AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells

Molecular and Cellular Biochemistry

Volumn 378, Issue 1-2, 2013, Pages 171-181

  Huo, Hai Zhong ^a   Wang, Bing ^a   Qin, Jian ^a   Guo, Shan Yu ^a   Liu, Wen Yong ^a   Gu, Yan ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

AMPK Ulk1 pathway; Autophagy; C6 ceramide; Colorectal cancer

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; ANTINEOPLASTIC AGENT; CERAMIDE; DRUG DERIVATIVE; EVEROLIMUS; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N (ALPHA HYDROXYOCTADECANOYL)PHYTOSPHINGOSINE; N-(ALPHA-HYDROXYOCTADECANOYL)PHYTOSPHINGOSINE; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; RIBONUCLEOTIDE; SIGNAL PEPTIDE; TEMSIROLIMUS; ULK1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRAIN HCT116; CELL STRAIN HT29; CELL SURVIVAL; COLORECTAL TUMOR; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL SURVIVAL; CERAMIDES; COLORECTAL NEOPLASMS; ENZYME ACTIVATION; HCT116 CELLS; HT29 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 84886772505     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1608-8     Document Type: Article

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