Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration

European Journal of Pharmacology

Volumn 699, Issue 1-3, 2013, Pages 188-193

  Ueda, Kaori ^a   Nakahara, Tsutomu ^a   Mori, Asami ^a   Sakamoto, Kenji ^a   Ishii, Kunio ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Endothelial cell; Excitotoxicity; Retinal blood vessel; Retinal degeneration; Transforming growth factor

Indexed keywords

4 [3 (2 PYRIDINYL) 1H PYRAZOL 4 L]QUINOLINE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; CYTOKINE RECEPTOR ANTAGONIST; LY 364947; N METHYL DEXTRO ASPARTIC ACID; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA CAPILLARY; RETINA DEGENERATION; RETINA GANGLION CELL; RETINA NERVE CELL; SIGNAL TRANSDUCTION;

ANIMALS; BENZAMIDES; CAPILLARIES; DIOXOLES; DISEASE MODELS, ANIMAL; INTRAVITREAL INJECTIONS; MALE; N-METHYLASPARTATE; PYRAZOLES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RETINAL DISEASES; RETINAL GANGLION CELLS; RETINAL VESSELS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84871972269     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.11.054     Document Type: Article

References (39)

1. M.M. Al-Gayyar, M.A. Abdelsaid, S. Matragoon, B.A. Pillai, and A.B. El-Remessy Neurovascular protective effect of FeTPPs in N-methyl-d-aspartate model: similarities to diabetes Am. J. Pathol. 177 2010 1187 1197
2. J. Ambati, K.V. Chalam, D.K Chawla, C.T. D'Angio, E.G. Guillet, S.J. Rose, R.E. Vanderlinde, and B.K. Ambati Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy Arch. Ophthalmol. 115 1997 1161 1166
3. C. Bucolo, G.M. Leggio, F. Drago, and S. Salomone Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats Biochem. Pharmacol. 84 2012 88 92
4. Bucolo, C., Salomone, S., Drago, F., Reibaldi, M., Longo, A., Uva, M.G., 2013. Pharmacological management of ocular hypertension: current approaches and future prospective. Curr. Opin. Pharmacol. 13, 50-55.
5. S.E. Bursell, A.C. Clermont, T. Shiba, and G.L. King Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats Curr. Eye Res. 11 1992 287 295
6. A.C. Clermont, and S.E. Bursell Retinal blood flow in diabetes Microcirculation 14 2007 49 61
7. O. Dkhissi, E. Chanut, M. Wasowicz, M. Savoldelli, J. Nguyen-Legros, F. Minvielle, and C. Versaux-Botteri Retinal TUNEL-positive cells and high glutamate levels in vitreous humor of mutant quail with a glaucoma-like disorder Invest. Ophthalmol. Vis. Sci. 40 1999 990 995
8. E.B. Dreyer, D. Zurakowski, R.A. Schumer, S.M. Podos, and S.A. Lipton Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma Arch. Ophthalmol. 114 1996 299 305
9. J. Flammer, I.O. Haefliger, S. Orgül, and T. Resink Vascular dysregulation: a principal risk factor for glaucomatous damage? J. Glaucoma 8 1999 212 219
10. A.G. Franke, C. Gubbe, M. Beier, and N. Duenker Transforming growth factor-beta and bone morphogenetic proteins: cooperative players in chick and murine programmed retinal cell death J. Comp. Neurol. 495 2006 263 278
11. C. Gerhardinger, Z. Dagher, P. Sebastiani, Y.S. Park, and M. Lorenzi The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy Diabetes 58 2009 1659 1667
12. M.J. Goumans, Z. Liu, and P. ten Dijke TGF-beta signaling in vascular biology and dysfunction Cell Res. 19 2009 116 127
13. M.R. Hernandez, H. Miao, and T. Lukas Astrocytes in glaucomatous optic neuropathy Prog. Brain Res. 173 2008 353 373
14. S. Hughes, and T. Chan-Ling Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo Invest. Ophthalmol. Vis. Sci. 45 2004 2795 2806
15. G.J. Inman, F.J. Nicolás, J.F. Callahan, J.D. Harling, L.M. Gaster, A.D. Reith, N.J. Laping, and C.S. Hill SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 Mol. Pharmacol. 62 2002 65 74
16. Y. Izumi, S.B. Hammerman, C.O. Kirby, A.M. Benz, J.W. Olney, and C.F. Zorumski Involvement of glutamate in ischemic neurodegeneration in isolated retina Vis. Neurosci. 20 2003 97 107
17. T.T. Lam, A.S. Abler, J.M. Kwong, and M.O. Tso N-methyl-d-aspartate (NMDA)-induced apoptosis in rat retina Invest. Ophthalmol. Vis. Sci. 40 1999 2391 2397
