Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling

Stem Cells

Volumn 29, Issue 6, 2011, Pages 981-991

  Yang, Fan ^a   Yang, Dazhi ^b   Tu, Jie ^a   Zheng, Qixin ^b   Cai, Lintao ^a   Wang, Liping ^a,c  

^a SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Shenzhen University Town   (China)

Author keywords

Mesenchymal stem cells; Strontium; Wnt catenin

Indexed keywords

BETA CATENIN; COLLAGEN; HYDROXYAPATITE; STRONTIUM; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE CELL; BONE REMODELING; CELL DIFFERENTIATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; NONHUMAN; OSSIFICATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SKULL DEFECT; UPREGULATION;

ANIMALS; BETA CATENIN; BONE REGENERATION; CELL DIFFERENTIATION; CELL SHAPE; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; OSTEOGENESIS; OSTEOPONTIN; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SKULL; STRONTIUM; TISSUE SCAFFOLDS; TRANSCRIPTION, GENETIC; WNT PROTEINS;

RATTUS;

EID: 79957626008     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.646     Document Type: Article

References (40)

1. Meunier PJ, Roux C, Seeman E et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350:459-468. (Pubitemid 38133766)
2. Ni GX, Chiu KY, Lu WW et al. Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty. Biomaterials 2006; 27:4348-4355. (Pubitemid 43674180)
3. Ammann P. Strontium ranelate: A physiological approach for an improved bone quality. Bone 2006;38(2 suppl 1):15-18.
4. Marie PJ. Strontium ranelate: A physiological approach for optimizing bone formation and resorption. Bone 2006;38(2 suppl 1):S10-S14. (Pubitemid 43190768)
5. Brown EM. Is the calcium receptor a molecular target for the actions of strontium on bone? Osteoporos Int 2003;14(suppl 3):S25-S34.
6. Hurtel-Lemaire AS, Mentaverri R, Caudrillier A et al. The calciumsensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. J Biol Chem 2009;284:575-584.
7. Fromigué O, Hay E, Barbara A et al. Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate. J Cell Mol Med 2009;13: 2189-2199.
8. Kumar S, Chanda D, Ponnazhagan S. Therapeutic potential of genetically modified mesenchymal stem cells. Gene Ther 2008;15:711-715. (Pubitemid 351627354)
9. Choudhary S, Halbout P, Alander C, Raisz L, Pilbeam C. Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: Involvement of prostaglandins. J Bone Miner Res 2007;22:1002-1010. (Pubitemid 351339722)
10. Peng S, Liu XS, Wang T et al. In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells. J Orthop Res 2010;28:1208-1214.
11. Peng S, Zhou G, Luk KD et al. Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway. Cell Physiol Biochem 2009;23:165-174.
12. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-480.
13. Minear S, Leucht P, Jiang J et al. Wnt proteins promote bone regeneration. Sci Transl Med 2010;2:29ra30.
14. Chen Y, Whetstone HC, Lin AC et al. Beta-catenin signaling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing. PLoS Med 2007;4:e249.
15. Ling L, Nurcombe V, Cool SM. Wnt signaling controls the fate of mesenchymal stem cells. Gene 2009;433:1-7.
16. Liu G, Vijayakumar S, Grumolato L et al. Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J Cell Biol 2009;185:67-75.
17. Fromigue O, Hay E, Barbara A, Marie PJ. Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. J Biol Chem 2010; 285:25251-25258.
18. Wu KH, Zhou B, Lu SH et al. In vitro and in vivo differentiation of human umbilical cord derived stem cells into endothelial cells. J Cell Biochem 2007;100:608-616.
19. Liao W, Zhong J, Yu J et al. Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: Implications of anti-inflammation and angiogenesis. Cell Physiol Biochem 2009;24:307-316.
20. Yang F, Leung VY, Luk KD et al. Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse. J Pathol 2009;218:113-121.
21. Pan HB, Li ZY, Lam WM et al. Solubility of strontium-substituted apatite by solid titration. Acta Biomater 2009;5:1678-1685.
22. Park JW, Bae SR, Suh JY et al. Evaluation of bone healing with egg-shell-derived bone graft substitutes in rat calvaria: A pilot study. J Biomed Mater Res 2008;A87:203-214.
23. Jaquiery C, Schaeren S, Farhadi J et al. In vitro osteogenic differentiation and in vivo bone-forming capacity of human isogenic jaw periosteal cells and bone marrow stromal cells. Ann Surg 2005;242:859-867, discussion 67-68.
24. Alford AI, Hankenson KD. Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration. Bone 2006;38:749-757. (Pubitemid 44498588)
25. Takada I, Kouzmenko AP, Kato S. Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol 2009;5:442-447.
26. Li X, Yost HJ, Virshup DM et al. Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J 2001;20:4122-4131. (Pubitemid 32751828)
27. Troyer DL, Weiss ML. Wharton's jelly-derived cells are a primitive stromal cell population. Stem Cells 2008;26:591-599.
28. Baksh D, Yao R, Tuan RS. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 2007;25:1384-1392. (Pubitemid 47106005)
29. Weiss ML, Anderson C, Medicetty S et al. Immune properties of human umbilical cord Wharton's jelly-derived cells. Stem Cells 2008;26:2865-2874.
30. Capuccini C, Torricelli P, Sima F et al. Strontium-substituted hydroxyapatite coatings synthesized by pulsed-laser deposition: In vitro osteoblast and osteoclast response. Acta Biomater 2008;4:1885-1893.
31. Lin L, Chow KL, Leng Y. Study of hydroxyapatite osteoinductivity with an osteogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A 2009;89:326-335.
32. Habibovic P, Kruyt MC, Juhl MV et al. Comparative in vivo study of six hydroxyapatite-based bone graft substitutes. J Orthop Res 2008;26:1363-1370.
33. MacLeod RJ, Hayes M, Pacheco I. Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am J Physiol Gastrointest Liver Physiol 2007;293:G403-G411. (Pubitemid 47105201)
34. Pacheco II, Macleod RJ. CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 2008;295:G748-G759.
35. Bikkavilli RK, Feigin ME, Malbon CC. p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta. J Cell Sci 2008;121(pt 21):3598-3607.
36. Thornton TM, Pedraza-Alva G, Deng B et al. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science 2008;320:667-670. (Pubitemid 351928349)
37. Caverzasio J, Manen D. Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells. Endocrinology 2007;148:5323-5330. (Pubitemid 350012642)
38. Fong EL, Chan CK, Goodman SB. Stem cell homing in musculoskeletal injury. Biomaterials 2011;32:395-409.
39. Weick JP, Johnson MA, Skroch SP et al. Functional control of transplantable human ESC-derived neurons via optogenetic targeting. Stem Cells 2010;28:2008-2016.
40. Stroh A, Tsai HC, Wang LP et al. Tracking stem cell differentiation in the setting of automated optogenetic stimulation. Stem Cells 2011;29:78-88.