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Volumn 10, Issue 11, 2013, Pages 648-661

Demystifying the management of hypertriglyceridaemia

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ANTISENSE OLIGONUCLEOTIDE; APOLIPOPROTEIN B100; APOLIPOPROTEIN C3; APOLIPOPROTEIN C3 INHIBITOR; ASPARAGINASE; ATYPICAL ANTIPSYCHOTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BILE ACID SEQUESTRANT; CYCLOSPORIN; DIACYLGLYCEROL ACYLTRANSFERASE; DIACYLGLYCEROL ACYLTRANSFERASE INHIBITOR; ESTROGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERFERON; LIPOPROTEIN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; NICOTINIC ACID; PROTEIN INHIBITOR; RAPAMYCIN; RETINOIC ACID DERIVATIVE; TAMOXIFEN; THIAZIDE DIURETIC AGENT; TRIACYLGLYCEROL; TRIGLYCERIDE RICH LIPOPROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84886727920     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2013.140     Document Type: Review
Times cited : (94)

References (180)
  • 1
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald, W. T., Levy, R. I. & Fredrickson, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502 (1972).
    • (1972) Clin. Chem. , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 2
    • 33751205350 scopus 로고    scopus 로고
    • Standard lipid profile
    • Tiyyagura, S. & Smith, D. Standard lipid profile. Clin. Lab. Med. 26, 707-732 (2006).
    • (2006) Clin. Lab. Med. , vol.26 , pp. 707-732
    • Tiyyagura, S.1    Smith, D.2
  • 3
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins
    • Baigent, C. et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 366, 1267-1278 (2005).
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1
  • 4
    • 84864832599 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials
    • Mihaylova, B. et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 380, 581-590 (2012).
    • (2012) Lancet , vol.380 , pp. 581-590
    • Mihaylova, B.1
  • 5
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • Reiner, Z. et al. ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur. Heart J. 32, 1769-1818 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 1769-1818
    • Reiner, Z.1
  • 7
    • 0031775430 scopus 로고    scopus 로고
    • Triglycerides are more important in atherosclerosis than epidemiology has suggested
    • Durrington, P. Triglycerides are more important in atherosclerosis than epidemiology has suggested. Atherosclerosis 141 (Suppl. 1), S57-S62 (1998).
    • (1998) Atherosclerosis , vol.141 , Issue.SUPPL. 1
    • Durrington, P.1
  • 8
    • 0025924025 scopus 로고
    • How independent are independent effects? Relative risk estimation when correlated exposures are measured imprecisely
    • Phillips, A. N. & Smith, G. D. How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely. J. Clin. Epidemiol. 44, 1223-1231 (1991).
    • (1991) J. Clin. Epidemiol. , vol.44 , pp. 1223-1231
    • Phillips, A.N.1    Smith, G.D.2
  • 9
    • 85027956925 scopus 로고    scopus 로고
    • Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association
    • Miller, M. et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 123, 2292-2333 (2011).
    • (2011) Circulation , vol.123 , pp. 2292-2333
    • Miller, M.1
  • 10
    • 79958148945 scopus 로고    scopus 로고
    • Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management
    • Chapman, M. J. et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur. Heart J. 32, 1345-1361 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 1345-1361
    • Chapman, M.J.1
  • 11
    • 0037126526 scopus 로고    scopus 로고
    • Third report of the national cholesterol education program (ncep) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel iii) final Report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 106, 3143-3421 (2002).
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 12
    • 84866146620 scopus 로고    scopus 로고
    • Evaluation and treatment of hypertriglyceridemia: An Endocrine Society clinical practice guideline
    • Berglund, L. et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 97, 2969-2989 (2012).
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 2969-2989
    • Berglund, L.1
  • 13
    • 84872712625 scopus 로고    scopus 로고
    • 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult
    • Anderson, T. J. et al. 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can. J. Cardiol. 29, 151-167 (2013).
    • (2013) Can. J. Cardiol. , vol.29 , pp. 151-167
    • Anderson, T.J.1
  • 14
    • 84879464821 scopus 로고    scopus 로고
    • Guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan-2012 version
    • Executive summary of Japan Atherosclerosis Society (JAS).
    • Teramoto, T. et al. Executive summary of Japan Atherosclerosis Society (JAS). Guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan-2012 version. J. Atheroscler. Thromb. 20, 517-523 (2013).
    • (2013) J. Atheroscler. Thromb. , vol.20 , pp. 517-523
    • Teramoto, T.1
  • 15
    • 48849108904 scopus 로고    scopus 로고
    • Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target
    • Shimano, H. et al. Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target. J. Atheroscler. Thromb. 15, 116-121 (2008).
    • (2008) J. Atheroscler. Thromb. , vol.15 , pp. 116-121
    • Shimano, H.1
  • 16
    • 84863413709 scopus 로고    scopus 로고
    • Diagnosis and management of type i and type v hyperlipoproteinemia
    • Gotoda, T. et al. Diagnosis and management of type I and type V hyperlipoproteinemia. J. Atheroscler. Thromb. 19, 1-12 (2012).
    • (2012) J. Atheroscler. Thromb. , vol.19 , pp. 1-12
    • Gotoda, T.1
  • 17
    • 80054682430 scopus 로고    scopus 로고
    • Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: Results of the Dyslipidaemia International Study
    • Leiter, L. A. et al. Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study. Diabet. Med. 28, 1343-1351 (2011).
    • (2011) Diabet. Med. , vol.28 , pp. 1343-1351
    • Leiter, L.A.1
  • 18
    • 34548433987 scopus 로고    scopus 로고
    • Clinical practice. Hypertriglyceridemia
    • Brunzell, J. D. Clinical practice. Hypertriglyceridemia. N. Engl. J. Med. 357, 1009-1017 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1009-1017
    • Brunzell, J.D.1
  • 19
    • 84861227604 scopus 로고    scopus 로고
    • The complex genetic basis of plasma triglycerides
    • Johansen, C. T. & Hegele, R. A. The complex genetic basis of plasma triglycerides. Curr. Atheroscler. Rep. 14, 227-234 (2012).
    • (2012) Curr. Atheroscler. Rep. , vol.14 , pp. 227-234
    • Johansen, C.T.1    Hegele, R.A.2
  • 20
    • 78751519853 scopus 로고    scopus 로고
    • Genetic determinants of plasma triglycerides
    • Johansen, C. T., Kathiresan, S. & Hegele, R. A. Genetic determinants of plasma triglycerides. J. Lipid Res. 52, 189-206 (2011).
    • (2011) J. Lipid Res. , vol.52 , pp. 189-206
    • Johansen, C.T.1    Kathiresan, S.2    Hegele, R.A.3
  • 21
    • 84863986988 scopus 로고    scopus 로고
    • Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia
    • Surendran, R. P. et al. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J. Intern. Med. 272, 185-196 (2012).
    • (2012) J. Intern. Med. , vol.272 , pp. 185-196
    • Surendran, R.P.1
  • 22
    • 77955070766 scopus 로고    scopus 로고
    • Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    • Johansen, C. T. et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat. Genet. 42, 684-687 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 684-687
    • Johansen, C.T.1
  • 25
    • 0042074140 scopus 로고    scopus 로고
    • Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: A case-control comparison from the national heart, lung, and blood institute family heart study
    • Hopkins, P. N. et al. Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 108, 519-523 (2003).
