메뉴 건너뛰기




Volumn 12, Issue 19, 2013, Pages 3364-3372

CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells

Author keywords

CD147; Lactate; MCT1; MCT4; Multiple myeloma

Indexed keywords

CD147 ANTIGEN; LACTIC ACID; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 4; SMALL INTERFERING RNA;

EID: 84886712582     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.26193     Document Type: Article
Times cited : (69)

References (36)
  • 1
    • 6944235003 scopus 로고    scopus 로고
    • Multiple myeloma
    • PMID:15509819
    • Kyle RA, Rajkumar SV. Multiple myeloma. N Engl J Med 2004; 351:1860-73; PMID:15509819; http://dx.doi.org/10.1056/NEJMra041875
    • (2004) N Engl J Med , vol.351 , pp. 1860-1873
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 3
    • 0036760289 scopus 로고    scopus 로고
    • Monoclonal gammopathies of undetermined significance
    • DOI 10.1046/j.1468-0734.2002.00076.x
    • Kyle RA, Rajkumar SV. Monoclonal gammopathies of undetermined significance. Rev Clin Exp Hematol 2002; 6:225-52; PMID:12616697; http://dx.doi.org/10.1046/j.1468-0734.2002.00076.x (Pubitemid 35408172)
    • (2002) Reviews in Clinical and Experimental Hematology , vol.6 , Issue.3 , pp. 225-252
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 4
    • 25144454122 scopus 로고    scopus 로고
    • Genomics in multiple myeloma: Biology and clinical implications
    • DOI 10.2217/14622416.6.6.563
    • Chng WJ, Fonseca R. Genomics in multiple myeloma: biology and clinical implications. Pharmacogenomics 2005; 6:563-73; PMID:16142997; http://dx.doi.org/10.2217/14622416.6.6.563 (Pubitemid 41341623)
    • (2005) Pharmacogenomics , vol.6 , Issue.6 , pp. 563-573
    • Chng, W.J.1    Fonseca, R.2
  • 5
    • 27244445489 scopus 로고    scopus 로고
    • Molecular pathogenesis and a consequent classification of multiple myeloma
    • DOI 10.1200/JCO.2005.05.021
    • Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 2005; 23:6333-8; PMID:16155016; http://dx.doi.org/10.1200/JCO.2005.05.021 (Pubitemid 46218843)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.26 , pp. 6333-6338
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 6
    • 84867405610 scopus 로고    scopus 로고
    • Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: Role in regulation of myeloma cell proliferation
    • PMID:22460757
    • Arendt BK, Walters DK, Wu X, Tschumper RC, Huddleston PM, Henderson KJ, Dispenzieri A, Jelinek DF. Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation. Leukemia 2012; 26:2286-96; PMID:22460757; http://dx.doi.org/10.1038/leu.2012.91
    • (2012) Leukemia , vol.26 , pp. 2286-2296
    • Arendt, B.K.1    Walters, D.K.2    Wu, X.3    Tschumper, R.C.4    Huddleston, P.M.5    Henderson, K.J.6    Dispenzieri, A.7    Jelinek, D.F.8
  • 7
    • 36048958229 scopus 로고    scopus 로고
    • CD147 immunoglobulin superfamily receptor function and role in pathology
    • DOI 10.1016/j.yexmp.2007.08.014, PII S0014480007001116
    • Iacono KT, Brown AL, Greene MI, Saouaf SJ. CD147 immunoglobulin superfamily receptor function and role in pathology. Exp Mol Pathol 2007; 83:283- 95; PMID:17945211; http://dx.doi.org/10.1016/j. yexmp.2007.08.014 (Pubitemid 350087035)
    • (2007) Experimental and Molecular Pathology , vol.83 , Issue.3 , pp. 283-295
    • Iacono, K.T.1    Brown, A.L.2    Greene, M.I.3    Saouaf, S.J.4
  • 8
    • 0034254638 scopus 로고    scopus 로고
    • CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
    • Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 2000; 19:3896- 904; PMID:10921872; http://dx.doi.org/10.1093/emboj/19.15.3896 (Pubitemid 30608530)
    • (2000) EMBO Journal , vol.19 , Issue.15 , pp. 3896-3904
    • Kirk, P.1    Wilson, M.C.2    Heddle, C.3    Brown, M.H.4    Barclay, A.N.5    Halestrap, A.P.6
  • 9
    • 84855444042 scopus 로고    scopus 로고
    • The monocarboxylate transporter family-Structure and functional characterization
    • PMID:22131303
    • Halestrap AP. The monocarboxylate transporter family-Structure and functional characterization. IUBMB Life 2012; 64:1-9; PMID:22131303; http://dx.doi.org/10.1002/iub.573
    • (2012) IUBMB Life , vol.64 , pp. 1-9
    • Halestrap, A.P.1
  • 10
    • 81455128226 scopus 로고    scopus 로고
    • Lactate shuttles at a glance: From physiological paradigms to anti-cancer treatments
    • PMID:22065843
    • Draoui N, Feron O. Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech 2011; 4:727-32; PMID:22065843; http://dx.doi.org/10.1242/dmm.007724
    • (2011) Dis Model Mech , vol.4 , pp. 727-732
    • Draoui, N.1    Feron, O.2
  • 11
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • PMID:19460998
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 12
    • 75149178349 scopus 로고    scopus 로고
    • Tumor metabolism of lactate: The influence and therapeutic potential for MCT and CD147 regulation
    • PMID:20021214
    • Kennedy KM, Dewhirst MW. Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future Oncol 2010; 6:127-48; PMID:20021214; http://dx.doi.org/10.2217/fon.09.145
    • (2010) Future Oncol , vol.6 , pp. 127-148
    • Kennedy, K.M.1    Dewhirst, M.W.2
  • 14
    • 84872548105 scopus 로고    scopus 로고
    • PDK1 inhibition is a novel therapeutic target in multiple myeloma
    • PMID:23321518
    • Fujiwara S, Kawano Y, Yuki H, Okuno Y, Nosaka K, Mitsuya H, Hata H. PDK1 inhibition is a novel therapeutic target in multiple myeloma. Br J Cancer 2013; 108:170-8; PMID:23321518; http://dx.doi.org/10.1038/bjc.2012.527
    • (2013) Br J Cancer , vol.108 , pp. 170-178
    • Fujiwara, S.1    Kawano, Y.2    Yuki, H.3    Okuno, Y.4    Nosaka, K.5    Mitsuya, H.6    Hata, H.7
  • 16
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family - From monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • DOI 10.1007/s00424-003-1067-2, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Halestrap AP, Meredith D. The SLC16 gene familyfrom monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 2004; 447:619-28; PMID:12739169; http://dx.doi.org/10.1007/s00424-003-1067- 2 (Pubitemid 38241446)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 17
    • 0036479231 scopus 로고    scopus 로고
    • Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in Situ
    • DOI 10.1074/jbc.M109658200
    • Wilson MC, Meredith D, Halestrap AP. Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. J Biol Chem 2002; 277:3666-72; PMID:11719518; http://dx.doi.org/10.1074/ jbc.M109658200 (Pubitemid 34953240)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.5 , pp. 3666-3672
    • Wilson, M.C.1    Meredith, D.2    Halestrap, A.P.3
  • 18
    • 80053640489 scopus 로고    scopus 로고
    • CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
    • PMID:21930917
    • Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J. CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A 2011; 108:16663-8; PMID:21930917; http://dx.doi.org/10.1073/pnas.1106123108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3    Naiken, T.4    Ilc, K.5    Murray, C.M.6    Critchlow, S.E.7    Roux, D.8    Simon, M.P.9    Pouysségur, J.10
