메뉴 건너뛰기




Volumn 86, Issue 5, 2001, Pages 2250-2257

5α-Reductases in human breast carcinoma: Possible modulator of in situ androgenic actions

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE 2; UNCLASSIFIED DRUG; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN RECEPTOR; ANDROSTANOLONE; HYDROXYSTEROID DEHYDROGENASE; ISOENZYME;

EID: 0034744032     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.5.2250     Document Type: Article
Times cited : (74)

References (46)
  • 1
    • 0021319221 scopus 로고
    • Do hormones cause cancer?
    • Thomas DB. 1984 Do hormones cause cancer? Cancer. 53:595-604.
    • (1984) Cancer , vol.53 , pp. 595-604
    • Thomas, D.B.1
  • 2
    • 0024517636 scopus 로고
    • Endogenous steroids in the pathophysiology of breast cancer
    • Vihko R, Apter D. 1989 Endogenous steroids in the pathophysiology of breast cancer. CRC Crit Rev Oncol Hematol. 9:1-16.
    • (1989) CRC Crit Rev Oncol Hematol , vol.9 , pp. 1-16
    • Vihko, R.1    Apter, D.2
  • 3
    • 0022006665 scopus 로고
    • CO human breast cancer cells by progestins: Implications for endocrine therapies
    • CO human breast cancer cells by progestins: implications for endocrine therapies. Cancer Res. 45:167-173.
    • (1985) Cancer Res , vol.45 , pp. 167-173
    • Horwitz, K.B.1    Freidenberg, G.R.2
  • 4
    • 0024264118 scopus 로고
    • Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line
    • Poulin R, Baker D, Labrie F. 1988 Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line. Breast Cancer Res Treat. 12:213-225.
    • (1988) Breast Cancer Res Treat , vol.12 , pp. 213-225
    • Poulin, R.1    Baker, D.2    Labrie, F.3
  • 6
    • 0031796249 scopus 로고
    • Adrenal androgens and human breast cancer: A new appraisal
    • Adams JB. 1988 Adrenal androgens and human breast cancer: a new appraisal. Breast Cancer Res Treat. 51:183-188.
    • (1988) Breast Cancer Res Treat , vol.51 , pp. 183-188
    • Adams, J.B.1
  • 7
    • 0031915998 scopus 로고    scopus 로고
    • Prognostic and predictive factors in breast cancer by immunohistochemical analysis
    • Allred DC, Harvey JM, Berardo M, Clark GM. 1998 Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 11:155-168.
    • (1998) Mod Pathol , vol.11 , pp. 155-168
    • Allred, D.C.1    Harvey, J.M.2    Berardo, M.3    Clark, G.M.4
  • 8
    • 0027264010 scopus 로고
    • Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors
    • Isola JJ. 1993 Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors. J Pathol. 170:31-35.
    • (1993) J Pathol , vol.170 , pp. 31-35
    • Isola, J.J.1
  • 10
    • 0001198305 scopus 로고    scopus 로고
    • Progesterone receptor A and B protein expression in human breast cancer
    • Graham JD, Yeates C, Balleine RL, et al. 1996 Progesterone receptor A and B protein expression in human breast cancer. J Steroid Biochem Mol Biol. 56:93-98.
    • (1996) J Steroid Biochem Mol Biol , vol.56 , pp. 93-98
    • Graham, J.D.1    Yeates, C.2    Balleine, R.L.3
  • 11
    • 0028173882 scopus 로고
    • Steroid 5α-reductase: Two genes/two enzymes
    • Russell DW, Wilson JD. 1994 Steroid 5α-reductase: two genes/two enzymes. Annu Rev Biochem. 63:25-61.
    • (1994) Annu Rev Biochem , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 13
    • 0026730788 scopus 로고
    • Molecular genetics of steroid 5α-reductase 2 deficiency
    • Thigpen AE, Davis DL, Milatovich A, et al. 1992 Molecular genetics of steroid 5α-reductase 2 deficiency. J Clin Invest. 90:799-809.
    • (1992) J Clin Invest , vol.90 , pp. 799-809
    • Thigpen, A.E.1    Davis, D.L.2    Milatovich, A.3
  • 14
    • 0029852637 scopus 로고    scopus 로고
    • The 5α-reductase system and its inhibitors
    • Chen W, Zouboulis ChC, Orfanos CE. 1996 The 5α-reductase system and its inhibitors. Dermatology. 193:177-184.
