MART-10, a less calcemic vitamin D analog, is more potent than 1α,25-dihydroxyvitamin D3 in inhibiting the metastatic potential of MCF-7 breast cancer cells in vitro

Journal of Steroid Biochemistry and Molecular Biology

Volumn 139, Issue , 2014, Pages 54-60

  Chiang, Kun Chun ^a,b   Chen, Shin Cheh ^a   Yeh, Chun Nan ^a   Pang, Jong Hwei S ^b   Shen, Shih Che ^a   Hsu, Jun Te ^a   Liu, Yu Yin ^a   Chen, Li Wei ^a   Kuo, Sheng Fong ^a   Takano, Masashi ^c   Kittaka, Atsushi ^c   Sun, Chi Chin ^a   Juang, Horng Heng ^b   Chen, Tai C ^d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c TEIKYO UNIVERSITY   (Japan)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; EMT; Invasion; MART 10; MCF 7; Metastasis; Migration; Vitamin D analog

Indexed keywords

19 NOR 2ALPHA (3 HYDROXYPROPYL) 1ALPHA,25 DIHYDROXYVITAMIN D 3; CALCITRIOL; CALCITRIOL DERIVATIVE; COLLAGENASE 3; GELATINASE A; GELATINASE B; MART 10; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; UVOMORULIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST METASTASIS; CANCER INHIBITION; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE ARREST; CELL INVASION; CELL MIGRATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS INHIBITION; METASTASIS POTENTIAL; PROTEIN EXPRESSION; SURVIVAL RATE; TUMOR INVASION; UPREGULATION;

1Α,25(OH)(2)D; 1Α,25-DIHYDROXYVITAMIN D; 19-NOR-2Α-(3-HYDROXYPROPYL)-1Α,25(OH)(2)D(3); BREAST CANCER; EMT; EPITHELIAL-MESENCHYMAL TRANSITION; FBS; FETAL BOVINE SERUM; INVASION; MART-10; MCF-7; METASTASIS; MIGRATION; VDR; VITAMIN D ANALOG; VITAMIN D RECEPTOR;

ANTIGENS, CD; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CADHERINS; CELL MOVEMENT; CHOLECALCIFEROL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MCF-7 CELLS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR; VITAMIN D;

ANIMALIA; GASTROPODA;

EID: 84886555004     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.10.005     Document Type: Article

