toxicol 23 429 435 (Pubitemid 29473394)
    • (1999) Journal of Analytical Toxicology , vol.23 , Issue.6 , pp. 429-435
    • Negrusz, A.1    Moore, C.2    Deitermann, D.3    Lewis, D.4    Kaleciak, K.5    Kronstrand, R.6    Feeley, B.7    Niedbala, R.S.8
  • 9
    • 34247179089 scopus 로고    scopus 로고
    • Simultaneous quantification of opiates, amphetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC-MS
    • DOI 10.1016/j.jchromb.2006.12.021, PII S1570023206010348
    • R Cordero S Paterson 2007 Simultaneous quantification of opiates, amphetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC-MS J Chromatogr B Analyt Technol Biomed Life Sci 850 423 431 10.1016/j.jchromb.2006.12.021 1:CAS:528:DC%2BD2sXkslKqu7g%3D (Pubitemid 46618192)
    • (2007) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.850 , Issue.1-2 , pp. 423-431
    • Cordero, R.1    Paterson, S.2
  • 10
    • 0036825817 scopus 로고    scopus 로고
    • Segmental ion spray LC-MS-MS analysis of benzodiazepines in hair of psychiatric patients
    • R Kronstrand I Nyström M Josefsson S Hodgins 2002 Segmental ion spray LC-MS-MS analysis of benzodiazepines in hair of psychiatric patients J Anal Toxicol 26 479 484 1:CAS:528:DC%2BD38XosFyqtLY%3D (Pubitemid 36206783)
    • (2002) Journal of Analytical Toxicology , vol.26 , Issue.7 , pp. 479-484
    • Kronstrand, R.1    Nystrom, I.2    Josefsson, M.3    Hodgins, S.4
  • 11
    • 4644363459 scopus 로고    scopus 로고
    • Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS: Application to forensic cases of drug facilitated crimes
    • DOI 10.1016/j.forsciint.2004.04.066, PII S0379073804002415
    • M Chèze M Villain G Pépin 2004 Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes Forensic Sci Int 145 123 130 10.1016/j.forsciint.2004.04.066 (Pubitemid 39296629)
    • (2004) Forensic Science International , vol.145 , Issue.2-3 , pp. 123-130
    • Cheze, M.1    Villain, M.2    Pepin, G.3
  • 12
    • 22444445633 scopus 로고    scopus 로고
    • Hair analysis by liquid chromatography-tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: Report of 128 cases over the period June 2003-May 2004 in metropolitan Paris
    • DOI 10.1016/j.forsciint.2005.04.021, PII S0379073805002112, 2004 Joint Meeting of SOFT and TIAFT
    • M Chèze G Duffort M Deveaux G Pépin 2005 Hair analysis by liquid chromatography-tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: report of 128 cases over the period June 2003-May 2004 in metropolitan Paris Forensic Sci Int 153 3 10 10.1016/j.forsciint.2005.04.021 (Pubitemid 41008645)
    • (2005) Forensic Science International , vol.153 , Issue.1 , pp. 3-10
    • Cheze, M.1    Duffort, G.2    Deveaux, M.3    Pepin, G.4
  • 13
    • 29144494822 scopus 로고    scopus 로고
    • Validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair
    • M Laloup M Del Mar Ramirez Fernandez G De Boeck M Wood V Maes N Samyn 2005 Validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine and hair J Anal Toxicol 29 616 626 1:CAS:528:DC%2BD2MXhtFChsL7O (Pubitemid 41803347)
    • (2005) Journal of Analytical Toxicology , vol.29 , Issue.7 , pp. 616-626
    • Laloup, M.1    Fernandez, M.D.M.R.2    De Boeck, G.3    Wood, M.4    Maes, V.5    Samyn, N.6
  • 14
    • 24344437125 scopus 로고    scopus 로고
    • Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometry
    • DOI 10.1016/j.jchromb.2004.12.036, PII S157002320500036X
    • M Villain M Concheiro V Cirimele P Kintz 2005 Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometry J Chromatogr B 825 72 78 10.1016/j.jchromb.2004.12.036 1:CAS:528:DC%2BD2MXpvV2ksrg%3D (Pubitemid 41262480)
    • (2005) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.825 , Issue.SPEC. ISS. , pp. 72-78