    • (1996) Dermatology , vol.193 , pp. 177-184
    • Chen, W.1    Zouboulis, C.H.C.2    Orfanos, C.E.3
  • 15
    • 0021800581 scopus 로고
    • The relationship between growth and androstenedione metabolism in four cell lines of human breast carcinoma cells in culture
    • Perel E, Daniilescu D, Kharlip L, Blackstein ME, Killinger DW. 1985 The relationship between growth and androstenedione metabolism in four cell lines of human breast carcinoma cells in culture. Mol Cell Endocrinol. 41:197-203.
    • (1985) Mol Cell Endocrinol , vol.41 , pp. 197-203
    • Perel, E.1    Daniilescu, D.2    Kharlip, L.3    Blackstein, M.E.4    Killinger, D.W.5
  • 16
    • 0034651239 scopus 로고    scopus 로고
    • The 4-pregnene and 5α-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion
    • Wiebe JP, Muzia D, Hu J, Szwajcer D, Hill SA, Seachrist JL. 2000 The 4-pregnene and 5α-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion. Cancer Res. 60:936-943.
    • (2000) Cancer Res , vol.60 , pp. 936-943
    • Wiebe, J.P.1    Muzia, D.2    Hu, J.3    Szwajcer, D.4    Hill, S.A.5    Seachrist, J.L.6
  • 17
    • 70449185514 scopus 로고
    • Histological grading and prognosis in breast cancer. A study of 1409 cases of which 359 have been followed for 15 years
    • Bloom HJG, Richardson WW. 1957 Histological grading and prognosis in breast cancer. A study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 11:359-377.
    • (1957) Br J Cancer , vol.11 , pp. 359-377
    • Bloom, H.J.G.1    Richardson, W.W.2
  • 18
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer. Experience from a large study with long-term follow-up
    • Elston CW, Ellis IO. 1991 Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer. Experience from a large study with long-term follow-up. Histopathology. 19:403-410.
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 19
    • 0033057937 scopus 로고    scopus 로고
    • Immunocytochemical localization of type 5 17β-hydroxysteroid dehydrogenase in human reproductive tissues
    • Pelletier G, Luu-The V, Tetu B, Labrie F. 1999 Immunocytochemical localization of type 5 17β-hydroxysteroid dehydrogenase in human reproductive tissues. J Histochem Cytochem. 47:731-738.
    • (1999) J Histochem Cytochem , vol.47 , pp. 731-738
    • Pelletier, G.1    Luu-The, V.2    Tetu, B.3    Labrie, F.4
  • 21
    • 0025295774 scopus 로고
    • 4-isomerase from placenta: Expression in non-steroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids
    • 4-isomerase from placenta: expression in non-steroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids. Endocrinology. 126:2493-2498.
    • (1990) Endocrinology , vol.126 , pp. 2493-2498
    • Lorence, M.C.1    Murry, B.A.2    Trant, J.M.3    Mason, J.I.4
  • 22
    • 0001837528 scopus 로고
    • Immunolocalization of 3β-hydroxysteroid dehydrogenase in human adrenal cortex and its disorders
    • Sasano H, Mason JI, Sasano N, Nagura H. 1990 Immunolocalization of 3β-hydroxysteroid dehydrogenase in human adrenal cortex and its disorders. Endocr Pathol. 1:94-101.
    • (1990) Endocr Pathol , vol.1 , pp. 94-101
    • Sasano, H.1    Mason, J.I.2    Sasano, N.3    Nagura, H.4
  • 23
    • 0026514838 scopus 로고
    • Structure and tissue-specific expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues
    • Labrie F, Simard J, Luu-The V, et al. 1992 Structure and tissue-specific expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues. J Steroid Biochem Mol Biol. 41:421-435.
    • (1992) J Steroid Biochem Mol Biol , vol.41 , pp. 421-435
    • Labrie, F.1    Simard, J.2    Luu-The, V.3
  • 24
    • 0033328138 scopus 로고    scopus 로고
    • Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle
    • Mote PA, Balleine RL, McGowan EM, Clarke CL. 1999 Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle. J Clin Endocrinol Metab. 84:2963-2971.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2963-2971
    • Mote, P.A.1    Balleine, R.L.2    McGowan, E.M.3    Clarke, C.L.4
  • 25
    • 0023229465 scopus 로고
    • Monoclonal antibodies to human progesterone receptor: Characterization by biochemical and immunohistochemical techniques
    • Clarke CL, Zaino RJ, Feil PD, et al. 1987 Monoclonal antibodies to human progesterone receptor: characterization by biochemical and immunohistochemical techniques. Endocrinology. 121:1123-1132.