    • (2003) Circulation , vol.108 , pp. 519-523
    • Hopkins, P.N.1
  • 26
    • 0034905682 scopus 로고    scopus 로고
    • Excess coronary heart disease in familial combined hyperlipidemia, in relation to genetic factors and central obesity
    • Voors-Pette, C. & de Bruin, T. W. Excess coronary heart disease in familial combined hyperlipidemia, in relation to genetic factors and central obesity. Atherosclerosis 157, 481-489 (2001).
    • (2001) Atherosclerosis , vol.157 , pp. 481-489
    • Voors-Pette, C.1    De Bruin, T.W.2
  • 28
    • 3042558196 scopus 로고    scopus 로고
    • Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study
    • Veerkamp, M. J., de Graaf, J., Hendriks, J. C., Demacker, P. N. & Stalenhoef, A. F. Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study. Circulation 109, 2980-2985 (2004).
    • (2004) Circulation , vol.109 , pp. 2980-2985
    • Veerkamp, M.J.1    De Graaf, J.2    Hendriks, J.C.3    Demacker, P.N.4    Stalenhoef, A.F.5
  • 29
    • 0026761495 scopus 로고
    • Genetic epidemiology of lipoprotein lipase deficiency in Saguenay-Lac-St-Jean (Québec, Canada)
    • Dionne, C. et al. Genetic epidemiology of lipoprotein lipase deficiency in Saguenay-Lac-St-Jean (Québec, Canada). Ann. Genet. 35, 89-92 (1992).
    • (1992) Ann. Genet. , vol.35 , pp. 89-92
    • Dionne, C.1
  • 30
    • 16244399190 scopus 로고    scopus 로고
    • Severe hypertriglyceridemia in a patient with lupus
    • Blom, D. J. & Marais, A. D. Severe hypertriglyceridemia in a patient with lupus. Am. J. Med. 118, 443-444 (2005)
    • (2005) Am. J. Med. , vol.118 , pp. 443-444
    • Blom, D.J.1    Marais, A.D.2
  • 31
    • 37649020778 scopus 로고    scopus 로고
    • Chylomicronemia and the chylomicronemia syndrome: A practical approach to management
    • Leaf, D. A. Chylomicronemia and the chylomicronemia syndrome: a practical approach to management. Am. J. Med. 121, 10-12 (2008).
    • (2008) Am. J. Med. , vol.121 , pp. 10-12
    • Leaf, D.A.1
  • 32
    • 78650442809 scopus 로고    scopus 로고
    • Dyslipidaemia in the metabolic syndrome and type 2 diabetes: Pathogenesis, priorities, pharmacotherapies
    • Chan, D. C. & Watts, G. F. Dyslipidaemia in the metabolic syndrome and type 2 diabetes: pathogenesis, priorities, pharmacotherapies. Expert Opin. Pharmacother. 12, 13-30 (2011).
    • (2011) Expert Opin. Pharmacother. , vol.12 , pp. 13-30
    • Chan, D.C.1    Watts, G.F.2
  • 33
    • 0037898380 scopus 로고    scopus 로고
    • Diabetic dyslipidaemia: From basic research to clinical practice
    • Taskinen, M. R. Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia 46, 733-749 (2003).
    • (2003) Diabetologia , vol.46 , pp. 733-749
    • Taskinen, M.R.1
  • 34
    • 80053914425 scopus 로고    scopus 로고
    • Clinical utility of inflammatory markers and advanced lipoprotein testing: Advice from an expert panel of lipid specialists
    • Davidson, M. H. et al. Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists. J. Clin. Lipidol. 5, 338-367 (2011).
    • (2011) J. Clin. Lipidol. , vol.5 , pp. 338-367
    • Davidson, M.H.1
  • 35
    • 80053927990 scopus 로고    scopus 로고
    • Dynamics of human adipose lipid turnover in health and metabolic disease
    • Arner, P. et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478, 110-113 (2011).
    • (2011) Nature , vol.478 , pp. 110-113
    • Arner, P.1
  • 37
    • 46249093117 scopus 로고    scopus 로고
    • Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    • Adiels, M., Olofsson, S. O., Taskinen, M. R. & Borén, J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler. Thromb. Vasc. Biol. 28, 1225-1236 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 1225-1236
    • Adiels, M.1    Olofsson, S.O.2    Taskinen, M.R.3    Borén, J.4
  • 38
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo, P. Nonalcoholic fatty liver disease. N. Engl. J. Med. 346, 1221-1231 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 39
    • 83455216207 scopus 로고    scopus 로고
    • Ectopic fat depots and cardiovascular disease
    • Britton, K. A. & Fox, C. S. Ectopic fat depots and cardiovascular disease. Circulation 124, e837-e841 (2011).
    • (2011) Circulation , vol.124
    • Britton, K.A.1    Fox, C.S.2
  • 40
    • 84879094909 scopus 로고    scopus 로고
    • Ectopic lipid storage and insulin resistance: A harmful relationship
    • Borén, J., Taskinen, M. R. & Olofsson, S. O. & Levin, M. Ectopic lipid storage and insulin resistance: a harmful relationship. J. Intern. Med. 274, 25-40 (2013).
    • (2013) J. Intern. Med. , vol.274 , pp. 25-40
    • Borén, J.1    Taskinen, M.R.2    Olofsson, S.O.3    Levin, M.4
  • 41
    • 84874868379 scopus 로고    scopus 로고
    • Cardiac steatosis associates with visceral obesity in nondiabetic obese men
    • Granér, M. et al. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. J. Clin. Endocrinol. Metab. 98, 1189-1197 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 1189-1197
    • Granér, M.1
  • 42
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt, A. et al. Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 17, 200-205 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 200-205
    • Bartelt, A.1
  • 43
    • 42549109081 scopus 로고    scopus 로고
    • Apolipoprotein C-III: Understanding an emerging cardiovascular risk factor
    • Ooi, E. M., Barrett, P. H., Chan, D. C. & Watts, G. F. Apolipoprotein C-III: understanding an emerging cardiovascular risk factor. Clin. Sci. 114, 611-624 (2008).
    • (2008) Clin. Sci. , vol.114 , pp. 611-624
    • Ooi, E.M.1    Barrett, P.H.2    Chan, D.C.3    Watts, G.F.4
  • 44
    • 80052175601 scopus 로고    scopus 로고
    • Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects
    • Taskinen, M. R. et al. Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects. Arterioscler. Thromb. Vasc. Biol. 31, 2144-2150 (2011).
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 2144-2150
    • Taskinen, M.R.1
  • 45
    • 0042762945 scopus 로고    scopus 로고
    • Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: The combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity
    • Rashid, S., Watanabe, T., Sakaue, T. & Lewis, G. F. Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity. Clin. Biochem. 36, 421-429 (2003).
    • (2003) Clin. Biochem. , vol.36 , pp. 421-429
    • Rashid, S.1    Watanabe, T.2    Sakaue, T.3    Lewis, G.F.4
  • 46
    • 68949220302 scopus 로고    scopus 로고
    • HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study
    • Arsenault, B. J. et al. HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. Atherosclerosis 206, 276-281 (2009).
    • (2009) Atherosclerosis , vol.206 , pp. 276-281
    • Arsenault, B.J.1
  • 47
    • 70450081001 scopus 로고    scopus 로고
    • Major lipids, apolipoproteins, and risk of vascular disease
    • Di Angelantonio, E. et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 302, 1993-2000 (2009).
