메뉴 건너뛰기




Volumn 65, Issue 4, 2013, Pages 854-862

Differential effects of LY294002 and Wortmannin on neurons and vascular endothelial cells in the rat retina

Author keywords

Excitotoxicity; Glutamate; Phosphatidylinositol 3 kinase (PI3K) Akt signaling pathway; Retinal blood vessel; Retinal neuron

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; N METHYL DEXTRO ASPARTIC ACID; WORTMANNIN;

EID: 84886510606     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(13)71066-1     Document Type: Article
Times cited : (10)

References (39)
  • 3
    • 0346753579 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocytederived cell line H9c2
    • Aki T, Yamaguchi K, Fujimiya T, Mizukami Y: Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocytederived cell line H9c2. Oncogene, 2003, 22, 8529-8535.
    • (2003) Oncogene , vol.22 , pp. 8529-8535
    • Aki, T.1    Yamaguchi, K.2    Fujimiya, T.3    Mizukami, Y.4
  • 4
    • 77956525896 scopus 로고    scopus 로고
    • Neurovascular protective effect of FeTPPs in N-methyl-D-Aspartate model: Similarities to diabetes
    • Al-Gayyar MM, Abdelsaid MA, Matragoon S, Pillai BA, El-Remessy AB: Neurovascular protective effect of FeTPPs in N-methyl-D-Aspartate model: similarities to diabetes. Am J Pathol, 2010, 177, 1187-1197.
    • (2010) Am J Pathol , vol.177 , pp. 1187-1197
    • Al-Gayyar, M.M.1    Abdelsaid, M.A.2    Matragoon, S.3    Pillai, B.A.4    El-Remessy, A.B.5
  • 5
    • 0030987654 scopus 로고    scopus 로고
    • Elevated g-Aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with pro- liferative diabetic retinopathy
    • Ambati J, Chalam KV, Chawla DK, D'Angio CT, Guillet EG, Rose SJ, Vanderlinde RE, Ambati BK: Elevated g-Aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with pro- liferative diabetic retinopathy. Arch Ophthalmol, 1997, 115, 1161-1166.
    • (1997) Arch Ophthalmol , vol.115 , pp. 1161-1166
    • Ambati, J.1    Chalam, K.V.2    Chawla, D.K.3    D'angio, C.T.4    Guillet, E.G.5    Rose, S.J.6    Vanderlinde, R.E.7    Ambati, B.K.8
  • 6
    • 81855161724 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kB inhibition, in a PI3K-independent mechanism
    • Avni D, Glucksam Y, Zor T: The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kB inhibition, in a PI3K-independent mechanism. Biochem Pharmacol, 2012, 83, 106-114.
    • (2012) Biochem Pharmacol , vol.83 , pp. 106-114
    • Avni, D.1    Glucksam, Y.2    Zor, T.3
  • 7
    • 0035369623 scopus 로고    scopus 로고
    • Transcriptiondependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway
    • Brunet A, Datta SR, Greenberg ME: Transcriptiondependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol, 2001, 11, 297-305.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 8
    • 0036172927 scopus 로고    scopus 로고
    • Phosphoinositol 3 kinase inhibitor LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells
    • Carbott DE, Duan L, Davis MA: Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. Apoptosis, 2002, 69-76.
    • (2002) Apoptosis , pp. 69-76
    • Carbott, D.E.1    Duan, L.2    Davis, M.A.3
  • 9
    • 0032788544 scopus 로고    scopus 로고
    • The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt
    • Crowder RJ, Freeman RS: The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt. J Neurochem, 1999, 73, 466-475.
    • (1999) J Neurochem , vol.73 , pp. 466-475
    • Crowder, R.J.1    Freeman, R.S.2
  • 12
  • 17
    • 41949089610 scopus 로고    scopus 로고
    • Differential roles of phosphatidylinositol 3-kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension
