In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer

Nuclear Medicine and Biology

Volumn 39, Issue 5, 2012, Pages 609-616

  Craft, Jeffrey M ^a   De Silva, Ravindra A ^a,b   Lears, Kimberly A ^a   Andrews, Rebecca ^a   Liang, Kexian ^b   Achilefu, Samuel ^b   Rogers, Buck E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bombesin; Cu 64; NOTA; Prostate cancer

Indexed keywords

COPPER 1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID 2 (4 ISOTHIOCYANATOBENZYL) 8 AMINOOCTANOIC ACID BOMBESIN[7-14] CU 64; GASTRIN RELEASING PEPTIDE RECEPTOR; IODINE TYROSINE BOMBESIN I 125; ISOTOPE; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BINDING COMPETITION; BIOACCUMULATION; CANCER CELL CULTURE; CELL INTERACTION; COMPLEX FORMATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; ISOTOPE LABELING; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; RADIATION DOSE DISTRIBUTION; RADIOASSAY; RECEPTOR AFFINITY; RECEPTOR BINDING;

ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; BOMBESIN; CAPRYLATES; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COPPER RADIOISOTOPES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROCYCLIC COMPOUNDS; HUMANS; ISOTHIOCYANATES; ISOTOPE LABELING; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; PROSTATIC NEOPLASMS; RECEPTORS, BOMBESIN;

EID: 84862609566     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.12.004     Document Type: Article

References (32)

1. Markwalder R., Reubi J.C. Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Cancer Res 1999, 59:1152-1159.
2. 14] Bombesin(6-14). Clin Cancer Res 2002, 8:1139-1146.
3. Anastasi A., Erspamer V., Bucci M. Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 1971, 27:166-167.
4. 111In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy. J Nucl Med 2002, 43:1650-1656.
5. Hoffman T.J., Smith C.J. True radiotracers: Cu-64 targeting vectors based upon bombesin peptide. Nucl Med Biol 2009, 36:579-585.
6. 2 GRP receptor-targeted radiotherapy and chemotherapy in PC-3 human prostate tumor cell xenografted SCID mice. Cancer Biother Radiopharm 2006, 21:155-166.
7. Lin K.S., Luu A., Baidoo K.E., Hashemzadeh-Gargari H., Chen M.K., Brenneman K., et al. A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation. Bioconjug Chem 2005, 16:43-50.
8. 177Lu-AMBA biodistribution, radiotherapeutic efficacy, imaging, and autoradiography in prostate cancer models with low GRP-R expression. J Nucl Med 2009, 50:2017-2024.
9. Mansi R., Wang X., Forrer F., Kneifel S., Tamma M.L., Waser B., et al. Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides. Clin Cancer Res 2009, 15:5240-5249.
10. Smith C.J., Volkert W.A., Hoffman T.J. Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes. Nucl Med Biol 2005, 32:733-740.
11. Zhang H., Chen J., Waldherr C., Hinni K., Wasser B., Reubi J.C., et al. Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors. Cancer Res 2004, 64:6707-6715.
12. Parry J.J., Andrews R., Rogers B.E. MicroPET imaging of breast cancer using radiolabeled bombesion analogs targeting the gastrin-releasing peptide receptor. Breast Cancer Res Treat 2007, 101:175-183.
13. 64Cu-labeled DOTA-linker-bombesin(7-14) analogues containing different amino acid linker moieties. Bioconjug Chem 2007, 18:1110-1117.
14. 64Cu-labeled bombesin analog. Bioconjug Chem 2003, 14:756-763.
15. 64Cu-labeled polyethylene glycol bombesin conjugate. Cancer Biother Radiopharm 2004, 19:25-34.
16. 4)-Bombesin(1-14). Bioconj Chem 2007, 18:724-730.
17. Boswell C.A., Sun X., Niu W., Weisman G.R., Wong E.H., Rheingold A.L., et al. Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes. J Med Chem 2004, 47:1465-1474.
18. 2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues. Proc Natl Acad Sci USA 2007, 104:12462-12467.
19. 2], in a prostate tumor xenografted mouse model. Nuc Med Biol 2010, 37:751-761.
20. 64Cu using a biomedical cyclotron. Nucl Med Biol 1997, 24:35-43.
21. Sun X., Wuest M., Weisman G.R., Wong E.H., Reed D.P., Boswell C.A., et al. Radiolabeling and in vivo behavior of copper-64-labeled crossbridged cyclam ligands. J Med Chem 2002, 45:469-477.
22. Bartolo N.M.D., Sargeson A.M., Donlevy T.M., Smith S.V. Synthesis of a new cage ligand, SarAr, and its complexation with selected transition metal ions for potential use in radioimaging. J Chem Soc, Dalton Trans 2001, 2303-2309.
23. Wieghardt K., Bossek U., Chaudhuri P., Herrmann W., Menke B.C., Weiss J. 1,4,7-Triazacyclononane-N,N',N″-triacetate (TCTA), a new hexadentate ligand for divalent and trivalent metal ions. Crystal structures of [CrIII(TCTA)], [FeIII(TCTA)], and Na[CuII(TCTA)]. Inorg Chem 1982, 21:4308-4314.
24. Anderegg G., Arnaud-Neu F., Delgado R., Felcman J., Popov K. Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications. Pure Appl Chem 2005, 77:1445-1495.
25. Meares C.F. Capturing copper for molecular imaging and therapy. Recent advances of bioconjugation chemistry in molecular imaging 2008, 227-241. Research Signpost, Kerala, India. X. Chen (Ed.).
26. Lears K.A., Ferdani R., Liang K., Zheleznyak A., Andrews R., Sherman C.D., et al. In vitro and in vivo evaluation of 64Cu-labeled SarAr-bombesin analogs in gastrin-releasing peptide receptor-expressing prostate cancer. J Nucl Med 2011, 52:470-477.
27. 2]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human breast cancer tumors. Nucl Med Biol 2009, 36:171-181.
28. 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems. J Nucl Med 2007, 48:1327-1337.
29. Cescato R., Maina T., Nock B., Nikolopoulou A., Charalambidis D., Piccand V., et al. Bombesin receptor antagonists may be preferable to agonists for tumor targeting. J Nucl Med 2008, 49:318-326.
30. Ginj M., Zhang H., Waser B., Cescato R., Wild D., Wang X., et al. Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors. Proc Natl Acad Sci USA 2006, 103:16436-16441.
31. Kukis D.L., Diril H., Greiner D.P., DeNardo S.J., DeNardo G.L., Salako Q.A., et al. A comparative study of copper-67 radiolabeling and kinetic stabilities of antibody-macrocycle chelate conjugates. Cancer (Suppl) 1994, 73:779-786.
32. Van der Merwe M.J., Boeyens J.C.A., Hancock R.D. Crystallographic and thermodynamic study of metal ion size selectivity in the ligand 1,4,7-triazacyclononane-N,N',N″-triacetate. Inorg Chem 1985, 24:1208-1213.