-
1
-
-
62249177821
-
Metabolites in safety testing (MIST): Considerations of mechanisms of toxicity with dose, abundance, and duration of treatment
-
Smith DA, Obach RS. Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment. Chem. Res. Toxicol. 22(2), 267-279 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, Issue.2
, pp. 267-279
-
-
Smith, D.A.1
Obach, R.S.2
-
2
-
-
62249142787
-
Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development
-
Leclercq L, Cuyckens F, Mannens GS et al. Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development. Chem. Res. Toxicol. 22(2), 280-293 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, Issue.2
, pp. 280-293
-
-
Leclercq, L.1
Cuyckens, F.2
Mannens, G.S.3
-
5
-
-
78449291591
-
Potential bias and mitigations when using stable isotope labeled parent drug as internal standard for LC-MS/MS quantitation of metabolites
-
Jian W, Edom RW, Xu Y et al. Potential bias and mitigations when using stable isotope labeled parent drug as internal standard for LC-MS/MS quantitation of metabolites. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(31), 3267-3276 (2010).
-
(2010)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.878
, Issue.31
, pp. 3267-3276
-
-
Jian, W.1
Edom, R.W.2
Xu, Y.3
-
6
-
-
75149185863
-
Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography
-
Jemal M, Ouyang Z, Xia YQ. Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography. Biomed. Chromatogr. 24(1), 2-19 (2010).
-
(2010)
Biomed. Chromatogr.
, vol.24
, Issue.1
, pp. 2-19
-
-
Jemal, M.1
Ouyang, Z.2
Xia, Y.Q.3
-
7
-
-
0142258161
-
Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous/organic mobile phases
-
DOI 10.1016/j.jchromb.2003.08.026
-
Naidong W. Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica column with aqueous/organic mobile phase. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 796, 209-224 (2003). (Pubitemid 37329666)
-
(2003)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.796
, Issue.2
, pp. 209-224
-
-
Naidong, W.1
-
8
-
-
45949097631
-
Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites
-
DOI 10.1002/jssc.200700451, Hydrophilic interaction chromatography
-
Hsieh Y. Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites. J. Sep. Sci. 31 (9), 1481-1491 (2008). (Pubitemid 351890775)
-
(2008)
Journal of Separation Science
, vol.31
, Issue.9
, pp. 1481-1491
-
-
Hsieh, Y.1
-
9
-
-
77950802246
-
Bioanalytical hydrophilic interaction chromatography: Recent challenges, solutions and applications
-
Xu RN, Reiser R, El-Shourbagy TA. Bioanalytical hydrophilic interaction chromatography: recent challenges, solutions and applications. Bioanalysis 1(1), 239-253 (2009).
-
(2009)
Bioanalysis
, vol.1
, Issue.1
, pp. 239-253
-
-
Xu, R.N.1
Reiser, R.2
El-Shourbagy, T.A.3
-
10
-
-
77950811207
-
Recent advances in application of hydrophilic interaction chromatography for quantitative bioanalysis
-
Jian W, Edom RW, Xu Y et al. Recent advances in application of hydrophilic interaction chromatography for quantitative bioanalysis. J. Sep. Sci. 33(6-7), 681-697 (2010).
-
(2010)
J. Sep. Sci.
, vol.33
, Issue.6-7
, pp. 681-697
-
-
Jian, W.1
Edom, R.W.2
Xu, Y.3
-
11
-
-
0025173758
-
Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds
-
DOI 10.1016/S0021-9673(00)96972-3
-
Alpert AJ. Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. J. Chromatogr. 499, 177-196 (1990). (Pubitemid 20044236)
-
(1990)
Journal of Chromatography
, vol.499
, pp. 177-196
-
-
Alpert, A.J.1
-
12
-
-
45949091683
-
Stationary phases for hydrophilic interaction chromatography, their characterization and implementation into multidimensional chromatography concepts
-
DOI 10.1002/jssc.200800051, Hydrophilic interaction chromatography
-
Jandera P. Stationary phases for hydrophilic interaction chromatography, their characterization and implementation into multidimensional chromatography concepts. J. Sep. Sci. 31(9), 1421-1437 (2008). (Pubitemid 351890771)
-
(2008)
Journal of Separation Science
, vol.31
, Issue.9
, pp. 1421-1437
-
-
Jandera, P.1
-
13
-
-
33748471966
-
Hydrophilic interaction chromatography
-
DOI 10.1002/jssc.200600199
-
Hemstrom P, Irgum K. Hydrophilic interaction chromatography. J. Sep. Sci. 29(12), 1784-1821 (2006). (Pubitemid 44348484)
-
(2006)
Journal of Separation Science
, vol.29
, Issue.12
, pp. 1784-1821
-
-
Hemstrom, P.1
Irgum, K.2
-
14
-
-
5444234890
-
Hydrophilic interaction chromatography using silica columns for the retention polar analytes and enhanced ESI-MS sensitivity
-
Grumbach ES, Wagrowski-Diehl DM, Mazzeo JR et al. Hydrophilic interaction chromatography using silica columns for the retention polar analytes and enhanced ESI-MS sensitivity. LCGC North America. 22, 1010-1023 (2004).
