A signal-amplification circuit between miR-218 and Wnt/β-catenin signal promotes human adipose tissue-derived stem cells osteogenic differentiation

Bone

Volumn 58, Issue , 2014, Pages 59-66

  Zhang, Wei Bing ^a   Zhong, Wei Jie ^b   Wang, Lin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Shanghai Stomatological Disease Center   (China)

Author keywords

Human adipose derived mesenchymal stem cells; MicroRNA; MiR 218; Osteogenic differentiation; Wnt

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; MICRORNA; MICRORNA 218; SECRETED FRIZZLED RELATED PROTEIN 2; UNCLASSIFIED DRUG; WNT PROTEIN;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ARTICLE; ATTENUATION; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME INHIBITION; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENE REGULATORY NETWORK; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; OSTEOBLAST; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WNT SIGNALING PATHWAY;

ALKALINE PHOSPHATASE; ALP; BMSCS; BONE MARROW-DERIVED MESENCHYMAL STEM CELLS; BONE SIALOPROTEIN; BSP; DICKKOPF-RELATED PROTEIN 2; DKK2; HASCS; HUMAN ADIPOSE-DERIVED MESENCHYMAL STEM CELLS; HUMAN ADIPOSE-DERIVED STEM CELLS; MESSENGER RNA; MICRORNA; MIR-218; MIRNA; MRNA; OCN; OSTEOCALCIN; OSTEOGENIC DIFFERENTIATION; QRT-PCR; QUANTITATIVE REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RUNT-RELATED TRANSCRIPTION FACTOR 2; RUNX2; SECRETED FRIZZLED RELATED PROTEIN 2; SFRP2; UNTRANSLATED REGION; UTR; WNT;

ADIPOSE TISSUE; ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICRORNAS; MODELS, BIOLOGICAL; OSTEOGENESIS; RNA, MESSENGER; STEM CELLS; WNT SIGNALING PATHWAY;

EID: 84886774405     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.09.015     Document Type: Article

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