New structure-activity relationships of A-and D-ring modified steroidal aromatase inhibitors: Design, synthesis, and biochemical evaluation

Journal of Medicinal Chemistry

Volumn 55, Issue 8, 2012, Pages 3992-4002

  Varela, Carla ^a   Tavares Da Silva, Elisiário J ^a   Amaral, Cristina ^b,c   Correia Da Silva, Georgina ^b,c   Baptista, Teresa ^a   Alcaro, Stefano ^d   Costa, Giosuè ^d   Carvalho, Rui A ^e   Teixeira, Natércia A A ^b,c   Roleira, Fernanda M F ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 EPOXIDE; 4,5 OLEFIN; ALKENE DERIVATIVE; ANDROSTENEDIONE DERIVATIVE; AROMATASE INHIBITOR; CARBONYL DERIVATIVE; EPOXIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITORS; BINDING SITES; EPOXY COMPOUNDS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MICROSOMES; MODELS, MOLECULAR; PLACENTA; PREGNANCY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860267099     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300262w     Document Type: Article

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