Synthesis and radiopharmacological evaluation of 64Cu-labeled bombesin analogs featuring a bis(2-pyridylmethyl)-1,4,7-triazacyclononane chelator

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 434-446

  Bergmann, R ^a   Ruffani, A ^a   Graham, B ^b   Spiccia, L ^b   Steinbach, J ^a,c   Pietzsch, J ^a,c   Stephan, H ^a  

^a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^b MONASH UNIVERSITY   (Australia)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Bombesin (BBN); Copper 64; Gastrin releasing peptide receptors; Human prostate adenocarcinoma cells (PC 3); Small animal positron emission tomography

Indexed keywords

2 [4,7 BIS(2 PYRIDYLMETHYL) 1,4,7 TRIAZACYCLONONAN 1 YL]ACETIC ACID; BOMBESIN CU 64 DERIVATIVE; BOMBESIN DERIVATIVE; CHELATING AGENT; GASTRIN RELEASING PEPTIDE RECEPTOR; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CYCLOTRON; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; ISOTOPE LABELING; LIPOPHILICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; PROSTATE CANCER; RAT; RECEPTOR BINDING;

BOMBESIN (BBN); COPPER-64; GASTRIN-RELEASING PEPTIDE RECEPTORS; HUMAN PROSTATE ADENOCARCINOMA CELLS (PC-3); JBGKGUKDMCUNFQ-UHFFFAOYSA-N; QFPVUEQQDDAEQA-UHFFFAOYSA-N; SMALL ANIMAL POSITRON EMISSION TOMOGRAPHY; XMGBKKSMXQSOJK-UHFFFAOYSA-N;

ANIMALS; BOMBESIN; CELL LINE, TUMOR; CHELATING AGENTS; COPPER RADIOISOTOPES; HUMANS; MALE; MICE; MICE, NUDE; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RECEPTORS, BOMBESIN; TISSUE DISTRIBUTION;

EID: 84886737224     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.013     Document Type: Article

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