Efficient gene delivery to pig airway epithelia and submucosal glands using helper-dependent adenoviral vectors

Molecular Therapy Nucleic Acids

Volumn 2, Issue OCT, 2013, Pages e127-

  Cao, Huibi ^a   Machuca, Tiago N ^c   Yeung, Jonathan C ^c   Wu, Jing ^a   Du, Kai ^d   Duan, Cathleen ^a   Hashimoto, Kohei ^c   Linacre, Virginia ^c   Coates, Allan L ^a,e   Leung, Kitty ^a   Wang, Jian ^a,b   Yeger, Herman ^d   Cutz, Ernest ^d   Liu, Mingyao ^c   Keshavjee, Shaf ^c   Hu, Jim ^a,d,e  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cystic fibrosis; Lung gene delivery; Pig

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKERATIN 18;

AEROSOL; AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BRONCHIOLE; BRONCHOSCOPY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL PIG; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG FUNCTION TEST; LUNG LAVAGE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OXYGEN TENSION; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RESPIRATORY EPITHELIUM; SAFETY; SUBMUCOSA; TIGHT JUNCTION; TISSUE DISTRIBUTION; TRACHEOBRONCHIAL TREE; TRANSGENE; WILD TYPE; ADENOVIRUS; CONTROLLED STUDY; EPITHELIUM CELL; GENE THERAPY; MUCUS GLAND; SUBMUCOSAL GLAND;

EID: 84886579581     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2013.55     Document Type: Article

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