    • (2009) JAMA , vol.302 , pp. 1993-2000
    • Di Angelantonio, E.1
  • 48
    • 84871705238 scopus 로고    scopus 로고
    • Using Mendelian randomization to determine causative factors in cardiovascular disease
    • Johansen, C. T. & Hegele, R. A. Using Mendelian randomization to determine causative factors in cardiovascular disease. J. Intern. Med. 273, 44-47 (2013).
    • (2013) J. Intern. Med. , vol.273 , pp. 44-47
    • Johansen, C.T.1    Hegele, R.A.2
  • 49
    • 84876175810 scopus 로고    scopus 로고
    • Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction
    • Jørgensen, A. B. et al. Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction. Eur. Heart J. 34, 1826-1833 (2013).
    • (2013) Eur. Heart J. , vol.34 , pp. 1826-1833
    • Jørgensen, A.B.1
  • 50
    • 77951875017 scopus 로고    scopus 로고
    • Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studies
    • Sarwar, N. et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 375, 1634-1639 (2010).
    • (2010) Lancet , vol.375 , pp. 1634-1639
    • Sarwar, N.1
  • 51
    • 38949171001 scopus 로고    scopus 로고
    • Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial
    • Miller, M. et al. Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J. Am. Coll. Cardiol. 51, 724-730 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 724-730
    • Miller, M.1
  • 52
    • 68049114763 scopus 로고    scopus 로고
    • Plasma triglycerides and cardiovascular events in the Treating to New Targets and Incremental Decrease in End-Points through Aggressive Lipid Lowering trials of statins in patients with coronary artery disease
    • Faergeman, O. et al. Plasma triglycerides and cardiovascular events in the Treating to New Targets and Incremental Decrease in End-Points through Aggressive Lipid Lowering trials of statins in patients with coronary artery disease. Am. J. Cardiol. 104, 459-463 (2009).
    • (2009) Am. J. Cardiol. , vol.104 , pp. 459-463
    • Faergeman, O.1
  • 53
    • 84859184996 scopus 로고    scopus 로고
    • Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: A meta-analysis
    • Boekholdt, S. M. et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA 307, 1302-1309 (2012).
    • (2012) JAMA , vol.307 , pp. 1302-1309
    • Boekholdt, S.M.1
  • 54
    • 0018649439 scopus 로고
    • Atherogenesis: A postprandial phenomenon
    • Zilversmit, D. B. Atherogenesis: a postprandial phenomenon. Circulation 60, 473-485 (1979).
    • (1979) Circulation , vol.60 , pp. 473-485
    • Zilversmit, D.B.1
  • 55
    • 0028067623 scopus 로고
    • Atherosclerosis and arterial influx of lipoproteins
    • Nordestgaard, B. G. & Nielsen, L. B. Atherosclerosis and arterial influx of lipoproteins. Curr. Opin. Lipidol. 5, 252-257 (1994).
    • (1994) Curr. Opin. Lipidol. , vol.5 , pp. 252-257
    • Nordestgaard, B.G.1    Nielsen, L.B.2
  • 56
    • 37349021003 scopus 로고    scopus 로고
    • Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications
    • Tabas, I., Williams, K. J. & Borén, J. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 116, 1832-1844 (2007).
    • (2007) Circulation , vol.116 , pp. 1832-1844
    • Tabas, I.1    Williams, K.J.2    Borén, J.3
  • 57
    • 0018827061 scopus 로고
    • Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins
    • Goldstein, J. L., Ho, Y. K., Brown, M. S., Innerarity, T. L. & Mahley, R. W. Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins. J. Biol. Chem. 255, 1839-1848 (1980).
    • (1980) J. Biol. Chem. , vol.255 , pp. 1839-1848
    • Goldstein, J.L.1    Ho, Y.K.2    Brown, M.S.3    Innerarity, T.L.4    Mahley, R.W.5
  • 58
    • 34548166870 scopus 로고    scopus 로고
    • Remnant-like lipoprotein particles impair endothelial function: Direct and indirect effects on nitric oxide synthase
    • Zheng, X. Y. & Liu, L. Remnant-like lipoprotein particles impair endothelial function: direct and indirect effects on nitric oxide synthase. J. Lipid Res. 48, 1673-1680 (2007).
    • (2007) J. Lipid Res. , vol.48 , pp. 1673-1680
    • Zheng, X.Y.1    Liu, L.2
  • 59
    • 0034660437 scopus 로고    scopus 로고
    • Plasminogen-activator inhibitor type 1 and coronary artery disease
    • Kohler, H. P. & Grant, P. J. Plasminogen-activator inhibitor type 1 and coronary artery disease. N. Engl. J. Med. 342, 1792-1801 (2000).
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1792-1801
    • Kohler, H.P.1    Grant, P.J.2
  • 60
    • 0031893737 scopus 로고    scopus 로고
    • Plasma lipoproteins support prothrombinase and other procoagulant enzymatic complexes
    • Moyer, M. P. et al. Plasma lipoproteins support prothrombinase and other procoagulant enzymatic complexes. Arterioscler. Thromb. Vasc. Biol. 18, 458-465 (1998).
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 458-465
    • Moyer, M.P.1
  • 61
    • 42249089376 scopus 로고    scopus 로고
    • Leukocyte activation by triglyceride-rich lipoproteins
    • Alipour, A. et al. Leukocyte activation by triglyceride-rich lipoproteins. Arterioscler. Thromb. Vasc. Biol. 28, 792-797 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 792-797
    • Alipour, A.1
  • 62
    • 64749100482 scopus 로고    scopus 로고
    • Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation
    • Wang, L. et al. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation. J. Lipid Res. 50, 204-213 (2009).
    • (2009) J. Lipid Res. , vol.50 , pp. 204-213
    • Wang, L.1
  • 63
    • 79955582390 scopus 로고    scopus 로고
    • Assessment and clinical relevance of non-fasting and postprandial triglycerides: An expert panel statement
    • Kolovou, G. D. et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr. Vasc. Pharmacol. 9, 258-270 (2011).
    • (2011) Curr. Vasc. Pharmacol. , vol.9 , pp. 258-270
    • Kolovou, G.D.1
  • 64
    • 34447511196 scopus 로고    scopus 로고
    • Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • Nordestgaard, B. G., Benn, M., Schnohr, P. & Tybjaerg-Hansen, A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 298, 299-308 (2007).
    • (2007) JAMA , vol.298 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 65
    • 84886724847 scopus 로고    scopus 로고
    • International Atherosclerosis Society. IAS Position Paper: Global Recommendations for the Management of Dyslipidemia [online]
    • International Atherosclerosis Society. IAS Position Paper: Global Recommendations for the Management of Dyslipidemia [online], http://www.athero.org/IASPositionPaper.asp (2013).
    • (2013)
  • 66
    • 3342958811 scopus 로고    scopus 로고
    • Non-HDL cholesterol and apolipoprotein B predict cardiovascular disease events among men with type 2 diabetes
    • Jiang, R. et al. Non-HDL cholesterol and apolipoprotein B predict cardiovascular disease events among men with type 2 diabetes. Diabetes Care 27, 1991-1997 (2004).
    • (2004) Diabetes Care , vol.27 , pp. 1991-1997
    • Jiang, R.1
  • 67
    • 22244446183 scopus 로고    scopus 로고
    • Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women
    • Ridker, P. M., Rifai, N., Cook, N. R., Bradwin, G. & Buring, J. E. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA 294, 326-333 (2005).
