메뉴 건너뛰기




Volumn 6, Issue 6, 2013, Pages 1649-1655

Identification of U251 glioma stem cells and their heterogeneous stem-like phenotypes

Author keywords

Glioma stem cells; Heterogeneity; Phenotype; U251

Indexed keywords

CD133 ANTIGEN; GELATINASE A; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; NESTIN;

EID: 84886781729     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1623     Document Type: Article
Times cited : (18)

References (39)
  • 3
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M, et al: Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828, 2003.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 4
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • Yuan X, Curtin J, Xiong Y, et al: Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23: 9392-9400, 2004.
    • (2004) Oncogene , vol.23 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3
  • 5
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli R, Binda E, Orfanelli U, et al: Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64: 7011-7021, 2004.
    • (2004) Cancer Res , vol.64 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3
  • 6
    • 79955501601 scopus 로고    scopus 로고
    • ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2
    • Jeon HM, Sohn YW, Oh SY, et al: ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2. Cancer Res 71: 3410-3421, 2011.
    • (2011) Cancer Res , vol.71 , pp. 3410-3421
    • Jeon, H.M.1    Sohn, Y.W.2    Oh, S.Y.3
  • 7
    • 78751640633 scopus 로고    scopus 로고
    • Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy
    • Ulasov IV, Nandi S, Dey M, Sonabend AM and Lesniak MS: Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy. Mol Med 17: 103-112, 2011.
    • (2011) Mol Med , vol.17 , pp. 103-112
    • Ulasov, I.V.1    Nandi, S.2    Dey, M.3    Sonabend, A.M.4    Lesniak, M.S.5
  • 8
    • 84861928544 scopus 로고    scopus 로고
    • Glioma stem cells: Their role in chemoresistance
    • Yamada R and Nakano I: Glioma stem cells: their role in chemoresistance. World Neurosurg 77: 237-240, 2012.
    • (2012) World Neurosurg , vol.77 , pp. 237-240
    • Yamada, R.1    Nakano, I.2
  • 9
    • 75349108271 scopus 로고    scopus 로고
    • Notch promotes radioresistance of glioma stem cells
    • Wang J, Wakeman TP, Lathia JD, et al: Notch promotes radioresistance of glioma stem cells. Stem Cells 28: 17-28, 2010.
    • (2010) Stem Cells , vol.28 , pp. 17-28
    • Wang, J.1    Wakeman, T.P.2    Lathia, J.D.3
  • 10
    • 79952947661 scopus 로고    scopus 로고
    • Molecular heterogeneity in glioblastoma: Therapeutic opportunities and challenges
    • Nicholas MK, Lukas RV, Chmura S, Yamini B, Lesniak M and Pytel P: Molecular heterogeneity in glioblastoma: therapeutic opportunities and challenges. Semin Oncol 38: 243-253, 2011.
    • (2011) Semin Oncol , vol.38 , pp. 243-253
    • Nicholas, M.K.1    Lukas, R.V.2    Chmura, S.3    Yamini, B.4    Lesniak, M.5    Pytel, P.6
  • 11
    • 79958849271 scopus 로고    scopus 로고
    • Heterogeneity maintenance in glioblastoma: A social network
    • Bonavia R, Inda MM, Cavenee WK and Furnari FB: Heterogeneity maintenance in glioblastoma: a social network. Cancer Res 71: 4055-4060, 2011.
    • (2011) Cancer Res , vol.71 , pp. 4055-4060
    • Bonavia, R.1    Inda, M.M.2    Cavenee, W.K.3    Furnari, F.B.4
  • 13
    • 77955911497 scopus 로고    scopus 로고
    • Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
    • Inda MM, Bonavia R, Mukasa A, et al: Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 24: 1731-1745, 2010.
    • (2010) Genes Dev , vol.24 , pp. 1731-1745
    • Inda, M.M.1    Bonavia, R.2    Mukasa, A.3
  • 14
    • 67649118749 scopus 로고    scopus 로고
    • Turning cancer stem cells inside out: An exploration of glioma stem cell signaling pathways
    • Li Z, Wang H, Eyler CE, Hjelmeland AB and Rich JN: Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J Biol Chem 284: 16705-16709, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 16705-16709
    • Li, Z.1    Wang, H.2    Eyler, C.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 16
    • 77952329017 scopus 로고    scopus 로고
    • Differentiation therapy exerts antitumor effects on stem-like glioma cells
