메뉴 건너뛰기




Volumn 209, Issue 2, 2012, Pages 193-201

The hormesis effect of BDE-47 in HepG 2 cells and the potential molecular mechanism

Author keywords

Akt; BDE 47; Cyclin D1; DNA PKcs; Hormesis; ROS

Indexed keywords

BDE 47; CELL NUCLEUS ANTIGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; CYCLIN D1; DNA; POLYBROMINATED DIPHENYL ETHER; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 84862816374     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.12.014     Document Type: Article
Times cited : (58)

References (44)
  • 1
    • 79952819172 scopus 로고    scopus 로고
    • The combined effects of BDE-47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism
    • An J., Yin L., Shang Y., Zhong Y., Zhang X., Wu M., Yu Z., Sheng G., Fu J., Huang Y. The combined effects of BDE-47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism. Mutat. Res. 2011, 721:192-198.
    • (2011) Mutat. Res. , vol.721 , pp. 192-198
    • An, J.1    Yin, L.2    Shang, Y.3    Zhong, Y.4    Zhang, X.5    Wu, M.6    Yu, Z.7    Sheng, G.8    Fu, J.9    Huang, Y.10
  • 2
    • 25644460477 scopus 로고    scopus 로고
    • Silencing of DNA-PKcs alters the transcriptional profile of certain signal transduction genes related to proliferation and differentiation in HeLa cells
    • An J., Xu Q.Z., Sui J.L., Bai B., Zhou P.K. Silencing of DNA-PKcs alters the transcriptional profile of certain signal transduction genes related to proliferation and differentiation in HeLa cells. Int. J. Mol. Med. 2005, 16:455-462.
    • (2005) Int. J. Mol. Med. , vol.16 , pp. 455-462
    • An, J.1    Xu, Q.Z.2    Sui, J.L.3    Bai, B.4    Zhou, P.K.5
  • 3
    • 33748423823 scopus 로고    scopus 로고
    • Polybrominated diphenyl ethers in South China maternal and fetal blood and breast milk
    • Bi X., Qu W., Sheng G., Zhang W., Mai B., Chen D., Yu L., Fu J. Polybrominated diphenyl ethers in South China maternal and fetal blood and breast milk. Environ. Pollut. 2006, 144:1024-1030.
    • (2006) Environ. Pollut. , vol.144 , pp. 1024-1030
    • Bi, X.1    Qu, W.2    Sheng, G.3    Zhang, W.4    Mai, B.5    Chen, D.6    Yu, L.7    Fu, J.8
  • 4
    • 74949086317 scopus 로고    scopus 로고
    • Applying research to public health questions: timing and environmentally relevant dose
    • Birnbaum L.S. Applying research to public health questions: timing and environmentally relevant dose. Environ. Health Perspect. 2009, 117:A478.
    • (2009) Environ. Health Perspect. , vol.117
    • Birnbaum, L.S.1
  • 5
    • 37749039218 scopus 로고    scopus 로고
    • Converging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis
    • Calabrese E.J. Converging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis. Ageing Res. Rev. 2008, 7:8-20.
    • (2008) Ageing Res. Rev. , vol.7 , pp. 8-20
    • Calabrese, E.J.1
  • 6
    • 0034895293 scopus 로고    scopus 로고
    • Hormesis: a generalizable and unifying hypothesis
    • Calabrese E.J., Baldwin L.A. Hormesis: a generalizable and unifying hypothesis. Crit. Rev. Toxicol. 2001, 31:353-424.
    • (2001) Crit. Rev. Toxicol. , vol.31 , pp. 353-424
    • Calabrese, E.J.1    Baldwin, L.A.2
  • 7
    • 0037434705 scopus 로고    scopus 로고
    • Toxicology rethinks its central belief-hormesis demands a reappraisal of the way risks are assessed
    • Calabrese E.J., Baldwin L.A. Toxicology rethinks its central belief-hormesis demands a reappraisal of the way risks are assessed. Nature 2003, 421:691-692.
