Inhibition of p38 Mitogen-Activated Protein Kinase Pathway as Prophylaxis of Postoperative Ileus in Mice

Gastroenterology

Volumn 136, Issue 2, 2009, Pages 619-629

  Wehner, Sven ^a   Straesser, Stefan ^a   Vilz, Tim O ^a   Pantelis, Dimitrios ^a   Sielecki, Thais ^b   de la Cruz, Vidal F ^b   Hirner, Andreas ^a   Kalff, Joerg C ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Cytokine PharmaSciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; NITRIC OXIDE; PLACEBO; SEMAPIMOD; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON MOTILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; HISTOCHEMISTRY; ILEUS; IMMUNOBLOTTING; INTESTINAL DYSMOTILITY; INTESTINE FUNCTION; INTESTINE MOTILITY; INTESTINE MUSCLE; INTESTINE SURGERY; JEJUNUM; LAPAROTOMY; MACROPHAGE; MALE; MOUSE; MUSCLE CONTRACTILITY; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; ORGAN CULTURE; POSTOPERATIVE COMPLICATION; POSTOPERATIVE ILEUS; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SMALL INTESTINE; SMOOTH MUSCLE; SUPERNATANT;

EID: 58649101351     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.10.017     Document Type: Article

References (32)

1. Prasad M., and Matthews J.B. Deflating post-operative ileus. Gastroenterology 117 (1999) 489-492
2. Livingston E.H., and Passaro Jr. E.P. Post-operative ileus. Dig Dis Sci 35 (1990) 121-132
3. Kalff J.C., Schraut W.H., Simmons R.L., et al. Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg 228 (1998) 652-663
4. Kalff J.C., Carlos T.M., Schraut W.H., et al. Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate post-operative ileus. Gastroenterology 117 (1999) 378-387
5. Kalff J.C., Schraut W.H., Billiar T.R., et al. Role of inducible nitric oxide synthase in post-operative intestinal smooth muscle dysfunction in rodents. Gastroenterology 118 (2000) 316-327
6. Schwarz N.T., Kalff J.C., Turler A., et al. Prostanoid production via COX-2 as a causative mechanism of rodent post-operative ileus. Gastroenterology 121 (2001) 1354-1371
7. Wehner S., Behrendt F.F., Lyutenski B.N., et al. Inhibition of macrophage function prevents intestinal inflammation and post-operative ileus in rodents. Gut 56 (2007) 176-185
8. Wehner S., Schwarz N.T., Hundsdoerfer R., et al. Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery 137 (2005) 436-446
9. Kalff J.C., Schwarz N.T., Walgenbach K.J., et al. Leukocytes of the intestinal muscularis externa: their phenotype and isolation. J Leukoc Biol 63 (1998) 683-691
10. Coates M.D., Johnson A.C., Greenwood-Van M.B., et al. Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse. Neurogastroenterol Motil 18 (2006) 464-471
11. Woessner Jr. J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid. Arch Biochem Biophys 93 (1961) 440-447
12. Ishimura K., Moroguchi A., Okano K., et al. Local expression of tumor necrosis factor-alpha and interleukin-10 on wound healing of intestinal anastomosis during endotoxemia in mice. J Surg Res 108 (2002) 91-97
13. Turler A., Moore B.A., Pezzone M.A., et al. Colonic post-operative inflammatory ileus in the rat. Ann Surg 236 (2002) 56-66
14. Turler A., Schnurr C., Nakao A., et al. Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Ann Surg 245 (2007) 734-744
15. Schwarz N.T., Kalff J.C., Turler A., et al. Selective jejunal manipulation causes post-operative pan-enteric inflammation and dysmotility. Gastroenterology 126 (2004) 159-169
16. The F.O., de Jonge W.J., Bennink R.J., et al. The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of post-operative ileus in mice. Br J Pharmacol 146 (2005) 252-258
17. Turler A., Schwarz N.T., Turler E., et al. MCP-1 causes leukocyte recruitment and subsequently endotoxemic ileus in rat. Am J Physiol Gastrointest Liver Physiol 282 (2002) G145-G155
18. Kalff J.C., Turler A., Schwarz N.T., et al. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 237 (2003) 301-315
19. Minnich D.J., and Moldawer L.L. Anti-cytokine and anti-inflammatory therapies for the treatment of severe sepsis: progress and pitfalls. Proc Nutr Soc 63 (2004) 437-441
20. Moore B.A., Turler A., Pezzone M.A., et al. Tyrphostin AG 126 inhibits development of post-operative ileus induced by surgical manipulation of murine colon. Am J Physiol Gastrointest Liver Physiol 286 (2004) G214-G224
21. Hollenbach E., Neumann M., Vieth M., et al. Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease. FASEB J 18 (2004) 1550-1552
22. Waetzig G.H., Seegert D., Rosenstiel P., et al. p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease. J Immunol 168 (2002) 5342-5351
23. Cohen P.S., Nakshatri H., Dennis J., et al. CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency. Proc Natl Acad Sci U S A 93 (1996) 3967-3971
24. Bianchi M., Bloom O., Raabe T., et al. Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. J Exp Med 183 (1996) 927-936
25. Bjork L., Tracey K.J., Ulrich P., et al. Targeted suppression of cytokine production in monocytes but not in T lymphocytes by a tetravalent guanylhydrazone (CNI-1493). J Infect Dis 176 (1997) 1303-1312
26. Löwenberg M., Verhaar A., van den Blink B., et al. Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease. J Immunol 175 (2005) 2293-2300
27. Wang H., Zhang M., Bianchi M., et al. Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophage deactivating molecules. Proc Natl Acad Sci U S A 95 (1998) 14429-14434
28. Salinthone S., Singer C.A., and Gerthoffer W.T. Inflammatory gene expression by human colonic smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 287 (2004) G627-G637
29. Bianchi M., Ulrich P., Bloom O., et al. An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality. Mol Med 1 (1995) 254-266
30. Bernik T.R., Friedman S.G., Ochani M., et al. Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med 195 (2002) 781-788
31. Oke S.L., and Tracey K.J. From CNI-1493 to the immunological homunculus: physiology of the inflammatory reflex. J Leukoc Biol 83 (2008) 512-517
32. de Jonge W.J., van der Zanden E.P., The F.O., et al. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol 6 (2005) 844-851