    • Villain, M.1    Concheiro, M.2    Cirimele, V.3    Kintz, P.4
  • 15
    • 33846252401 scopus 로고    scopus 로고
    • Molecularly imprinted solid-phase extraction of diazepam and its metabolites from hair samples
    • DOI 10.1021/ac061062w
    • MM Ariffin EI Miller PAG Cormack RA Anderson 2007 Molecularly imprinted solid-phase extraction of diazepam and its metabolites from hair samples Anal Chem 79 256 262 10.1021/ac061062w 1:CAS:528:DC%2BD28Xht1Clu7rJ (Pubitemid 46095057)
    • (2007) Analytical Chemistry , vol.79 , Issue.1 , pp. 256-262
    • Ariffin, M.M.1    Miller, E.I.2    Cormack, P.A.G.3    Anderson, R.A.4
  • 16
    • 33846533634 scopus 로고    scopus 로고
    • The detection of sedatives in hair and nail samples using tandem LC-MS-MS
    • DOI 10.1016/j.forsciint.2006.03.027, PII S037907380600199X
    • RC Irving SJ Dickson 2007 The detection of sedatives in hair and nail samples using tandem LC-MS-MS Forensic Sci Int 166 58 67 10.1016/j.forsciint. 2006.03.027 1:CAS:528:DC%2BD2sXht1Oktbk%3D (Pubitemid 46162012)
    • (2007) Forensic Science International , vol.166 , Issue.1 , pp. 58-67
    • Irving, R.C.1    Dickson, S.J.2
  • 17
    • 36749004411 scopus 로고    scopus 로고
    • Comparison of molecularly imprinted solid-phase extraction (MISPE) with classical solid-phase extraction (SPE) for the detection of benzodiazepines in post-mortem hair samples
    • DOI 10.1016/j.forsciint.2007.03.002, PII S0379073807001387
    • RA Anderson MM Ariffin PAG Cormack EI Miller 2008 Comparison of molecularly imprinted solid-phase extraction (MISPE) with classical solid-phase extraction (SPE) for the detection of benzodiazepines in post-mortem hair samples Forensic Sci Int 174 40 46 10.1016/j.forsciint.2007.03.002 1:CAS:528:DC%2BD2sXhsVSlsr%2FP (Pubitemid 350213332)
    • (2008) Forensic Science International , vol.174 , Issue.1 , pp. 40-46
    • Anderson, R.A.1    Ariffin, M.M.2    Cormack, P.A.G.3    Miller, E.I.4
  • 18
    • 79954449531 scopus 로고    scopus 로고
    • Segmental hair analysis using liquid chromatography-tandem mass spectrometry after a single dose of benzodiazepines
    • (in press)
    • Xiang P, Sun Q, Shen B, Chen P, Liu W, Shen M (2010) Segmental hair analysis using liquid chromatography-tandem mass spectrometry after a single dose of benzodiazepines. Forensic Sci Int (in press)
    • (2010) Forensic Sci Int
    • Xiang, P.1    Sun, Q.2    Shen, B.3    Chen, P.4    Liu, W.5    Shen, M.6
  • 19
    • 0035881208 scopus 로고    scopus 로고
    • Determination of triazolam involving its hydroxy metabolites in hair shaft and hair root by reversed-phase liquid chromatography with electrospray ionization mass spectrometry and application to human hair analysis
    • DOI 10.1006/abio.2001.5203
    • T Toyo'oka M Kanbori Y Kumaki Y Nakahara 2001 Determination of triazolam involving its hydroxy metabolites in hair shaft and hair root by reversed-phase liquid chromatography with electrospray ionization mass spectrometry and application to human hair analysis Anal Biochem 295 172 179 10.1006/abio.2001. 5203 (Pubitemid 32756971)
    • (2001) Analytical Biochemistry , vol.295 , Issue.2 , pp. 172-179
    • Toyo'oka, T.1    Kanbori, M.2    Kumaki, Y.3    Nakahara, Y.4
  • 20
    • 26444545617 scopus 로고    scopus 로고
    • Windows of detection of tetrazepam in urine, oral fluid, beard, and hair, with a special focus on drug-facilitated crimes
    • DOI 10.1097/01.ftd.0000164610.14808.45
    • M Concheiro M Villain S Bouchet B Ludes M Lopez-Rivadulla P Kintz 2005 Windows of detection of tetrazepam in urine, oral fluid, beard, and hair, with a special focus on drug-facilitated crimes Ther Drug Monit 27 565 570 10.1097/01.ftd.0000164610.14808.45 1:CAS:528:DC%2BD2MXhtVWmurrM (Pubitemid 41437632)