    • (2003) Nature , vol.421 , pp. 691-692
    • Calabrese, E.J.1    Baldwin, L.A.2
  • 9
    • 0242319564 scopus 로고    scopus 로고
    • Toxic effects of brominated flame retardants in man and in wildlife
    • Darnerud P.O. Toxic effects of brominated flame retardants in man and in wildlife. Environ. Int. 2003, 29:841-853.
    • (2003) Environ. Int. , vol.29 , pp. 841-853
    • Darnerud, P.O.1
  • 10
    • 77449141842 scopus 로고    scopus 로고
    • Role of cell cycle regulators in lung carcinogenesis
    • Eymin B., Gazzeri S. Role of cell cycle regulators in lung carcinogenesis. Cell Adh. Migr. 2010, 4:114-123.
    • (2010) Cell Adh. Migr. , vol.4 , pp. 114-123
    • Eymin, B.1    Gazzeri, S.2
  • 11
    • 33750365146 scopus 로고    scopus 로고
    • Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk-levels, correlations, trends and exposure through breastfeeding
    • Fuerst P. Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk-levels, correlations, trends and exposure through breastfeeding. Mol. Nutr. Food Res. 2006, 50:922-933.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 922-933
    • Fuerst, P.1
  • 12
    • 5444251638 scopus 로고    scopus 로고
    • Polybrominated diphenyl ethers: human tissue levels and toxicology
    • Gill U., Chu I., Ryan J.J., Feeley M. Polybrominated diphenyl ethers: human tissue levels and toxicology. Rev. Environ. Contam. Toxicol. 2004, 183:55-97.
    • (2004) Rev. Environ. Contam. Toxicol. , vol.183 , pp. 55-97
    • Gill, U.1    Chu, I.2    Ryan, J.J.3    Feeley, M.4
  • 13
    • 38049027339 scopus 로고    scopus 로고
    • PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons
    • He P., He W., Wang A., Xia T., Xu B., Zhang M., Chen X. PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons. Neurotoxicology 2008, 29:124-129.
    • (2008) Neurotoxicology , vol.29 , pp. 124-129
    • He, P.1    He, W.2    Wang, A.3    Xia, T.4    Xu, B.5    Zhang, M.6    Chen, X.7
  • 14
    • 58749107492 scopus 로고    scopus 로고
    • Mechanism of the neurotoxic effect of PBDE-47 and interaction of PBDE-47 and PCB153 in enhancing toxicity in SH-SY5Y cells
    • He P., Wang A.-G., Xia T., Gao P., Niu Q., Guo L.J., Xu B.-Y., Chen X.-M. Mechanism of the neurotoxic effect of PBDE-47 and interaction of PBDE-47 and PCB153 in enhancing toxicity in SH-SY5Y cells. Neurotoxicology 2009, 30:10-15.
    • (2009) Neurotoxicology , vol.30 , pp. 10-15
    • He, P.1    Wang, A.-G.2    Xia, T.3    Gao, P.4    Niu, Q.5    Guo, L.J.6    Xu, B.-Y.7    Chen, X.-M.8
  • 15
    • 37049027074 scopus 로고    scopus 로고
    • Effects of PBDE-47 on cytotoxicity and genotoxicity in human neuroblastoma cells in vitro
    • He W., He P., Wang A., Xia T., Xu B., Chen X. Effects of PBDE-47 on cytotoxicity and genotoxicity in human neuroblastoma cells in vitro. Mutat. Res.: Gen. Toxicol. Environ. 2008, 649:62-70.
    • (2008) Mutat. Res.: Gen. Toxicol. Environ. , vol.649 , pp. 62-70
    • He, W.1    He, P.2    Wang, A.3    Xia, T.4    Xu, B.5    Chen, X.6
  • 16
    • 1242297693 scopus 로고    scopus 로고
    • Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations
    • Hites R.A. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 2004, 38:945-956.