    • (2005) JAMA , vol.294 , pp. 326-333
    • Ridker, P.M.1    Rifai, N.2    Cook, N.R.3    Bradwin, G.4    Buring, J.E.5
  • 68
    • 0037479469 scopus 로고    scopus 로고
    • Non-HDL cholesterol as a predictor of cardiovascular disease in type 2 diabetes: The Strong Heart Study
    • Lu, W. et al. Non-HDL cholesterol as a predictor of cardiovascular disease in type 2 diabetes: the Strong Heart Study. Diabetes Care 26, 16-23 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 16-23
    • Lu, W.1
  • 69
    • 0034912018 scopus 로고    scopus 로고
    • Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality
    • Cui, Y. et al. Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality. Arch. Intern. Med. 161, 1413-1419 (2001).
    • (2001) Arch. Intern. Med. , vol.161 , pp. 1413-1419
    • Cui, Y.1
  • 70
    • 0035894648 scopus 로고    scopus 로고
    • High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): A prospective study
    • Walldius, G. et al. High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study. Lancet 358, 2026-2033 (2001).
    • (2001) Lancet , vol.358 , pp. 2026-2033
    • Walldius, G.1
  • 71
    • 84876949721 scopus 로고    scopus 로고
    • Association of apolipoprotein B and nuclear magnetic resonance spectroscopy-derived LDL particle number with outcomes in 25 clinical studies: Assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices
    • Cole, T. G. et al. Association of apolipoprotein B and nuclear magnetic resonance spectroscopy-derived LDL particle number with outcomes in 25 clinical studies: assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices. Clin. Chem. 59, 752-770 (2013).
    • (2013) Clin. Chem. , vol.59 , pp. 752-770
    • Cole, T.G.1
  • 72
    • 77952956709 scopus 로고    scopus 로고
    • Diagnosis and treatment of apolipoprotein B dyslipoproteinemias
    • Sniderman, A., Couture, P. & de Graaf, J. Diagnosis and treatment of apolipoprotein B dyslipoproteinemias. Nat. Rev. Endocrinol. 6, 335-346 (2010).
    • (2010) Nat. Rev. Endocrinol. , vol.6 , pp. 335-346
    • Sniderman, A.1    Couture, P.2    De Graaf, J.3
  • 74
    • 0030934629 scopus 로고    scopus 로고
    • The beneficial effects of modest weight loss on cardiovascular risk factors
    • van Gaal, L. F., Wauters, M. A. & De Leeuw, I. H. The beneficial effects of modest weight loss on cardiovascular risk factors. Int. J. Obes. Relat. Metab. Disord. 21 (Suppl. 1), S5-S9 (1997).
    • (1997) Int. J. Obes. Relat. Metab. Disord. , vol.21 , Issue.SUPPL. 1
    • Van Gaal, L.F.1    Wauters, M.A.2    De Leeuw, I.H.3
  • 75
    • 0026781014 scopus 로고
    • Effects of weight reduction on blood lipids and lipoproteins: A meta-analysis
    • Dattilo, A. M. & Kris-Etherton, P. M. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am. J. Clin. Nutr. 56, 320-328 (1992).
    • (1992) Am. J. Clin. Nutr. , vol.56 , pp. 320-328
    • Dattilo, A.M.1    Kris-Etherton, P.M.2
  • 76
    • 61449183682 scopus 로고    scopus 로고
    • Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    • Sacks, F. M. et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N. Engl. J. Med. 360, 859-873 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 859-873
    • Sacks, F.M.1
  • 77
    • 47549110641 scopus 로고    scopus 로고
    • Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet
    • Shai, I. et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N. Engl. J. Med. 359, 229-241 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 229-241
    • Shai, I.1
  • 78
    • 0038135048 scopus 로고    scopus 로고
    • Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials
    • Mensink, R. P., Zock, P. L., Kester, A. D. & Katan, M. B. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am. J. Clin. Nutr. 77, 1146-1155 (2003).
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 1146-1155
    • Mensink, R.P.1    Zock, P.L.2    Kester, A.D.3    Katan, M.B.4
  • 79
    • 0036151904 scopus 로고    scopus 로고
    • Lipoproteins nutrition, and heart disease
    • Schaefe, E. J. Lipoproteins, nutrition, and heart disease. Am. J. Clin. Nutr. 75, 191-212 (2002).
    • (2002) Am. J. Clin. Nutr. , vol.75 , pp. 191-212
    • Schaefe, E.J.1
  • 80
    • 27744494434 scopus 로고    scopus 로고
    • Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: Results of the OmniHeart randomized trial
    • Appel, L. J. et al. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA 294, 2455-2464 (2005).
    • (2005) JAMA , vol.294 , pp. 2455-2464
    • Appel, L.J.1
  • 81
    • 55849086887 scopus 로고    scopus 로고
    • Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: Meta-analyses and meta-regression models of intervention studies
    • Livesey, G. & Taylor, R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am. J. Clin. Nutr. 88, 1419-1437 (2008).
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 1419-1437
    • Livesey, G.1    Taylor, R.2
  • 82
    • 1042299826 scopus 로고    scopus 로고
    • Carbohydrate and fiber recommendations for individuals with diabetes: A quantitative assessment and meta-analysis of the evidence
    • Anderson, J. W., Randles, K. M., Kendall, C. W. & Jenkins, D. J. Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidence. J. Am. Coll. Nutr. 23, 5-17 (2004).
    • (2004) J. Am. Coll. Nutr. , vol.23 , pp. 5-17
    • Anderson, J.W.1    Randles, K.M.2    Kendall, C.W.3    Jenkins, D.J.4
  • 83
    • 72749105175 scopus 로고    scopus 로고
    • Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring Cohort
    • Rumawas, M. E., Meigs, J. B., Dwyer, J. T., McKeown, N. M. & Jacques, P. F. Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring Cohort. Am. J. Clin. Nutr. 90, 1608-1614 (2009).
    • (2009) Am. J. Clin. Nutr. , vol.90 , pp. 1608-1614
    • Rumawas, M.E.1    Meigs, J.B.2    Dwyer, J.T.3    McKeown, N.M.4    Jacques, P.F.5
  • 84
    • 84875787136 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with a Mediterranean diet
    • Estruch, R. et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N. Engl. J. Med. 368, 1279-1290 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1279-1290
    • Estruch, R.1
  • 85
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler, W. C. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393-403 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 393-403
    • Knowler, W.C.1
  • 86
    • 79960969194 scopus 로고    scopus 로고
    • Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes
    • Wing, R. R. et al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 34, 1481-1486 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 1481-1486
    • Wing, R.R.1
  • 87
    • 33745161871 scopus 로고    scopus 로고
    • Resistance exercise training: Its role in the prevention of cardiovascular disease
    • Braith, R. W. & Stewart, K. J. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation 113, 2642-2650 (2006).
    • (2006) Circulation , vol.113 , pp. 2642-2650
    • Braith, R.W.1    Stewart, K.J.2
  • 88
  • 89
    • 84880323061 scopus 로고    scopus 로고
    • Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
    • Wing, R. R. et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N. Engl. J. Med. 369, 145-154 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 145-154
    • Wing, R.R.1
  • 91
    • 32544443164 scopus 로고    scopus 로고
    • Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia
    • Ginsberg, H. N. Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia. J. Clin. Endocrinol. Metab. 91, 383-392 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 383-392
    • Ginsberg, H.N.1
  • 92
    • 12844271249 scopus 로고    scopus 로고
    • Effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on atherogenic dyslipidemia in patients with characteristics of the metabolic syndrome
    • Deedwania, P. C. et al. Effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on atherogenic dyslipidemia in patients with characteristics of the metabolic syndrome. Am. J. Cardiol. 95, 360-366 (2005).
