Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis

Apoptosis

Volumn 18, Issue 11, 2013, Pages 1426-1436

  Amaral, Cristina ^a,b   Varela, Carla ^c   Borges, Margarida ^a,b   Tavares Da Silva, Elisiário ^c   Roleira, Fernanda M F ^c   Correia Da Silva, Georgina ^a,b   Teixeira, Natércia ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Apoptosis; Cell cycle; Cell death; Cell proliferation; ER positive aromatase overexpressing breast cancer cell line; Hormone dependent breast cancer; Steroidal aromatase inhibitors

Indexed keywords

3BETA HYDROXYANDROST 4 EN 17 ONE; 4ALPHA,5ALPHA EPOXYANDROSTAN 17 ONE; 5ALPHA ANDROST 2 EN 17 ONE; ANDROGEN; ANDROST 4 EN 17 ONE; AROMATASE INHIBITOR; CASPASE 7; CASPASE 8; CASPASE 9; ESTROGEN; ESTROGEN RECEPTOR; REACTIVE OXYGEN METABOLITE; STEROIDAL AROMATASE INHIBITOR; TAMOXIFEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CATALYSIS; CELL CYCLE; CELL CYCLE ARREST; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; HORMONE DEPENDENT BREAST CANCER; HUMAN; HUMAN CELL; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL;

ANDROSTENES; ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; AROMATASE INHIBITORS; BREAST NEOPLASMS; CASPASE 8; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOCHONDRIA; NEOPLASMS, HORMONE-DEPENDENT; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886434710     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0879-6     Document Type: Article

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