19-Nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D 3 (MART-10) is a potent cell growth regulator with enhanced chemotherapeutic potency in liver cancer cells

Steroids

Volumn 76, Issue 13, 2011, Pages 1513-1519

  Chiang, Kun Chun ^a   Yeh, Chun Nan ^a   Chen, Huang Yang ^a   Lee, Jim Ming ^a   Juang, Horng Heng ^a   Chen, Miin Fu ^a   Takano, Masashi ^b   Kittaka, Atsushi ^b   Chen, Tai C ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b TEIKYO UNIVERSITY   (Japan)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiproliferation; Apoptosis; Cell cycle; Hepatoma; Vitamin D analog

Indexed keywords

19 NOR 2ALPHA (3 HYDROXYPROPYL) 1ALPHA,25 DIHYDROXYVITAMIN D3; ANTINEOPLASTIC AGENT; CALCITRIOL; CASPASE 3; PROTEIN P21; PROTEIN P27; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL COUNT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER CANCER; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CHOLECALCIFEROL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; VITAMIN D;

ANIMALIA;

EID: 80053568935     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.08.006     Document Type: Article

References (58)

1. D.M. Parkin, F.I. Bray, and S.S. Devesa Cancer burden in the year 2000. The global picture Eur J Cancer 37 8 2001 S4 S66
2. J.M. Llovet, A. Burroughs, and J. Bruix Hepatocellular carcinoma Lancet 362 2003 1907 1917 (Pubitemid 37518510)
3. J. Bruix, A. Castells, J. Bosch, F. Feu, J. Fuster, J.C. Garcia-Pagan, J. Visa, C. Bru, and J. Rodes Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure Gastroenterology 111 1996 1018 1022 (Pubitemid 26327605)
4. J.M. Llovet, J. Fuster, and J. Bruix Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation Hepatology 30 1999 1434 1440
5. J.M. Llovet, and J. Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival Hepatology 37 2003 429 442 (Pubitemid 36152543)
6. J.M. Llovet, J. Bustamante, A. Castells, R. Vilana, C. Ayuso Mdel, M. Sala, C. Bru, J. Rodes, and J. Bruix Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials Hepatology 29 1999 62 67 (Pubitemid 29023987)
7. J.D. Schwartz, M. Schwartz, J. Mandeli, and M. Sung Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: review of the randomised clinical trials Lancet Oncol 3 2002 593 603 (Pubitemid 35174678)
8. A. Villanueva, P. Newell, D.Y. Chiang, S.L. Friedman, and J.M. Llovet Genomics and signaling pathways in hepatocellular carcinoma Semin Liver Dis 27 2007 55 76
9. J.M. Llovet, S. Ricci, V. Mazzaferro, P. Hilgard, E. Gane, J.F. Blanc, A.C. de Oliveira, A. Santoro, J.L. Raoul, A. Forner, M. Schwartz, C. Porta, S. Zeuzem, L. Bolondi, T.F. Greten, P.R. Galle, J.F. Seitz, I. Borbath, D. Haussinger, T. Giannaris, M. Shan, M. Moscovici, D. Voliotis, and J. Bruix Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
10. J.M. Llovet, and J. Bruix Molecular targeted therapies in hepatocellular carcinoma Hepatology 48 2008 1312 1327
11. H. Tanaka, E. Abe, C. Miyaura, T. Kuribayashi, K. Konno, Y. Nishii, and T. Suda 1Alpha,25-dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60) Biochem J 204 1982 713 719
12. T.C. Chen, and M.F. Holick Vitamin D and prostate cancer prevention and treatment Trends Endocrinol Metab 14 2003 423 430 (Pubitemid 37392215)
13. L.V. Stewart, and N.L. Weigel Vitamin D and prostate cancer Exp Biol Med Maywood 22 2004 277 284 (Pubitemid 38372891)
14. 3 in human colon cancer cells Anticancer Res. 26 2006 2669 2681 (Pubitemid 44155548)
15. K.W. Colston, L.C. Lowe, J.L. Mansi, and M.J. Campbell Vitamin D status and breast cancer risk Anticancer Res 26 2006 2573 2580 (Pubitemid 44155537)