    • (2005) Am. J. Cardiol. , vol.95 , pp. 360-366
    • Deedwania, P.C.1
  • 93
    • 38049033935 scopus 로고    scopus 로고
    • Efficacy of cholesterol-lowering therapy in 18, 686 people with diabetes in 14 randomised trials of statins: A meta-analysis
    • Kearney, P. M. et al. Efficacy of cholesterol-lowering therapy in 18, 686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 371, 117-125 (2008).
    • (2008) Lancet , vol.371 , pp. 117-125
    • Kearney, P.M.1
  • 94
    • 58249086417 scopus 로고    scopus 로고
    • Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk
    • Robinson, J. G., Wang, S., Smith, B. J. & Jacobson, T. A. Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. J. Am. Coll. Cardiol. 53, 316-322 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 316-322
    • Robinson, J.G.1    Wang, S.2    Smith, B.J.3    Jacobson, T.A.4
  • 95
    • 36248963194 scopus 로고    scopus 로고
    • Atorvastatin decreases triacylglycerol-associated risk of vascular events in coronary heart disease patients
    • Athyros, V. G. et al. Atorvastatin decreases triacylglycerol-associated risk of vascular events in coronary heart disease patients. Lipids 42, 999-1009 (2007).
    • (2007) Lipids , vol.42 , pp. 999-1009
    • Athyros, V.G.1
  • 96
    • 84879512429 scopus 로고    scopus 로고
    • Factors underlying regression of coronary atheroma with potent statin therapy
    • Puri, R. et al. Factors underlying regression of coronary atheroma with potent statin therapy. Eur. Heart J. 34, 1818-1825 (2013).
    • (2013) Eur. Heart J. , vol.34 , pp. 1818-1825
    • Puri, R.1
  • 97
    • 79751506305 scopus 로고    scopus 로고
    • Triglycerides and atherogenic dyslipidaemia: Extending treatment beyond statins in the high-risk cardiovascular patient
    • Watts, G. F. & Karpe, F. Triglycerides and atherogenic dyslipidaemia: extending treatment beyond statins in the high-risk cardiovascular patient. Heart 97, 350-356 (2011).
    • (2011) Heart , vol.97 , pp. 350-356
    • Watts, G.F.1    Karpe, F.2
  • 98
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • Ginsberg, H. et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N. Engl. J. Med. 362, 1563-1574 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1563-1574
    • Ginsberg, H.1
  • 99
    • 0032506273 scopus 로고    scopus 로고
    • Mechanism of action of fibrates on lipid and lipoprotein metabolism
    • Staels, B. et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 98, 2088-2093 (1998).
    • (1998) Circulation , vol.98 , pp. 2088-2093
    • Staels, B.1
  • 100
    • 77952955394 scopus 로고    scopus 로고
    • Niacin and fibrates in atherogenic dyslipidemia: Pharmacotherapy to reduce cardiovascular risk
    • Chapman, M. J., Redfern, J. S., McGovern, M. E. & Giral, P. Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular risk. Pharmacol. Ther. 126, 314-345 (2010).
    • (2010) Pharmacol. Ther. , vol.126 , pp. 314-345
    • Chapman, M.J.1    Redfern, J.S.2    McGovern, M.E.3    Giral, P.4
  • 101
    • 0037339775 scopus 로고    scopus 로고
    • Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome
    • Watts, G. F. et al. Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome. Diabetes 52, 803-811 (2003).
    • (2003) Diabetes , vol.52 , pp. 803-811
    • Watts, G.F.1
  • 102
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
    • Jun, M. et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 375, 1875-1884 (2010).
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1
  • 103
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick, M. H. et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med. 317, 1237-1245 (1987).
    • (1987) N. Engl. J. Med. , vol.317 , pp. 1237-1245
    • Frick, M.H.1
  • 104
    • 0026597808 scopus 로고
    • Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment
    • Manninen, V. et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation 85, 37-45 (1992).
    • (1992) Circulation , vol.85 , pp. 37-45
    • Manninen, V.1
  • 105
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins, H. B. et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med. 341, 410-418 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 410-418
    • Rubins, H.B.1
  • 106
    • 0037049366 scopus 로고    scopus 로고
    • Diabetes, plasma insulin, and cardiovascular disease: Subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT)
    • Rubin, H. B. et al. Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT). Arch. Intern. Med. 162, 2597-2604 (2002).
    • (2002) Arch. Intern. Med. , vol.162 , pp. 2597-2604
    • Rubin, H.B.1
  • 107
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) Study
    • The BIP Study Group
    • The BIP Study Group. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) Study. Circulation 102, 21-27 (2000).
    • (2000) Circulation , vol.102 , pp. 21-27
  • 108
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9, 795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • Keech, A. et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9, 795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 366, 1849-1861 (2005).
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1
  • 109
    • 64749095070 scopus 로고    scopus 로고
    • Effects of fenofibrate treatment on cardiovascular disease risk in 9, 795 individuals with type 2 diabetes and various components of the metabolic syndrome: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    • Scott, R. et al. Effects of fenofibrate treatment on cardiovascular disease risk in 9, 795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetes Care 32, 493-498 (2009).
    • (2009) Diabetes Care , vol.32 , pp. 493-498
    • Scott, R.1
  • 110
    • 85048354213 scopus 로고    scopus 로고
    • Combination lipid therapy in type 2 diabetes
    • Sacks, F. M., Carey, V. J. & Fruchart, J. C. Combination lipid therapy in type 2 diabetes. N. Engl. J. Med. 363, 692-695 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 692-695
    • Sacks, F.M.1    Carey, V.J.2    Fruchart, J.C.3
  • 111
    • 36049001784 scopus 로고    scopus 로고
    • Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial
    • Keech, A. C. et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet 370, 1687-1697 (2007).
    • (2007) Lancet , vol.370 , pp. 1687-1697
    • Keech, A.C.1
  • 112
    • 77954654472 scopus 로고    scopus 로고
    • Effects of medical therapies on retinopathy progression in type 2 diabetes
    • Chew, E. Y. et al. Effects of medical therapies on retinopathy progression in type 2 diabetes. N. Engl. J. Med. 363, 233-244 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 233-244
    • Chew, E.Y.1
  • 113
    • 84868533549 scopus 로고    scopus 로고
    • Effects of fibrates in kidney disease: A systematic review and meta-analysis
    • Jun, M. et al. Effects of fibrates in kidney disease: a systematic review and meta-analysis. J. Am. Coll. Cardiol. 60, 2061-2071 (2012).
    • (2012) J. Am. Coll. Cardiol. , vol.60 , pp. 2061-2071
    • Jun, M.1
  • 114
    • 0023001772 scopus 로고
    • Fifteen-year mortality in Coronary Drug Project patients: Long-term benefit with niacin
    • Canner, P. L. et al. Fifteen-year mortality in Coronary Drug Project patients: long-term benefit with niacin. J. Am. Coll. Cardiol. 8, 1245-1255 (1986).
