Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 699-706

  Zhang, Shun ^a   Kuang, Gang ^a   Zhao, Guodong ^a   Wu, Xue ^a   Zhang, Cheng ^a   Lei, Rongrong ^a   Xia, Tao ^a   Chen, Jianbin ^b   Wang, Zhenglun ^a   Ma, Rulin ^a   Li, Bei ^a   Yang, Lu ^a   Wang, Aiguo ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Methylation; Neurotoxicity; P53 Pathway; PBDE 47

Indexed keywords

2,2',4,4' TETRABROMODIPHENYL ETHER; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 3; CYTOCHROME C; DNA; POLYBROMINATED DIPHENYL ETHER; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL LEVEL; CELL STRAIN SH SY5Y; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOSOL; DNA METHYLATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME RELEASE; GENOME ANALYSIS; HUMAN; HUMAN CELL; MITOCHONDRION; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; PROMOTER REGION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

APOPTOSIS; METHYLATION; NEUROTOXICITY; P53 PATHWAY; PBDE-47;

APOPTOSIS; BASE SEQUENCE; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; HALOGENATED DIPHENYL ETHERS; HUMANS; METHYLATION; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84886805828     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.10.008     Document Type: Article

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