    • (2004) Environ. Sci. Technol. , vol.38 , pp. 945-956
    • Hites, R.A.1
  • 17
    • 67649337506 scopus 로고    scopus 로고
    • PI-3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells
    • Jin D., Ning B., Yi H., Zhang D., Li J., Chen C.-Y., Huang C. PI-3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells. Curr. Cancer Drug Targets 2009, 9:500-509.
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 500-509
    • Jin, D.1    Ning, B.2    Yi, H.3    Zhang, D.4    Li, J.5    Chen, C.-Y.6    Huang, C.7
  • 18
    • 20544442213 scopus 로고    scopus 로고
    • Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro
    • Kodavanti P.R.S., Ward T.R. Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro. Toxicol. Sci. 2005, 85:952-962.
    • (2005) Toxicol. Sci. , vol.85 , pp. 952-962
    • Kodavanti, P.R.S.1    Ward, T.R.2
  • 19
    • 14744274118 scopus 로고    scopus 로고
    • Developmental exposure to low-dose PBDE-99: effects on male fertility and neurobehavior in rat offspring
    • Kuriyama S.N., Talsness C.E., Grote K., Chahoud I. Developmental exposure to low-dose PBDE-99: effects on male fertility and neurobehavior in rat offspring. Environ. Health Perspect. 2005, 113:149-154.
    • (2005) Environ. Health Perspect. , vol.113 , pp. 149-154
    • Kuriyama, S.N.1    Talsness, C.E.2    Grote, K.3    Chahoud, I.4
  • 21
    • 58149340464 scopus 로고    scopus 로고
    • Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain
    • Lema S.C., Dickey J.T., Schultz I.R., Swanson P. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain. Environ. Health Perspect. 2008, 116:1694-1699.
    • (2008) Environ. Health Perspect. , vol.116 , pp. 1694-1699
    • Lema, S.C.1    Dickey, J.T.2    Schultz, I.R.3    Swanson, P.4
  • 22
    • 79960488021 scopus 로고    scopus 로고
    • Derivation by infrared spectroscopy with multivariate analysis of bimodal contaminant-induced dose-response effects in MCF-7 Cells
    • Llabjani V., Trevisan J., Jones K.C., Shore R.F., Martin F.L. Derivation by infrared spectroscopy with multivariate analysis of bimodal contaminant-induced dose-response effects in MCF-7 Cells. Environ. Sci. Technol. 2011, 45:6129-6135.
    • (2011) Environ. Sci. Technol. , vol.45 , pp. 6129-6135
    • Llabjani, V.1    Trevisan, J.2    Jones, K.C.3    Shore, R.F.4    Martin, F.L.5
  • 24
    • 0036222972 scopus 로고    scopus 로고
    • A perspective on the potential health risks of PBDEs
    • McDonald T.A. A perspective on the potential health risks of PBDEs. Chemosphere 2002, 46:745-755.
    • (2002) Chemosphere , vol.46 , pp. 745-755
    • McDonald, T.A.1
  • 25
    • 34447121327 scopus 로고    scopus 로고
    • Superoxide signaling mediates N-acetyl-l-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase
    • Menon S.G., Sarsour E.H., Kalen A.L., Venkataraman S., Hitchler M.J., Domann F.E., Oberley L.W., Goswami P.C. Superoxide signaling mediates N-acetyl-l-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase. Cancer Res. 2007, 67:6392-6399.
    • (2007) Cancer Res. , vol.67 , pp. 6392-6399
    • Menon, S.G.1    Sarsour, E.H.2    Kalen, A.L.3    Venkataraman, S.4    Hitchler, M.J.5    Domann, F.E.6    Oberley, L.W.7    Goswami, P.C.8
  • 26
    • 0042127214 scopus 로고    scopus 로고
    • Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas
    • Nguyen D.C., Parsa B., Close A., Magnusson B., Crowe D.L., Sinha U.K. Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas. Int. J. Oncol. 2003, 22:1285-1290.