    • (1987) Endocrinology , vol.121 , pp. 1123-1132
    • Clarke, C.L.1    Zaino, R.J.2    Feil, P.D.3
  • 26
    • 0027977836 scopus 로고
    • Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: Relationship to expression of steroidogenic enzymes
    • Suzuki T, Sasano H, Kimura N, et al. 1994 Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: relationship to expression of steroidogenic enzymes. Hum Reprod. 9:1589-1595.
    • (1994) Hum Reprod , vol.9 , pp. 1589-1595
    • Suzuki, T.1    Sasano, H.2    Kimura, N.3
  • 27
    • 0031594679 scopus 로고    scopus 로고
    • 5α-Reductase and 17β-hydroxysterold dehydrogenase expression in epithelial cells from hyper-plastic and malignant human prostate
    • Delos S, Carsol JL, Fina F, Raynaud JP, Martin PM. 1998 5α-Reductase and 17β-hydroxysterold dehydrogenase expression in epithelial cells from hyper-plastic and malignant human prostate. Int J Cancer. 75:840-846.
    • (1998) Int J Cancer , vol.75 , pp. 840-846
    • Delos, S.1    Carsol, J.L.2    Fina, F.3    Raynaud, J.P.4    Martin, P.M.5
  • 28
    • 0026055914 scopus 로고
    • Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
    • Andersson S, Berman DM, Jenkins EP, Russell DW. 1991 Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism. Nature. 354:159-161.
    • (1991) Nature , vol.354 , pp. 159-161
    • Andersson, S.1    Berman, D.M.2    Jenkins, E.P.3    Russell, D.W.4
  • 29
    • 0030738545 scopus 로고    scopus 로고
    • Identification of an exon 3 deletion splice variant androgen receptor mRNA in human breast cancer
    • Zhu X, Daffada AAI, Chan CMW, Dowsett M. 1997 Identification of an exon 3 deletion splice variant androgen receptor mRNA in human breast cancer. Int J Cancer. 72:574-580.
    • (1997) Int J Cancer , vol.72 , pp. 574-580
    • Zhu, X.1    Daffada, A.A.I.2    Chan, C.M.W.3    Dowsett, M.4
  • 30
    • 0032113394 scopus 로고    scopus 로고
    • Expression measurement of many genes simultaneously by quantitative RT-PCR using standardized mixtures of competitive templates
    • Willey JC, Crawford EL, Jackson CM, et al. 1998 Expression measurement of many genes simultaneously by quantitative RT-PCR using standardized mixtures of competitive templates. Am J Respir Cell Mol Biol. 19:6-17.
    • (1998) Am J Respir Cell Mol Biol , vol.19 , pp. 6-17
    • Willey, J.C.1    Crawford, E.L.2    Jackson, C.M.3
  • 31
    • 0019401051 scopus 로고
    • Steroid-metabolizing enzymes in human breast cancer cells. II. 5α-Reductase, 3α-hydroxysteroid oxidoreductase, and 17β-hydroxysteroid oxidoreductase
    • MacIndoe JH, Woods GR. 1981 Steroid-metabolizing enzymes in human breast cancer cells. II. 5α-Reductase, 3α-hydroxysteroid oxidoreductase, and 17β-hydroxysteroid oxidoreductase. Endocrinology. 108:1407-1413.
    • (1981) Endocrinology , vol.108 , pp. 1407-1413
    • MacIndoe, J.H.1    Woods, G.R.2
  • 32
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (150) of an enzymatic reaction
    • Cheng Y, Prusoff WH. 1973 Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (150) of an enzymatic reaction. Biochem Pharmacol. 22:3099-3108.
    • (1973) Biochem Pharmacol , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 33
    • 0016241117 scopus 로고
    • Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle
    • Abraham GE. 1974 Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin Endocrinol Metab. 39:340-346.
    • (1974) J Clin Endocrinol Metab , vol.39 , pp. 340-346
    • Abraham, G.E.1
  • 34
    • 0018647327 scopus 로고
    • Factors affecting- sex hormone levels in postmenopausal women
    • Vermeulen A, Verdonck L. 1979 Factors affecting- sex hormone levels in postmenopausal women. J Steroid Biochem. 11:899-904.
    • (1979) J Steroid Biochem , vol.11 , pp. 899-904
    • Vermeulen, A.1    Verdonck, L.2
  • 35
    • 0022556653 scopus 로고
    • 19-steroids and oestradiol levels in human primary breast tumour tissues and their correlation with androgen and oestrogen receptors
    • 19-steroids and oestradiol levels in human primary breast tumour tissues and their correlation with androgen and oestrogen receptors. J Steroid Biochem. 24:1117-1125.
