Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D 3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 127, Issue 3-5, 2011, Pages 269-275

  Iglesias Gato, Diego ^a   Zheng, Shasha ^b   Flanagan, John N ^a   Jiang, Lan ^b   Kittaka, Atsushi ^c   Sakaki, Toshiyuki ^d   Yamamoto, Keiko ^e   Itoh, Toshimasa ^e   Lebrasseur, Nathan K ^b   Norstedt, Gunnar ^a   Chen, Tai C ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TEIKYO UNIVERSITY   (Japan)

^d TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^e SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Invasion; PC 3; Proliferation; Prostate cancer; Vitamin D analogue

Indexed keywords

19 NOR 2ALPHA (3 HYDROXYPROPYL) 1ALPHA,25 DIHYDROXYVITAMIN D3; CALCITRIOL; CALCIUM; GELATINASE B; MART 10; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM BLOOD LEVEL; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; GENE EXPRESSION; MALE; MOLECULAR DOCKING; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; RAT;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CALCITRIOL; CARBON; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYLATION; MALE; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; STEROID HYDROXYLASES;

HUMAN PAPILLOMAVIRUS; RATTUS;

EID: 81255142150     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.08.010     Document Type: Article

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