Inhibition of MK2 shows promise for preventing postoperative ileus in mice

Journal of Surgical Research

Volumn 185, Issue 1, 2013, Pages 102-112

  Liu, Xiaodong ^a   Wu, Ting ^b   Chi, Pan ^a  

^a Department of Colon and Rectal Surgery   (China)

^b XIAMEN UNIVERSITY   (China)

Author keywords

Inflammation; Mitogen activated protein kinase activated protein kinase 2; Postoperative ileus

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2 INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPERIMENTAL MODEL; GASTROINTESTINAL TRANSIT; GENE EXPRESSION; HISTOCHEMISTRY; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY INFILTRATE; INTESTINE MUSCLE; INTESTINE SURGERY; LAPAROTOMY; MACROPHAGE ACTIVATION; MALE; MAST CELL; MOUSE; NEUTROPHIL; NONHUMAN; POSTOPERATIVE ILEUS; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CONTRACTILITY; UPREGULATION;

INFLAMMATION; MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE 2; POSTOPERATIVE ILEUS;

ANIMALS; DISEASE MODELS, ANIMAL; ENTERITIS; ILEUS; INTESTINE, SMALL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MACROPHAGES, PERITONEAL; MALE; MAST CELLS; MICE; MICE, INBRED BALB C; MUSCLE, SMOOTH; NEUTROPHILS; PHOSPHORYLATION; POSTOPERATIVE COMPLICATIONS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES;

EID: 84886719328     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.05.028     Document Type: Article

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