16. X. Zhang, S.V. Nicosia, and W. Bai Vitamin D receptor is a novel drug target for ovarian cancer treatment Curr Cancer Drug Targets 6 2006 229 244 (Pubitemid 43764742)
17. S. Kawa, T. Nikaido, Y. Aoki, Y. Zhai, T. Kumagai, K. Furihata, S. Fujii, and K. Kiyosawa Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines Br J Cancer 76 1997 884 889 (Pubitemid 27401939)
18. K.C. Chiang, and T.C. Chen Vitamin D for the prevention and treatment of pancreatic cancer World J Gastroenterol 15 2009 3349 3354
19. Z. Ghous, J. Akhter, M.H. Pourgholami, and D.L. Morris Inhibition of hepatocellular cancer by EB1089: in vitro and in vivo study Anticancer Res 28 2008 3757 3761
20. 3 on liver cancer cells Anticancer Res 29 2009 3591 3596
21. R. Bouillon, A. Verstuyf, L. Verlinden, K. Allewaert, D. Branisteanu, C. Mathieu, and H. van Baelen Non-hypercalcemic pharmacological aspects of vitamin D analogs Biochem Pharmacol 50 1995 577 583
22. K.Z. Guyton, T.W. Kensler, and G.H. Posner Cancer chemoprevention using natural vitamin D and synthetic analogs Annu Rev Pharmacol Toxicol 41 2001 421 442 (Pubitemid 32385894)
23. J. Akhter, Y. Lu, I. Finlay, M.H. Pourgholami, and D.L. Morris 1alpha,25-Dihydroxyvitamin D3 and its analogues, EB1089 and CB1093, profoundly inhibit the in vitro proliferation of the human hepatoblastoma cell line HepG2 ANZ J Surg 71 2001 414 417
24. K. Ono, A. Yoshida, N. Saito, T. Fujishima, S. Honzawa, Y. Suhara, S. Kishimoto, T. Sugiura, K. Waku, H. Takayama, and A. Kittaka Efficient synthesis of 2-modified 1alpha,25-dihydroxy-19-norvitamin D3 with Julia olefination: high potency in induction of differentiation on HL-60 cells J Org Chem 68 2003 7407 7415 (Pubitemid 37122492)
25. 3 as a therapeutic agent for androgen-dependent prostate cancer Anticancer Res 29 2009 3547 3553
26. 3 analogs as therapeutic agents for prostate cancer J Steroid Biochem Mol Biol 103 2007 717 720 (Pubitemid 46401314)
27. 2 as therapeutic agents for prostate cancer Clin Cancer Res 6 2000 901 908 (Pubitemid 30159347)
28. 3 are potentiated by epidermal growth factor and attenuated by insulin in cultured human keratinocytes J Invest Dermatol 104 1995 113 117
29. W. Ouyang, Q. Ma, J. Li, D. Zhang, Z.G. Liu, A.K. Rustgi, and C. Huang Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes Cancer Res 65 2005 9287 9293 (Pubitemid 41507995)
30. I. Vermes, C. Haanen, and C. Reutelingsperger Flow cytometry of apoptotic cell death J Immunol Methods 243 2000 167 190
31. E. Jaruga, S. Salvioli, J. Dobrucki, S. Chrul, J. Bandorowicz-Pikula, E. Sikora, C. Franceschi, A. Cossarizza, and G. Bartosz Apoptosis-like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes FEBS Lett 433 1998 287 293 (Pubitemid 128369980)
32. A. Chawla, J.J. Repa, R.M. Evans, and D.J. Mangelsdorf Nuclear receptors and lipid physiology: opening the X-files Science 294 2001 1866 1870 (Pubitemid 33101573)
33. R.M. Evans The steroid and thyroid hormone receptor superfamily Science 240 1988 889 895
34. M.J. Tsai, and B.W. O'Malley Molecular mechanisms of action of steroid/thyroid receptor superfamily members Annu Rev Biochem 63 1994 451 486 (Pubitemid 24218640)
35. 3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid Science 206 1979 1188 1190 (Pubitemid 10159658)
36. A.W. Norman From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health Am J Clin Nutr 88 2008 491S 499S
37. 2 (paricalcitol) in advanced, androgen-insensitive prostate cancer Clin Cancer Res 11 2005 8680 8685 (Pubitemid 43005917)
38. T. Gulliford, J. English, K.W. Colston, P. Menday, S. Moller, and R.C. Coombes A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer Br J Cancer 78 1998 6 13 (Pubitemid 28276762)