    • (1986) J Steroid Biochem , vol.24 , pp. 1117-1125
    • Mistry, P.1    Griffiths, K.2    Maynard, P.V.3
  • 37
    • 0001429526 scopus 로고    scopus 로고
    • Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase
    • Dufort I, Rheault P, Huang XF, Soucy P, Luu-The V. 1999 Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase. Endocrinology. 140:568-574.
    • (1999) Endocrinology , vol.140 , pp. 568-574
    • Dufort, I.1    Rheault, P.2    Huang, X.F.3    Soucy, P.4    Luu-The, V.5
  • 38
    • 0032914659 scopus 로고    scopus 로고
    • Localization of type 5 17β-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry
    • El-Alfy M, Luu-The V, Huang XF, Berger L, Labrie F, Pelletier G. 1999 Localization of type 5 17β-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. Endocrinology. 140:1481-1491.
    • (1999) Endocrinology , vol.140 , pp. 1481-1491
    • El-Alfy, M.1    Luu-The, V.2    Huang, X.F.3    Berger, L.4    Labrie, F.5    Pelletier, G.6
  • 39
    • 0031593569 scopus 로고    scopus 로고
    • Expression of 3β-hydroxysteroid dehydrogenase-5,4-en isomerase activity by infiltrating ductal human breast carcinoma in vitro
    • Gunasegaram R, Peh KL, Loganath A, Ratnam SS. 1998 Expression of 3β-hydroxysteroid dehydrogenase-5,4-en isomerase activity by infiltrating ductal human breast carcinoma in vitro. Breast Cancer Res Treat. 50:117-123.
    • (1998) Breast Cancer Res Treat , vol.50 , pp. 117-123
    • Gunasegaram, R.1    Peh, K.L.2    Loganath, A.3    Ratnam, S.S.4
  • 40
    • 0028302746 scopus 로고
    • Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders
    • Sasano H, Nagura H, Harada N, Goukon Y, Kimura M. 1994 Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum Pathol. 25:530-535.
    • (1994) Hum Pathol , vol.25 , pp. 530-535
    • Sasano, H.1    Nagura, H.2    Harada, N.3    Goukon, Y.4    Kimura, M.5
  • 41
    • 0020694123 scopus 로고
    • Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
    • Gerdes J, Schwab U, Lemke H, Stein H. 1983 Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer. 31:13-20.
    • (1983) Int J Cancer , vol.31 , pp. 13-20
    • Gerdes, J.1    Schwab, U.2    Lemke, H.3    Stein, H.4
  • 43
    • 0020326596 scopus 로고
    • Significance of aromatase activity in human breast cancer
    • Miller WR, Hawkins RA, Forrest AM. 1982 Significance of aromatase activity in human breast cancer. Cancer Res. 42:3365-3368.
    • (1982) Cancer Res , vol.42 , pp. 3365-3368
    • Miller, W.R.1    Hawkins, R.A.2    Forrest, A.M.3
  • 44
    • 0026557238 scopus 로고
    • Immunohistochemical analysis of 17β-hydroxysteroid dehydrogenase in benign and malignant human breast tissue
    • Poutanen M, Isomaa V, Lehto VP, Vihko R. 1992 Immunohistochemical analysis of 17β-hydroxysteroid dehydrogenase in benign and malignant human breast tissue. Int J Cancer. 50:386-390.
    • (1992) Int J Cancer , vol.50 , pp. 386-390
    • Poutanen, M.1    Isomaa, V.2    Lehto, V.P.3    Vihko, R.4
  • 45
    • 0029817523 scopus 로고    scopus 로고
    • Aromatase and 17β-hydroxysteroid dehydrogenase type 1 in human breast carcinoma
    • Sasano H, Frost AR, Saltoh R, et al. 1996 Aromatase and 17β-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. J Clin Endocrinol Metab. 81:4042-4046.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4042-4046
    • Sasano, H.1    Frost, A.R.2    Saltoh, R.3
  • 46
    • 0034132569 scopus 로고    scopus 로고
    • 17β-Hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: A correlation to clinicopathological parameters
    • Suzuki T, Moriya T, Ariga N, Kaneko C, Kanazawa M, Sasano H. 2000 17β-Hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Br J Cancer. 82: 524-528.
    • (2000) Br J Cancer , vol.82 , pp. 524-528
    • Suzuki, T.1    Moriya, T.2    Ariga, N.3    Kaneko, C.4    Kanazawa, M.5    Sasano, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.