    • Huang Y, Cen LP, Luo JM, Wang N, Zhang MZ, van Rooijen N, Pang CP, Cui Q: Differential roles of phosphatidylinositol 3-kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension. Neuroscience, 2008, 153, 214-225.
    • (2008) Neuroscience , vol.153 , pp. 214-225
    • Huang, Y.1    Cen, L.P.2    Luo, J.M.3    Wang, N.4    Zhang, M.Z.5    Van Rooijen, N.6    Pang, C.P.7    Cui, Q.8
  • 19
    • 0033775701 scopus 로고    scopus 로고
    • N-methyl-D-Aspartate (NMDA) induced apoptosis in adult rabbit retinas
    • Kwong JM, Lam TT: N-methyl-D-Aspartate (NMDA) induced apoptosis in adult rabbit retinas. Exp Eye Res, 2000, 71, 437-444.
    • (2000) Exp Eye Res , vol.71 , pp. 437-444
    • Kwong, J.M.1    Lam, T.T.2
  • 21
    • 0030896545 scopus 로고    scopus 로고
    • Ameliorative effect of MK-801 on retinal ischemia
    • Lam TT, Siew E, Chu R, Tso MO: Ameliorative effect of MK-801 on retinal ischemia. J Ocul Pharmacol Ther, 1997, 13, 129-137.
    • (1997) J Ocul Pharmacol Ther , vol.13 , pp. 129-137
    • Lam, T.T.1    Siew, E.2    Chu, R.3    Tso, M.O.4
  • 22
    • 34548024202 scopus 로고    scopus 로고
    • PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury
    • Luo JM, Cen LP, Zhang XM, Chiang SW, Huang Y, Lin D, Fan YM et al.: PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury. Eur J Neurosci, 2007, 26, 828-842.
    • (2007) Eur J Neurosci , vol.26 , pp. 828-842
    • Luo, J.M.1    Cen, L.P.2    Zhang, X.M.3    Chiang, S.W.4    Huang, Y.5    Lin, D.6    Fan, Y.M.7
  • 23
    • 0037250472 scopus 로고    scopus 로고
    • Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina
    • Manabe S, Lipton SA: Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina. Invest Ophthalmol Vis Sci, 2003, 44, 385-392.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 385-392
    • Manabe, S.1    Lipton, S.A.2
  • 24
    • 67651102918 scopus 로고    scopus 로고
    • The prostanoid EP2 receptor agonist ONO-AE1-259-01 protects against glutamateinduced neurotoxicity in rat retina
    • Mori A, Ishii T, Kuroki T, Shigeta N, Sakamoto K, Nakahara T, Ishii K: The prostanoid EP2 receptor agonist ONO-AE1-259-01 protects against glutamateinduced neurotoxicity in rat retina. Eur J Pharmacol, 2009, 616, 64-67.
    • (2009) Eur J Pharmacol , vol.616 , pp. 64-67
    • Mori, A.1    Ishii, T.2    Kuroki, T.3    Shigeta, N.4    Sakamoto, K.5    Nakahara, T.6    Ishii, K.7
  • 25
    • 29644446632 scopus 로고    scopus 로고
    • N-Methyl-D-Aspartic acid suppresses Akt activity through protein phosphatase in retinal ganglion cells
    • Nakazawa T, Shimura M, Endo S, Takahashi H, Mori N, Tamai M: N-Methyl-D-Aspartic acid suppresses Akt activity through protein phosphatase in retinal ganglion cells. Mol Vis, 2005, 11, 1173-1182.
    • (2005) Mol Vis , vol.11 , pp. 1173-1182
    • Nakazawa, T.1    Shimura, M.2    Endo, S.3    Takahashi, H.4    Mori, N.5    Tamai, M.6
  • 26
    • 0042266463 scopus 로고    scopus 로고
    • Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury
    • Nakazawa T, Shimura M, Tomita H, Akiyama H, Yoshioka Y, Kudou H, Tamai M: Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury. Curr Eye Res, 2003, 26, 55-63.
    • (2003) Curr Eye Res , vol.26 , pp. 55-63
    • Nakazawa, T.1    Shimura, M.2    Tomita, H.3    Akiyama, H.4    Yoshioka, Y.5    Kudou, H.6    Tamai, M.7
  • 28
    • 3242688018 scopus 로고    scopus 로고
    • Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats
    • Ng YK, Zeng XX, Ling EA: Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats. Brain Res, 2004, 1018, 66-72.