    • (2003) Int. J. Oncol. , vol.22 , pp. 1285-1290
    • Nguyen, D.C.1    Parsa, B.2    Close, A.3    Magnusson, B.4    Crowe, D.L.5    Sinha, U.K.6
  • 27
  • 28
    • 79959350253 scopus 로고    scopus 로고
    • Extending life span by increasing oxidative stress
    • Ristow M., Schmeisser S. Extending life span by increasing oxidative stress. Free Radic. Biol. Med. 2011, 51:327-336.
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 327-336
    • Ristow, M.1    Schmeisser, S.2
  • 29
    • 0037291764 scopus 로고    scopus 로고
    • Hormesis and toxicological risk assessment
    • Rodricks J.V. Hormesis and toxicological risk assessment. Toxicol. Sci. 2003, 71:134-136.
    • (2003) Toxicol. Sci. , vol.71 , pp. 134-136
    • Rodricks, J.V.1
  • 31
    • 0001826680 scopus 로고    scopus 로고
    • The German environmental specimen bank-application in trend monitoring of polybrominated diphenyl ethers in human blood
    • Schröter-Kermani C., Helm D., Herrmann T., Papke O. The German environmental specimen bank-application in trend monitoring of polybrominated diphenyl ethers in human blood. Organohalogen Compd. 2000, 47:49-52.
    • (2000) Organohalogen Compd. , vol.47 , pp. 49-52
    • Schröter-Kermani, C.1    Helm, D.2    Herrmann, T.3    Papke, O.4
  • 32
    • 77951705618 scopus 로고    scopus 로고
    • Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 phosphorylation in response to DNA damage
    • Shang Z.F., Huang B., Xu Q.Z., Zhang S.M., Fan R., Liu X.D., Wang Y., Zhou P.K. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 phosphorylation in response to DNA damage. Cancer Res. 2010, 70:3657-3666.
    • (2010) Cancer Res. , vol.70 , pp. 3657-3666
    • Shang, Z.F.1    Huang, B.2    Xu, Q.Z.3    Zhang, S.M.4    Fan, R.5    Liu, X.D.6    Wang, Y.7    Zhou, P.K.8
  • 33
    • 77549085874 scopus 로고    scopus 로고
    • Flow cytometric analysis of BDE 47 mediated injury to rainbow trout gill epithelial cells
    • Shao J., Dabrowski M.J., White C.C., Kavanagh T.J., Gallagher E.P. Flow cytometric analysis of BDE 47 mediated injury to rainbow trout gill epithelial cells. Aquat. Toxicol. 2010, 97:42-50.
    • (2010) Aquat. Toxicol. , vol.97 , pp. 42-50
    • Shao, J.1    Dabrowski, M.J.2    White, C.C.3    Kavanagh, T.J.4    Gallagher, E.P.5
  • 34
    • 57249108335 scopus 로고    scopus 로고
    • Facing the challenge of data transfer from animal models to humans: the case of persistent organohalogens
    • Suvorov A., Takser L. Facing the challenge of data transfer from animal models to humans: the case of persistent organohalogens. Environ. Health Perspect. 2008, 7:58.
    • (2008) Environ. Health Perspect. , vol.7 , pp. 58
    • Suvorov, A.1    Takser, L.2
  • 35
    • 51749113333 scopus 로고    scopus 로고
    • Perinatal exposure to low-dose BDE-47, an emergent environmental contaminant, causes hyperactivity in rat offspring
    • Suvorov A., Girard S., Lachapelle S., Abdelouahab N., Sebire G., Takser L. Perinatal exposure to low-dose BDE-47, an emergent environmental contaminant, causes hyperactivity in rat offspring. Neonatology 2009, 95:203-209.