  • 21
    • 70349307027 scopus 로고    scopus 로고
    • CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models
    • PMID:19505879
    • Schneiderhan W, Scheler M, Holzmann KH, Marx M, Gschwend JE, Bucholz M, Gress TM, Seufferlein T, Adler G, Oswald F. CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models. Gut 2009; 58:1391-8; PMID:19505879; http://dx.doi.org/10. 1136/gut.2009.181412
    • (2009) Gut , vol.58 , pp. 1391-1398
    • Schneiderhan, W.1    Scheler, M.2    Holzmann, K.H.3    Marx, M.4    Gschwend, J.E.5    Bucholz, M.6    Gress, T.M.7    Seufferlein, T.8    Adler, G.9    Oswald, F.10
  • 24
    • 84858703378 scopus 로고    scopus 로고
    • Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)
    • PMID:22281667
    • de Oliveira AT, Pinheiro C, Longatto-Filho A, Brito MJ, Martinho O, Matos D, Carvalho AL, Vazquez VL, Silva TB, Scapulatempo C, et al. Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs). J Bioenerg Biomembr 2012; 44:171- 8; PMID:22281667; http://dx.doi.org/10.1007/ s10863-012-9408-5
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 171-178
    • De Oliveira, A.T.1    Pinheiro, C.2    Longatto-Filho, A.3    Brito, M.J.4    Martinho, O.5    Matos, D.6    Carvalho, A.L.7    Vazquez, V.L.8    Silva, T.B.9    Scapulatempo, C.10
  • 26
    • 84857716739 scopus 로고    scopus 로고
    • Multiple biological activities of lactic acid in cancer: Influences on tumor growth, angiogenesis and metastasis
    • PMID:22360558
    • Dhup S, Dadhich RK, Porporato PE, Sonveaux P. Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr Pharm Des 2012; 18:1319-30; PMID:22360558; http://dx.doi.org/10.2174/138161212799504902
    • (2012) Curr Pharm des , vol.18 , pp. 1319-1330
    • Dhup, S.1    Dadhich, R.K.2    Porporato, P.E.3    Sonveaux, P.4
  • 27
    • 84857222449 scopus 로고    scopus 로고
    • Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors
    • PMID:22184616
    • Boidot R, Végran F, Meulle A, Le Breton A, Dessy C, Sonveaux P, Lizard-Nacol S, Feron O. Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Cancer Res 2012; 72:939-48; PMID:22184616; http://dx.doi.org/10.1158/0008-5472.CAN-11- 2474
    • (2012) Cancer Res , vol.72 , pp. 939-948
    • Boidot, R.1    Végran, F.2    Meulle, A.3    Le Breton, A.4    Dessy, C.5    Sonveaux, P.6    Lizard-Nacol, S.7    Feron, O.8
  • 28
    • 4043110513 scopus 로고    scopus 로고
    • Lactate metabolism: A new paradigm for the third millennium
    • DOI 10.1113/jphysiol.2003.058701
    • Gladden LB. Lactate metabolism: a new paradigm for the third millennium. J Physiol 2004; 558:5- 30; PMID:15131240; http://dx.doi.org/10.1113/jphysiol. 2003.058701 (Pubitemid 39077388)
    • (2004) Journal of Physiology , vol.558 , Issue.1 , pp. 5-30
    • Gladden, L.B.1
  • 29
    • 77957733923 scopus 로고    scopus 로고
    • Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients
    • PMID:20574050
    • Broyl A, Hose D, Lokhorst H, de Knegt Y, Peeters J, Jauch A, Bertsch U, Buijs A, Stevens-Kroef M, Beverloo HB, et al. Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients. Blood 2010; 116:2543- 53; PMID:20574050; http://dx.doi.org/10.1182/blood-2009-12- 261032
    • (2010) Blood , vol.116 , pp. 2543-2553
    • Broyl, A.1    Hose, D.2    Lokhorst, H.3    De Knegt, Y.4    Peeters, J.5    Jauch, A.6    Bertsch, U.7    Buijs, A.8    Stevens-Kroef, M.9    Beverloo, H.B.10