    • (1986) J. Am. Coll. Cardiol. , vol.8 , pp. 1245-1255
    • Canner, P.L.1
  • 115
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown, B. G. et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N. Engl. J. Med. 345, 1583-1592 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1583-1592
    • Brown, B.G.1
  • 116
    • 10044281651 scopus 로고    scopus 로고
    • Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor, A. J., Sullenberger, L. E., Lee, H. J., Lee, J. K. & Grace, K. A. Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 110, 3512-3517 (2004).
    • (2004) Circulation , vol.110 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3    Lee, J.K.4    Grace, K.A.5
  • 117
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • Taylor, A. J. et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N. Engl. J. Med. 361, 2113-2122 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2113-2122
    • Taylor, A.J.1
  • 118
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • Boden, W. E. et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N. Engl. J. Med. 365, 2255-2267 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2255-2267
    • Boden, W.E.1
  • 119
    • 84877299845 scopus 로고    scopus 로고
    • HPS2-THRIVE randomized placebo-controlled trial in 25, 673 high-risk patients of ER niacin/laropiprant: Trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
    • HPS2-THRIVE Collaborative Group
    • HPS2-THRIVE Collaborative Group. HPS2-THRIVE randomized placebo-controlled trial in 25, 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur. Heart J. 34, 1279-1291 (2013).
    • (2013) Eur. Heart J. , vol.34 , pp. 1279-1291
  • 120
    • 84886000801 scopus 로고    scopus 로고
    • Relationship of lipoproteins to cardiovascular events in the atherothrombosis intervention in metabolic syndrome with low hdl/high triglycerides and impact on global health outcomes (AIM-HIGH) trial
    • Guyton, J. R. et al. Relationship of lipoproteins to cardiovascular events in the atherothrombosis intervention in metabolic syndrome with low hdl/high triglycerides and impact on global health outcomes (AIM-HIGH) trial. J. Am. Coll. Cardiol. http://dx.doi.org/10.1016/j.jacc.2013.07.023.
    • J. Am. Coll. Cardiol
    • Guyton, J.R.1
  • 121
    • 22644437126 scopus 로고    scopus 로고
    • Nicotinic acid: The broad-spectrum lipid drug. A 50th anniversary review
    • Carlson L. A. Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. J. Intern. Med. 258, 94-114 (2005).
    • (2005) J. Intern. Med. , vol.258 , pp. 94-114
    • Carlson, L.A.1
  • 122
    • 77956063072 scopus 로고    scopus 로고
    • Cardiovascular effects of marine omega-3 fatty acids
    • Saravanan, P., Davidson, N. C., Schmidt, E. B. & Calder, P. C. Cardiovascular effects of marine omega-3 fatty acids. Lancet 376, 540-550 (2010).
    • (2010) Lancet , vol.376 , pp. 540-550
    • Saravanan, P.1    Davidson, N.C.2    Schmidt, E.B.3    Calder, P.C.4
  • 123
    • 84864219466 scopus 로고    scopus 로고
    • N-3 fatty acids and cardiovascular outcomes in patients with dysglycemia
    • Bosch J. et al. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N. Engl. J. Med. 367, 309-318 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 309-318
    • Bosch, J.1
  • 124
    • 84877624255 scopus 로고    scopus 로고
    • N-3 fatty acids in patients with multiple cardiovascular risk factors
    • Roncaglioni, M. C. et al. n-3 fatty acids in patients with multiple cardiovascular risk factors. N. Engl. J. Med. 368, 1800-1808 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1800-1808
    • Roncaglioni, M.C.1
  • 125
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin e after myocardial infarction: Results of the GISSI-Prevenzione trial
    • GISSI-Prevenzione Investigators.
    • GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354, 447-455 (1999).
    • (1999) Lancet , vol.354 , pp. 447-455
  • 126
    • 34548319692 scopus 로고    scopus 로고
    • Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: An 8-week, randomized, double-blind, placebo-controlled study
    • Davidson, M. H. et al. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin. Ther. 29, 1354-1367 (2007).
    • (2007) Clin. Ther. , vol.29 , pp. 1354-1367
    • Davidson, M.H.1
  • 127
    • 84866124338 scopus 로고    scopus 로고
    • Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study)
    • Ballantyne, C. M. et al. Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Am. J. Cardiol. 110, 984-992 (2012).
    • (2012) Am. J. Cardiol. , vol.110 , pp. 984-992
    • Ballantyne, C.M.1
  • 128
    • 84874674177 scopus 로고    scopus 로고
    • Apolipoprotein C-III is significantly reduced by prescription omega-3 free fatty acids (Epanova) in patients with severe hypertriglyceridemia and changes correlate with increases in LDL-C: A sub-analysis of the EVOLVE trial (abstract)
    • Rader, D. J. et al. Apolipoprotein C-III is significantly reduced by prescription omega-3 free fatty acids (Epanova) in patients with severe hypertriglyceridemia and changes correlate with increases in LDL-C: a sub-analysis of the EVOLVE trial (abstract). Circulation 126, A19030 (2012).
    • (2012) Circulation , vol.126
    • Rader, D.J.1
  • 129
    • 84886725262 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online] http://clinicaltrials.gov/show/NCT01492361 (2012).
    • (2012)
  • 130
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis
    • Yokoyama, M. et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369, 1090-1098 (2007).
    • (2007) Lancet , vol.369 , pp. 1090-1098
    • Yokoyama, M.1
  • 131
    • 84881656596 scopus 로고    scopus 로고
    • Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial
    • Brasky, T. M. et al. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. J. Natl Cancer Inst. http://dx.doi.org/10.1093/jnci/ djt174.
    • J. Natl Cancer Inst
    • Brasky, T.M.1
  • 132
    • 64249120001 scopus 로고    scopus 로고
    • Ezetimibe monotherapy for cholesterol lowering in 2, 722 people: Systematic review and meta-analysis of randomized controlled trials
    • Pandor, A. et al. Ezetimibe monotherapy for cholesterol lowering in 2, 722 people: systematic review and meta-analysis of randomized controlled trials. J. Intern. Med. 265, 568-580 (2009).
    • (2009) J. Intern. Med. , vol.265 , pp. 568-580
    • Pandor, A.1
  • 133
    • 84871738435 scopus 로고    scopus 로고
    • Double-blind randomized clinical trial of the effects of ezetimibe on postprandial hyperlipidaemia and hyperglycaemia
    • Kikuchi, K. et al. Double-blind randomized clinical trial of the effects of ezetimibe on postprandial hyperlipidaemia and hyperglycaemia. J. Atheroscler. Thromb. 19, 1093-1101 (2012).
    • (2012) J. Atheroscler. Thromb. , vol.19 , pp. 1093-1101
    • Kikuchi, K.1
  • 134
    • 84864026904 scopus 로고    scopus 로고
    • A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy
    • Nakamura, T. et al. A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy. J. Cardiol. 60, 12-17 (2012).
    • (2012) J. Cardiol. , vol.60 , pp. 12-17
    • Nakamura, T.1
  • 135
    • 77952674608 scopus 로고    scopus 로고
    • Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet
    • Chan, D. C., Watts, G. F., Gan, S. K., Ooi, E. M. & Barrett, P. H. Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet. Diabetes Care 33, 1134-1139 (2010).
    • (2010) Diabetes Care , vol.33 , pp. 1134-1139
    • Chan, D.C.1    Watts, G.F.2    Gan, S.K.3    Ooi, E.M.4    Barrett, P.H.5
  • 136
    • 67650552637 scopus 로고    scopus 로고
    • Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia
    • Tremblay, A. J., Lamarche, B., Hogue, J. C. & Couture, P. Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia. J. Lipid Res. 50, 1463-1471 (2009).