18. T.T. Lam, E. Siew, R. Chu, and M.O. Tso Ameliorative effect of MK-801 on retinal ischemia J. Ocul. Pharmacol. Ther. 13 1997 129 137
19. N.J. Laping, E. Grygielko, A. Mathur, S. Butter, J. Bomberger, C. Tweed, W. Martin, J. Fornwald, R. Lehr, J. Harling, L. Gaster, J.F. Callahan, and B.A. Olson Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542 Mol. Pharmacol. 62 2002 58 64
20. A. Mori, T. Ishii, T. Kuroki, N. Shigeta, K. Sakamoto, T. Nakahara, and K. Ishii The prostanoid EP2 receptor agonist ONO-AE1-259-01 protects against glutamate-induced neurotoxicity in rat retina Eur. J. Pharmacol. 616 2009 64 67
21. Y.K. Ng, X.X. Zeng, and E.A. Ling Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats Brain Res. 1018 2004 66 72
22. C. Nucci, R. Tartaglione, L. Rombolà, L.A. Morrone, E. Fazzi, and G. Bagetta Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat Neurotoxicology 26 2005 935 941
23. H. Obata, Y. Kaji, H. Yamada, M. Kato, T. Tsuru, and H. Yamashita Expression of transforming growth factor-beta superfamily receptors in rat eyes Acta. Ophthalmol. Scand. 77 1999 151 156
24. N. Ogata, C. Yamamoto, M. Miyashiro, H. Yamada, M. Matsushima, and M. Uyama Expression of transforming growth factor-beta mRNA in experimental choroidal neovascularization Curr. Eye Res. 16 1997 9 18
25. E. Pardali, M.J. Goumans, and P. ten Dijke Signaling by members of the TGF-beta family in vascular morphogenesis and disease Trends Cell Biol. 20 2010 556 567
26. M.S. Pepper Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity Cytokine Growth Factor Rev. 8 1997 21 43
27. J.E. Pulido, J.S. Pulido, J.C. Erie, J. Arroyo, K. Bertram, M.J. Lu, and S.A. Shippy A role for excitatory amino acids in diabetic eye disease Exp. Diabetes Res. 2007 2007 36150
28. J.S. Sawyer, B.D. Anderson, D.W. Beight, R.M. Campbell, M.L. Jones, D.K. Herron, J.W. Lampe, J.R. McCowan, W.T. McMillen, N. Mort, S. Parsons, E.C. Smith, M. Vieth, L.C. Weir, L. Yan, F. Zhang, and J.M. Yingling Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain J. Med. Chem. 46 2003 3953 3956
29. R. Siliprandi, R. Canella, G. Carmignoto, N. Schiavo, A. Zanellato, R. Zanoni, and G. Vantini N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina Vis. Neurosci. 8 1992 567 573
30. Q. Sun, V.E. Ooi, and S.O. Chan N-methyl-d-aspartate-induced excitotoxicity in adult rat retina is antagonized by single systemic injection of MK-801 Exp. Brain Res. 138 2001 37 45
31. P. ten Dijke, and H.M. Arthur Extracellular control of TGFbeta signalling in vascular development and disease Nat. Rev. Mol. Cell Biol. 8 2007 857 869
32. K. Ueda, T. Nakahara, M. Hoshino, A. Mori, K. Sakamoto, and K. Ishii Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration Neurosci. Lett. 485 2010 55 59
33. R.J. Van Geest, I. Klaassen, I.M. Vogels, C.J. Van Noorden, and R.O. Schlingemann Differential TGF-β signaling in retinal vascular cells: a role in diabetic retinopathy? Invest. Ophthalmol. Vis. Sci. 51 2010 1857 1865
34. S.T. Venkataraman, J.G. Flanagan, and C. Hudson Vascular reactivity of optic nerve head and retinal blood vessels in glaucoma - a review Microcirculation 17 2010 568 581
35. T.E. Walshe, L.L. Leach, and P.A. D'Amore TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival Neuroscience 189 2011 123 131
36. T.E. Walshe, M. Saint-Geniez, A.S. Maharaj, E. Sekiyama, A.E. Maldonado, and P.A. D'Amore TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature PLoS One 4 2009 e5149
37. R. Yamanaka, N. Ogata, C. Yamamoto, M. Matsushita, K. Matsuzaki, M. Uyama, and M. Matsumura Expression of transforming growth factor-beta receptors in normal rat retina and experimental choroidal neovascularization Jpn. J. Ophthalmol. 46 2002 525 532
38. L. Yuan, and A.H. Neufeld Activated microglia in the human glaucomatous optic nerve head J. Neurosci. Res. 64 2001 523 532
39. L. Zheng, B. Gong, D.A. Hatala, and T.S. Kern Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes Invest. Ophthalmol. Vis. Sci. 48 2007 361 367