    • (2009) Neonatology , vol.95 , pp. 203-209
    • Suvorov, A.1    Girard, S.2    Lachapelle, S.3    Abdelouahab, N.4    Sebire, G.5    Takser, L.6
  • 36
    • 51749113333 scopus 로고    scopus 로고
    • Perinatal exposure to low-dose BDE-47, an emergent environmental contaminant, causes hyperactivity in rat offspring
    • Suvorov A., Girard S., Lachapelle S., Abdelouahab N., Sebire G., Takser L. Perinatal exposure to low-dose BDE-47, an emergent environmental contaminant, causes hyperactivity in rat offspring. Neonatology 2008, 95:203-209.
    • (2008) Neonatology , vol.95 , pp. 203-209
    • Suvorov, A.1    Girard, S.2    Lachapelle, S.3    Abdelouahab, N.4    Sebire, G.5    Takser, L.6
  • 37
    • 67349112685 scopus 로고    scopus 로고
    • Perinatal exposure to low-dose 2,2',4,4'-tetrabromodiphenyl ether affects growth in rat offspring: what is the role of IGF-1?
    • Suvorov A., Battista M.C., Takser L. Perinatal exposure to low-dose 2,2',4,4'-tetrabromodiphenyl ether affects growth in rat offspring: what is the role of IGF-1?. Toxicology 2009, 260(1-3):126-131.
    • (2009) Toxicology , vol.260 , Issue.1-3 , pp. 126-131
    • Suvorov, A.1    Battista, M.C.2    Takser, L.3
  • 41
    • 77955922878 scopus 로고    scopus 로고
    • Polybrominated diphenyl ethers and arylhydrocarbon receptor agonists: different toxicity and target gene expression
    • Wahl M., Guenther R., Yang L., Bergman A., Straehle U., Strack S., Weiss C. Polybrominated diphenyl ethers and arylhydrocarbon receptor agonists: different toxicity and target gene expression. Toxicol. Lett. 2010, 198:119-126.
    • (2010) Toxicol. Lett. , vol.198 , pp. 119-126
    • Wahl, M.1    Guenther, R.2    Yang, L.3    Bergman, A.4    Straehle, U.5    Strack, S.6    Weiss, C.7
  • 42
    • 50049095883 scopus 로고    scopus 로고
    • A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE-47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity
    • Wahl M., Lahni B., Guenther R., Kuch B., Yang L., Straehle U., Strack S., Weiss C. A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE-47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity. Chemosphere 2008, 73:209-215.
    • (2008) Chemosphere , vol.73 , pp. 209-215
    • Wahl, M.1    Lahni, B.2    Guenther, R.3    Kuch, B.4    Yang, L.5    Straehle, U.6    Strack, S.7    Weiss, C.8
  • 43
    • 77952950916 scopus 로고    scopus 로고
    • Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies
    • Wei R.G., Zhao Y.X., Liu P.Y., Qin Z.F., Yan S.S., Li Y., Qin X.F., Xia X.J., Xu X.B., Yan M.C. Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies. Toxicol. In Vitro 2010, 24:1078-1085.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 1078-1085
    • Wei, R.G.1    Zhao, Y.X.2    Liu, P.Y.3    Qin, Z.F.4    Yan, S.S.5    Li, Y.6    Qin, X.F.7    Xia, X.J.8    Xu, X.B.9    Yan, M.C.10
  • 44
    • 79955962986 scopus 로고    scopus 로고
    • The involvement of ROS overproduction and mitochondrial dysfunction in PBDE-47-induced apoptosis on Jurkat cells
    • Yan C., Huang D., Zhang Y. The involvement of ROS overproduction and mitochondrial dysfunction in PBDE-47-induced apoptosis on Jurkat cells. Exp. Toxicol. Pathol. 2011, 63:413-417.
    • (2011) Exp. Toxicol. Pathol. , vol.63 , pp. 413-417
    • Yan, C.1    Huang, D.2    Zhang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.