39. T.R. Evans, K.W. Colston, F.J. Lofts, D. Cunningham, D.A. Anthoney, H. Gogas, J.S. de Bono, K.J. Hamberg, T. Skov, and J.L. Mansi A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer Br J Cancer 86 2002 680 685 (Pubitemid 34250805)
40. 3 for liver cancers J Gastroenterol Hepatol 16 2001 333 337 (Pubitemid 32374851)
41. K. Dalhoff, J. Dancey, L. Astrup, T. Skovsgaard, K.J. Hamberg, F.J. Lofts, O. Rosmorduc, S. Erlinger, J. Bach Hansen, W.P. Steward, T. Skov, F. Burcharth, and T.R. Evans A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma Br J Cancer 89 2003 252 257 (Pubitemid 36976311)
42. 3. A novel vitamin D-related compound with potential therapeutic activity Tetrahedron Lett 31 1990 1823 1824 (Pubitemid 20106899)
43. K.L. Perman, R.E. Swenson, H.E. Paaren, H.K. Schnoes, and H.F. DeLuca Novel synthesis of 19-nor-vitamin D compounds Tetrahedron Lett 32 1991 7663 7666
44. 2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia Am J Kidney Dis 26 1995 852 860
45. 2 Am J Kidney Dis 32 1998 S48 S54
46. R.R. Sicinski, P. Rotkiewicz, A. Kolinski, W. Sicinska, J.M. Prahl, C.M. Smith, and H.F. DeLuca 2-Ethyl and 2-ethylidene analogues of 1alpha,25-dihydroxy-19-norvitamin D(3): synthesis, conformational analysis, biological activities, and docking to the modeled rVDR ligand binding domain J Med Chem 45 2002 3366 3380 (Pubitemid 34824025)
47. 3 with selected 2 alpha-substituted analogues J Med Chem 49 2006 5199 5205 (Pubitemid 44260215)
48. J.T. Powers, S. Hong, C.N. Mayhew, P.M. Rogers, E.S. Knudsen, and D.G. Johnson E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis Mol Cancer Res 2 2004 203 214 (Pubitemid 39031081)
49. A. Krtolica, N.A. Krucher, and J.W. Ludlow Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities Oncogene 17 1998 2295 2304 (Pubitemid 28515382)
50. W. Luo, Y. Chen, M. Liu, K. Du, G. Zheng, T. Cai, W. Zhang, F. Zhao, T. Yao, R. Yang, and J. Chen EB1089 induces Skp2-dependent p27 accumulation, leading to cell growth inhibition and cell cycle G1 phase arrest in human hepatoma cells Cancer Invest 27 2009 29 37
51. E.S. Yang, and K.L. Burnstein Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm J Biol Chem 278 2003 46862 46868 (Pubitemid 37452267)
52. E.S. Yang, C.A. Maiorino, B.A. Roos, S.R. Knight, and K.L. Burnstein Vitamin D-mediated growth inhibition of an androgen-ablated LNCaP cell line model of human prostate cancer Mol Cell Endocrinol 186 2002 69 79 (Pubitemid 34189780)
53. O. Flores, Z. Wang, K.E. Knudsen, and K.L. Burnstein Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition Endocrinology 151 2010 896 908
54. T. Ylikomi, I. Laaksi, Y.R. Lou, P. Martikainen, S. Miettinen, P. Pennanen, S. Purmonen, H. Syvala, A. Vienonen, and P. Tuohimaa Antiproliferative action of vitamin D Vitam Horm 64 2002 357 406 (Pubitemid 135763169)
55. 3 analog, ILX-23-7553, enhances the response to adriamycin and irradiation in MCF-7 breast tumor cells Cancer Chemother Pharmacol 47 2001 429 436 (Pubitemid 32397620)
56. A.M. Gown, and M.C. Willingham Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3 J Histochem Cytochem 50 2002 449 454 (Pubitemid 34250583)
57. W.R. Duan, D.S. Garner, S.D. Williams, C.L. Funckes-Shippy, I.S. Spath, and E.A. Blomme Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts J Pathol 199 2003 221 228 (Pubitemid 36176028)
58. A.R. Resendes, N. Majo, J. Segales, E. Mateu, M. Calsamiglia, and M. Domingo Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2 J Gen Virol 85 2004 2837 2844 (Pubitemid 39360026)