    • (2004) Brain Res , vol.1018 , pp. 66-72
    • Ng, Y.K.1    Zeng, X.X.2    Ling, E.A.3
  • 29
    • 26444562936 scopus 로고    scopus 로고
    • Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat
    • Nucci C, Tartaglione R, Rombolà L, Morrone LA, Fazzi E, Bagetta G: Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat. Neurotoxicology, 2005, 26, 935-941.
    • (2005) Neurotoxicology , vol.26 , pp. 935-941
    • Nucci, C.1    Tartaglione, R.2    Rombolà, L.3    Morrone, L.A.4    Fazzi, E.5    Bagetta, G.6
  • 30
    • 10044292873 scopus 로고    scopus 로고
    • Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells
    • Park K, Luo JM, Hisheh S, Harvey AR, Cui Q: Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J Neurosci, 2004, 24, 10806-10815.
    • (2004) J Neurosci , vol.24 , pp. 10806-10815
    • Park, K.1    Luo, J.M.2    Hisheh, S.3    Harvey, A.R.4    Cui, Q.5
  • 33
    • 0033018576 scopus 로고    scopus 로고
    • Ocular blood flow and associated functional deviations in diabetic retinopathy
    • Schmetterer L, Wolzt M: Ocular blood flow and associated functional deviations in diabetic retinopathy. Diabetologia, 1999, 42, 387-405.
    • (1999) Diabetologia , vol.42 , pp. 387-405
    • Schmetterer, L.1    Wolzt, M.2
  • 34
    • 77957242117 scopus 로고    scopus 로고
    • Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration
    • Ueda K, Nakahara T, Hoshino M, Mori A, Sakamoto K, Ishii K: Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration. Neurosci Lett, 2010, 485, 55-59.
    • (2010) Neurosci Lett , vol.485 , pp. 55-59
    • Ueda, K.1    Nakahara, T.2    Hoshino, M.3    Mori, A.4    Sakamoto, K.5    Ishii, K.6
  • 35
    • 84871972269 scopus 로고    scopus 로고
    • Protective effects of TGF-b inhibitors in a rat model of NMDA-induced retinal degeneration
    • Ueda K, Nakahara T, Mori A, Sakamoto K, Ishii K: Protective effects of TGF-b inhibitors in a rat model of NMDA-induced retinal degeneration. Eur J Pharmacol, 2013, 699, 188-193.
    • (2013) Eur J Pharmacol , vol.699 , pp. 188-193
    • Ueda, K.1    Nakahara, T.2    Mori, A.3    Sakamoto, K.4    Ishii, K.5
  • 36
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)- 8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ, Matter WF, Hui KY, Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)- 8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem, 1994, 269, 5241-5248.
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 37
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
    • Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL: Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell, 2000, 6, 909-919.
    • (2000) Mol Cell , vol.6 , pp. 909-919
    • Walker, E.H.1    Pacold, M.E.2    Perisic, O.3    Stephens, L.4    Hawkins, P.T.5    Wymann, M.P.6    Williams, R.L.7
  • 38
    • 0035069801 scopus 로고    scopus 로고
    • Mechanism by which wortmannin and LY294002 inhibit catecholamine secretion in the rat adrenal medullary cells
    • Warashina A: Mechanism by which wortmannin and LY294002 inhibit catecholamine secretion in the rat adrenal medullary cells. Cell Calcium, 2001, 29, 239-247.
    • (2001) Cell Calcium , vol.29 , pp. 239-247
    • Warashina, A.1
  • 39
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol- 3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao R, Cooper GM: Requirement for phosphatidylinositol- 3 kinase in the prevention of apoptosis by nerve growth factor. Science, 1995, 267, 2003-2006
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.