-
(2004)
LCGC North America.
, vol.22
, pp. 1010-1023
-
-
Grumbach, E.S.1
Wagrowski-Diehl, D.M.2
Mazzeo, J.R.3
-
15
-
-
18144382597
-
Retention behavior of small polar compounds on polar stationary phases in hydrophilic interaction chromatography
-
DOI 10.1016/j.chroma.2005.03.058
-
Guo Y, Gaiki S. Retention behavior of small polar compounds on polar stationary phases in hydrophilic interaction chromatography. J. Chromatogr. A 1074(1-2), 71-80 (2005). (Pubitemid 40615045)
-
(2005)
Journal of Chromatography A
, vol.1074
, Issue.1-2
, pp. 71-80
-
-
Guo, Y.1
Gaiki, S.2
-
16
-
-
0034307387
-
Mixed-mode anion-cation exchange/ hydrophilic interaction liquid chromatography-electrospray mass spectrometry as an alternative to reversed phase for small molecule drug discovery
-
Strege MA, Stevenson S, Lawrence SM. Mixed-mode anion-cation exchange/ hydrophilic interaction liquid chromatography-electrospray mass spectrometry as an alternative to reversed phase for small molecule drug discovery. Anal. Chem. 72(19), 4629-4633 (2000).
-
(2000)
Anal. Chem.
, vol.72
, Issue.19
, pp. 4629-4633
-
-
Strege, M.A.1
Stevenson, S.2
Lawrence, S.M.3
-
17
-
-
4644302069
-
Direct injection of solid-phase extraction eluents onto silica columns for the analysis of polar compounds isoniazid and cetirizine in plasma using hydrophilic interaction chromatography with tandem mass spectrometry
-
DOI 10.1002/rcm.1623
-
Li AC, Junga H, Shou WZ et al. Direct injection of solid-phase extraction eluents onto silica columns for the analysis of polar compounds isoniazid and cetirizine in plasma using hydrophilic interaction chromatography with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 18(19), 2343-2350 (2004). (Pubitemid 39297373)
-
(2004)
Rapid Communications in Mass Spectrometry
, vol.18
, Issue.19
, pp. 2343-2350
-
-
Li, A.C.1
Junga, H.2
Shou, W.Z.3
Bryant, M.S.4
Jiang, X.-Y.5
Naidong, W.6
-
18
-
-
9644272516
-
Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase [2]
-
DOI 10.1002/rcm.1695
-
Naidong W, Zhou W, Song Q et al. Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/ tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase. Rapid Commun. Mass Spectrom. 18(23), 2963-2968 (2004). (Pubitemid 39576842)
-
(2004)
Rapid Communications in Mass Spectrometry
, vol.18
, Issue.23
, pp. 2963-2968
-
-
Naidong, W.1
Zhou, W.2
Song, Q.3
Zhou, S.4
-
19
-
-
33646428353
-
A 96-well single-pot liquid-liquid extraction, hydrophilic interaction liquid chromatography-mass spectrometry method for the determination of muraglitazar in human plasma
-
Xue YJ, Liu J, Unger S. A 96-well single-pot liquid-liquid extraction, hydrophilic interaction liquid chromatography-mass spectrometry method for the determination of muraglitazar in human plasma. J. Pharm. Biomed. Anal. 41(3), 979-988 (2006).