    • (2009) J. Lipid Res. , vol.50 , pp. 1463-1471
    • Tremblay, A.J.1    Lamarche, B.2    Hogue, J.C.3    Couture, P.4
  • 137
    • 33845296148 scopus 로고    scopus 로고
    • Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: The VYTAL study
    • Goldberg, R. B. et al. Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: the VYTAL study. Mayo Clin. Proc. 81, 1579-1588 (2006).
    • (2006) Mayo Clin. Proc. , vol.81 , pp. 1579-1588
    • Goldberg, R.B.1
  • 138
    • 52649120889 scopus 로고    scopus 로고
    • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • Rossebø, A. et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N. Engl. J. Med. 359, 1343-1356 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1343-1356
    • Rossebø, A.1
  • 139
    • 57449105069 scopus 로고    scopus 로고
    • Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial
    • Fleg, J. et al. Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial. J. Am. Coll. Cardiol. 52, 2198-2205 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 2198-2205
    • Fleg, J.1
  • 140
    • 41649107358 scopus 로고    scopus 로고
    • Simvastatin with or without ezetimibe in familial hypercholesterolemia
    • Kastelein, J. J. et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N. Engl. J. Med. 358, 1431-1443 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1431-1443
    • Kastelein, J.J.1
  • 141
    • 52649138998 scopus 로고    scopus 로고
    • Analyses of cancer data from three ezetimibe trials
    • Peto, R. et al. Analyses of cancer data from three ezetimibe trials. N. Engl. J. Med. 359, 1357-1366 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1357-1366
    • Peto, R.1
  • 142
    • 79959746706 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial
    • Baigent, C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181-2192 (2011).
    • (2011) Lancet , vol.377 , pp. 2181-2192
    • Baigent, C.1
  • 143
    • 77951622890 scopus 로고    scopus 로고
    • An update on the IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design
    • Califf, R. M. et al. An update on the IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design. Am. Heart J. 159, 705-709 (2010).
    • (2010) Am. Heart J. , vol.159 , pp. 705-709
    • Califf, R.M.1
  • 144
    • 58149090676 scopus 로고    scopus 로고
    • The role of incretins in glucose homeostasis and diabetes treatment
    • Kim, W. & Egan, J. M. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol. Rev. 60, 470-512 (2008).
    • (2008) Pharmacol. Rev. , vol.60 , pp. 470-512
    • Kim, W.1    Egan, J.M.2
  • 145
    • 84873040246 scopus 로고    scopus 로고
    • Novel insights into the regulation of postprandial lipemia by glucagon-like peptides: Significance for diabetes
    • Watts, G. F. & Chan, D. C. Novel insights into the regulation of postprandial lipemia by glucagon-like peptides: significance for diabetes. Diabetes 62, 336-338 (2013).
    • (2013) Diabetes , vol.62 , pp. 336-338
    • Watts, G.F.1    Chan, D.C.2
  • 146
    • 84855770694 scopus 로고    scopus 로고
    • Saxagliptin for the treatment of type 2 diabetes mellitus: Assessing cardiovascular data
    • Cobble, M. E. & Frederich, R. Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data. Cardiovasc. Diabetol. 11, 6 (2012).
    • (2012) Cardiovasc. Diabetol. , vol.11 , pp. 6
    • Cobble, M.E.1    Frederich, R.2
  • 147
    • 84875962928 scopus 로고    scopus 로고
    • Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: An open-label trial
    • Gaudet, D. et al. Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial. Gene Ther. 20, 361-369 (2013).
    • (2013) Gene Ther. , vol.20 , pp. 361-369
    • Gaudet, D.1
  • 148
    • 84870874338 scopus 로고    scopus 로고
    • Alipogene tiparvovec: Gene therapy for lipoprotein lipase deficiency
    • Wierzbicki A. S. & Viljoen, A. Alipogene tiparvovec: gene therapy for lipoprotein lipase deficiency. Expert Opin. Biol. Ther. 13, 7-10 (2013).
    • (2013) Expert Opin. Biol. Ther. , vol.13 , pp. 7-10
    • Wierzbicki, A.S.1    Viljoen, A.2
  • 149
    • 84876348493 scopus 로고    scopus 로고
    • Medical resource use and costs associated with chylomicronemia
    • Gaudet, D. et al. Medical resource use and costs associated with chylomicronemia. J. Med. Econ. 16, 657-666 (2013).
    • (2013) J. Med. Econ. , vol.16 , pp. 657-666
    • Gaudet, D.1
  • 150
    • 84885405205 scopus 로고    scopus 로고
    • Dual peroxisome proliferator-activated receptor α/{delta} agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects
    • Cariou, B. et al. Dual peroxisome proliferator-activated receptor α/{delta} agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes Care http://dx.doi.org/10. 2337/dc12-2012.
    • Diabetes Care
    • Cariou, B.1
  • 151
    • 79960988152 scopus 로고    scopus 로고
    • Effects of the new dual PPAR α/δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism
    • Cariou, B., Zaïr, Y., Staels, B. & Bruckert, E. Effects of the new dual PPAR α/δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care 34, 2008-2014 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 2008-2014
    • Cariou, B.1    Zaïr, Y.2    Staels, B.3    Bruckert, E.4
  • 152
    • 84885631651 scopus 로고    scopus 로고
    • Hepato-protective effects of the dual PPARα/δ agonist GFT505 in rodent models of NAFLD/NASH
    • Staels, B. et al. Hepato-protective effects of the dual PPARα/δ agonist GFT505 in rodent models of NAFLD/NASH. Hepatology http://dx.doi.org/10.1002/hep.26461.
    • Hepatology
    • Staels, B.1
  • 153
    • 67649839953 scopus 로고    scopus 로고
    • Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): A phase II, randomised, dose-ranging study
    • Henry, R. R. et al. Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study. Lancet 374, 126-135 (2009).
    • (2009) Lancet , vol.374 , pp. 126-135
    • Henry, R.R.1
  • 154
    • 84886720560 scopus 로고    scopus 로고
    • Media Release: Roche halts investigation of aleglitazar following regular safety review of phase III trial [online]
    • Roche. Media Release: Roche halts investigation of aleglitazar following regular safety review of phase III trial [online], http://www.roche.com/media/ mediareleases/med-cor-2013-07-10.htm (2013).
    • (2013)
    • Roche1
  • 155
    • 84863789387 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk
    • Barter, P. J. & Rye, K. A. Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk. J. Lipid Res. 53, 1755-1766 (2012).
    • (2012) J. Lipid Res. , vol.53 , pp. 1755-1766
    • Barter, P.J.1    Rye, K.A.2
  • 156
    • 80255122648 scopus 로고    scopus 로고
    • Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): A randomised clinical trial
    • Fayad, Z. A. et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial. Lancet 378, 1547-1559 (2011).
    • (2011) Lancet , vol.378 , pp. 1547-1559
    • Fayad, Z.A.1
  • 157
    • 84870045994 scopus 로고    scopus 로고
    • Effects of dalcetrapib in patients with a recent acute coronary syndrome
    • Schwartz, G. G. et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N. Engl. J. Med. 367, 2089-2099 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 2089-2099
    • Schwartz, G.G.1
  • 158
    • 84878698846 scopus 로고    scopus 로고
    • The DGAT1 inhibitor LCQ908 decreases triglyceride levels in patients with the familial chylomicronemia syndrome
    • Meyers, C. et al. The DGAT1 inhibitor LCQ908 decreases triglyceride levels in patients with the familial chylomicronemia syndrome. J. Clin. Lipidol. 6, 266-267 (2012).