References (45)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2013 CA: Cancer J. Clin. 63 2013 11 30
2. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2012 CA: Cancer J. Clin. 62 1 2012 10 29
3. S.A. Rabbani, and A.P. Mazar Evaluating distant metastases in breast cancer: from biology to outcomes Cancer Metastasis Rev. 26 3-4 2007 663 674 (Pubitemid 350115115)
4. S. Valastyan, and R.A. Weinberg Tumor metastasis: molecular insights and evolving paradigms Cell 147 2 2011 275 292
5. K.C. Chiang, and T.C. Chen The anti-cancer actions of vitamin D Anti-Cancer Agents Med. Chem. 13 1 2013 126 139
6. A. Kittaka, A. Yoshida, K.C. Chiang, M. Takano, D. Sawada, T. Sakaki, and T.C. Chen Potent 19-norvitamin D analogs for prostate and liver cancer therapy Future Med. Chem. 4 16 2012 2049 2065
7. S.S. Jensen, M.W. Madsen, J. Lukas, L. Binderup, and J. Bartek Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery Mol. Endocrinol. 15 8 2001 1370 1380 (Pubitemid 32703484)
8. 3 analog EB 1089 enhances the antiproliferative and apoptotic effects of adriamycin in MCF-7 breast tumor cells Breast Cancer Res. Treat. 63 1 2000 1 10
9. 3 analog, ILX-23-7553, enhances the response to adriamycin and irradiation in MCF-7 breast tumor cells Cancer Chemother. Pharmacol. 47 5 2001 429 436 (Pubitemid 32397620)
10. J. Abe-Hashimoto, T. Kikuchi, T. Matsumoto, Y. Nishii, E. Ogata, and K. Ikeda Antitumor effect of 22-oxa-calcitriol, a noncalcemic analogue of calcitriol, in athymic mice implanted with human breast carcinoma and its synergism with tamoxifen Cancer Res. 53 11 1993 2534 2537 (Pubitemid 23168018)
11. 3 analogs and paclitaxel on the growth of MCF-7 breast cancer cells in vivo Breast Cancer Res. Treat. 53 2 1999 113 120 (Pubitemid 29161117)
12. D.J. Mantell, P.E. Owens, N.J. Bundred, E.B. Mawer, and A.E. Canfield 1 alpha,25-Dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo Circ. Res. 87 3 2000 214 220 (Pubitemid 30626429)
13. M. Bower, K.W. Colston, R.C. Stein, A. Hedley, J.C. Gazet, H.T. Ford, and R.C. Combes Topical calcipotriol treatment in advanced breast cancer Lancet 337 8743 1991 701 702
14. T. Gulliford, J. English, K.W. Colston, P. Menday, S. Moller, and R.C. Coombes A phase 'I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer Br. J. Cancer 78 1 1998 6 13 (Pubitemid 28276762)
15. 3 Biochemistry 22 15 1983 3636 3640 (Pubitemid 13032714)
16. 3, a novel vitamin D-related compound with potential therapeutic activity Tetra. Lett. 31 13 1990 1823 1824 (Pubitemid 20106899)
17. A. Kittaka, N. Saito, S. Honzawa, K. Takenouchi, S. Ishizuka, T.C. Chen, S. Peleg, S. Kato, and M.A. Arai Creative synthesis of novel vitamin D analogs for health and disease J. Steroid Biochem. Mol. Biol. 103 3-5 2007 269 276 (Pubitemid 46401300)
18. K. Ono, A. Yoshida, N. Saito, T. Fujishima, S. Honzawa, Y. Suhara, S. Kishimoto, T. Sugiura, K. Waku, H. Takayama, and A. Kittaka Efficient synthesis of 2-modified 1alpha,25-dihydroxy-19-norvitamin D3 with Julia olefination: high potency in induction of differentiation on HL-60 cells J. Org. Chem. 68 19 2003 7407 7415 (Pubitemid 37122492)
19. 3 as a therapeutic agent for androgen-dependent prostate cancer Anticancer Res. 29 9 2009 3547 3553
20. 3 analogs as therapeutic agents for prostate cancer J. Steroid Biochem. Mol. Biol. 103 3-5 2007 717 720 (Pubitemid 46401314)
21. 3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells J. Steroid Biochem. Mol. Biol. 127 3-5 2011 269 275
22. 3 (MART-10) is a potent cell growth regulator with enhanced chemotherapeutic potency in liver cancer cells Steroids 76 13 2011 1513 1519
23. K.C. Chiang, C.N. Yeh, J.T. Hsu, T.S. Yeh, Y.Y. Jan, C.T. Wu, H.Y. Chen, S.C. Jwo, M. Takano, A. Kittaka, H.H. Juang, and T.C. Chen Evaluation of the potential therapeutic role of a new generation of vitamin D analog, MART-10, in human pancreatic cancer cells in vitro and in vivo Cell Cycle 12 8 2013 1316 1325