-
(2006)
J. Pharm. Biomed. Anal.
, vol.41
, Issue.3
, pp. 979-988
-
-
Xue, Y.J.1
Liu, J.2
Unger, S.3
-
20
-
-
29244481496
-
Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS) - Eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction
-
DOI 10.1016/j.jchromb.2005.10.042, PII S1570023205007798
-
Song Q, Naidong W. Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS) - eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 830(1), 135-142 (2006). (Pubitemid 41831399)
-
(2006)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.830
, Issue.1
, pp. 135-142
-
-
Song, Q.1
Naidong, W.2
-
21
-
-
0036393151
-
Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - A novel approach of eliminating evaporation and reconstitution steps in 96-well SPE
-
Naidong W, Shou WZ, Addison T et al. Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE. Rapid Commun. Mass Spectrom. 16(20), 1965-1975 (2002).
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, Issue.20
, pp. 1965-1975
-
-
Naidong, W.1
Shou, W.Z.2
Addison, T.3
-
22
-
-
0036023982
-
Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns
-
Shou WZ, Chen YL, Eerkes A et al. Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns. Rapid Commun. Mass Spectrom. 16(17), 1613-1621 (2002).
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, Issue.17
, pp. 1613-1621
-
-
Shou, W.Z.1
Chen, Y.L.2
Eerkes, A.3
-
23
-
-
45949093560
-
Fast hydrophilic interaction liquid chromatographic separations on bonded zwitterionic stationary phase
-
DOI 10.1002/jssc.200800080, Hydrophilic interaction chromatography
-
Appelblad P, Jonsson T, Jiang W et al. Fast hydrophilic interaction liquid chromatographic separations on bonded zwitterionic stationary phase. J. Sep. Sci. 31(9), 1529-1536 (2008). (Pubitemid 351890780)
-
(2008)
Journal of Separation Science
, vol.31
, Issue.9
, pp. 1529-1536
-
-
Appelblad, P.1
Jonsson, T.2
Jiang, W.3
Irgum, K.4
-
24
-
-
66149182893
-
Ultraperformance hydrophilic interaction liquid chromatography/tandem mass spectrometry for the determination of everolimus in mouse plasma
-
Hsieh Y, Galviz G, Long BJ. Ultraperformance hydrophilic interaction liquid chromatography/tandem mass spectrometry for the determination of everolimus in mouse plasma. Rapid Commun. Mass Spectrom. 23 (10), 1461-1466 (2009).
-
(2009)
Rapid Commun. Mass Spectrom.
, vol.23
, Issue.10
, pp. 1461-1466
-
-
Hsieh, Y.1
Galviz, G.2
Long, B.J.3
-
25
-
-
2942525420
-
Chromatographic behavior of epirubicin and its analogues on high-purity silica in hydrophilic interaction chromatography
-
DOI 10.1016/j.chroma.2004.04.033, PII S0021967304006338
-
Li R, Huang J. Chromatographic behavior of epirubicin and its analogues on high-purity silica in hydrophilic interaction chromatography. J. Chromatogr. A 1041(1-2), 163-169 (2004). (Pubitemid 38760221)
-
(2004)
Journal of Chromatography A
, vol.1041
, Issue.1-2
, pp. 163-169
-
-
Li, R.1
Huang, J.2
-
26
-
-
0032892520
-
Peptide separation in normal-phase liquid chromatography. Study of selectivity and mobile phase effects on various columns
-
DOI 10.1016/S0021-9673(99)00223-X, PII S002196739900223X
-
Yoshida T, Okada T. Peptide separation in normal-phase liquid chromatography. Study of selectivity and mobile phase effects on various columns. J. Chromatogr. A 840(1), 1-9 (1999). (Pubitemid 29187238)
-
(1999)
Journal of Chromatography A
, vol.840
, Issue.1
, pp. 1-9
-
-
Yoshida, T.1
Okada, T.2
-
27
-
-
0021707968
-
Properties of acyl glucuronides: Implications for studies of the pharmacokinetics and metabolism of acidic drugs
-
Faed EM. Properties of acyl glucuronide: implications for studies of the pharmacokinetics and metabolism of acidic drugs. Drug Metab. Rev. 15, 1213-1249 (1984). (Pubitemid 15158041)
-
(1984)
Drug Metabolism Reviews
, vol.15
, Issue.5-6
, pp. 1213-1249
-
-
Faed, E.M.1
-
28
-
-
0035497973
-
Morphine-6β-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies
-
DOI 10.1016/S0006-2952(01)00761-4, PII S0006295201007614
-
Ulens C, Baker L, Ratka A et al. Morphine-6- beta-glucuronide and morphine-3- glucuronide, opioid receptor agonists with different potencies. Biochem. Pharmacol. 62 (9), 1273-1282 (2001). (Pubitemid 33055632)
-
(2001)
Biochemical Pharmacology
, vol.62
, Issue.9
, pp. 1273-1282