    • (2012) J. Clin. Lipidol. , vol.6 , pp. 266-267
    • Meyers, C.1
  • 159
    • 84871938822 scopus 로고    scopus 로고
    • Proof of mechanism for the DGAT1 inhibitor AZD7687: Results from a first-time-in-human single-dose study
    • Denison, H. et al. Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study. Diabetes Obes. Metab. 15, 136-143 (2013).
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 136-143
    • Denison, H.1
  • 160
    • 84871945617 scopus 로고    scopus 로고
    • Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: A single-arm, open-label, phase 3 study
    • Cuchel, M. et al. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 381, 40-46 (2013).
    • (2013) Lancet , vol.381 , pp. 40-46
    • Cuchel, M.1
  • 161
    • 77949485460 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial
    • Raal, F. J. et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet 375, 998-1006 (2010).
    • (2010) Lancet , vol.375 , pp. 998-1006
    • Raal, F.J.1
  • 162
    • 84878637167 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans
    • Graham, M. J. et al. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans. Circ. Res. 112, 1479-1490 (2013).
    • (2013) Circ. Res. , vol.112 , pp. 1479-1490
    • Graham, M.J.1
  • 163
    • 84886727067 scopus 로고    scopus 로고
    • Antisense suppression of serum ApoC-III improves hypertriglyceridemia and insulin sensitivity in multiple species (abstract 51-LB)
    • rd Scientific Sessions (2013).
    • (2013) rd Scientific Sessions
    • Lee, R.G.1
  • 165
    • 67649389843 scopus 로고    scopus 로고
    • Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)
    • Lee, E. C. et al. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J. Biol. Chem. 284, 13735-13745 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 13735-13745
    • Lee, E.C.1
  • 166
    • 44649098307 scopus 로고    scopus 로고
    • Lipoprotein management in patients with cardiometabolic risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation
    • Brunzell, J. D. et al. Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care 31, 811-822 (2008).
    • (2008) Diabetes Care , vol.31 , pp. 811-822
    • Brunzell, J.D.1
  • 167
    • 0027283846 scopus 로고
    • Calculated low-density lipoprotein cholesterol should not be used for management of lipoprotein abnormalities in patients with diabetes mellitus
    • Rubiés-Prat, J. et al. Calculated low-density lipoprotein cholesterol should not be used for management of lipoprotein abnormalities in patients with diabetes mellitus. Diabetes Care 16, 1081-1086 (1993).
    • (1993) Diabetes Care , vol.16 , pp. 1081-1086
    • Rubiés-Prat, J.1
  • 169
    • 39149125755 scopus 로고    scopus 로고
    • Differential response of cholesterol and particle measures of atherogenic lipoproteins to LDL-lowering therapy: Implications for clinical practice
    • Sniderman, A. D. Differential response of cholesterol and particle measures of atherogenic lipoproteins to LDL-lowering therapy: implications for clinical practice. J. Clin. Lipidol. 2, 36-42 (2008).
    • (2008) J. Clin. Lipidol. , vol.2 , pp. 36-42
    • Sniderman, A.D.1
  • 170
    • 1842505376 scopus 로고    scopus 로고
    • Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia
    • Hunninghake, D. B. et al. Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia. Coron. Artery Dis. 15, 115-123 (2004).
    • (2004) Coron. Artery Dis. , vol.15 , pp. 115-123
    • Hunninghake, D.B.1
  • 171
    • 78650505723 scopus 로고    scopus 로고
    • Trig-onometry': Non-high-density lipoprotein cholesterol as a therapeutic target in dyslipidaemia
    • Jacobson, T. A. 'Trig-onometry': non-high-density lipoprotein cholesterol as a therapeutic target in dyslipidaemia. Int. J. Clin. Pract. 65, 82-101 (2011).
    • (2011) Int. J. Clin. Pract. , vol.65 , pp. 82-101
    • Jacobson, T.A.1
  • 172
    • 77952048634 scopus 로고    scopus 로고
    • Colesevelam lowers glucose and lipid levels in type 2 diabetes: The clinical evidence
    • Fonseca, V., Handelsman, Y. & Staels, B. Colesevelam lowers glucose and lipid levels in type 2 diabetes: the clinical evidence. Diabetes Obes. Metab. 12, 384-392 (2010).
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 384-392
    • Fonseca, V.1    Handelsman, Y.2    Staels, B.3
  • 173
    • 57349155535 scopus 로고    scopus 로고
    • Long-term safety and efficacy of fenofibric acid in combination with statin therapy for the treatment of patients with mixed dyslipidemia
    • Bays, H. E. et al. Long-term safety and efficacy of fenofibric acid in combination with statin therapy for the treatment of patients with mixed dyslipidemia. J. Clin. Lipidol. 2, 426-435 (2008).
    • (2008) J. Clin. Lipidol. , vol.2 , pp. 426-435
    • Bays, H.E.1
  • 175
    • 77956230636 scopus 로고    scopus 로고
    • Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients
    • Costet, P. et al. Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients. Atherosclerosis 212, 246-251 (2010).
    • (2010) Atherosclerosis , vol.212 , pp. 246-251
    • Costet, P.1
  • 176
    • 84877982021 scopus 로고    scopus 로고
    • Statin intolerance: Why and what to do-with a focus on diabetic people
    • Matteucci, E. & Giampietro, O. Statin intolerance: why and what to do-with a focus on diabetic people. Curr. Med. Chem. 20, 1397-1408 (2013).
    • (2013) Curr. Med. Chem. , vol.20 , pp. 1397-1408
    • Matteucci, E.1    Giampietro, O.2
  • 177
    • 84870297571 scopus 로고    scopus 로고
    • Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on lipoprotein particle concentration and size in patients with very high triglyceride levels (the MARINE study)
    • Bays, H. E. et al. Icosapent ethyl, a pure EPA omega-3 fatty acid:
    • (2012) J. Clin. Lipidol. , vol.6 , pp. 565-572
    • Bays, H.E.1
  • 178
    • 77957792308 scopus 로고    scopus 로고
    • Treating mixed hyperlipidemia and the atherogenic lipid phenotype for prevention of cardiovascular events
    • Rubenfire, M., Brook, R. D. & Rosenson, R. S. Treating mixed hyperlipidemia and the atherogenic lipid phenotype for prevention of cardiovascular events. Am. J. Med. 123, 892-898 (2010).
    • (2010) Am. J. Med. , vol.123 , pp. 892-898
    • Rubenfire, M.1    Brook, R.D.2    Rosenson, R.S.3
  • 179
    • 84865413263 scopus 로고    scopus 로고
    • Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience
    • Bonds, D. E. et al. Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience. Diabetologia 55, 1641-1650 (2012).
    • (2012) Diabetologia , vol.55 , pp. 1641-1650
    • Bonds, D.E.1
  • 180
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • Guyton, J. R. & Bays, H. E. Safety considerations with niacin therapy. Am. J. Cardiol. 99, 22C-31C (2007).
    • (2007) Am. J. Cardiol. , vol.99
    • Guyton, J.R.1    Bays, H.E.2


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