Amyloid precursor protein in human breast cancer: An androgen-induced gene associated with cell proliferation

Cancer Science

Volumn 104, Issue 11, 2013, Pages 1532-1538

  Takagi, Kiyoshi ^a   Ito, Shigehiro ^a   Miyazaki, Toshiaki ^b   Miki, Yasuhiro ^a   Shibahara, Yukiko ^a   Ishida, Takanori ^a   Watanabe, Mika ^c   Inoue, Satoshi ^b   Sasano, Hironobu ^a,c   Suzuki, Takashi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANDROGEN RECEPTOR; ANDROSTANOLONE; KI 67 ANTIGEN; MESSENGER RNA;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER PROGNOSIS; CANCER SPECIFIC SURVIVAL; CARCINOMA CELL; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IN VITRO STUDY; LABELING INDEX; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE RISK; TIME;

ADULT; AGED; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN PRECURSOR; ANDROGENS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL PROLIFERATION; DIHYDROTESTOSTERONE; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; MCF-7 CELLS; MIDDLE AGED; PROGNOSIS; RECEPTORS, ANDROGEN;

EID: 84886773832     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12239     Document Type: Article

References (31)

1. Søreide JA, Lea OA, Varhaug JE, Skarstein A, Kvinnsland S. Androgen receptors in operable breast cancer: relation to other steroid hormone receptors, correlations to prognostic factors and predictive value for effect of adjuvant tamoxifen treatment. Eur J Surg Oncol 1992; 18: 112-8.
2. Isola JJ. Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors. J Pathol 1993; 170: 31-5.
3. Suzuki T, Darnel AD, Akahira JI et al. 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions. J Clin Endocrinol Metab 2001; 86: 2250-7.
4. Poulin R, Baker D, Labrie F. Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line. Breast Cancer Res Treat 1988; 12: 213-25.
5. de Launoit Y, Dauvois S, Dufour M, Simard J, Labrie F. Inhibition of cell cycle kinetics and proliferation by the androgen 5 alpha-dihydrotestosterone and antiestrogen N, n-butyl-N-methyl-11-[16' alpha-chloro-3', 17 beta-dihydroxy-estra-1', 3', 5'-(10')triene-7' alpha-yl] undecanamide in human breast cancer ZR-75-1 cells. Cancer Res 1991; 51: 2797-802.
6. Birrell SN, Bentel JM, Hickey TE et al. Androgens induce divergent proliferative responses in human breast cancer cell lines. J Steroid Biochem Mol Biol 1995; 52: 459-67.
7. Zhang J, Sun Y, Liu Y, Sun Y, Liao DJ. Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland. Oncol Rep 2004; 12: 709-16.
8. LaFerla FM, Green KN, Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 2007; 8: 499-509.
9. Di Luca M, Colciaghi F, Pastorino L, Borroni B, Padovani A, Cattabeni F. Platelets as a peripheral district where to study pathogenetic mechanisms of alzheimer disease: the case of amyloid precursor protein. Eur J Pharmacol 2000; 405: 277-83.
10. Itoh H, Kataoka H, Koita H et al. Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung. Int J Cancer 1991; 49: 436-43.
11. Meng JY, Kataoka H, Itoh H, Koono M. Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo. Int J Cancer 2001; 92: 31-9.
12. Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ, Maitra A. Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res 2003; 63: 7032-7.
13. Haven CJ, Howell VM, Eilers PH et al. Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype. Cancer Res 2004; 64: 7405-11.
14. Krause K, Karger S, Sheu SY et al. Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol 2008; 198: 291-9.
15. Takayama K, Tsutsumi S, Suzuki T et al. Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth. Cancer Res 2009; 69: 137-42.
16. Rossjohn J, Cappai R, Feil SC et al. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 1999; 6: 327-31.
17. Suzuki S, Takagi K, Miki Y et al. Nucleobindin 2 in human breast carcinoma as a potent prognostic factor. Cancer Sci 2012; 103: 136-43.
18. Gearing M, Wilson RW, Unger ER et al. Amyloid precursor protein (APP) in the striatum in Alzheimer's disease: an immunohistochemical study. J Neuropathol Exp Neurol 1993; 52: 22-30.
19. Takagi K, Miki Y, Nagasaki S et al. Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment. Endocr Relat Cancer 2010; 17: 415-30.
20. Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 2011; 22: 1736-47.
21. Nicolaou KA, Liapis V, Evdokiou A et al. Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells. Biochem Biophys Res Commun 2012; 42: 76-82.
22. Fukaya Y, Kuroda M, Aoyagi Y et al. Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system. Exp Mol Med 2012; 44: 330-9.
23. Horwitz KB, Costlow ME, McGuire WL. MCF-7; a human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors. Steroids 1975; 26: 785-95.
24. van Diest PJ, van der Wall E, Baak JP. Prognostic value of proliferation in invasive breast cancer: a review. J Clin Pathol 2004; 57: 675-81.
25. de Azambuja E, Cardoso F, de Castro G Jr et al. Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12, 155 patients. Br J Cancer 2007; 96: 1504-13.
26. Ko SY, Lin SC, Chang KW et al. Increased expression of amyloid precursor protein in oral squamous cell carcinoma. Int J Cancer 2004; 111: 727-32.
27. Yang Z, Fan Y, Deng Z, Wu B, Zheng Q. Amyloid precursor protein as a potential marker of malignancy and prognosis in papillary thyroid carcinoma. Oncol Lett 2012; 3: 1227-30.
28. Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J Biol Chem 1994; 269: 13065-8.
29. Doane AS, Danso M, Lal P et al. An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 2006; 25: 3994-4008.
30. Naderi A, Hughes-Davies L. A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer. Neoplasia 2008; 10: 542-8.
31. Takagi K, Miki Y, Onodera Y et al. Kruppel-like factor 5 in human breast carcinoma: a potent prognostic factor induced by androgens. Endocr Relat Cancer 2012; 19: 741-50.