-
-
Ulens, C.1
Baker, L.2
Ratka, A.3
Waumans, D.4
Tytgat, J.5
-
29
-
-
0032806517
-
Molecular biology of the human cytosolic sulfotransferase gene superfamily implicated in the bioactivation of minoxidil and cholesterol in skin
-
Dooley TP. Molecular biology of the human cytosolic sulfotransferase gene superfamily implicated in the bioactivation of minoxidil and cholesterol in skin. Exp. Dermatol. 8(4), 328-329 (1999). (Pubitemid 29370881)
-
(1999)
Experimental Dermatology
, vol.8
, Issue.4
, pp. 328-329
-
-
Dooley, T.P.1
-
30
-
-
33144456906
-
Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis
-
DOI 10.1021/ac051705s
-
Wagner S, Scholz K, Donegan M et al. Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis. Anal. Chem. 78(4), 1296-1305 (2006). (Pubitemid 43271864)
-
(2006)
Analytical Chemistry
, vol.78
, Issue.4
, pp. 1296-1305
-
-
Wagner, S.1
Scholz, K.2
Donegan, M.3
Burton, L.4
Wingate, J.5
Volkel, W.6
-
31
-
-
27844579198
-
Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer
-
DOI 10.1016/j.jasms.2005.08.003, PII S1044030505007075
-
Scholz K, Dekant W, Volkel W et al. Rapid detection and identification of N-acetyl-lcysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer. J. Am. Soc. Mass Spectrom. 16 (12), 1976-1984 (2005). (Pubitemid 41642961)
-
(2005)
Journal of the American Society for Mass Spectrometry
, vol.16
, Issue.12
, pp. 1976-1984
-
-
Scholz, K.1
Dekant, W.2
Volkel, W.3
Pahler, A.4
-
32
-
-
58149345889
-
Rapid and sensitive HILIC-ESI-MS/MS quantitation of polar metabolites of acrylamide in human urine using column switching with an online trap column
-
Kopp EK, Sieber M, Kellert M et al. Rapid and sensitive HILIC-ESI-MS/MS quantitation of polar metabolites of acrylamide in human urine using column switching with an online trap column. J. Agric. Food Chem. 56(21), 9828-9834 (2008).
-
(2008)
J. Agric. Food Chem.
, vol.56
, Issue.21
, pp. 9828-9834
-
-
Kopp, E.K.1
Sieber, M.2
Kellert, M.3
-
33
-
-
77956873546
-
Determination of six hydroxyalkyl mercapturic acids in human urine using hydrophilic interaction liquid chromatography with tandem mass spectrometry (HILIC-ESI-MS/MS)
-
Eckert E, Drexler H, Goen T. Determination of six hydroxyalkyl mercapturic acids in human urine using hydrophilic interaction liquid chromatography with tandem mass spectrometry (HILIC-ESI-MS/MS). J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(27), 2506-2514 (2010).
-
(2010)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.878
, Issue.27
, pp. 2506-2514
-
-
Eckert, E.1
Drexler, H.2
Goen, T.3
-
34
-
-
67651020757
-
Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2- dichlorovinyl)glutathione and S-(1,2- dichlorovinyl)-l-cysteine
-
Kim S, Collins LB, Boysen G et al. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2- dichlorovinyl)glutathione and S-(1,2- dichlorovinyl)-l-cysteine. Toxicology 262(3), 230-238 (2009).
-
(2009)
Toxicology
, vol.262
, Issue.3
, pp. 230-238
-
-
Kim, S.1
Collins, L.B.2
Boysen, G.3
-
35
-
-
1642281756
-
Drug-Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development
-
DOI 10.1021/tx034170b
-
Evans DC, Watt AP, Nicoll-Griffith DA et al. Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development. Chem. Res. Toxicol. 17(1), 3-16 (2004). (Pubitemid 38134055)
-
(2004)
Chemical Research in Toxicology
, vol.17
, Issue.1
, pp. 3-16
-
-
Evans, D.C.1
Watt, A.P.2
Nicoll-Griffith, D.A.3
Baillie, T.A.4
-
36
-
-
17644404394
-
Negative ion tandem mass spectrometry for the detection of glutathione conjugates
-
DOI 10.1021/tx049741u
-
Dieckhaus CM, Fernandez-Metzler CL, King R et al. Negative ion tandem mass spectrometry for the detection of glutathione conjugates. Chem. Res. Toxicol. 18(4), 630-638 (2005). (Pubitemid 40563277)
-
(2005)
Chemical Research in Toxicology
, vol.18
, Issue.4
, pp. 630-638
-
-
Dieckhaus, C.M.1
Fernandez-Metzler, C.L.2
King, R.3
Krolikowski, P.H.4
Baillie, T.A.5
-
37
-
-
59649106977
-
Recent advances in applications of liquid chromatographytandem mass spectrometry to the analysis of reactive drug metabolites
-
Ma S, Zhu M. Recent advances in applications of liquid chromatographytandem mass spectrometry to the analysis of reactive drug metabolites. Chem. Biol. Interact. 179(1), 25-37 (2009).