    • (2005) Therapeutic Drug Monitoring , vol.27 , Issue.5 , pp. 565-570
    • Concheiro, M.1    Villain, M.2    Bouchet, S.3    Ludes, B.4    Lopez-Rivadulla, M.5    Kintz, P.6
  • 21
    • 24044542270 scopus 로고    scopus 로고
    • Identification of alprazolam in hair in two cases of drug-facilitated incidents
    • DOI 10.1016/j.forsciint.2004.10.025, PII S0379073804007467
    • P Kintz M Villain M Chèze G Pépin 2005 Identification of alprazolam in hair in two cases of drug-facilitated incidents Forensic Sci Int 153 222 226 10.1016/j.forsciint.2004.10.025 1:CAS:528:DC%2BD2MXpslars74%3D (Pubitemid 41219678)
    • (2005) Forensic Science International , vol.153 , Issue.2-3 , pp. 222-226
    • Kintz, P.1    Villain, M.2    Cheze, M.3    Pepin, G.4
  • 23
    • 50949107472 scopus 로고    scopus 로고
    • Simultaneous detection and quantification of amphetamines, diazepam and its metabolites, cocaine and its metabolite, and opiates in hair by LC-ESI-MS-MS using a single extraction method
    • 1:CAS:528:DC%2BD1cXps1eksrc%3D
    • EL Miller FM Wylie JS Oliver 2008 Simultaneous detection and quantification of amphetamines, diazepam and its metabolites, cocaine and its metabolite, and opiates in hair by LC-ESI-MS-MS using a single extraction method J Anal Toxicol 32 457 469 1:CAS:528:DC%2BD1cXps1eksrc%3D
    • (2008) J Anal Toxicol , vol.32 , pp. 457-469
    • Miller, E.L.1    Wylie, F.M.2    Oliver, J.S.3
  • 24
    • 57749102003 scopus 로고    scopus 로고
    • Screening for basic drugs in hair of drug addicts by liquid chromatography/time-of-flight mass spectrometry
    • 10.1097/FTD.0b013e3181897cfa 1:CAS:528:DC%2BD1cXhsVKnt73L
    • A Pelander J Ristimaa I Rasanen E Vuori I Ojanperä 2008 Screening for basic drugs in hair of drug addicts by liquid chromatography/time-of-flight mass spectrometry Ther Drug Monit 30 717 24 10.1097/FTD.0b013e3181897cfa 1:CAS:528:DC%2BD1cXhsVKnt73L
    • (2008) Ther Drug Monit , vol.30 , pp. 717-24
    • Pelander, A.1    Ristimaa, J.2    Rasanen, I.3    Vuori, E.4    Ojanperä, I.5
  • 25
    • 76549094091 scopus 로고    scopus 로고
    • Simultaneous screening and quantification of 52 common pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS
    • 10.1016/j.forsciint.2009.12.027 1:CAS:528:DC%2BC3cXit1Kit7Y%3D
    • MK Nielsen SS Johansen PW Dalsgaard K Linnet 2010 Simultaneous screening and quantification of 52 common pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS Forensic Sci Int 196 85 92 10.1016/j.forsciint.2009.12.027 1:CAS:528:DC%2BC3cXit1Kit7Y%3D
    • (2010) Forensic Sci Int , vol.196 , pp. 85-92
    • Nielsen, M.K.1    Johansen, S.S.2    Dalsgaard, P.W.3    Linnet, K.4
  • 27
    • 0036827348 scopus 로고    scopus 로고
    • Bioanalytical method validation and its implications for forensic and clinical toxicology - A review
    • DOI 10.1007/s00769-002-0516-5
    • FT Peters HH Maurer 2002 Bioanalytical method validation and its implications for forensic and clinical toxicology: a review Accred Qual Assur 7 441 449 10.1007/s00769-002-0516-5 1:CAS:528:DC%2BD38Xos1Whu7o%3D (Pubitemid 36165305)
    • (2002) Accreditation and Quality Assurance , vol.7 , Issue.11 , pp. 441-449
    • Peters, F.T.1    Maurer, H.H.2
  • 29
    • 79954439886 scopus 로고    scopus 로고
    • ISO 5725-1:1994. Accuracy (trueness and precision) of measurement methods and results. Part 1: General principles and definitions
    • ISO 5725-1:1994. Accuracy (trueness and precision) of measurement methods and results. Part 1: General principles and definitions
  • 30
    • 0037663202 scopus 로고    scopus 로고
    • Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS
    • DOI 10.1021/ac020361s