24. K.C. Chiang, C.N. Yeh, S.C. Chen, S.C. Shen, J.T. Hsu, T.S. Yeh, J.H. Pang, L.J. Su, M. Takano, A. Kittaka, H.H. Juang, and T.C. Chen MART-10, a new generation of vitamin D Analog is more potent than 1alpha,25-dihydroxyvitamin D(3) in inhibiting cell proliferation and inducing apoptosis in ER + MCF-7 breast cancer cells Evid. Based Complement. Altern. Med.: eCAM 2012 2012 310872
25. K.H. Tsui, L.C. Chung, T.H. Feng, P.L. Chang, and H.H. Juang Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell prolifertation and cell invasion in prostate carcinoma cells Int. J. Cancer 2011
26. J. Brasch, O.J. Harrison, B. Honig, and L. Shapiro Thinking outside the cell: how cadherins drive adhesion Trends Cell. Biol. 2012
27. U.H. Frixen, and Y. Nagamine Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin-dependent cell-cell adhesion Cancer Res. 53 15 1993 3618 3623 (Pubitemid 23229646)
28. M.J. Duffy, P. O'Grady, D. Devaney, L. O'Siorain, J.J. Fennelly, and H.J. Lijnen Urokinase-plasminogen activator, a marker for aggressive breast carcinomas: preliminary report Cancer 62 3 1988 531 533
29. M.J. Duffy, D. Reilly, C. O'Sullivan, N. O'Higgins, J.J. Fennelly, and P. Andreasen Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer Cancer Res. 50 21 1990 6827 6829 (Pubitemid 20361075)
30. W. Birchmeier, J. Hulsken, and J. Behrens Adherens junction proteins in tumour progression Cancer Surveys 24 1995 129 140
31. E. Tsanou, D. Peschos, A. Batistatou, A. Charalabopoulos, and K. Charalabopoulos The E-cadherin adhesion molecule and colorectal cancer: a global literature approach Anticancer Res. 28 6A 2008 3815 3826
32. L.D. Derycke, and M.E. Bracke N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling Int. J. Develop. Biol. 48 5-6 2004 463 476 (Pubitemid 39360397)
33. Y. Katsuno, S. Lamouille, and R. Derynck TGF-beta signaling and epithelial-mesenchymal transition in cancer progression Curr. Opin. Oncol. 25 1 2013 76 84
34. J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial- mesenchymal transitions in development and disease Cell 139 5 2009 871 890
35. C. Scheel, E.N. Eaton, S.H. Li, C.L. Chaffer, F. Reinhardt, K.J. Kah, G. Bell, W. Guo, J. Rubin, A.L. Richardson, and R.A. Weinberg Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast Cell 145 6 2011 926 940
36. S.A. Mani, W. Guo, M.J. Liao, E.N. Eaton, A. Ayyanan, A.Y. Zhou, M. Brooks, F. Reinhard, C.C. Zhang, M. Shipitsin, L.L. Campbell, K. Polyak, C. Brisken, J. Yang, and R.A. Weinberg The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 4 2008 704 715 (Pubitemid 351636299)
37. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 5 2011 646 674
38. H. Peinado, D. Olmeda, and A. Cano Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7 6 2007 415 428 (Pubitemid 46809165)
39. M.H. Chui Insights into cancer metastasis from a clinicopathologic perspective: epithelial-mesenchymal transition is not a necessary step In. J. Cancer Journal international du cancer 132 7 2013 1487 1495
40. 3 and its analogues down-regulate cell invasion-associated proteases in cultured malignant cells Cell Growth Differ. 11 4 2000 221 229 (Pubitemid 30211011)
41. M. Polette, C. Clavel, M. Cockett, S. Girod de Bentzmann, G. Murphy, and P. Birembaut Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology Invasion Metastasis 13 1 1993 31 37 (Pubitemid 23275219)
42. H. Ueno, H. Nakamura, M. Inoue, K. Imai, M. Noguchi, H. Sato, M. Seiki, and Y. Okada Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas Cancer Res. 57 10 1997 2055 2060 (Pubitemid 27209741)
43. C.M. Hansen, T.L. Frandsen, N. Brunner, and L. Binderup 1 alpha,25-Dihydroxyvitamin D3 inhibits the invasive potential of human breast cancer cells in vitro Clin. Exp. Metastasis 12 3 1994 195 202
44. C.J. Narvaez, G. Zinser, and J. Welsh Functions of 1alpha,25- dihydroxyvitamin D(3) in mammary gland: from normal development to breast cancer Steroids 66 3-5 2001 301 308 (Pubitemid 32140908)
45. J. Welsh Cellular and molecular effects of vitamin D on carcinogenesis Arch. Biochem. Biophys. 523 1 2012 107 114