-
(2009)
Chem. Biol. Interact.
, vol.179
, Issue.1
, pp. 25-37
-
-
Ma, S.1
Zhu, M.2
-
38
-
-
67651007115
-
Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching
-
Jian W, Yao M, Zhang D et al. Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching. Chem. Res. Toxicol. 22(7), 1246-1255 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, Issue.7
, pp. 1246-1255
-
-
Jian, W.1
Yao, M.2
Zhang, D.3
-
39
-
-
65249125136
-
LC-MS/MS-based approach for obtaining exposure estimates of metabolites in early clinical trials using radioactive metabolites as reference standards
-
Zhang D, Raghavan N, Chando T et al. LC-MS/MS-based approach for obtaining exposure estimates of metabolites in early clinical trials using radioactive metabolites as reference standards. Drug Metab. Lett. 1(4), 293-298 (2007).
-
(2007)
Drug Metab. Lett.
, vol.1
, Issue.4
, pp. 293-298
-
-
Zhang, D.1
Raghavan, N.2
Chando, T.3
-
40
-
-
33847166320
-
A rapid method for quantitatively estimating metabolites in human plasma in the absence of synthetic standards using a combination of liquid chromatography/mass spectrometry and radiometric detection
-
DOI 10.1002/rcm.2863
-
Yu C, Chen CL, Gorycki FL et al. A rapid method for quantitatively estimating metabolites in human plasma in the absence of synthetic standards using a combination of liquid chromatography/mass spectrometry and radiometric detection. Rapid Commun. Mass Spectrom. 21(4), 497-502 (2007). (Pubitemid 46294297)
-
(2007)
Rapid Communications in Mass Spectrometry
, vol.21
, Issue.4
, pp. 497-502
-
-
Yu, C.1
Chen, C.L.2
Gorycki, F.L.3
Neiss, T.G.4
-
41
-
-
62249210251
-
Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: Implications in metabolites in safety testing
-
Espina R, Yu L, Wang J et al. Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing. Chem. Res. Toxicol. 22(2), 299-310 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, Issue.2
, pp. 299-310
-
-
Espina, R.1
Yu, L.2
Wang, J.3
-
42
-
-
62249117708
-
Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: Addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards
-
Vishwanathan K, Babalola K, Wang J et al. Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards. Chem. Res. Toxicol. 22(2), 311-322 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, Issue.2
, pp. 311-322
-
-
Vishwanathan, K.1
Babalola, K.2
Wang, J.3
-
43
-
-
0036027807
-
An automatic 96-well solid phase extraction and liquid chromatography-tandem mass spectrometry method for the analysis of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma
-
DOI 10.1016/S0731-7085(01)00497-6, PII S0731708501004976
-
Shou WZ, Pelzer M, Addison T et al. An automatic 96-well solid phase extraction and liquid chromatography-tandem mass spectrometry method for the analysis of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma. J. Pharm. Biomed. Anal. 27(1-2), 143-152 (2002). (Pubitemid 33001391)
-
(2002)
Journal of Pharmaceutical and Biomedical Analysis
, vol.27
, Issue.1-2
, pp. 143-152
-
-
Shou, W.Z.1
Pelzer, M.2
Addison, T.3
Jiang, X.4
Naidong, W.5
-
44
-
-
23044470693
-
On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry
-
DOI 10.1002/rcm.2035
-
Bengtsson J, Jansson B, Hammarlund- Udenaes M. Online desalting and determination of morphine, morphine-3- glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 19(15), 2116-2122 (2005). (Pubitemid 41059867)
-
(2005)
Rapid Communications in Mass Spectrometry
, vol.19
, Issue.15
, pp. 2116-2122
-
-
Bengtsson, J.1
Jansson, B.2
Hammarlund-Udenaes, M.3
-
45
-
-
77957956297
-
Hydrophilic interaction liquid chromatography and accurate mass measurement for quantification and confirmation of morphine, codeine and their glucuronide conjugates in human urine
-
Kolmonen M, Leinonen A, Kuuranne T et al. Hydrophilic interaction liquid chromatography and accurate mass measurement for quantification and confirmation of morphine, codeine and their glucuronide conjugates in human urine. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(29), 2959-2966 (2010).
