Platelets as a peripheral district where to study pathogenetic mechanisms of Alzheimer disease: The case of amyloid precursor protein

European Journal of Pharmacology

Volumn 405, Issue 1-3, 2000, Pages 277-283

  Di Luca, Monica ^a   Colciaghi, Francesca ^a   Pastorino, Lucia ^a   Borroni, Barbara ^b   Padovani, Alessandro ^b   Cattabeni, Flaminio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Alzheimer disease; Amyloid precursor protein (APP); Diagnosis; Platelet

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BIOCHEMICAL MARKER; ISOPROTEIN;

ALZHEIMER DISEASE; BRAIN BLOOD VESSEL; COGNITIVE DEFECT; CONFERENCE PAPER; CORRELATION FUNCTION; DEGENERATIVE DISEASE; DEMENTIA; DIFFERENTIAL DIAGNOSIS; HUMAN; HUMAN CELL; LABORATORY; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PARENCHYMA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; SENILE PLAQUE; THROMBOCYTE; VASCULAR AMYLOIDOSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMAL; BIOLOGICAL MARKERS; BLOOD PLATELETS; HUMAN;

EID: 0034730466     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00559-8     Document Type: Conference Paper

References (52)

1. Nonneural markers in Alzheimer's disease
2. The amyloid precursor protein of Alzheimer's disease is released by human platelets
3. Processing of Alzheimer beta-A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation
4. Cholinergic agonists and interleukine 1 regulate processing and secretion of theAlzheimer (β/A4 amyloid protein precursor
5. Calcium regulates processing of Alzheimer amyloid protein precursor in a protein kinase-independent manner
6. Evidence that tumor necrosis factor alfa-converting enzyme is involved in regulated alfa-secretase cleavage of the Alzheimer amyloid precursor protein
7. Protein phosphorilation regulates secretion of Alzheimer b/A4 amyloid precursor protein
8. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with constitutive up-regulation of protein kinase C
9. Stimulated platelets release amyloid beta-protein precursor
10. Flow cytometric measurement of cytoplasmic changes in human platelets
11. Activated Alzheimer disease platelets retain more beta amyloid precursor protein
12. Moderate and advanced Alzheimer's patients exhibit platelet activation differences
13. Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome
14. Differential level of platelet amyloid beta precursor protein isoforms: an early marker for Alzheimer disease
15. Regulated secretion of β amyloid precursor protein in rat brain
16. Peripheral markers in testing pathophysiological hypothesis and diagnosis Alzheimer's disease
17. Intact Alzheimer amyloid precursor protein (APP) is present in platelet membrane and is encoded by platelet mRNA
18. Characterization of Alzheimer Amyloid Precursor protein transcripts in platelets and megakaryocytes
19. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface receptor
20. A novel Precursor of Alzheimer's disease Amyloid protein shows protease inhibitory activity
21. Precursor of amyloid protein in Alzheimer's disease undergoes fast anterograde axonal transport
22. Constitutive and regulated a-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
23. Membrane associated forms of βA4 amyloid precursor protein of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelets
24. Proteolytic processing of Alzheimer's disease βA4 Amyloid precursor protein in human platelets
25. Secretion of Alzheimer's disease Aβ amyloid peptide by activated human platelets
26. Protease nexin-2/amyloid b protein inhibits factor Xa in the prothrombinase complex
27. Platelets protein kinase C levels in Alzheimer's disease
28. Reduction of platelet phospholipase C activity in patients with Alzheimer's disease
29. Secreted forms of β-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons
30. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
31. Evidence for ibntraneuroanl calcium-regulating roles for secreted forms of b-amyloid precursor protein
32. Reduction of beta-amyloid peptide 42 in the cerebrospinal fluid of patients with Alzheimer's disease
33. Inhibitory action of amyloid precursor protein against human Hageman factor (factor XII)
34. The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway
35. The role of glycosylation in synthesis and secretion of beta-amyloid precursor protein by Chinese hamster ovary cells
36. N-linked glycosylation of β-amyloid precursor protein
37. Altered amyloid protein processing in platelets of patients with Alzheimer disease
38. Kinetics of changes in intracellular calcium cincentration inFura-2-loaded human platelets
39. Protease nexin-2/amyloid b protein precursor: a tight-biding inhibitor of coagulation factor IXa
40. Beta Amyloid Precursor protein of Alzheimer's disease occurs as 110- to 135-kDa membrane- associated proteins in neural and non-neural tissues
41. Secretion of β amyloid precursor protein cleaved at the amino-terminus of the β amyloid peptide
42. Platelet coagulation factor XIa- inhibitor, a form of Alzheimer amyloid precursor protein
43. Amyloid β protein gene: cDNA, mRNA distribution, and gentic linkage near the Alzheimer's disease
44. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein
45. Zinc (II) selectively enhances the inhibition of coagulation factor Xia by protease nexin-2/amyloid b-protein precursor
46. Protease Nexin II, a potent anti-chymotripsin, shows identity to amyloid b-protein precursor
47. Protease Nexin II (Amyloid beta Protein Precursor): a platelet β-granule protein
48. β-secretase cleavage of Alzheimer's Amyloid Precursor Protein by the transmembrane Aspertic Protease BACE
49. Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease
50. Identification, biogenesis and localization of precursor of Alzheimer's disease A4 amyloid protein
51. Mutation of potential N-linked glycosylation sites in the Alzheimer's disease amyloid precursor protein (APP)
52. Family study of platelet membrane fluidity in Alzheimer's disease