    • BK Matuszewski ML Constanzer CM Chavez-Eng 2003 Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS Anal Chem 75 3019 3030 10.1021/ac020361s 1:CAS:528: DC%2BD3sXltV2jsL8%3D (Pubitemid 36830428)
    • (2003) Analytical Chemistry , vol.75 , Issue.13 , pp. 3019-3030
    • Matuszewski, B.K.1    Constanzer, M.L.2    Chavez-Eng, C.M.3
  • 31
    • 75649131835 scopus 로고    scopus 로고
    • Neonatal hair analysis by liquid chromatography-high-resolution mass spectrometry to reveal gestational exposure to venlafaxine
    • 10.1097/FTD.0b013e3181c01e16 1:CAS:528:DC%2BC3cXhtVGqtr0%3D
    • D Favretto G Stocchero S Vogliardi G Frison D Trevisanuto F Castagna SD Ferrara 2010 Neonatal hair analysis by liquid chromatography-high-resolution mass spectrometry to reveal gestational exposure to venlafaxine Ther Drug Monit 32 30 39 10.1097/FTD.0b013e3181c01e16 1:CAS:528:DC%2BC3cXhtVGqtr0%3D
    • (2010) Ther Drug Monit , vol.32 , pp. 30-39
    • Favretto, D.1    Stocchero, G.2    Vogliardi, S.3    Frison, G.4    Trevisanuto, D.5    Castagna, F.6    Ferrara, S.D.7
  • 32
    • 33645510278 scopus 로고    scopus 로고
    • Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/Time-of-flight mass spectrometry
    • 10.1002/rcm.2429
    • S Ojanperä A Pelander M Pelzing I Krebs E Vuori I Ojanperä 2006 Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/Time-of-flight mass spectrometry Rapid Commun Mass Spectrom 20 1161 1167 10.1002/rcm.2429
    • (2006) Rapid Commun Mass Spectrom , vol.20 , pp. 1161-1167
    • Ojanperä, S.1    Pelander, A.2    Pelzing, M.3    Krebs, I.4    Vuori, E.5    Ojanperä, I.6
  • 33
    • 33846895151 scopus 로고    scopus 로고
    • Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques
    • 10.1016/j.aca.2006.08.055 1:CAS:528:DC%2BD2sXhvVyns78%3D
    • MWF Nielen MC van Engelen R Zuiderent R Ramaker 2007 Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques Anal Chim Acta 586 122 129 10.1016/j.aca.2006.08.055 1:CAS:528:DC%2BD2sXhvVyns78%3D
    • (2007) Anal Chim Acta , vol.586 , pp. 122-129
    • Nielen, M.W.F.1    Van Engelen, M.C.2    Zuiderent, R.3    Ramaker, R.4
  • 34
    • 47749089748 scopus 로고    scopus 로고
    • Introduction of HPLC/orbitrap mass spectrometry as screening method for doping control
    • DOI 10.1002/jms.1447
    • E Virus T Sobolevsky G Rodchenkov 2008 Introduction of HPLC/Orbitrap mass spectrometry as screening method for doping control J Mass Spectrom 43 949 957 10.1002/jms.1447 1:CAS:528:DC%2BD1cXptVehu7w%3D (Pubitemid 352029663)
    • (2008) Journal of Mass Spectrometry , vol.43 , Issue.7 , pp. 949-957
    • Virus, E.D.1    Sobolevsky, T.G.2    Rodchenkov, G.M.3
  • 35
    • 60649086153 scopus 로고    scopus 로고
    • Full-scan accurate mass selectivity of ultra-performance liquid chromatography combined with time-of-flight and orbitrap mass spectrometry in hormone and veterinary drug residue analysis
    • 10.1016/j.jasms.2008.11.002
    • E van der Heeft YJC Bolck B Beumer AWJM Nijrolder AAM Stolker MWF Nielen 2009 Full-scan accurate mass selectivity of ultra-performance liquid chromatography combined with time-of-flight and orbitrap mass spectrometry in hormone and veterinary drug residue analysis J Am Soc Mass Spectrom 20 451 463 10.1016/j.jasms.2008.11.002
    • (2009) J Am Soc Mass Spectrom , vol.20 , pp. 451-463
    • Van Der Heeft, E.1    Bolck, Y.J.C.2    Beumer, B.3    Awjm, N.4    Stolker, A.A.M.5    Nielen, M.W.F.6
  • 36
    • 0013285756 scopus 로고    scopus 로고
    • European Commission Commission Decision 2002/657/EC
    • European Commission (2002) Commission Decision 2002/657/EC. Off J Eur Commun L221:8
    • (2002) Off J Eur Commun , vol.221 L , pp. 8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.