-
(2010)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.878
, Issue.29
, pp. 2959-2966
-
-
Kolmonen, M.1
Leinonen, A.2
Kuuranne, T.3
-
46
-
-
42949149708
-
Hydrophilic interaction liquid chromatography-tandem mass spectrometry determination of estrogen conjugates in human urine
-
DOI 10.1021/ac702613k
-
Qin F, Zhao YY, Sawyer MB et al. Hydrophilic interaction liquid chromatography-tandem mass spectrometry determination of estrogen conjugates in human urine. Anal. Chem. 80(9), 3404-3411 (2008). (Pubitemid 351620727)
-
(2008)
Analytical Chemistry
, vol.80
, Issue.9
, pp. 3404-3411
-
-
Qin, F.1
Zhao, Y.-Y.2
Sawyer, M.B.3
Li, X.-F.4
-
47
-
-
51249101077
-
Columnswitching reversed phase-hydrophilic interaction liquid chromatography/tandem mass spectrometry method for determination of free estrogens and their conjugates in river water
-
Qin F, Zhao YY, Sawyer MB et al. Columnswitching reversed phase-hydrophilic interaction liquid chromatography/tandem mass spectrometry method for determination of free estrogens and their conjugates in river water. Anal. Chim. Acta 627(1), 91-98 (2008).
-
(2008)
Anal. Chim. Acta
, vol.627
, Issue.1
, pp. 91-98
-
-
Qin, F.1
Zhao, Y.Y.2
Sawyer, M.B.3
-
48
-
-
77950823519
-
Online desorption of dried blood spots coupled to hydrophilic interaction/reversed-phase LC-MS/MS system for the simultaneous analysis of drugs and their polar metabolites
-
Thomas A, Deglon J, Steimer T et al. Online desorption of dried blood spots coupled to hydrophilic interaction/reversed-phase LC-MS/MS system for the simultaneous analysis of drugs and their polar metabolites. J. Sep. Sci. 33(6-7), 873-879 (2010).
-
(2010)
J. Sep. Sci.
, vol.33
, Issue.6-7
, pp. 873-879
-
-
Thomas, A.1
Deglon, J.2
Steimer, T.3
-
49
-
-
0347320519
-
Separation of Nicotinic Acid and Six Metabolites within 60 Seconds Using High-Flow Gradient Chromatography on Silica Column with Tandem Mass Spectrometric Detection
-
Li AC, Chen YL, Junga H et al. Separation of nicotinic acid and six metabolites within 60 seconds using high-flow gradient chromatography on silica column with tandem mass spectrometric detection. Chromatographia 58, 723-731 (2003). (Pubitemid 38064644)
-
(2003)
Chromatographia
, vol.58
, Issue.11-12
, pp. 723-731
-
-
Li, A.C.1
Chen, Y.-L.2
Junga, H.3
Shou, W.Z.4
Jiang, X.5
Naidong, W.6
-
50
-
-
77950811675
-
Hydrophilic interaction chromatography coupled to MS for metabonomic/ metabolomic studies
-
Spagou K, Tsoukali H, Raikos N et al. Hydrophilic interaction chromatography coupled to MS for metabonomic/ metabolomic studies. J. Sep. Sci. 33(6-7), 716-727 (2010).
-
(2010)
J. Sep. Sci.
, vol.33
, Issue.6-7
, pp. 716-727
-
-
Spagou, K.1
Tsoukali, H.2
Raikos, N.3
-
51
-
-
77957806588
-
Metabolomic applications of HILIC-LC-MS
-
Cubbon S, Antonio C, Wilson J et al. Metabolomic applications of HILIC-LC-MS. Mass Spectrom. Rev. 29 (5), 671-684 (2010).
-
(2010)
Mass Spectrom. Rev.
, vol.29
, Issue.5
, pp. 671-684
-
-
Cubbon, S.1
Antonio, C.2
Wilson, J.3
|