  • 30
    • 79954603194 scopus 로고    scopus 로고
    • Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
    • PMID:21306479
    • Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, Sasaguri Y, Nishizawa S, Kohno K. Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci 2011; 102:1007-13; PMID:21306479; http://dx.doi.org/10.1111/j.1349-7006.2011.01908.x
    • (2011) Cancer Sci , vol.102 , pp. 1007-1013
    • Izumi, H.1    Takahashi, M.2    Uramoto, H.3    Nakayama, Y.4    Oyama, T.5    Wang, K.Y.6    Sasaguri, Y.7    Nishizawa, S.8    Kohno, K.9
  • 31
    • 74349094033 scopus 로고    scopus 로고
    • AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10
    • PMID:19929853
    • Ovens MJ, Davies AJ, Wilson MC, Murray CM, Halestrap AP. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J 2010; 425:523- 30; PMID:19929853; http://dx.doi.org/10.1042/BJ20091515
    • (2010) Biochem J , vol.425 , pp. 523-530
    • Ovens, M.J.1    Davies, A.J.2    Wilson, M.C.3    Murray, C.M.4    Halestrap, A.P.5
  • 32
    • 80051785331 scopus 로고    scopus 로고
    • Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX
    • PMID:21566653
    • Walters DK, Wu X, Tschumper RC, Arendt BK, Huddleston PM, Henderson KJ, Dispenzieri A, Jelinek DF. Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX. Leukemia 2011; 25:1344- 53; PMID:21566653; http://dx.doi.org/10.1038/leu.2011.94
    • (2011) Leukemia , vol.25 , pp. 1344-1353
    • Walters, D.K.1    Wu, X.2    Tschumper, R.C.3    Arendt, B.K.4    Huddleston, P.M.5    Henderson, K.J.6    Dispenzieri, A.7    Jelinek, D.F.8
  • 33
    • 0029889061 scopus 로고    scopus 로고
    • Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6
    • Westendorf JJ, Ahmann GJ, Greipp PR, Witzig TE, Lust JA, Jelinek DF. Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6. Leukemia 1996; 10:866-76; PMID:8656685 (Pubitemid 26168407)
    • (1996) Leukemia , vol.10 , Issue.5 , pp. 866-876
    • Westendorf, J.J.1    Ahmann, G.J.2    Greipp, P.R.3    Witzig, T.E.4    Kyle, R.A.5    Lust, J.A.6    Jelinek, D.F.7
  • 34
    • 0027420353 scopus 로고
    • Coexistence of aneuploid subclones within a myeloma cell line that exhibits clonal immunoglobulin gene rearrangement: Clinical implications
    • Jelinek DF, Ahmann GJ, Greipp PR, Jalal SM, Westendorf JJ, Katzmann JA, Kyle RA, Lust JA. Coexistence of aneuploid subclones within a myeloma cell line that exhibits clonal immunoglobulin gene rearrangement: clinical implications. Cancer Res 1993; 53:5320-7; PMID:8221668 (Pubitemid 23333406)
    • (1993) Cancer Research , vol.53 , Issue.21 , pp. 5320-5327
    • Jelinek, D.F.1    Ahmann, G.J.2    Greipp, P.R.3    Jalal, S.M.4    Westendorf, J.J.5    Katzmann, J.A.6    Kyle, R.A.7    Lust, J.A.8
  • 36
    • 0038798673 scopus 로고    scopus 로고
    • Atypical expression of ErbB3 in myeloma cells: Cross-talk between ErbB3 and the interferon-α signaling complex
    • DOI 10.1038/sj.onc.1206512
    • Walters DK, French JD, Arendt BK, Jelinek DF. Atypical expression of ErbB3 in myeloma cells: cross-talk between ErbB3 and the interferon-alpha signaling complex. Oncogene 2003; 22:3598- 607; PMID:12789268; http://dx.doi.org/10.1038/sj.onc.1206512 (Pubitemid 36765319)
    • (2003) Oncogene , vol.22 , Issue.23 , pp. 3598-3607
    • Walters, D.K.1    French, J.D.2    Arendt, B.K.3    Jelinek, D.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.