    • Campos B, Wan F, Farhadi M, et al: Differentiation therapy exerts antitumor effects on stem-like glioma cells. Clin Cancer Res 16: 2715-2728, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 2715-2728
    • Campos, B.1    Wan, F.2    Farhadi, M.3
  • 17
    • 66049085403 scopus 로고    scopus 로고
    • Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens
    • Pollard SM, Yoshikawa K, Clarke ID, et al: Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 4: 568-580, 2009.
    • (2009) Cell Stem Cell , vol.4 , pp. 568-580
    • Pollard, S.M.1    Yoshikawa, K.2    Clarke, I.D.3
  • 18
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 19
    • 77955158299 scopus 로고    scopus 로고
    • The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research
    • Wan F, Zhang S, Xie R, et al: The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research. Brain Pathol 20: 877-889, 2010.
    • (2010) Brain Pathol , vol.20 , pp. 877-889
    • Wan, F.1    Zhang, S.2    Xie, R.3
  • 20
    • 80053471856 scopus 로고    scopus 로고
    • Comparative study on the stem cell phenotypes of C6 cells under different culture conditions
    • Zhang SJ, Ye F, Xie RF, et al: Comparative study on the stem cell phenotypes of C6 cells under different culture conditions. Chin Med J (Engl) 124: 3118-3126, 2011.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 3118-3126
    • Zhang, S.J.1    Ye, F.2    Xie, R.F.3
  • 21
    • 65749087298 scopus 로고    scopus 로고
    • Neurosphere formation is an independent predictor of clinical outcome in malignant glioma
    • Laks DR, Masterman-Smith M, Visnyei K, et al: Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells 27: 980-987, 2009.
    • (2009) Stem Cells , vol.27 , pp. 980-987
    • Laks, D.R.1    Masterman-Smith, M.2    Visnyei, K.3
  • 22
    • 40749155451 scopus 로고    scopus 로고
    • Stem cell marker CD133 affects clinical outcome in glioma patients
    • Zeppernick F, Ahmadi R, Campos B, et al: Stem cell marker CD133 affects clinical outcome in glioma patients. Clin Cancer Res 14: 123-129, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 123-129
    • Zeppernick, F.1    Ahmadi, R.2    Campos, B.3
  • 23
    • 77950221879 scopus 로고    scopus 로고
    • Transcriptional profiles of CD133+ and CD133-glioblastoma-derived cancer stem cell lines suggest different cells of origin
    • Lottaz C, Beier D, Meyer K, et al: Transcriptional profiles of CD133+ and CD133-glioblastoma-derived cancer stem cell lines suggest different cells of origin. Cancer Res 70: 2030-2040, 2010.
    • (2010) Cancer Res , vol.70 , pp. 2030-2040
    • Lottaz, C.1    Beier, D.2    Meyer, K.3
  • 24
    • 82955235579 scopus 로고    scopus 로고
    • The CD133+ tumor stem-like cell-associated antigen may elicit highly intense immune responses against human malignant glioma
    • Hua W, Yao Y, Chu Y, et al: The CD133+ tumor stem-like cell-associated antigen may elicit highly intense immune responses against human malignant glioma. J Neurooncol 105: 149-157, 2011.
    • (2011) J Neurooncol , vol.105 , pp. 149-157
    • Hua, W.1    Yao, Y.2    Chu, Y.3
  • 25
    • 69349095324 scopus 로고    scopus 로고
    • CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines
    • McCord AM, Jamal M, Williams ES, Camphausen K and Tofilon PJ: CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines. Clin Cancer Res 15: 5145-5153, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 5145-5153
    • McCord, A.M.1    Jamal, M.2    Williams, E.S.3    Camphausen, K.4    Tofilon, P.J.5
  • 27
    • 84858058074 scopus 로고    scopus 로고
    • The brain microenvironment preferentially enhances the radioresistance of CD133(+) glioblastoma stem-like cells
    • Jamal M, Rath BH, Tsang PS, Camphausen K and Tofilon PJ: The brain microenvironment preferentially enhances the radioresistance of CD133(+) glioblastoma stem-like cells. Neoplasia 14: 150-158, 2012.
    • (2012) Neoplasia , vol.14 , pp. 150-158
    • Jamal, M.1    Rath, B.H.2    Tsang, P.S.3    Camphausen, K.4    Tofilon, P.J.5
  • 28
    • 38349075007 scopus 로고    scopus 로고
    • CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    • Wang J, Sakariassen PØ, Tsinkalovsky O, et al: CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer 122: 761-768, 2008.
    • (2008) Int J Cancer , vol.122 , pp. 761-768
    • Wang, J.1    Sakariassen, P.O.2    Tsinkalovsky, O.3
  • 29
    • 34248547533 scopus 로고    scopus 로고
    • Most C6 cells are cancer stem cells: Evidence from clonal and population analyses
    • Zheng X, Shen G, Yang X and Liu W: Most C6 cells are cancer stem cells: evidence from clonal and population analyses. Cancer Res 67: 3691-3697, 2007.
    • (2007) Cancer Res , vol.67 , pp. 3691-3697
    • Zheng, X.1    Shen, G.2    Yang, X.3    Liu, W.4
  • 30
    • 0029958876 scopus 로고    scopus 로고
    • Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    • Goodell MA, Brose K, Paradis G, Conner AS and Mulligan RC: Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183: 1797-1806, 1996.
    • (1996) J Exp Med , vol.183 , pp. 1797-1806
    • Goodell, M.A.1    Brose, K.2    Paradis, G.3    Conner, A.S.4    Mulligan, R.C.5
  • 31
    • 57749091753 scopus 로고    scopus 로고
    • Cancer stem cells are enriched in the side population cells in a mouse model of glioma
    • Harris MA, Yang H, Low BE, et al: Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res 68: 10051-10059, 2008.
    • (2008) Cancer Res , vol.68 , pp. 10051-10059
    • Harris, M.A.1    Yang, H.2    Low, B.E.3
  • 32
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau AM, Hambardzumyan D, Ozawa T, et al: PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4: 226-235, 2009.
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3
  • 33
    • 22244433866 scopus 로고    scopus 로고
    • Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2-cancer cells are similarly tumorigenic
    • Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K and Tang DG: Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2-cancer cells are similarly tumorigenic. Cancer Res 65: 6207-6219, 2005.
    • (2005) Cancer Res , vol.65 , pp. 6207-6219
    • Patrawala, L.1    Calhoun, T.2    Schneider-Broussard, R.3    Zhou, J.4    Claypool, K.5    Tang, D.G.6
  • 34
    • 75849133698 scopus 로고    scopus 로고
    • The functional role of Notch signaling in human gliomas
    • Stockhausen MT, Kristoffersen K and Poulsen HS: The functional role of Notch signaling in human gliomas. Neuro Oncol 12: 199-211, 2010.
    • (2010) Neuro Oncol , vol.12 , pp. 199-211
    • Stockhausen, M.T.1    Kristoffersen, K.2    Poulsen, H.S.3
  • 35
    • 77956623598 scopus 로고    scopus 로고
    • Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
    • Hovinga KE, Shimizu F, Wang R, et al: Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Stem Cells 28: 1019-1029, 2010.
    • (2010) Stem Cells , vol.28 , pp. 1019-1029
    • Hovinga, K.E.1    Shimizu, F.2    Wang, R.3
  • 36
    • 77949261572 scopus 로고    scopus 로고
    • The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo
    • Xu P, Qiu M, Zhang Z, et al: The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo. J Neurooncol 97: 41-51, 2010.
    • (2010) J Neurooncol , vol.97 , pp. 41-51
    • Xu, P.1    Qiu, M.2    Zhang, Z.3
  • 37
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • Fan X, Matsui W, Khaki L, et al: Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 66: 7445-7452, 2006.
    • (2006) Cancer Res , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3
  • 38
    • 80053515159 scopus 로고    scopus 로고
    • Glioma stem cell maintenance: The role of the microenvironment
    • Heddleston JM, Hitomi M, Venere M, et al: Glioma stem cell maintenance: the role of the microenvironment. Curr Pharm Des 17: 2386-2401, 2011.
    • (2011) Curr Pharm Des , vol.17 , pp. 2386-2401
    • Heddleston, J.M.1    Hitomi, M.2    Venere, M.3
  • 39
    • 80052526409 scopus 로고    scopus 로고
    • CD133+ niches and single cells in glioblastoma have different phenotypes
    • Christensen K, Schrøder HD and Kristensen BW: CD133+ niches and single cells in glioblastoma have different phenotypes. J Neurooncol 104: 129-143, 2011.
    • (2011) J Neurooncol , vol.104 , pp. 129-143
    • Christensen, K.1    Schrøder, H.D.2    Kristensen, B.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.